JP2012527967A - 薬物を経皮送達する方法及び装置 - Google Patents
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/84—Drainage tubes; Aspiration tips
- A61M1/87—Details of the aspiration tip, not otherwise provided for
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
-
- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/368—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/04—Skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
- A61N5/0617—Hair treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
Abstract
Description
本願は、2009年5月26日に出願された米国仮特許出願第61/181,228号の優先権を主張し、その開示は、その全体が、参照により本明細書に組み込まれている。
Claims (30)
- 皮膚組織の表面に接触するように構成されているハウジング;
ハウジングの下部表面に設けられた少なくとも1つの開口部;
高圧下で少なくとも1つの開口部を通って皮膚組織へ薬物を送達するように構成され、ハウジング内に設けられた送達器具;及び
少なくとも1つの開口部の少なくとも一部の近くの少なくとも1つの低圧チャネル:
を含有してなり、
そこでは低圧チャネルは、減少した圧力が低圧チャネルに提供されると、少なくとも1つの開口部を皮膚組織の表面に対して位置決めするように構成されている、
皮膚組織へ薬物を送達するための装置。 - 装置が、皮膚組織の表面に沿って平行移動するように構成されている、請求項1に記載の装置。
- 少なくとも1つの低圧チャネルが、さらに皮膚組織に送達された薬物の一部を回収するように構成されている、請求項1又は2の何れか一項に記載の装置。
- 装置の下部表面が皮膚組織の表面に接触していないときに、薬物の送達を防止するように構成されている送達制御器具をさらに含有してなる、請求項1〜3の何れか一項に記載の装置。
- 下部表面に沿って低圧チャネルの少なくとも一部の近くに高圧チャネルをさらに含有してなり、そこでは高圧チャネルは、減少した圧力が低圧チャネルに提供されるときに、装置が皮膚上を平行移動することを容易にするように構成されている、請求項1〜4の何れか一項に記載の装置。
- 高圧チャネル内の圧力が、変動されるか又はパルス化されるかの少なくとも一方であるように構成されている、請求項5に記載の装置。
- 送達器具又は低圧チャネルの少なくとも一方の圧力が、変動されるか又はパルス化されるかの少なくとも一方であるよう構成されている、請求項1〜6の何れか一項に記載の装置。
- 下部表面の少なくとも一部に熱接触して設けられている加熱器具をさらに含有してなる、請求項1〜7の何れか一項に記載の装置。
- 少なくとも1つの低圧チャネルが、皮膚に存在する皮脂又は懐死組織片の少なくとも1つを除去するように構成されている、請求項1〜8の何れか一項に記載の装置。
- ハウジングに機械的に連結された振動器具をさらに含有してなり、そこでは振動器具は、装置が皮膚表面上を平行移動することを容易にするか、又は皮膚に存在する皮脂及び/又は懐死組織片の除去を容易にするか、の少なくとも一方であるように構成されている、請求項1〜9の何れか一項に記載の装置。
- 薬物が、光線力学療法に使用できる光増感剤又は光増感剤前駆物質の少なくとも1つである、請求項1〜10の何れか一項に記載の装置。
- 薬物が、育毛に影響を与えることができる治療剤である、請求項1〜10の何れか一項に記載の装置。
- 薬物が、にきびを治療するために使用できる治療剤である、請求項1〜10の何れか一項に記載の装置。
- 高い圧力下で、基板の少なくとも1つの開口部を通って皮膚組織へ薬物を送達すること;及び
少なくとも1つの開口部の少なくとも一部の近くに基板の下部表面に沿って少なくとも1つの低圧チャネルを提供することを含有してなり、
そこでは低圧チャネルは、減少した圧力が低圧チャネルに提供されるときに、皮膚組織の表面の近くに基板の下部表面を保持するように構成されている、
皮膚組織へ薬物を送達する方法。 - 皮膚組織の表面で基板を平行移動することをさらに含有してなる、請求項14に記載の方法。
- 基板の下部表面に沿って低圧チャネルの少なくとも一部の近くに少なくとも1つの高圧チャネルを提供することをさらに含有してなり、そこでは高圧チャネルは、皮膚組織の表面で前記基板を平行移動することを容易にするよう構成されている、請求項15に記載の方法。
- 薬物を送達する前に、皮膚組織の一部を加熱することをさらに含有してなる、請求項14〜16の何れか一項に記載の方法。
- 低圧チャネルを使用して、皮膚組織から皮脂又は懐死組織片の少なくとも1つを除去することをさらに含有してなる、請求項14〜17の何れか一項に記載の方法。
- 高い圧力又は低圧チャネルの圧力を変動すること又はパルス化することの少なくとも一方をさらに含有してなる、請求項14〜18の何れか一項に記載の方法。
- 薬物が、にきび、毛孔性角化症又は脱毛の少なくとも1つを治療するために使用できる治療化合物を包含している、請求項14〜19の何れか一項に記載の方法。
- 高い圧力下で基板の少なくとも1つの開口部を通って対象の皮膚組織へ治療有効量の薬物を送達すること;及び
少なくとも1つの開口部の少なくとも一部の近くに基板の下部表面に沿って少なくとも1つの低圧チャネルを提供することを含有してなり、そこでは低圧チャネルは、減少した圧力が低圧チャネルに提供されるときに、皮膚組織の表面の近くに基板の下部表面を保持するように構成されていて、
