JP2012521858A - 涙点プラグ - Google Patents
涙点プラグ Download PDFInfo
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- JP2012521858A JP2012521858A JP2012503554A JP2012503554A JP2012521858A JP 2012521858 A JP2012521858 A JP 2012521858A JP 2012503554 A JP2012503554 A JP 2012503554A JP 2012503554 A JP2012503554 A JP 2012503554A JP 2012521858 A JP2012521858 A JP 2012521858A
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- 229960004380 tramadol Drugs 0.000 description 1
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- 238000001721 transfer moulding Methods 0.000 description 1
- 229960003962 trifluridine Drugs 0.000 description 1
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- 229960004791 tropicamide Drugs 0.000 description 1
- 229960004317 unoprostone Drugs 0.000 description 1
- TVHAZVBUYQMHBC-SNHXEXRGSA-N unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O TVHAZVBUYQMHBC-SNHXEXRGSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
Abstract
Description
Wacker Silicones(Adrian,Michigan)から得られる架橋剤及び触媒を有する0.35〜0.75mgの2部のシリコーンゴム混合物が、射出成型されて、図1に示される涙点プラグを形成する。プラグの寸法は以下のとおりであった:全長は1.85mm、本体長さは1.00mm、フランジ及び矢尻の直径又は半径は1.2mm、中央軸からのオフセットの度合いは5〜15μm、約0.4mmの孔直径を有する2〜5のねじ山が存在した。
(1) 第1端部、第2端部、及び前記2つの端部の間に延びる外側表面を有する本体と、前記本体内に含まれるリザーバであって、前記リザーバは少なくとも1つの開口部を含み、少なくとも1つの活性剤を含む活性剤含有物質を含む、リザーバと、前記本体周囲の巻回部と、を含む、涙点プラグ。
(2) 前記本体の前記外側表面は、実質的に円形の外径を有し、前記外側表面の一部が前記外側表面の残部のものよりも大きな外径を有する、実施態様1に記載の涙点プラグ。
(3) 前記活性剤含有物質が少なくとも部分的に水溶性であり、時間と共に溶解し、これが溶解すると共に前記リザーバの開口部を通じて前記活性剤を放出する、実施態様1に記載の涙点プラグ。
(4) 前記活性剤含有物質は生分解性であり、時間と共に分解し、これが分解すると共に前記リザーバの開口部を通じて前記活性剤を放出する、実施態様1に記載の涙点プラグ。
(5) 前記活性剤含有物質は不水溶性及び非生分解性であり、前記活性剤が、前記リザーバの開口部を通じて前記物質から受動的に拡散する、実施態様1に記載の涙点プラグ。
(6) 前記巻回部は、前記涙点プラグが涙小管内に挿入される際に、前記涙点プラグを前記涙小管内に固定する、実施態様2に記載の涙点プラグ。
(7) 前記涙点プラグが眼の涙小管内に挿入される際に、前記リザーバの開口部が前記眼に面し、前記活性剤が前記眼の涙液内に放出される、実施態様2に記載の涙点プラグ。
(8) 前記涙点プラグが眼の涙小管に挿入される際、前記リザーバの開口部が鼻涙管に面し、前記活性剤が前記鼻涙管内に放出される、実施態様7に記載の涙点プラグ。
(9) カラレットを有する、実施態様1に記載の涙点プラグ。
(10) 前記巻回部が螺旋状である、実施態様1に記載の涙点プラグ。
(12) 前記リザーバ及び前記本体が境界を共有する、実施態様11に記載の涙点プラグ。
(13) 前記涙点プラグが前記涙小管内に挿入される際に、前記リザーバの開口部が前記眼に面し、前記活性剤が前記眼の涙液内に放出される、実施態様12に記載の涙点プラグ。
(14) 前記巻回部が、前記本体の周囲で1旋回する、実施態様10に記載の涙点プラグ。
(15) 前記巻回部が、前記本体の周囲で少なくとも1回と半分旋回する、実施態様11に記載の涙点プラグ。
(16) 前記巻回部は、前記本体から20〜150μm外側に延びる、実施態様10に記載の涙点プラグ。
(17) 前記巻回部は、前記本体から80〜120μm外側に延びる、実施態様10に記載の涙点プラグ。
Claims (17)
