JP2012519484A5 - - Google Patents
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- JP2012519484A5 JP2012519484A5 JP2011552950A JP2011552950A JP2012519484A5 JP 2012519484 A5 JP2012519484 A5 JP 2012519484A5 JP 2011552950 A JP2011552950 A JP 2011552950A JP 2011552950 A JP2011552950 A JP 2011552950A JP 2012519484 A5 JP2012519484 A5 JP 2012519484A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- sequence
- seq
- mre
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091070501 miRNA Proteins 0.000 claims 32
- 239000002679 microRNA Substances 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 241000712461 unidentified influenza virus Species 0.000 claims 6
- 108091026890 Coding region Proteins 0.000 claims 4
- 108091047577 miR-149 stem-loop Proteins 0.000 claims 4
- 108091035696 miR-149-1 stem-loop Proteins 0.000 claims 4
- 108091031096 miR-149-2 stem-loop Proteins 0.000 claims 4
- 108091027943 miR-16 stem-loop Proteins 0.000 claims 4
- 108091091751 miR-17 stem-loop Proteins 0.000 claims 4
- 108091069239 miR-17-2 stem-loop Proteins 0.000 claims 4
- 108091038599 miR-181b-2 stem-loop Proteins 0.000 claims 4
- 108091074848 miR-19 stem-loop Proteins 0.000 claims 4
- 108091085564 miR-25 stem-loop Proteins 0.000 claims 4
- 108091080167 miR-25-1 stem-loop Proteins 0.000 claims 4
- 108091083056 miR-25-2 stem-loop Proteins 0.000 claims 4
- 108091074487 miR-34 stem-loop Proteins 0.000 claims 4
- 108091092493 miR-34-1 stem-loop Proteins 0.000 claims 4
- 108091059780 miR-34-2 stem-loop Proteins 0.000 claims 4
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims 4
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims 4
- 108091032902 miR-93 stem-loop Proteins 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 206010022000 influenza Diseases 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 2
- -1 miR-1977 Proteins 0.000 claims 2
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 2
- 238000002255 vaccination Methods 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 210000000991 chicken egg Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000012045 magnetic resonance elastography Methods 0.000 claims 1
- 108091007420 miR‐142 Proteins 0.000 claims 1
- 230000008488 polyadenylation Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15823309P | 2009-03-06 | 2009-03-06 | |
| US61/158,233 | 2009-03-06 | ||
| PCT/US2010/000709 WO2010101663A2 (en) | 2009-03-06 | 2010-03-08 | Live attenuated influenza virus vaccines comprising microrna response elements |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012519484A JP2012519484A (ja) | 2012-08-30 |
| JP2012519484A5 true JP2012519484A5 (cg-RX-API-DMAC7.html) | 2013-04-25 |
Family
ID=42710158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011552950A Pending JP2012519484A (ja) | 2009-03-06 | 2010-03-08 | マイクロｒｎａ応答要素を含む弱毒化生インフルエンザウイルスワクチン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8883995B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2403527A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2012519484A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2754826A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010101663A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004028930D1 (de) | 2003-04-29 | 2010-10-14 | Avi Biopharma Inc | Zusammensetzungen zur verbesserung der antisense-wirksamkeit und des transports von nukleinsäureanalog in zellen |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| US9789129B2 (en) | 2008-04-17 | 2017-10-17 | Pds Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
