JP2012520697A - 能動型網膜インプラント - Google Patents
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Abstract
Description
Claims (27)
- 網膜(22)の細胞へ刺激信号を送出する刺激素子(17)のアレイ(16)を有し、この刺激素子(17)が放射線送出素子として設計されていることを特徴とする、眼球(20)内へ埋め込むための能動型網膜インプラント。
- 入射周囲光(23)を空間的に分解された電気信号へと変換する画像受信機(13)を有し、該電気信号が放射線送出素子(17)のアレイ(16)を制御することを特徴とする、請求項1に記載の網膜インプラント。
- 画像受信機(13)が眼球(20)外に配置される外付け画像受信機(13)として設計されていることを特徴とする、請求項2に記載の網膜インプラント。
- 画像受信機(13)が埋め込み可能な画像増幅器(13)として設計されていることを特徴とする、請求項2に記載の網膜インプラント。
- 画像受信機(13)と放射線送出素子(17)のアレイ(16)とが互いから分離された構成要素であることを特徴とする、請求項4に記載の網膜インプラント。
- 画像受信機(13)と放射線送出素子(17)のアレイ(16)とが好ましくは柔軟性を有する支持体(27)上または該支持体を介して配置されていることを特徴とする、請求項5に記載の網膜インプラント。
- 画像受信機(13)と放射線送出素子(17)のアレイ(16)とが支持体(27)上または該支持体を介して互いに隣接して配置されていることを特徴とする、請求項6に記載の網膜インプラント。
- 画像受信機(13)と放射線送出素子(17)のアレイ(16)とが一方が他方の上になるよう配置されていることを特徴とする、請求項5に記載の網膜インプラント。
- 画像受信機(13)と放射線送出素子(17)のアレイ(16)とが1つのチップ(26)に組み込まれる形で配置されていることを特徴とする、請求項5に記載の網膜インプラント。
- 放射線送出素子(17)が可視スペクトル内および/または可視スペクトル外の電磁放射線を送出することを特徴とする、請求項1〜9のいずれか1項に記載の網膜インプラント。
- 画像受信機(13)と放射線送出素子(17)のアレイ(16)とが異なる電磁スペクトル領域で作動することを特徴とする、請求項2〜10のいずれか1項に記載の網膜インプラント。
- 画像受信機(13)が可視スペクトル領域での電磁放射を、また放射線送出素子(17)のアレイ(16)が可視スペクトル領域外、好ましくは近赤外領域での電磁放射を行うことを特徴とする、請求項11に記載の網膜インプラント。
- 放射線送出素子(17)が発光ダイオード、好ましくは有機発光ダイオード(OLED)であることを特徴とする、請求項1〜12のいずれか1項に記載の網膜インプラント。
- 画像受信機(13)が光学フィルター(25)を備え、該フィルターによって放射線送出素子(17)のアレイ(16)から送出された電磁放射線スペクトルが遮断されることを特徴とする、請求項2〜13のいずれか1項に記載の網膜インプラント。
- 画像受信機(13)と放射線送出素子(17)のアレイ(16)とが時間オフセットで作動することを特徴とする、請求項2〜14のいずれか1項に記載の網膜インプラント。
- 放射線送出素子(17)のアレイ(16)が異なるスペクトル放射を行う素子(17)を含むことを特徴とする、請求項1〜15のいずれか1項に記載の網膜インプラント。
- 放射線送出素子(17)のアレイ(16)において素子(17)が規定された幾何学的配置で提供されることを特徴とする、請求項1〜16のいずれか1項に記載の網膜インプラント。
- 放射線送出素子(17)のアレイ(16)において素子(17)が互いに間隔をあけて配置され、異なる集団に属する神経細胞が別々に反応することを特徴とする、請求項1〜17のいずれか1項に記載の網膜インプラント。
- たとえばチャネルロドプシン−2発現用のベクター、場合によってはウイルスベクターの導入等によって光受容性チャネルを備えた細胞、細胞培養物、および/または器官型細胞凝集体(51)のための試験装置であって、細胞、細胞培養物、および/または器官型細胞凝集体(51)をその上で培養するための微小電極(53)のアレイ(52)、可視スペクトル内および/または可視スペクトル外の電磁放射線を使用して、細胞、細胞培養物、および/または器官型細胞凝集体(51)に対する空間分解型の電磁放射を行うための放射線送出素子(55)のアレイ(54)、空間分解型の電磁放射線を送出するための放射線送出素子(55)のアレイ(54)を作動させるための駆動デバイス(56)、ならびに放射線送出素子(55)のアレイ(54)による照射を受けて、細胞、細胞培養物、および/または器官型細胞凝集体(51)から微小電極(53)に向けて送出される信号を検知し評価するための評価ユニット(58)を含む試験装置。
- 放射線送出素子(55)のアレイ(54)が細胞、細胞培養物、および/または器官型細胞凝集体(51)の上方に配置されていることを特徴とする、請求項19に記載の試験装置。
- 放射線送出素子(55)のアレイが微小電極(53)のアレイ(52)に組み込まれていることを特徴とする、請求項19に記載の試験装置。
- 放射線送出素子(55)のアレイ(54)が請求項1〜18のいずれか1項に記載のアレイ(16)であることを特徴とする、請求項19に記載の試験装置。
- 駆動デバイス(56)が請求項1〜18のいずれか1項に記載の画像受信機(13)であることを特徴とする、請求項22に記載の試験装置。
- 網膜インプラント(10)のための試験装置であって、たとえばチャネルロドプシン−2発現用のベクター、場合によってはウイルスベクターの導入等によって光受容性チャネルを備えた細胞、細胞培養物、および/または器官型細胞凝集体(51)をその上で培養するための微小電極(53)のアレイ(52)、可視スペクトル内および/または可視スペクトル外の電磁放射線を使用して、細胞、細胞培養物、および/または器官型細胞凝集体(51)に対する空間分解型の電磁放射を行うための請求項1〜18のいずれか1項に記載の網膜インプラント(10)、ならびに網膜インプラント(10)が照射を受けた際に、細胞、細胞培養物、および/または器官型細胞凝集体(51)から微小電極(53)に向けて送出される信号を検知し評価するための評価ユニット(58)を含むことを特徴とする試験装置。
- 治療の必要な患者を治療する方法であって、盲目のあるいは視覚障害のある人々の少なくとも片眼の神経細胞へ光受容性チャネルを導入し、光の照射により神経細胞の電気的活動を調節できるようにする工程、およびそのような処置を施した眼球内に請求項1〜18のいずれか1項に記載の網膜インプラントを埋め込む工程を含む方法。
- 分光感度の異なるロドプシンまたはロドプシン誘導体を使用して、光で作動するチャネルを遺伝子組み換え技術によってオン双極細胞およびオフ双極細胞内に作製することを特徴とする、請求項25に記載の方法。
- たとえばチャネルロドプシン−2の発現のための(ウイルス)ベクターの導入等によって、網膜の神経細胞に光受容性チャネルが付与されていることを特徴とする、請求項26に記載の方法。
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