JP2012522753A - 炎症の治療のための4−イソプロピル−3−メチルフェノール - Google Patents
炎症の治療のための4−イソプロピル−3−メチルフェノール Download PDFInfo
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- JP2012522753A JP2012522753A JP2012502687A JP2012502687A JP2012522753A JP 2012522753 A JP2012522753 A JP 2012522753A JP 2012502687 A JP2012502687 A JP 2012502687A JP 2012502687 A JP2012502687 A JP 2012502687A JP 2012522753 A JP2012522753 A JP 2012522753A
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- Prior art keywords
- zinc
- composition
- ipmp
- inflammation
- oral
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
【選択図】なし
Description
古典的炎症モデルであるLPS刺激したRaw264.7マクロファージ細胞で抗炎症活性を評価した。細胞からのプロスタグランジンE2(PGE2)の放出を測定することによって、炎症応答を定量化した。アッセイ前に、IPMP有りまたは無しで、細胞を大腸菌(E.coli)リポ多糖類(LPS)に24時間暴露した。IPMPは、細胞のLPSへの暴露によって誘導される全般的炎症のレベルを有意に低下させた。IPMP自体は、細胞を刺激しなかった。すべての値を、同じサンプルの細胞生存率に対して、次いで薬剤またはLPS(100%)の添加なしでの細胞の炎症応答に対して正規化した。
口腔におけるIPMPの抗炎症活性をさらに評価するために、同様の実験をヒト歯肉線維芽細胞に対して行った。細胞を、LPS並びに3つの非刺激性の用量のIPMPに暴露した(実施例1を参照されたい)。
Claims (10)
- 炎症との闘いにおける使用のための、4−イソプロピル−3−メチルフェノール(IPMP)を含む組成物。
- 亜鉛イオンの供給源をさらに含む、請求項1に記載の組成物。
- 前記亜鉛イオンの供給源が、塩化亜鉛、クエン酸亜鉛、酢酸亜鉛、硫酸亜鉛、グルコン酸亜鉛、サリチル酸亜鉛、乳酸亜鉛、リンゴ酸亜鉛、マレイン酸亜鉛、酒石酸亜鉛、炭酸亜鉛、リン酸亜鉛、酸化亜鉛、または硫酸亜鉛から選択される、請求項2に記載の組成物。
- 前記亜鉛イオンの供給源が塩化亜鉛である、請求項3に記載の組成物。
- 製薬上許容される担体または賦形剤を含む医薬組成物である、請求項1〜4のいずれか1項に記載の組成物。
- パーソナルケア用途に許容される担体または賦形剤を含む、口腔、咽喉、または皮膚のケアのためのパーソナルケア組成物である、請求項1〜4のいずれか1項に記載の組成物。
- 経口的に許容される担体または賦形剤を含む口腔ケア組成物である、請求項6に記載の組成物。
- 陰イオン性界面活性剤を含む、請求項7に記載の組成物。
- 炎症と闘うための組成物の製造におけるIPMPの使用。
- 炎症との闘いを必要とする患者における炎症と闘うための方法であって、有効量のIPMPを含む組成物を投与する工程を含む、上記方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0905864.5 | 2009-04-03 | ||
GBGB0905864.5A GB0905864D0 (en) | 2009-04-03 | 2009-04-03 | Novel use |
PCT/EP2010/054394 WO2010112578A1 (en) | 2009-04-03 | 2010-04-01 | 4 -isopropyl-3-methylphenol for the treatment of inflammation |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012522753A true JP2012522753A (ja) | 2012-09-27 |
JP5629754B2 JP5629754B2 (ja) | 2014-11-26 |
Family
ID=40750109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012502687A Expired - Fee Related JP5629754B2 (ja) | 2009-04-03 | 2010-04-01 | 炎症の治療のための4−イソプロピル−3−メチルフェノール |
Country Status (5)
Country | Link |
---|---|
US (1) | US20120034312A1 (ja) |
EP (1) | EP2413921A1 (ja) |
JP (1) | JP5629754B2 (ja) |
GB (1) | GB0905864D0 (ja) |
WO (1) | WO2010112578A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020100583A (ja) * | 2018-12-21 | 2020-07-02 | 小林製薬株式会社 | 乳化組成物 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102013222120A1 (de) | 2013-10-30 | 2015-04-30 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel zur Verringerung der Wiederanfärbung von Zähnen |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002068971A (ja) * | 2000-08-25 | 2002-03-08 | Lion Corp | 歯肉炎改善組成物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4022880A (en) | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
JP3031004B2 (ja) * | 1991-11-06 | 2000-04-10 | ライオン株式会社 | 口腔用組成物 |
US5665333A (en) * | 1995-01-17 | 1997-09-09 | Homola; Andrew M. | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
WO2007148551A1 (ja) * | 2006-06-23 | 2007-12-27 | Lion Corporation | イソプロピルメチルフェノール含有液体口腔用組成物 |
US20080069784A1 (en) * | 2006-06-30 | 2008-03-20 | Millikin Cheri L | Regulation of mammalian keratinous tissue using skin and/or hair care actives |
JP5013790B2 (ja) * | 2006-09-12 | 2012-08-29 | 株式会社マンダム | 殺菌剤組成物、並びに該殺菌剤組成物を含有した皮膚外用剤 |
US20080253976A1 (en) * | 2007-04-16 | 2008-10-16 | Douglas Craig Scott | Personal Care Compositions Comprising An Antimicrobial Blend of Essential Oils or Constituents Thereof |
-
2009
- 2009-04-03 GB GBGB0905864.5A patent/GB0905864D0/en not_active Ceased
-
2010
- 2010-04-01 US US13/262,646 patent/US20120034312A1/en not_active Abandoned
- 2010-04-01 EP EP10712083A patent/EP2413921A1/en not_active Withdrawn
- 2010-04-01 WO PCT/EP2010/054394 patent/WO2010112578A1/en active Application Filing
- 2010-04-01 JP JP2012502687A patent/JP5629754B2/ja not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002068971A (ja) * | 2000-08-25 | 2002-03-08 | Lion Corp | 歯肉炎改善組成物 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020100583A (ja) * | 2018-12-21 | 2020-07-02 | 小林製薬株式会社 | 乳化組成物 |
Also Published As
Publication number | Publication date |
---|---|
EP2413921A1 (en) | 2012-02-08 |
GB0905864D0 (en) | 2009-05-20 |
WO2010112578A1 (en) | 2010-10-07 |
US20120034312A1 (en) | 2012-02-09 |
JP5629754B2 (ja) | 2014-11-26 |
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