JP2012526520A5 - - Google Patents

Info

Publication number

JP2012526520A5

JP2012526520A5 JP2012510073A JP2012510073A JP2012526520A5 JP 2012526520 A5 JP2012526520 A5 JP 2012526520A5 JP 2012510073 A JP2012510073 A JP 2012510073A JP 2012510073 A JP2012510073 A JP 2012510073A JP 2012526520 A5 JP2012526520 A5 JP 2012526520A5

Authority

JP

Japan

Prior art keywords

oocyte

concentration

maturation

phosphodiesterase inhibitor

ligand

Prior art date

2010-05-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 210000000287 oocyte Anatomy 0.000 claims 29
• 230000035800 maturation Effects 0.000 claims 20
• 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 13
• 238000000034 method Methods 0.000 claims 13
• 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 13
• 239000003446 ligand Substances 0.000 claims 10
• 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 6
• 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 6
• 229940028334 follicle stimulating hormone Drugs 0.000 claims 6
• 230000001939 inductive effect Effects 0.000 claims 6
• 230000003834 intracellular effect Effects 0.000 claims 5
• 239000000126 substance Substances 0.000 claims 5
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 4
• 238000012258 culturing Methods 0.000 claims 3
• 230000021121 meiosis Effects 0.000 claims 3
• 102000009024 Epidermal Growth Factor Human genes 0.000 claims 2
• 101800003838 Epidermal growth factor Proteins 0.000 claims 2
• UIAYVIIHMORPSJ-UHFFFAOYSA-N N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide Chemical group C=1C=C2NC(=O)C=CC2=CC=1OCCCC(=O)N(C)C1CCCCC1 UIAYVIIHMORPSJ-UHFFFAOYSA-N 0.000 claims 2
• 229950002934 cilostamide Drugs 0.000 claims 2
• 239000002131 composite material Substances 0.000 claims 2
• 238000005516 engineering process Methods 0.000 claims 2
• 229940116977 epidermal growth factor Drugs 0.000 claims 2
• OHCQJHSOBUTRHG-KGGHGJDLSA-N forskolin group Chemical group C(C)(=O)O[C@H]1[C@H]([C@@H]2[C@@]([C@]3(C(C[C@](O[C@]13C)(C)C=C)=O)O)([C@H](CCC2(C)C)O)C)O OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 claims 2
• 239000004615 ingredient Substances 0.000 claims 2
• 210000001161 mammalian embryo Anatomy 0.000 claims 2
• 238000011084 recovery Methods 0.000 claims 2
• 241000283690 Bos taurus Species 0.000 claims 1
• SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 claims 1
• 230000003491 cAMP production Effects 0.000 claims 1
• 230000015556 catabolic process Effects 0.000 claims 1
• OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 claims 1
• 230000007423 decrease Effects 0.000 claims 1
• 238000006731 degradation reaction Methods 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1