JP2012525397A5 - - Google Patents
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- JP2012525397A5 JP2012525397A5 JP2012508606A JP2012508606A JP2012525397A5 JP 2012525397 A5 JP2012525397 A5 JP 2012525397A5 JP 2012508606 A JP2012508606 A JP 2012508606A JP 2012508606 A JP2012508606 A JP 2012508606A JP 2012525397 A5 JP2012525397 A5 JP 2012525397A5
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- 239000000203 mixture Substances 0.000 claims description 59
- 238000009472 formulation Methods 0.000 claims description 53
- 230000007812 deficiency Effects 0.000 claims description 52
- 208000011580 syndromic disease Diseases 0.000 claims description 52
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 40
- 208000024412 Friedreich ataxia Diseases 0.000 claims description 38
- 230000006378 damage Effects 0.000 claims description 31
- 208000035475 disorder Diseases 0.000 claims description 29
- 102000014461 Ataxins Human genes 0.000 claims description 22
- 108010078286 Ataxins Proteins 0.000 claims description 22
- 208000014644 Brain disease Diseases 0.000 claims description 22
- 206010008025 Cerebellar ataxia Diseases 0.000 claims description 22
- 208000032274 Encephalopathy Diseases 0.000 claims description 22
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims description 22
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 22
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims description 22
- 208000002780 macular degeneration Diseases 0.000 claims description 22
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims description 20
- 201000002169 Mitochondrial myopathy Diseases 0.000 claims description 19
- 208000036572 Myoclonic epilepsy Diseases 0.000 claims description 19
- 201000009028 early myoclonic encephalopathy Diseases 0.000 claims description 19
- 239000000835 fiber Substances 0.000 claims description 19
- 208000023692 inborn mitochondrial myopathy Diseases 0.000 claims description 19
- 208000017442 Retinal disease Diseases 0.000 claims description 17
- 208000014674 injury Diseases 0.000 claims description 17
- 230000000750 progressive effect Effects 0.000 claims description 17
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims description 16
- 208000030768 Optic nerve injury Diseases 0.000 claims description 16
- 206010038923 Retinopathy Diseases 0.000 claims description 16
- 230000001684 chronic effect Effects 0.000 claims description 16
- 208000018737 Parkinson disease Diseases 0.000 claims description 14
- 230000008733 trauma Effects 0.000 claims description 14
- LNOVHERIIMJMDG-KTWAZNHYSA-N 2-[(6e,10e)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl]-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O LNOVHERIIMJMDG-KTWAZNHYSA-N 0.000 claims description 13
- 208000012268 mitochondrial disease Diseases 0.000 claims description 12
- 230000004770 neurodegeneration Effects 0.000 claims description 12
- 208000024827 Alzheimer disease Diseases 0.000 claims description 11
- 201000004569 Blindness Diseases 0.000 claims description 11
- 208000010412 Glaucoma Diseases 0.000 claims description 11
- 208000002569 Machado-Joseph Disease Diseases 0.000 claims description 11
- 208000036834 Spinocerebellar ataxia type 3 Diseases 0.000 claims description 11
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 11
- 108010007425 oligomycin sensitivity conferring protein Proteins 0.000 claims description 11
- 206010030875 ophthalmoplegia Diseases 0.000 claims description 11
- 230000004393 visual impairment Effects 0.000 claims description 11
- 208000027073 Stargardt disease Diseases 0.000 claims description 10
- 208000027653 severe early-childhood-onset retinal dystrophy Diseases 0.000 claims description 10
- 208000002155 Cytochrome-c Oxidase Deficiency Diseases 0.000 claims description 8
- 208000023105 Huntington disease Diseases 0.000 claims description 8
- 208000026072 Motor neurone disease Diseases 0.000 claims description 8
- 206010033799 Paralysis Diseases 0.000 claims description 8
- 208000035965 Postoperative Complications Diseases 0.000 claims description 8
- 230000001154 acute effect Effects 0.000 claims description 8
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 8
- 238000002647 laser therapy Methods 0.000 claims description 8
- 208000005264 motor neuron disease Diseases 0.000 claims description 8
- 210000003205 muscle Anatomy 0.000 claims description 8
- 208000021090 palsy Diseases 0.000 claims description 8
- 238000002428 photodynamic therapy Methods 0.000 claims description 8
- 208000032253 retinal ischemia Diseases 0.000 claims description 8
