JP2012522758A - 5−ht受容体調節化合物 - Google Patents
5−ht受容体調節化合物 Download PDFInfo
- Publication number
- JP2012522758A JP2012522758A JP2012502774A JP2012502774A JP2012522758A JP 2012522758 A JP2012522758 A JP 2012522758A JP 2012502774 A JP2012502774 A JP 2012502774A JP 2012502774 A JP2012502774 A JP 2012502774A JP 2012522758 A JP2012522758 A JP 2012522758A
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- compound
- cycloalkyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CNCc(cc1)ccc1-c1c(*)cccc1 Chemical compound CNCc(cc1)ccc1-c1c(*)cccc1 0.000 description 2
- RYFIZEWWGNARPU-UHFFFAOYSA-N CC(C)(C)C(OC[n]1nnc(-c(cccc2)c2-c2ccc(CN3CCC(COC(c4c5OCCC[n]5c5ccccc45)=O)CC3)cc2)n1)=O Chemical compound CC(C)(C)C(OC[n]1nnc(-c(cccc2)c2-c2ccc(CN3CCC(COC(c4c5OCCC[n]5c5ccccc45)=O)CC3)cc2)n1)=O RYFIZEWWGNARPU-UHFFFAOYSA-N 0.000 description 1
- UTKUAUJCYKQTFS-UHFFFAOYSA-N O=C(c1c2OCCC[n]2c2ccccc12)OCC1CCN(Cc(cc2)ccc2-c2ccccc2-c2n[nH]nn2)CC1 Chemical compound O=C(c1c2OCCC[n]2c2ccccc12)OCC1CCN(Cc(cc2)ccc2-c2ccccc2-c2n[nH]nn2)CC1 UTKUAUJCYKQTFS-UHFFFAOYSA-N 0.000 description 1
- MSRUMHDSLFSWRT-UHFFFAOYSA-N OC(c1ccccc1-c1ccc(CN2CCC(COC(c3c4OCCC[n]4c4ccccc34)=O)CC2)cc1)=O Chemical compound OC(c1ccccc1-c1ccc(CN2CCC(COC(c3c4OCCC[n]4c4ccccc34)=O)CC2)cc1)=O MSRUMHDSLFSWRT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0905641.7 | 2009-04-01 | ||
GBGB0905641.7A GB0905641D0 (en) | 2009-04-01 | 2009-04-01 | Compounds |
PCT/GB2010/000656 WO2010112865A1 (en) | 2009-04-01 | 2010-04-01 | 5-ht receptor modulating compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2012522758A true JP2012522758A (ja) | 2012-09-27 |
Family
ID=40672123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012502774A Pending JP2012522758A (ja) | 2009-04-01 | 2010-04-01 | 5−ht受容体調節化合物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20120094989A1 (de) |
EP (1) | EP2414331A1 (de) |
JP (1) | JP2012522758A (de) |
CA (1) | CA2757106A1 (de) |
GB (1) | GB0905641D0 (de) |
MX (1) | MX2011010215A (de) |
WO (1) | WO2010112865A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
MX2012012204A (es) | 2010-04-22 | 2012-12-05 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
CN110840847B (zh) | 2014-04-15 | 2022-07-29 | 沃泰克斯药物股份有限公司 | 用于治疗囊性纤维化跨膜传导调节因子介导的疾病的药物组合物 |
JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4β7インテグリンの阻害のための化合物 |
CA3115820A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
JP7192139B2 (ja) | 2018-10-30 | 2022-12-19 | ギリアード サイエンシーズ, インコーポレイテッド | α4β7インテグリン阻害剤としてのキノリン誘導体 |
EP4013499A1 (de) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Verbindungen zur inhibierung von alpha-4-beta-7-integrin |
CN110950843B (zh) * | 2019-11-28 | 2022-12-27 | 广东东阳光药业有限公司 | 取代的苯酰胺衍生物及其用途 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07504433A (ja) * | 1992-03-12 | 1995-05-18 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5ht↓4−受容体アンタゴニストとしての縮合インドール誘導体 |
JPH07507290A (ja) * | 1992-05-23 | 1995-08-10 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 不安症の治療のための医薬 |
WO2007007072A1 (en) * | 2005-07-07 | 2007-01-18 | Bio-Medisinsk Innovasjon As | 5-htx modulators |
JP2007516278A (ja) * | 2003-12-23 | 2007-06-21 | ビオ−メディシンスク イノバショーン アクスィエ セルスカプ | 末梢性5−ht受容体の修飾因子 |
WO2007149929A1 (en) * | 2006-06-23 | 2007-12-27 | Aryx Therapeutics, Inc. | Piperidine derivatives for the treatment of gastrointestinal and cns disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
US5998409A (en) * | 1992-03-12 | 1999-12-07 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT4 -receptor antagonists |
ES2103675B1 (es) * | 1995-01-10 | 1998-07-01 | Almirall Lab | Nuevas piperidinas sustituidas. |
-
2009
- 2009-04-01 GB GBGB0905641.7A patent/GB0905641D0/en not_active Ceased
-
2010
- 2010-04-01 CA CA2757106A patent/CA2757106A1/en not_active Abandoned
- 2010-04-01 EP EP10712115A patent/EP2414331A1/de not_active Withdrawn
- 2010-04-01 MX MX2011010215A patent/MX2011010215A/es not_active Application Discontinuation
- 2010-04-01 WO PCT/GB2010/000656 patent/WO2010112865A1/en active Application Filing
- 2010-04-01 JP JP2012502774A patent/JP2012522758A/ja active Pending
- 2010-04-01 US US13/262,356 patent/US20120094989A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07504433A (ja) * | 1992-03-12 | 1995-05-18 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5ht↓4−受容体アンタゴニストとしての縮合インドール誘導体 |
JPH07507290A (ja) * | 1992-05-23 | 1995-08-10 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 不安症の治療のための医薬 |
JP2007516278A (ja) * | 2003-12-23 | 2007-06-21 | ビオ−メディシンスク イノバショーン アクスィエ セルスカプ | 末梢性5−ht受容体の修飾因子 |
WO2007007072A1 (en) * | 2005-07-07 | 2007-01-18 | Bio-Medisinsk Innovasjon As | 5-htx modulators |
WO2007149929A1 (en) * | 2006-06-23 | 2007-12-27 | Aryx Therapeutics, Inc. | Piperidine derivatives for the treatment of gastrointestinal and cns disorders |
Also Published As
Publication number | Publication date |
---|---|
MX2011010215A (es) | 2012-02-28 |
WO2010112865A1 (en) | 2010-10-07 |
GB0905641D0 (en) | 2009-05-13 |
US20120094989A1 (en) | 2012-04-19 |
CA2757106A1 (en) | 2010-10-07 |
EP2414331A1 (de) | 2012-02-08 |
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Legal Events
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