それによって、対象の皮膚疾患を治療する、
皮膚疾患を有する対象を治療する方法。 - 皮膚疾患が、にきび、毛孔性角化症、及び脱毛よりなる群から選択される、請求項21に記載の方法。
- 薬物が、光線力学療法に使用できる、光増感剤又は光増感剤前駆物質の少なくとも1つである、請求項22に記載の方法。
- 薬物が、育毛に影響を与えることができる治療剤である、請求項22に記載の方法。
- 薬物が、にきびを治療するために使用できる治療剤である、請求項22に記載の方法。
- 皮膚組織の表面で前記基板を平行移動することをさらに含有してなる、請求項21に記載の方法。
- 基板の下部表面に沿って低圧チャネルの少なくとも一部の近くに少なくとも1つの高圧チャネルを提供することをさらに含有してなり、
そこでは高圧チャネルは、皮膚組織の表面で基板が平行移動することを容易にするよう構成されている、請求項26に記載の方法。 - 薬物を送達する前に、皮膚組織の一部を加熱することをさらに含有してなる、請求項21〜27の何れか一項に記載の方法。
- 低圧チャネルを使用して、皮膚組織から皮脂又は懐死組織片の少なくと1つを除去することをさらに含有してなる、請求項21〜28の何れか一項に記載の方法。
- 請求項1〜13の何れか一項に記載の装置、及び請求項14〜29の何れか一項に記載の方法にしたがって使用するための指示書を含有してなる、キット。
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US18122809P | 2009-05-26 | 2009-05-26 | |
US61/181,228 | 2009-05-26 | ||
PCT/US2010/036156 WO2010144257A1 (en) | 2009-05-26 | 2010-05-26 | Method and apparatus for dermal delivery of a substance |
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JP2016025917A (ja) * | 2009-05-26 | 2016-02-12 | ザ ジェネラル ホスピタル コーポレイション | 薬物を経皮送達する方法及び装置 |
JP2017530850A (ja) * | 2014-10-20 | 2017-10-19 | レキシントン インターナショナル エルエルシーLexington International,LLC | ハンズフリー発光デバイス |
KR20180030607A (ko) * | 2015-07-08 | 2018-03-23 | 엣지 시스템즈 엘엘씨 | 모발 성장을 촉진하기 위한 디바이스, 시스템 및 방법 |
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US11744999B2 (en) | 2014-12-23 | 2023-09-05 | Hydra Facial LLC | Devices and methods for treating the skin |
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US10172644B2 (en) | 2006-03-29 | 2019-01-08 | Edge Systems Llc | Devices, systems and methods for treating the skin |
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CA2974972A1 (en) | 2010-12-16 |
US10449218B2 (en) | 2019-10-22 |
US20100305495A1 (en) | 2010-12-02 |
CA2763221A1 (en) | 2010-12-16 |
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HK1169051A1 (zh) | 2013-01-18 |
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BRPI1011316B1 (pt) | 2020-11-17 |
AU2020244375A1 (en) | 2020-10-29 |
CA2974972C (en) | 2018-12-04 |
WO2010144257A1 (en) | 2010-12-16 |
BRPI1011316A2 (pt) | 2016-03-15 |
AU2016202383B2 (en) | 2018-03-01 |
ES2607493T3 (es) | 2017-03-31 |
US9730958B2 (en) | 2017-08-15 |
JP2019000696A (ja) | 2019-01-10 |
BRPI1011316B8 (pt) | 2021-06-22 |
US9687508B2 (en) | 2017-06-27 |
EP2435125A1 (en) | 2012-04-04 |
US20170027983A1 (en) | 2017-02-02 |
US20150165180A1 (en) | 2015-06-18 |
CA2763221C (en) | 2019-01-08 |
AU2016202383A1 (en) | 2016-05-05 |
EP2435125B1 (en) | 2016-09-14 |
US20170312314A1 (en) | 2017-11-02 |
AU2010259094B2 (en) | 2016-01-21 |
EP3078364A1 (en) | 2016-10-12 |
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