- 102000007371 Ataxin-3 Human genes 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 7
- 238000011476 stem cell transplantation Methods 0.000 claims description 7
- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims description 6
- FGYKUFVNYVMTAM-UHFFFAOYSA-N (R)-2,5,8-trimethyl-2-(4,8,12-trimethyl-trideca-3t,7t,11-trienyl)-chroman-6-ol Natural products OC1=CC(C)=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1C FGYKUFVNYVMTAM-UHFFFAOYSA-N 0.000 claims description 5
- SFVAYPRWECRHTF-QRCIITMISA-N 2-[(6e,10e)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl]-6-methylcyclohexa-2,5-diene-1,4-dione Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(C)(O)CCC1=CC(=O)C=C(C)C1=O SFVAYPRWECRHTF-QRCIITMISA-N 0.000 claims description 5
- FGYKUFVNYVMTAM-YMCDKREISA-N beta-Tocotrienol Natural products Oc1c(C)c2c(c(C)c1)O[C@@](CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)(C)CC2 FGYKUFVNYVMTAM-YMCDKREISA-N 0.000 claims description 5
- FGYKUFVNYVMTAM-MUUNZHRXSA-N epsilon-Tocopherol Natural products OC1=CC(C)=C2O[C@@](CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1C FGYKUFVNYVMTAM-MUUNZHRXSA-N 0.000 claims description 5
- 235000019151 β-tocotrienol Nutrition 0.000 claims description 5
- 239000011723 β-tocotrienol Substances 0.000 claims description 5
- FGYKUFVNYVMTAM-WAZJVIJMSA-N β-tocotrienol Chemical compound OC1=CC(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C FGYKUFVNYVMTAM-WAZJVIJMSA-N 0.000 claims description 5
- 208000006136 Leigh Disease Diseases 0.000 claims description 4
- 208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 claims description 3
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 3
- 208000014060 Niemann-Pick disease Diseases 0.000 claims description 3
- 206010030113 Oedema Diseases 0.000 claims description 3
- 230000001919 adrenal effect Effects 0.000 claims description 3
- 208000001749 optic atrophy Diseases 0.000 claims description 3
- 210000004885 white matter Anatomy 0.000 claims description 3
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 claims description 2
- 239000003732 agents acting on the eye Substances 0.000 claims description 2
- 239000003889 eye drop Substances 0.000 claims description 2
- 229940113601 irrigation solution Drugs 0.000 claims description 2
- 229940125702 ophthalmic agent Drugs 0.000 claims description 2
- 229930003802 tocotrienol Natural products 0.000 claims description 2
- 239000011731 tocotrienol Substances 0.000 claims description 2
- 235000019148 tocotrienols Nutrition 0.000 claims description 2
- 229940064063 alpha tocotrienol Drugs 0.000 claims 3
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 claims 3
- 235000019145 α-tocotrienol Nutrition 0.000 claims 3
- 239000011730 α-tocotrienol Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000010444 Acidosis Diseases 0.000 claims 1
- 206010048804 Kearns-Sayre syndrome Diseases 0.000 claims 1
- 208000017507 Leigh syndrome Diseases 0.000 claims 1
- 206010058799 Mitochondrial encephalomyopathy Diseases 0.000 claims 1
- 208000002678 Mucopolysaccharidoses Diseases 0.000 claims 1
- 206010068786 Overlap syndrome Diseases 0.000 claims 1
- 230000007950 acidosis Effects 0.000 claims 1
- 208000026545 acidosis disease Diseases 0.000 claims 1
- 206010028093 mucopolysaccharidosis Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 34
- 208000024891 symptom Diseases 0.000 description 7
- 208000027993 eye symptom Diseases 0.000 description 6
- 238000002054 transplantation Methods 0.000 description 6
- 230000032683 aging Effects 0.000 description 5
- 230000000642 iatrogenic effect Effects 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000000472 traumatic effect Effects 0.000 description 4
- OTXNTMVVOOBZCV-UHFFFAOYSA-N 2R-gamma-tocotrienol Natural products OC1=C(C)C(C)=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 OTXNTMVVOOBZCV-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- OTXNTMVVOOBZCV-YMCDKREISA-N gamma-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)(C)CCc2c1 OTXNTMVVOOBZCV-YMCDKREISA-N 0.000 description 3
- 208000018769 loss of vision Diseases 0.000 description 3
- 231100000864 loss of vision Toxicity 0.000 description 3
- 210000001525 retina Anatomy 0.000 description 3
- 230000001568 sexual effect Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- 235000019150 γ-tocotrienol Nutrition 0.000 description 3
- 239000011722 γ-tocotrienol Substances 0.000 description 3
- OTXNTMVVOOBZCV-WAZJVIJMSA-N γ-tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 OTXNTMVVOOBZCV-WAZJVIJMSA-N 0.000 description 3
