JP2012521355A - 熱傷及び二次性合併症の予防及び治療方法 - Google Patents

熱傷及び二次性合併症の予防及び治療方法 Download PDF

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Publication number
JP2012521355A
JP2012521355A JP2012500991A JP2012500991A JP2012521355A JP 2012521355 A JP2012521355 A JP 2012521355A JP 2012500991 A JP2012500991 A JP 2012500991A JP 2012500991 A JP2012500991 A JP 2012500991A JP 2012521355 A JP2012521355 A JP 2012521355A
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burn
medicament
burns
peptide
use according
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JP2012521355A5 (https=
Inventor
ロナルド ジー トンプキンス
エー アリア ツィーカ
ローレンス ラメー
ヨン‐ミン ユ
ジーベンドラ エー マーティン
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General Hospital Corp
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General Hospital Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
JP2012500991A 2009-03-20 2010-03-19 熱傷及び二次性合併症の予防及び治療方法 Pending JP2012521355A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US16206009P 2009-03-20 2009-03-20
US61/162,060 2009-03-20
US24965809P 2009-10-08 2009-10-08
US61/249,658 2009-10-08
US25853309P 2009-11-05 2009-11-05
US61/258,533 2009-11-05
US25934909P 2009-11-09 2009-11-09
US61/259,349 2009-11-09
PCT/US2010/027953 WO2010120431A2 (en) 2009-03-20 2010-03-19 Methods for the prevention and treatment of burn injuries and secondary complications

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014211820A Division JP6005707B2 (ja) 2009-03-20 2014-10-16 熱傷及び二次性合併症の予防及び治療方法

Publications (2)

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JP2012521355A true JP2012521355A (ja) 2012-09-13
JP2012521355A5 JP2012521355A5 (https=) 2013-05-16

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Family Applications (5)

Application Number Title Priority Date Filing Date
JP2012500991A Pending JP2012521355A (ja) 2009-03-20 2010-03-19 熱傷及び二次性合併症の予防及び治療方法
JP2014211820A Active JP6005707B2 (ja) 2009-03-20 2014-10-16 熱傷及び二次性合併症の予防及び治療方法
JP2016174286A Pending JP2016210801A (ja) 2009-03-20 2016-09-07 熱傷及び二次性合併症の予防及び治療方法
JP2018153359A Pending JP2018172442A (ja) 2009-03-20 2018-08-17 熱傷及び二次性合併症の予防及び治療方法
JP2020150963A Pending JP2020196762A (ja) 2009-03-20 2020-09-09 熱傷及び二次性合併症の予防及び治療方法

Family Applications After (4)

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JP2014211820A Active JP6005707B2 (ja) 2009-03-20 2014-10-16 熱傷及び二次性合併症の予防及び治療方法
JP2016174286A Pending JP2016210801A (ja) 2009-03-20 2016-09-07 熱傷及び二次性合併症の予防及び治療方法
JP2018153359A Pending JP2018172442A (ja) 2009-03-20 2018-08-17 熱傷及び二次性合併症の予防及び治療方法
JP2020150963A Pending JP2020196762A (ja) 2009-03-20 2020-09-09 熱傷及び二次性合併症の予防及び治療方法

Country Status (5)

Country Link
US (5) US20100331265A1 (https=)
EP (4) EP3563862B1 (https=)
JP (5) JP2012521355A (https=)
CN (2) CN102573881A (https=)
WO (1) WO2010120431A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019523260A (ja) * 2016-04-11 2019-08-22 カーノット， エルエルシー キラルペプチド