- 第1端部、第2端部、及び前記2つの端部の間に延びる外側表面を有する本体と、前記本体内に含まれるリザーバであって、前記リザーバは少なくとも1つの開口部を含み、少なくとも1つの活性剤を含む活性剤含有物質を含む、リザーバと、前記本体周囲の巻回部と、を含む、涙点プラグ。
- 前記本体の前記外側表面は、実質的に円形の外径を有し、前記外側表面の一部が前記外側表面の残部のものよりも大きな外径を有する、請求項1に記載の涙点プラグ。
- 前記活性剤含有物質が少なくとも部分的に水溶性であり、時間と共に溶解し、これが溶解すると共に前記リザーバの開口部を通じて前記活性剤を放出する、請求項1に記載の涙点プラグ。
- 前記活性剤含有物質は生分解性であり、時間と共に分解し、これが分解すると共に前記リザーバの開口部を通じて前記活性剤を放出する、請求項1に記載の涙点プラグ。
- 前記活性剤含有物質は不水溶性及び非生分解性であり、前記活性剤が、前記リザーバの開口部を通じて前記物質から受動的に拡散する、請求項1に記載の涙点プラグ。
- 前記巻回部は、前記涙点プラグが涙小管内に挿入される際に、前記涙点プラグを前記涙小管内に固定する、請求項2に記載の涙点プラグ。
- 前記涙点プラグが眼の涙小管内に挿入される際に、前記リザーバの開口部が前記眼に面し、前記活性剤が前記眼の涙液内に放出される、請求項2に記載の涙点プラグ。
- 前記涙点プラグが眼の涙小管に挿入される際、前記リザーバの開口部が鼻涙管に面し、前記活性剤が前記鼻涙管内に放出される、請求項7に記載の涙点プラグ。
- カラレットを有する、請求項1に記載の涙点プラグ。
- 前記巻回部が螺旋状である、請求項1に記載の涙点プラグ。
- 前記巻回部が前記本体の周囲で非連続的である、請求項10に記載の涙点プラグ。
- 前記リザーバ及び前記本体が境界を共有する、請求項11に記載の涙点プラグ。
- 前記涙点プラグが前記涙小管内に挿入される際に、前記リザーバの開口部が前記眼に面し、前記活性剤が前記眼の涙液内に放出される、請求項12に記載の涙点プラグ。
- 前記巻回部が、前記本体の周囲で1旋回する、請求項10に記載の涙点プラグ。
- 前記巻回部が、前記本体の周囲で少なくとも1回と半分旋回する、請求項11に記載の涙点プラグ。
- 前記巻回部は、前記本体から20〜150μm外側に延びる、請求項10に記載の涙点プラグ。
- 前記巻回部は、前記本体から80〜120μm外側に延びる、請求項10に記載の涙点プラグ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16541709P | 2009-03-31 | 2009-03-31 | |
US61/165,417 | 2009-03-31 | ||
PCT/US2010/029048 WO2010117722A1 (en) | 2009-03-31 | 2010-03-29 | Punctal plugs |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2012521858A true JP2012521858A (ja) | 2012-09-20 |
Family
ID=42320849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012503554A Pending JP2012521858A (ja) | 2009-03-31 | 2010-03-29 | 涙点プラグ |
Country Status (14)
Country | Link |
---|---|
US (1) | US20100256578A1 (ja) |
EP (1) | EP2413853A1 (ja) |
JP (1) | JP2012521858A (ja) |
KR (1) | KR20120013346A (ja) |
CN (1) | CN102448412A (ja) |
AR (1) | AR077739A1 (ja) |
AU (1) | AU2010234879A1 (ja) |
BR (1) | BRPI1014062A2 (ja) |
CA (1) | CA2758054A1 (ja) |
RU (1) | RU2011143792A (ja) |
SG (2) | SG10201401086VA (ja) |
TW (1) | TWI495459B (ja) |
UY (1) | UY32538A (ja) |
WO (1) | WO2010117722A1 (ja) |
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US9421127B2 (en) * | 2009-03-31 | 2016-08-23 | Johnson & Johnson Vision Care, Inc. | Punctal plugs |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
US9259352B2 (en) * | 2010-03-29 | 2016-02-16 | Johnson & Johnson Vision Care, Inc. | Punctal plugs |
US9259351B2 (en) | 2010-03-29 | 2016-02-16 | Johnson & Johnson Vision Care, Inc. | Punctal plugs |