- 208000010055 Globoid Cell Leukodystrophy Diseases 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 208000028226 Krabbe disease Diseases 0.000 description 2
- 102100026784 Myelin proteolipid protein Human genes 0.000 description 2
- 208000017493 Pelizaeus-Merzbacher disease Diseases 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 102000015782 Electron Transport Complex III Human genes 0.000 description 1
- 108010024882 Electron Transport Complex III Proteins 0.000 description 1
- 125000004151 quinonyl group Chemical group 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21479509P | 2009-04-28 | 2009-04-28 | |
| US61/214,795 | 2009-04-28 | ||
| US31873710P | 2010-03-29 | 2010-03-29 | |
| US61/318,737 | 2010-03-29 | ||
| PCT/US2010/032621 WO2010126909A1 (en) | 2009-04-28 | 2010-04-27 | Formulation of tocotrienol quinones for the treatment of ophthalmic diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014235405A Division JP2015038154A (ja) | 2009-04-28 | 2014-11-20 | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012525397A JP2012525397A (ja) | 2012-10-22 |
| JP2012525397A5 true JP2012525397A5 (https=) | 2013-07-11 |
Family
ID=42236620
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508606A Withdrawn JP2012525397A (ja) | 2009-04-28 | 2010-04-27 | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
| JP2014235405A Withdrawn JP2015038154A (ja) | 2009-04-28 | 2014-11-20 | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
| JP2016078793A Pending JP2016128523A (ja) | 2009-04-28 | 2016-04-11 | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
| JP2017152470A Pending JP2017193594A (ja) | 2009-04-28 | 2017-08-07 | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014235405A Withdrawn JP2015038154A (ja) | 2009-04-28 | 2014-11-20 | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
| JP2016078793A Pending JP2016128523A (ja) | 2009-04-28 | 2016-04-11 | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
| JP2017152470A Pending JP2017193594A (ja) | 2009-04-28 | 2017-08-07 | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20100273892A1 (https=) |
| EP (1) | EP2424494A1 (https=) |
| JP (4) | JP2012525397A (https=) |
| BR (1) | BRPI1013377A2 (https=) |
| CA (1) | CA2759984A1 (https=) |
| EA (1) | EA201101576A1 (https=) |
| MX (1) | MX2011011310A (https=) |
| WO (1) | WO2010126909A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005033093A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| ES2619303T3 (es) * | 2005-06-01 | 2017-06-26 | Edison Pharmaceuticals, Inc. | Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos |
| WO2007100652A2 (en) | 2006-02-22 | 2007-09-07 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| EA038941B1 (ru) | 2007-11-06 | 2021-11-12 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ |
| US8952071B2 (en) * | 2008-01-08 | 2015-02-10 | Edison Pharmaceuticals, Inc. | (Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases |
| WO2009111576A2 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc. | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| JP5798481B2 (ja) * | 2008-06-25 | 2015-10-21 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス疾患を治療するための２−ヘテロシクリルアミノアルキル−（ｐ−キノン）誘導体 |
| MX363223B (es) | 2008-09-10 | 2019-03-15 | Bioelectron Tech Corp | Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox. |
| EP2362726B1 (en) | 2008-10-14 | 2018-08-08 | Bioelectron Technology Corporation | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| ES2553557T3 (es) | 2008-10-28 | 2015-12-10 | Edison Pharmaceuticals, Inc. | Proceso para la producción de alfa-tocotrienol y derivados |
| CA2777479C (en) | 2009-04-28 | 2017-10-17 | Ptc Therapeutics, Inc. | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
| AU2009347921B8 (en) * | 2009-06-10 | 2014-07-24 | Mitotech Sa | Pharmaceutical composition for use in medical and veterinary ophthalmology |
| NO2470168T3 (https=) * | 2009-08-26 | 2018-06-30 | ||
| US20110172312A1 (en) * | 2009-12-31 | 2011-07-14 | Miller Guy M | Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones |
| CA2795726A1 (en) * | 2010-04-06 | 2011-10-13 | Edison Pharmaceuticals, Inc. | Treatment of ataxia telangiectasia |
| US20120295985A1 (en) * | 2010-11-19 | 2012-11-22 | Miller Guy M | Methods for improving blood glucose control |
| EP2714024B1 (en) | 2011-06-03 | 2018-10-03 | Mitotech SA | Oral formulations of mitochondrially-targeted antioxidants and their preparation and use |