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3563862B1 (en) * 2009-03-20 2021-05-05 The General Hospital Corporation d/b/a Massachusetts General Hospital D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries
PL2470191T3 (pl) 2009-08-24 2014-09-30 Stealth Peptides Int Inc Sposoby i kompozycje do profilaktyki lub leczenia stanów okulistycznych
EP2485749A4 (en) 2009-10-05 2013-07-24 Univ Cornell METHOD FOR THE PREVENTION AND TREATMENT OF HEART FAILURE
EP3332795A1 (en) * 2010-02-26 2018-06-13 Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy
JP2013532124A (ja) * 2010-05-03 2013-08-15 ステルス ペプチドズ インターナショナル インコーポレイテッド 芳香族系陽イオンペプチド及びその使用
AU2012315586B2 (en) 2011-09-29 2017-07-20 Mayo Foundation For Medical Education And Research Aromatic-cationic peptides and methods for using same
JP6317324B2 (ja) * 2012-03-30 2018-04-25 ステルス ペプチドズ インターナショナル インコーポレイテッド 神経障害を予防および処置するための方法および組成物
EP3626252A1 (en) 2013-03-01 2020-03-25 Stealth Biotherapeutics Corp Methods and compositions for the prevention or treatment of barth syndrome
CN110339339A (zh) 2013-03-01 2019-10-18 康德生物医疗技术公司 治疗线粒体疾病的方法
US10047395B2 (en) 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
CN109069572A (zh) * 2015-12-31 2018-12-21 康德生物医疗技术公司 包含肽的治疗性组合物和其用途
CN115160402A (zh) * 2016-03-11 2022-10-11 隐形生物治疗公司 结晶盐形式
JP7427448B2 (ja) 2018-08-23 2024-02-05 積水化学工業株式会社 合わせガラス用中間膜、合わせガラス、及びガラス構成体

