JP2012522508A - シェーグレン症候群の診断および治療のためのバイオマーカーとしての示差的に発現されるマイクロｒｎａ - Google Patents

シェーグレン症候群の診断および治療のためのバイオマーカーとしての示差的に発現されるマイクロｒｎａ Download PDF

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JP2012522508A
JP2012522508A JP2012503638A JP2012503638A JP2012522508A JP 2012522508 A JP2012522508 A JP 2012522508A JP 2012503638 A JP2012503638 A JP 2012503638A JP 2012503638 A JP2012503638 A JP 2012503638A JP 2012522508 A JP2012522508 A JP 2012522508A
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syndrome
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sjogren
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イリアス アレビゾス，
ガボアー イレイ，
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US Department of Health and Human Services
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012503638A 2009-03-31 2010-03-31 シェーグレン症候群の診断および治療のためのバイオマーカーとしての示差的に発現されるマイクロｒｎａ Pending JP2012522508A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16514209P 2009-03-31 2009-03-31
US61/165,142 2009-03-31
PCT/US2010/029307 WO2010117829A2 (en) 2009-03-31 2010-03-31 Differentially expressed micrornas as biomarkers for the diagnosis and treatment of sjögren's syndrome

Publications (2)

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JP2012522508A true JP2012522508A (ja) 2012-09-27
JP2012522508A5 JP2012522508A5 (https=) 2013-03-28

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JP2012503638A Pending JP2012522508A (ja) 2009-03-31 2010-03-31 シェーグレン症候群の診断および治療のためのバイオマーカーとしての示差的に発現されるマイクロｒｎａ

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Country Link
US (1) US8785414B2 (https=)
EP (1) EP2414549A4 (https=)
JP (1) JP2012522508A (https=)
AU (1) AU2010234806B2 (https=)
CA (1) CA2754412A1 (https=)
WO (1) WO2010117829A2 (https=)

Cited By (1)

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JP2018527915A (ja) * 2015-09-18 2018-09-27 ヴァナディス ダイアグノスティクス Ｄｎａ試料を分析するためのプローブ組及びその使用方法

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CA2833389C (en) * 2011-04-18 2022-01-11 Diamir, Llc Mirna-based universal screening test (ust)
US20140275211A1 (en) * 2011-06-21 2014-09-18 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
US9970932B2 (en) 2013-03-15 2018-05-15 Arizona Board Of Regents On Behalf Of Arizona State University Non-covalent patterned chemical features and use thereof in MALDI-based quality control
WO2014145123A2 (en) 2013-03-15 2014-09-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State Unversity Peptide array quality control
JP6930832B2 (ja) 2013-11-18 2021-09-01 ディアミール, エルエルシーDiamir, Llc パーキンソン病（ＰＤ）の検出およびモニタリングのための、体液からのｍｉＲＮＡを使用する方法
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
US11584956B2 (en) 2018-12-21 2023-02-21 Microsoft Technology Licensing, Llc Selectively controllable cleavable linkers
US12415171B2 (en) 2018-12-21 2025-09-16 Microsoft Technology Licensing, Llc Regulation of DNA synthesis by nucleotides linked to protecting groups
GB201901120D0 (en) * 2019-01-28 2019-03-20 Imperial Innovations Ltd Methods
US12226746B2 (en) 2019-06-07 2025-02-18 Microsoft Technology Licensing, Llc Reversing bias in polymer synthesis electrode array
US11773422B2 (en) 2019-08-16 2023-10-03 Microsoft Technology Licensing, Llc Regulation of polymerase using cofactor oxidation states
US11795450B2 (en) 2019-09-06 2023-10-24 Microsoft Technology Licensing, Llc Array-based enzymatic oligonucleotide synthesis
US11896945B2 (en) 2019-10-09 2024-02-13 Microsoft Technology Licensing, Llc High surface area coatings for solid-phase synthesis
US20250075258A1 (en) * 2021-07-16 2025-03-06 Exosome Diagnostics, Inc. Methods of detecting sjogren's syndrome using salivary exosomes
WO2023172087A1 (ko) * 2022-03-11 2023-09-14 연세대학교 산학협력단 Klk5, klk7, cstb, ube2v2, tmsb10 또는 pi3을 유효성분으로 포함하는 쇼그렌 증후군 진단용 바이오마커 조성물
WO2024054572A1 (en) * 2022-09-07 2024-03-14 Exosome Diagnostics, Inc. Methods of detecting sjögren's syndrome using salivary exosomes

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US20060185027A1 (en) * 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
WO2008147430A2 (en) * 2006-10-11 2008-12-04 Nucleonics, Inc. Microrna-formatted multitarget interfering rna vector constructs and methods of using the same
JP2009531019A (ja) * 2006-01-05 2009-09-03 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 固形癌の診断及び治療のためのマイクロｒｎａに基づく方法及び組成物
JP2011511804A (ja) * 2008-02-08 2011-04-14 メディミューン，エルエルシー 疾患マーカーおよびその使用

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US7635563B2 (en) 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
CA2857881A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
CN102943108B (zh) 2006-01-05 2014-05-21 俄亥俄州立大学研究基金会 用于肺癌的诊断、预后和治疗的基于微小rna的方法和组合物
CA2648132C (en) 2006-04-03 2019-05-28 Santaris Pharma A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
US8415096B2 (en) * 2007-05-23 2013-04-09 University Of South Florida Micro-RNAs modulating immunity and inflammation
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US20060185027A1 (en) * 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
JP2009531019A (ja) * 2006-01-05 2009-09-03 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 固形癌の診断及び治療のためのマイクロｒｎａに基づく方法及び組成物
WO2008147430A2 (en) * 2006-10-11 2008-12-04 Nucleonics, Inc. Microrna-formatted multitarget interfering rna vector constructs and methods of using the same
JP2011511804A (ja) * 2008-02-08 2011-04-14 メディミューン，エルエルシー 疾患マーカーおよびその使用

Non-Patent Citations (1)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018527915A (ja) * 2015-09-18 2018-09-27 ヴァナディス ダイアグノスティクス Ｄｎａ試料を分析するためのプローブ組及びその使用方法
US10822640B2 (en) 2015-09-18 2020-11-03 Vanadis Diagnostics Probe set for analyzing a DNA sample and method for using the same
US11591639B2 (en) 2015-09-18 2023-02-28 Vanadis Diagnostics Probe set for analyzing a DNA sample and method for using the same
US12378599B2 (en) 2015-09-18 2025-08-05 Vanadis Diagnostics Probe set for analyzing a DNA sample and method for using the same

Also Published As

Publication number Publication date
US8785414B2 (en) 2014-07-22
AU2010234806B2 (en) 2014-05-22
EP2414549A2 (en) 2012-02-08
EP2414549A4 (en) 2013-08-28
AU2010234806A1 (en) 2011-09-08
US20120029056A1 (en) 2012-02-02
WO2010117829A2 (en) 2010-10-14
WO2010117829A8 (en) 2011-10-20
WO2010117829A3 (en) 2011-03-31
CA2754412A1 (en) 2010-10-14

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