| WO2012174286A1 (en) * | 2011-06-14 | 2012-12-20 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| WO2013006736A1 (en) * | 2011-07-06 | 2013-01-10 | Edison Pharmaceuticals, Inc | Treatment of leigh syndrome and leigh-like syndrome, including complications of sucla2 mutations, with tocotrienol quinones |
| ES2795798T3 (es) * | 2011-07-06 | 2020-11-24 | Ptc Therapeutics Inc | Tratamiento de aciduria metilmalónica, aciduria isovalérica, y otras acidurias orgánicas con tocotrienol quinonas |
| EP2734512B1 (en) | 2011-07-19 | 2019-11-20 | Bioelectron Technology Corporation | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| EP2573063A1 (en) | 2011-09-23 | 2013-03-27 | DSM IP Assets B.V. | Process for preparing chiral quinone |
| CA2883882A1 (en) | 2012-09-07 | 2014-03-13 | Ptc Therapeutics, Inc. | Benzoquinone derivatives for treating oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US10189830B2 (en) | 2013-03-15 | 2019-01-29 | Bioelectron Technology Corporation | Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| WO2015183963A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including redox-active parabenzoquinones and uses thereof |
| DK3233786T3 (da) | 2014-12-16 | 2022-05-09 | Ptc Therapeutics Inc | Polymorfe og amorfe former af (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6- dioxocyclohexa-1,4-dienyl)butanamid |
| WO2017106786A1 (en) | 2015-12-16 | 2017-06-22 | Bioelectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| WO2018136871A1 (en) * | 2017-01-20 | 2018-07-26 | Ohio State Innovation Foundation | Topical tocotrienol compositions and methods of increasing skin stem cells |
| TN2021000075A1 (en) | 2018-10-17 | 2023-01-05 | Ptc Therapeutics Inc | 2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING α-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS |
| MX2024000445A (es) | 2021-07-08 | 2024-04-05 | Ptc Therapeutics Inc | Composiciones farmaceuticas que comprenden 2,3,5-trimetil-6-nonilc iclohexa-2,5-dieno-1,4-diona. |
| WO2024259130A1 (en) * | 2023-06-16 | 2024-12-19 | Ptc Therapeutics, Inc. | Methods for increasing vatiquinone plasma exposure with food |
| WO2025024247A1 (en) * | 2023-07-21 | 2025-01-30 | Stealth Biotherapeutics Inc. | Methods, compositions and uses related to the treatment and prevention of leigh's syndrome |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5318993A (en) * | 1993-04-16 | 1994-06-07 | Bristol-Myers Squibb Company | Antihyperlipidemic benzoquinones |
| EP1378753B1 (en) * | 2002-07-01 | 2006-05-31 | Santhera Pharmaceuticals (Schweiz) GmbH | A screening method and compounds for treating Friedreich Ataxia |
| US7015243B2 (en) * | 2003-08-28 | 2006-03-21 | Allergan, Inc. | Cyclohexyl prostaglandin analogs as EP4-receptor agonists |
| WO2005033093A1 (en) * | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| WO2005032478A2 (en) * | 2003-10-01 | 2005-04-14 | Yasoo Health, Inc. | Treatment for diabetic microvascular and macrovascular complications |
| JP5129563B2 (ja) * | 2004-03-18 | 2013-01-30 | ラスク・インテレクチュアル・リザーブ・アクチェンゲゼルシャフト | 視神経症に対する感受性を診断または予測するための方法 |
| ES2619303T3 (es) * | 2005-06-01 | 2017-06-26 | Edison Pharmaceuticals, Inc. | Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos |
| WO2007100652A2 (en) * | 2006-02-22 | 2007-09-07 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| WO2008157747A1 (en) * | 2007-06-21 | 2008-12-24 | The Jackson Laboratory | Use of inhibition of exonuclease 1 in methods for therapy and diagnostic of neurodegenerative diseases, eye diseases, and mitochondrial disorders |
-
2010
- 2010-04-27 EA EA201101576A patent/EA201101576A1/ru unknown
- 2010-04-27 JP JP2012508606A patent/JP2012525397A/ja not_active Withdrawn
- 2010-04-27 WO PCT/US2010/032621 patent/WO2010126909A1/en not_active Ceased
- 2010-04-27 MX MX2011011310A patent/MX2011011310A/es not_active Application Discontinuation
- 2010-04-27 CA CA2759984A patent/CA2759984A1/en not_active Abandoned
- 2010-04-27 EP EP10715649A patent/EP2424494A1/en not_active Withdrawn
- 2010-04-27 US US12/768,554 patent/US20100273892A1/en not_active Abandoned
- 2010-04-27 BR BRPI1013377A patent/BRPI1013377A2/pt not_active Application Discontinuation
-
2013
- 2013-01-10 US US13/738,827 patent/US20140031433A1/en not_active Abandoned
-
2014
- 2014-11-20 JP JP2014235405A patent/JP2015038154A/ja not_active Withdrawn
-
2016
- 2016-04-11 JP JP2016078793A patent/JP2016128523A/ja active Pending
-
2017
- 2017-08-07 JP JP2017152470A patent/JP2017193594A/ja active Pending
- 2017-12-20 US US15/849,557 patent/US20180116978A1/en not_active Abandoned
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