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006505290A (ja) * 2002-11-10 2006-02-16 インスティテュート オブ セル バイオフィジクス ロシアン アカデミー オブ サイエンシーズ 抗酸化医薬化合物、ポリペプチドの産生方法、治療方法
JP2006516652A (ja) * 2003-02-04 2006-07-06 コーネル リサーチ ファウンデイション インコーポレイテッド ミトコンドリア透過性転移の阻止方法
JP2007518818A (ja) * 2004-01-23 2007-07-12 コーネル リサーチ ファウンデイション インコーポレイテッド 酸化的損傷を低減する方法
JP2009509941A (ja) * 2005-09-16 2009-03-12 コーネル リサーチ ファウンデイション インコーポレイテッド Ｃｄ３６の発現を減少させる方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
EP0350221B1 (en) * 1988-06-30 1996-04-17 Astra Aktiebolag Dermorphin analogs, their methods of preparation, pharmaceutical compositions, and methods of therapeutic treatment using the same
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity
US5670617A (en) * 1989-12-21 1997-09-23 Biogen Inc Nucleic acid conjugates of tat-derived transport polypeptides
US5858784A (en) * 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5674534A (en) * 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5716644A (en) * 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
ATE255450T1 (de) * 1995-06-09 2003-12-15 Hisamitsu Pharmaceutical Co Matrix für iontophorese
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
CA2314267A1 (en) * 1997-12-10 1999-06-17 Washington University Anti-pathogen system and methods of use thereof
JP2002512954A (ja) * 1998-04-24 2002-05-08 マイトコー ミトコンドリア関連疾患を処置するための化合物および方法
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
SE9900961D0 (sv) * 1999-03-16 1999-03-16 Astra Ab Novel compounds
WO2001012130A1 (en) * 1999-08-16 2001-02-22 Dung Phan Compositions and methods of treatment for skin conditions using extracts of turmeric
AU7855900A (en) * 1999-10-04 2001-05-10 University Of Medicine And Dentistry Of New Jersey Methods for identifying rna binding compounds
US6759520B1 (en) * 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
US20050192215A1 (en) * 2000-01-21 2005-09-01 Malabika Ghosh Methods and materials relating to novel polypeptides and polynucleotides
EP1303186B1 (en) * 2000-07-18 2011-01-26 Cornell Research Foundation, Inc. Medicinal uses of mu-opioid receptor agonists
US6900178B2 (en) * 2000-09-12 2005-05-31 University Of Kentucky Research Foundation Protection against ischemia and reperfusion injury
US20070015146A1 (en) 2001-05-22 2007-01-18 Gene Logic, Inc. Molecular nephrotoxicology modeling
JP4879020B2 (ja) * 2003-05-01 2012-02-15 コーネル リサーチ ファウンデイション インコーポレイテッド 細胞に分子を送達する方法及び担体複合体
EP1667684A1 (en) * 2003-09-17 2006-06-14 ICOS Corporation Use of chk1 inhibitors to control cell proliferation
US7232824B2 (en) * 2003-09-30 2007-06-19 Scios, Inc. Quinazoline derivatives as medicaments
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
US7804249B2 (en) * 2004-09-15 2010-09-28 Koninklijke Philips Electronics N.V. Light-transmitting substrate provided with a light-absorbing coating, light absorbing coating as well as method of preparing a light-absorbing coating
US20070259377A1 (en) * 2005-10-11 2007-11-08 Mickey Urdea Diabetes-associated markers and methods of use thereof
US20080027082A1 (en) * 2006-06-19 2008-01-31 Berthold Hocher Use of adenosine a1 antagonists in radiocontrast media induced nephropathy
WO2008063558A2 (en) * 2006-11-17 2008-05-29 Schering Corporation Combination of an inhibitor of dna polymerase-alpha and an inhibitor of a checkpoint kinase for proliferative disorders
EP3103467A1 (en) * 2008-02-07 2016-12-14 Cornell University Methods for preventing or treating insulin resistance
DK2262520T3 (en) * 2008-02-26 2017-08-07 Univ Cornell COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury
JP6005359B2 (ja) * 2008-08-28 2016-10-12 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 対象のサイズの変更を決定する装置
EP3563862B1 (en) * 2009-03-20 2021-05-05 The General Hospital Corporation d/b/a Massachusetts General Hospital D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006505290A (ja) * 2002-11-10 2006-02-16 インスティテュート オブ セル バイオフィジクス ロシアン アカデミー オブ サイエンシーズ 抗酸化医薬化合物、ポリペプチドの産生方法、治療方法
JP2006516652A (ja) * 2003-02-04 2006-07-06 コーネル リサーチ ファウンデイション インコーポレイテッド ミトコンドリア透過性転移の阻止方法
JP2007518818A (ja) * 2004-01-23 2007-07-12 コーネル リサーチ ファウンデイション インコーポレイテッド 酸化的損傷を低減する方法
JP2009509941A (ja) * 2005-09-16 2009-03-12 コーネル リサーチ ファウンデイション インコーポレイテッド Ｃｄ３６の発現を減少させる方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DOLCA A.THOMAS ET AL, J AM SOC NEPHROL, vol. 18, JPN6014016038, 2007, pages 213 - 222, ISSN: 0002793501 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019523260A (ja) * 2016-04-11 2019-08-22 カーノット， エルエルシー キラルペプチド

Also Published As

Publication number Publication date
JP6005707B2 (ja) 2016-10-12
EP3906933A1 (en) 2021-11-10
EP3563862A1 (en) 2019-11-06
EP2408463B1 (en) 2016-10-19
JP2018172442A (ja) 2018-11-08
WO2010120431A2 (en) 2010-10-21
US9457057B2 (en) 2016-10-04
EP3199173A1 (en) 2017-08-02
CN103933542A (zh) 2014-07-23
WO2010120431A3 (en) 2011-01-13
US20140288012A1 (en) 2014-09-25
US20230201299A1 (en) 2023-06-29
EP2408463A4 (en) 2012-12-12
US20170216394A1 (en) 2017-08-03
JP2015078190A (ja) 2015-04-23
EP3199173B1 (en) 2019-04-24
JP2016210801A (ja) 2016-12-15
JP2020196762A (ja) 2020-12-10
CN102573881A (zh) 2012-07-11
EP2408463A2 (en) 2012-01-25
EP3563862B1 (en) 2021-05-05
US20200323945A1 (en) 2020-10-15
US20100331265A1 (en) 2010-12-30

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