JP2012522748A

JP2012522748A - ステアロイル−ｃｏａデサチュラーゼ調節用スピロ誘導体

ステアロイル−ｃｏａデサチュラーゼ調節用スピロ誘導体 Download PDF

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Publication number: JP2012522748A
Authority: JP; Japan
Prior art keywords: alkyl; piperidine; cycloalkyl; carboxamide; pyridin
Prior art date: 2009-04-01
Legal status : Withdrawn

Application number

JP2012502648A

Other languages

English (en)

Japanese (ja)

Other versions

JP2012522748A5 (cg-RX-API-DMAC7.html

Inventor

ナタリー・デールス

ジュリア・フォナレブ

ジャンミン・フ

ザイフイ・チャン

Current Assignee

Xenon Pharmaceuticals Inc

Original Assignee

Xenon Pharmaceuticals Inc

Priority date

2009-04-01

Filing date

2010-03-30

Publication date

2012-09-27

2010-03-30 Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc

2012-09-27 Publication of JP2012522748A publication Critical patent/JP2012522748A/ja

2013-05-16 Publication of JP2012522748A5 publication Critical patent/JP2012522748A5/ja

Status Withdrawn legal-status Critical Current

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125000003003 spiro group Chemical group 0.000 title abstract description 4
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238000000034 method Methods 0.000 claims abstract description 83
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 28
102000016553 Stearoyl-CoA Desaturase Human genes 0.000 claims abstract 6
150000001875 compounds Chemical class 0.000 claims description 276
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125000000753 cycloalkyl group Chemical group 0.000 claims description 104
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 103
125000003118 aryl group Chemical group 0.000 claims description 86
125000000623 heterocyclic group Chemical group 0.000 claims description 86
125000001072 heteroaryl group Chemical group 0.000 claims description 84
125000000217 alkyl group Chemical group 0.000 claims description 83
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239000001257 hydrogen Substances 0.000 claims description 64
229910052739 hydrogen Inorganic materials 0.000 claims description 64
125000005843 halogen group Chemical group 0.000 claims description 55
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 53
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