| CA2754826A1 (en) * | 2009-03-06 | 2010-09-10 | Mount Sinai School Of Medicine | Live attenuated influenza virus vaccines comprising microrna response elements |
| US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| WO2011131193A1 (en) * | 2010-04-24 | 2011-10-27 | Statens Serum Institut | Diagnosing and treating fibrotic diseases using micro-rna 17 |
| SI2772265T1 (en) | 2010-05-14 | 2018-06-29 | Oregon Health & Science University | HCMV AND RHCMV RECOMBINANT VECTORS AND THEIR APPLICATIONS |
| WO2012051491A1 (en) * | 2010-10-14 | 2012-04-19 | The United States Of America, As Represented By The Secretary National Institutes Of Health | Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting |
| WO2012136851A1 (en) * | 2011-04-08 | 2012-10-11 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for inhibiting influenza viruses replication |
| US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| US20130280215A1 (en) * | 2011-10-18 | 2013-10-24 | Geovax, Inc. | Mva vectors expressing polypeptides and having high level production in certain cell lines |
| EP2859103B1 (en) | 2012-06-06 | 2019-04-17 | Boehringer Ingelheim International GmbH | CELL ENGINEERING USING RNAs |
| EP3632464A1 (en) | 2012-06-15 | 2020-04-08 | PDS Biotechnology Corporation | Cationic lipid vaccine compositions and methods of use |
| EP4091630A1 (en) | 2012-09-21 | 2022-11-23 | PDS Biotechnology Corporation | Vaccines comprising r-dotap |
| ES2696703T3 (es) | 2013-03-05 | 2019-01-17 | Univ Oregon Health & Science | Vectores de citomegalovirus que permiten el control del direccionamiento de los linfocitos T |
| US10226528B2 (en) | 2013-03-15 | 2019-03-12 | The Trustees Of The University Of Pennsylvania | Vaccines with biomolecular adjuvants |
| CN104694541A (zh) * | 2013-12-09 | 2015-06-10 | 江苏命码生物科技有限公司 | 禽流感病毒miRNA及其鉴定、检测和应用 |
| US20170130229A1 (en) * | 2014-06-18 | 2017-05-11 | The Regents Of The University Of California | Methods and compositions for inhibiting infection by influenza and viruses |
| CA3113595A1 (en) | 2014-07-16 | 2016-01-21 | Oregon Health & Science University | Human cytomegalovirus comprising exogenous antigens |
| WO2016061200A1 (en) * | 2014-10-14 | 2016-04-21 | Texas Tech University System | Live attenuated viral vaccine created by self-attenuation with species-specific artificial microrna |
| JP6620294B2 (ja) * | 2014-12-03 | 2019-12-18 | 公益財団法人ヒューマンサイエンス振興財団 | ムンプスウイルスの弱毒化方法、ムンプスウイルス、及び、生ワクチン |
| KR20170136512A (ko) | 2015-02-10 | 2017-12-11 | 오레곤 헬스 앤드 사이언스 유니버시티 | 넌-캐노니컬 cd8+ t 세포 반응 생성에 유용한 방법 및 조성물 |
| US11020417B2 (en) | 2015-06-04 | 2021-06-01 | Sarepta Therapeutics, Inc | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| CA2986701A1 (en) | 2015-06-09 | 2016-12-15 | Sanofi Pasteur, Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| US10086063B2 (en) | 2015-09-23 | 2018-10-02 | Regents Of The University Of Minnesota | Methods of making and using live attenuated viruses |
| US10383935B2 (en) | 2015-09-23 | 2019-08-20 | Regents Of The University Of Minnesota | Methods of making and using live attenuated viruses |
| US11612652B2 (en) | 2015-11-13 | 2023-03-28 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| CA3005136A1 (en) * | 2015-11-20 | 2017-05-26 | Oregon Health & Science University | Cmv vectors comprising microrna recognition elements |
| JP7046848B2 (ja) * | 2016-07-08 | 2022-04-04 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 弱毒化突然変異体ジカウイルスをコードするゲノム配列 |
| CA3040303A1 (en) | 2016-10-18 | 2018-04-26 | Oregon Health & Science University | Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules |
