JP2012522758A - ５−ｈｔ受容体調節化合物 - Google Patents

５−ｈｔ受容体調節化合物 Download PDF

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Publication number
JP2012522758A
JP2012522758A JP2012502774A JP2012502774A JP2012522758A JP 2012522758 A JP2012522758 A JP 2012522758A JP 2012502774 A JP2012502774 A JP 2012502774A JP 2012502774 A JP2012502774 A JP 2012502774A JP 2012522758 A JP2012522758 A JP 2012522758A
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JP
Japan
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group
alkyl
compound
cycloalkyl
optionally substituted
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JP2012502774A
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English (en)
Japanese (ja)
Inventor
クラベネス ヨ
ブルーデリ ブヤメ
オラブ レビー フィン
ロマン モルツァウ リセ
グルブランドセン トリグベ
Original Assignee
セロドス アクスイェ セルスカブ
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Application filed by セロドス アクスイェ セルスカブ filed Critical セロドス アクスイェ セルスカブ
Publication of JP2012522758A publication Critical patent/JP2012522758A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
JP2012502774A 2009-04-01 2010-04-01 ５−ｈｔ受容体調節化合物 Pending JP2012522758A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0905641.7 2009-04-01
GBGB0905641.7A GB0905641D0 (en) 2009-04-01 2009-04-01 Compounds
PCT/GB2010/000656 WO2010112865A1 (en) 2009-04-01 2010-04-01 5-ht receptor modulating compounds

Publications (1)

Publication Number Publication Date
JP2012522758A true JP2012522758A (ja) 2012-09-27

Family

ID=40672123

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012502774A Pending JP2012522758A (ja) 2009-04-01 2010-04-01 ５−ｈｔ受容体調節化合物

Country Status (7)

Country Link
US (1) US20120094989A1 (de)
EP (1) EP2414331A1 (de)
JP (1) JP2012522758A (de)
CA (1) CA2757106A1 (de)
GB (1) GB0905641D0 (de)
MX (1) MX2011010215A (de)
WO (1) WO2010112865A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX2012012204A (es) 2010-04-22 2012-12-05 Vertex Pharma Proceso para producir compuestos de cicloalquilcarboxamido-indol.
CN110840847B (zh) 2014-04-15 2022-07-29 沃泰克斯药物股份有限公司 用于治疗囊性纤维化跨膜传导调节因子介导的疾病的药物组合物
JP7189369B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ， インコーポレイテッド アルファ４β７インテグリンの阻害のための化合物
CA3115820A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
JP7192139B2 (ja) 2018-10-30 2022-12-19 ギリアード サイエンシーズ， インコーポレイテッド α４β７インテグリン阻害剤としてのキノリン誘導体
EP4013499A1 (de) 2019-08-14 2022-06-22 Gilead Sciences, Inc. Verbindungen zur inhibierung von alpha-4-beta-7-integrin
CN110950843B (zh) * 2019-11-28 2022-12-27 广东东阳光药业有限公司 取代的苯酰胺衍生物及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07504433A (ja) * 1992-03-12 1995-05-18 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ↓４−受容体アンタゴニストとしての縮合インドール誘導体
JPH07507290A (ja) * 1992-05-23 1995-08-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 不安症の治療のための医薬
WO2007007072A1 (en) * 2005-07-07 2007-01-18 Bio-Medisinsk Innovasjon As 5-htx modulators
JP2007516278A (ja) * 2003-12-23 2007-06-21 ビオ−メディシンスク イノバショーン アクスィエ セルスカプ 末梢性５−ｈｔ受容体の修飾因子
WO2007149929A1 (en) * 2006-06-23 2007-12-27 Aryx Therapeutics, Inc. Piperidine derivatives for the treatment of gastrointestinal and cns disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07504433A (ja) * 1992-03-12 1995-05-18 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ↓４−受容体アンタゴニストとしての縮合インドール誘導体
JPH07507290A (ja) * 1992-05-23 1995-08-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 不安症の治療のための医薬
JP2007516278A (ja) * 2003-12-23 2007-06-21 ビオ−メディシンスク イノバショーン アクスィエ セルスカプ 末梢性５−ｈｔ受容体の修飾因子
WO2007007072A1 (en) * 2005-07-07 2007-01-18 Bio-Medisinsk Innovasjon As 5-htx modulators
WO2007149929A1 (en) * 2006-06-23 2007-12-27 Aryx Therapeutics, Inc. Piperidine derivatives for the treatment of gastrointestinal and cns disorders

Also Published As

Publication number Publication date
MX2011010215A (es) 2012-02-28
WO2010112865A1 (en) 2010-10-07
GB0905641D0 (en) 2009-05-13
US20120094989A1 (en) 2012-04-19
CA2757106A1 (en) 2010-10-07
EP2414331A1 (de) 2012-02-08

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