JP2012522531A5 - - Google Patents
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- Publication number
- JP2012522531A5 JP2012522531A5 JP2012504066A JP2012504066A JP2012522531A5 JP 2012522531 A5 JP2012522531 A5 JP 2012522531A5 JP 2012504066 A JP2012504066 A JP 2012504066A JP 2012504066 A JP2012504066 A JP 2012504066A JP 2012522531 A5 JP2012522531 A5 JP 2012522531A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody molecule
- domain
- seq
- antibody
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008176 lyophilized powder Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16680809P | 2009-04-06 | 2009-04-06 | |
| US61/166,808 | 2009-04-06 | ||
| GBGB0905972.6A GB0905972D0 (en) | 2009-04-06 | 2009-04-06 | Antibodies against IL-17BR |
| GB0905972.6 | 2009-04-06 | ||
| PCT/GB2010/000639 WO2010116123A1 (en) | 2009-04-06 | 2010-03-31 | Antibodies against il-17br |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522531A JP2012522531A (ja) | 2012-09-27 |
| JP2012522531A5 true JP2012522531A5 (https=) | 2013-05-16 |
| JP5767625B2 JP5767625B2 (ja) | 2015-08-19 |
Family
ID=40750206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012504066A Active JP5767625B2 (ja) | 2009-04-06 | 2010-03-31 | Ｉｌ−１７ｂｒに対する抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8586037B2 (https=) |
| EP (1) | EP2417161B1 (https=) |
| JP (1) | JP5767625B2 (https=) |
| CN (1) | CN102482352B (https=) |
| AU (1) | AU2010233535B2 (https=) |
| CA (1) | CA2757104C (https=) |
| DK (1) | DK2417161T3 (https=) |
| ES (1) | ES2633767T3 (https=) |
| GB (1) | GB0905972D0 (https=) |
| WO (1) | WO2010116123A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130209485A1 (en) * | 2011-10-31 | 2013-08-15 | Riken | Therapeutic agent of non-allergic airway inflammation and/or non-allergic hyperresponsive airway |
| JP2015521591A (ja) | 2012-06-12 | 2015-07-30 | オレガ・バイオテック | Ｉｌ−１７アイソフォームのアンタゴニストおよびその使用 |
| EP2858670B8 (en) * | 2012-06-12 | 2018-09-12 | Orega Biotech | Antagonists of il-17 isoforms and their uses |
| TW201613615A (en) * | 2014-06-30 | 2016-04-16 | Academia Sinica | Antagonists for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B for cancer therapy |
| US10372718B2 (en) * | 2014-11-03 | 2019-08-06 | SavantX, Inc. | Systems and methods for enterprise data search and analysis |
| EP3247396B1 (en) | 2015-01-20 | 2024-08-28 | Lankenau Institute for Medical Research | Methods and compositions for the treatment of diseases and disorders |
| CN112955548B (zh) * | 2018-07-09 | 2023-11-24 | 普众发现医药科技(上海)有限公司 | 叶酸受体α特异性抗体 |
| GB201820006D0 (en) * | 2018-12-07 | 2019-01-23 | Lifearc | Humanised anti-IL17BR antibody |
| EP3946377B1 (en) | 2019-04-03 | 2025-12-10 | Orega Biotech | Combination therapies based on pd1 and il-17b inhibitors |
| WO2021170750A1 (en) | 2020-02-28 | 2021-09-02 | Orega Biotech | Combination therapies based on ctla4 and il-17b inhibitors |
| WO2025118126A1 (zh) * | 2023-12-05 | 2025-06-12 | 中国抗体制药有限公司 | 抗il-17rb抗体、或其抗原结合片段或组合物的用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US5071972A (en) | 1986-01-31 | 1991-12-10 | Genetics Institute, Inc. | DNA sequences encoding novel thrombolytic proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| EP0276846A3 (en) | 1987-01-29 | 1989-07-26 | Zymogenetics, Inc. | Colony-stimulating factor derivatives |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US6482923B1 (en) * | 1997-09-17 | 2002-11-19 | Human Genome Sciences, Inc. | Interleukin 17-like receptor protein |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| ES2379101T3 (es) * | 1999-12-23 | 2012-04-20 | Genentech, Inc. | Polipéptidos homólogos IL-17 y usos terapéuticos de los mismos |
| WO2001057202A2 (en) | 2000-02-04 | 2001-08-09 | The Board Of Trustees Of The University Of Arkansas | Evi27 gene sequences and protein encoded thereby |
| TWI322154B (en) * | 2000-03-16 | 2010-03-21 | Amgen Inc | Il-17 receptor like molecules and uses thereof |
| GB0707505D0 (en) | 2007-04-18 | 2007-05-30 | Medical Res Council | Antibodies against il-25 |
| BRPI0810561A2 (pt) | 2007-04-23 | 2019-09-24 | Wyeth Corp | métodos e composições para tratar e monitorar tratamento de desordens associadas à il-13. |
| US8454955B2 (en) | 2007-11-28 | 2013-06-04 | Riken | Methods for treating allergic airway inflammation, airway hypersensitivity, and eosinophilia |
| WO2009136976A2 (en) * | 2008-02-21 | 2009-11-12 | Amgen Inc | Il-17ra-il-17rb antagonists and uses thereof |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2009
- 2009-04-06 GB GBGB0905972.6A patent/GB0905972D0/en not_active Ceased
-
2010
- 2010-03-31 CN CN201080022541.4A patent/CN102482352B/zh active Active
- 2010-03-31 JP JP2012504066A patent/JP5767625B2/ja active Active
- 2010-03-31 DK DK10712110.5T patent/DK2417161T3/en active
- 2010-03-31 US US13/262,123 patent/US8586037B2/en active Active
- 2010-03-31 CA CA2757104A patent/CA2757104C/en active Active
- 2010-03-31 WO PCT/GB2010/000639 patent/WO2010116123A1/en not_active Ceased
- 2010-03-31 EP EP10712110.5A patent/EP2417161B1/en active Active
- 2010-03-31 ES ES10712110.5T patent/ES2633767T3/es active Active
- 2010-03-31 AU AU2010233535A patent/AU2010233535B2/en active Active
-
2013
- 2013-10-17 US US14/056,559 patent/US8852589B2/en active Active
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