| AU2018357917B2 (en) | 2017-10-30 | 2024-08-01 | Takeda Pharmaceutical Company Limited | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| WO2019126690A1 (en) | 2017-12-22 | 2019-06-27 | Codagenix Inc. | Recombinant virus with codon-pair deoptimized region and uses thereof for the treatment of cancer |
| US12168049B2 (en) | 2018-03-08 | 2024-12-17 | Codagenix Inc. | Attenuated flaviviruses |
| US11389526B2 (en) | 2018-04-20 | 2022-07-19 | Texas Tech University System | Self-attenuated prophylactic and therapeutic vaccines against pathogens |
| US20220226463A1 (en) * | 2019-06-04 | 2022-07-21 | National Cheng Kung University | Recombinant non-structural protein 1, recombinant influenza virus and immunological composition including the same, and method of treating or preventing disease or condition caused by or associated with influenza virus |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003291433B2 (en) | 2002-11-13 | 2008-05-22 | Thomas Jefferson University | Compositions and methods for cancer diagnosis and therapy |
| MXPA05011250A (es) * | 2003-04-23 | 2006-03-30 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza que mantienen una mutacion en un gen de proteina transmembranal. |
| WO2005017111A2 (en) * | 2003-07-15 | 2005-02-24 | The Trustees Of The University Of Pennsylvania | Methods and systems for identifying micro-rna targets and synthesizing novel micro-rnas and uses of the same |
| US8106180B2 (en) * | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US7279275B2 (en) | 2003-11-03 | 2007-10-09 | Washington University | Methods and compositions for detection of segmented negative strand RNA viruses |
| EP1771584A4 (en) | 2004-07-02 | 2010-01-27 | Henry L Niman | COPY CHOICE RECOMBINATION AND USE THEREOF |
| US20070213293A1 (en) | 2005-04-08 | 2007-09-13 | Nastech Pharmaceutical Company Inc. | Rnai therapeutic for respiratory virus infection |
| US20070054872A1 (en) * | 2005-08-24 | 2007-03-08 | Mirus Bio Corporation | Regulatable or conditional expression systems |
| US20080045472A1 (en) * | 2006-03-31 | 2008-02-21 | Council Of Scientific And Industrial Research Bharat Biotech | Targets for human micro rnas in avian influenza virus (h5n1) genome |
| US9072701B2 (en) * | 2006-04-21 | 2015-07-07 | St. Jude Children's Research Hospital | Avian influenza viruses, vaccines, compositions, formulations, and methods |
| JP2010514424A (ja) * | 2006-12-22 | 2010-05-06 | ザ ペン ステート リサーチ ファウンデーション | 改変ポリメラーゼおよび弱毒化ウイルスならびにそれらの使用方法 |
| US8410334B2 (en) | 2007-02-20 | 2013-04-02 | Monsanto Technology Llc | Invertebrate microRNAs |
| PL2139515T5 (pl) * | 2007-03-30 | 2024-04-08 | The Research Foundation Of The State University Of New York | Atenuowane wirusy przydatne w szczepionkach |
| US20120115131A1 (en) * | 2007-05-31 | 2012-05-10 | Yale University | Genetic lesion associated with cancer |
| US9090894B2 (en) * | 2007-12-17 | 2015-07-28 | California Institute Of Technology | Modulating immune system development and function through microRNA MIR-146 |
| WO2009111892A1 (en) * | 2008-03-14 | 2009-09-17 | Ottawa Health Research Institute | Microrna mediated oncolytic targeting |
| CA2754826A1 (en) * | 2009-03-06 | 2010-09-10 | Mount Sinai School Of Medicine | Live attenuated influenza virus vaccines comprising microrna response elements |
-
2010
- 2010-03-08 CA CA2754826A patent/CA2754826A1/en not_active Abandoned
- 2010-03-08 WO PCT/US2010/000709 patent/WO2010101663A2/en not_active Ceased
- 2010-03-08 EP EP10749069A patent/EP2403527A4/en not_active Withdrawn
- 2010-03-08 US US13/255,040 patent/US8883995B2/en active Active
- 2010-03-08 JP JP2011552950A patent/JP2012519484A/ja active Pending
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