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US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
WO2015184173A1 (en) | 2014-05-29 | 2015-12-03 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
CN104398328A (zh) * | 2014-09-30 | 2015-03-11 | 浦易(上海)生物技术有限公司 | 一种可完全降解的载药的鼻泪管支架及其植入系统 |
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2010
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- 2010-03-29 JP JP2012503554A patent/JP2012521858A/ja active Pending
- 2010-03-29 AR ARP100101012A patent/AR077739A1/es unknown
- 2010-03-29 EP EP10722840A patent/EP2413853A1/en not_active Withdrawn
- 2010-03-29 SG SG10201401086VA patent/SG10201401086VA/en unknown
- 2010-03-29 CN CN2010800237996A patent/CN102448412A/zh active Pending
- 2010-03-29 KR KR1020117025338A patent/KR20120013346A/ko not_active Application Discontinuation
- 2010-03-29 WO PCT/US2010/029048 patent/WO2010117722A1/en active Application Filing
- 2010-03-29 AU AU2010234879A patent/AU2010234879A1/en not_active Abandoned
- 2010-03-29 RU RU2011143792/14A patent/RU2011143792A/ru not_active Application Discontinuation
- 2010-03-29 CA CA2758054A patent/CA2758054A1/en not_active Abandoned
- 2010-03-29 US US12/749,085 patent/US20100256578A1/en not_active Abandoned
- 2010-03-29 SG SG2011070877A patent/SG174972A1/en unknown
- 2010-03-29 BR BRPI1014062A patent/BRPI1014062A2/pt not_active IP Right Cessation
- 2010-04-05 UY UY0001032538A patent/UY32538A/es not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002529144A (ja) * | 1998-11-06 | 2002-09-10 | イーグル・ヴィジョン・インコーポレーテッド | 点口プラグ |
US6629533B1 (en) * | 2000-06-30 | 2003-10-07 | Eagle Vision, Inc. | Punctum plug with at least one anchoring arm |
JP2008018234A (ja) * | 2006-06-21 | 2008-01-31 | Johnson & Johnson Vision Care Inc | 活性剤の投与のための涙点プラグ |
Also Published As
Publication number | Publication date |
---|---|
WO2010117722A1 (en) | 2010-10-14 |
CA2758054A1 (en) | 2010-10-14 |
AU2010234879A1 (en) | 2011-10-27 |
SG174972A1 (en) | 2011-11-28 |
BRPI1014062A2 (pt) | 2016-04-12 |
TW201039805A (en) | 2010-11-16 |
RU2011143792A (ru) | 2013-05-10 |
SG10201401086VA (en) | 2014-10-30 |
AR077739A1 (es) | 2011-09-21 |
US20100256578A1 (en) | 2010-10-07 |
EP2413853A1 (en) | 2012-02-08 |
TWI495459B (zh) | 2015-08-11 |
KR20120013346A (ko) | 2012-02-14 |
UY32538A (es) | 2010-09-30 |
CN102448412A (zh) | 2012-05-09 |
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