JP2012517483A5 - - Google Patents
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- JP2012517483A5 JP2012517483A5 JP2011550278A JP2011550278A JP2012517483A5 JP 2012517483 A5 JP2012517483 A5 JP 2012517483A5 JP 2011550278 A JP2011550278 A JP 2011550278A JP 2011550278 A JP2011550278 A JP 2011550278A JP 2012517483 A5 JP2012517483 A5 JP 2012517483A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- biopharmaceutical
- disease
- site
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 97
- 229960000074 biopharmaceutical Drugs 0.000 claims description 62
- 210000001519 tissue Anatomy 0.000 claims description 31
- 230000002792 vascular Effects 0.000 claims description 30
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 26
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 26
- 229940112869 bone morphogenetic protein Drugs 0.000 claims description 26
- 208000014674 injury Diseases 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 230000006378 damage Effects 0.000 claims description 15
- 201000010099 disease Diseases 0.000 claims description 15
- 208000027418 Wounds and injury Diseases 0.000 claims description 14
- 210000000845 cartilage Anatomy 0.000 claims description 14
- 208000037816 tissue injury Diseases 0.000 claims description 14
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims description 12
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims description 12
- 208000026062 Tissue disease Diseases 0.000 claims description 11
- 235000018102 proteins Nutrition 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 102000007453 TGF-beta Superfamily Proteins Human genes 0.000 claims description 8
- 108010085004 TGF-beta Superfamily Proteins Proteins 0.000 claims description 8
- 230000007547 defect Effects 0.000 claims description 8
- 230000002093 peripheral effect Effects 0.000 claims description 8
- 238000007910 systemic administration Methods 0.000 claims description 8
- 108010090254 Growth Differentiation Factor 5 Proteins 0.000 claims description 6
- 108010090250 Growth Differentiation Factor 6 Proteins 0.000 claims description 6
- 102100035379 Growth/differentiation factor 5 Human genes 0.000 claims description 6
- 102100035368 Growth/differentiation factor 6 Human genes 0.000 claims description 6
- 102100035363 Growth/differentiation factor 7 Human genes 0.000 claims description 6
- 101710204283 Growth/differentiation factor 7 Proteins 0.000 claims description 6
- 230000007850 degeneration Effects 0.000 claims description 6
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 4
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 4
- 206010007710 Cartilage injury Diseases 0.000 claims description 4
- 208000003618 Intervertebral Disc Displacement Diseases 0.000 claims description 4
- 206010061246 Intervertebral disc degeneration Diseases 0.000 claims description 4
- 206010030113 Oedema Diseases 0.000 claims description 4
- 210000001188 articular cartilage Anatomy 0.000 claims description 4
- 210000004899 c-terminal region Anatomy 0.000 claims description 4
- 208000015100 cartilage disease Diseases 0.000 claims description 4
- 235000018417 cysteine Nutrition 0.000 claims description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 208000017169 kidney disease Diseases 0.000 claims description 4
- 210000003041 ligament Anatomy 0.000 claims description 4
- 201000008482 osteoarthritis Diseases 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 231100000241 scar Toxicity 0.000 claims description 4
- 238000007920 subcutaneous administration Methods 0.000 claims description 4
- 210000001258 synovial membrane Anatomy 0.000 claims description 4
- 210000002435 tendon Anatomy 0.000 claims description 4
- 230000008733 trauma Effects 0.000 claims description 4
- 206010003226 Arteriovenous fistula Diseases 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims description 2
- 108010049976 Bone Morphogenetic Protein 5 Proteins 0.000 claims description 2
- 108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 claims description 2
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims description 2
- 102100022526 Bone morphogenetic protein 5 Human genes 0.000 claims description 2
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims description 2
- 241001260012 Bursa Species 0.000 claims description 2
- 206010016654 Fibrosis Diseases 0.000 claims description 2
- 206010061459 Gastrointestinal ulcer Diseases 0.000 claims description 2
- 238000012752 Hepatectomy Methods 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 206010023421 Kidney fibrosis Diseases 0.000 claims description 2
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 claims description 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 208000010191 Osteitis Deformans Diseases 0.000 claims description 2
- 201000009859 Osteochondrosis Diseases 0.000 claims description 2
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 208000027868 Paget disease Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 206010038895 Retinal scar Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 230000005856 abnormality Effects 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 238000012386 biopharmaceutical delivery Methods 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 208000020832 chronic kidney disease Diseases 0.000 claims description 2
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 208000018180 degenerative disc disease Diseases 0.000 claims description 2
- 208000018138 dendritic cell deficiency Diseases 0.000 claims description 2
- 210000004268 dentin Anatomy 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000030533 eye disease Diseases 0.000 claims description 2
- 210000003191 femoral vein Anatomy 0.000 claims description 2
- 230000004761 fibrosis Effects 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 210000000281 joint capsule Anatomy 0.000 claims description 2
- 210000004731 jugular vein Anatomy 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 208000019423 liver disease Diseases 0.000 claims description 2
- 208000027202 mammary Paget disease Diseases 0.000 claims description 2
- 210000002161 motor neuron Anatomy 0.000 claims description 2
- 210000000653 nervous system Anatomy 0.000 claims description 2
- 201000001119 neuropathy Diseases 0.000 claims description 2
- 230000007823 neuropathy Effects 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 230000003239 periodontal effect Effects 0.000 claims description 2
- 201000001245 periodontitis Diseases 0.000 claims description 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 2
- 230000000770 proinflammatory effect Effects 0.000 claims description 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 2
- 238000002271 resection Methods 0.000 claims description 2
- 208000020431 spinal cord injury Diseases 0.000 claims description 2
- 210000001321 subclavian vein Anatomy 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
- 230000017423 tissue regeneration Effects 0.000 claims description 2
- 230000000472 traumatic effect Effects 0.000 claims description 2
- 210000002620 vena cava superior Anatomy 0.000 claims description 2
- 210000000264 venule Anatomy 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003124 biologic agent Substances 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 35
- 150000001413 amino acids Chemical group 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15190209P | 2009-02-12 | 2009-02-12 | |
| US61/151,902 | 2009-02-12 | ||
| PCT/US2010/024124 WO2010093941A2 (en) | 2009-02-12 | 2010-02-12 | COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014128943A Division JP2014169337A (ja) | 2009-02-12 | 2014-06-24 | ＴＧＦ−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012517483A JP2012517483A (ja) | 2012-08-02 |
| JP2012517483A5 true JP2012517483A5 (enExample) | 2013-03-07 |
| JP5819734B2 JP5819734B2 (ja) | 2015-11-24 |
Family
ID=42111852
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550278A Expired - Fee Related JP5819734B2 (ja) | 2009-02-12 | 2010-02-12 | ＴＧＦ−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法 |
| JP2014128943A Pending JP2014169337A (ja) | 2009-02-12 | 2014-06-24 | ＴＧＦ−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014128943A Pending JP2014169337A (ja) | 2009-02-12 | 2014-06-24 | ＴＧＦ−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20100204124A1 (enExample) |
| EP (1) | EP2396026A2 (enExample) |
| JP (2) | JP5819734B2 (enExample) |
| CN (1) | CN102369017A (enExample) |
| AU (1) | AU2010213591B2 (enExample) |
| CA (1) | CA2752160A1 (enExample) |
| SG (1) | SG173634A1 (enExample) |
| WO (1) | WO2010093941A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009137613A2 (en) * | 2008-05-06 | 2009-11-12 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
| US9158383B2 (en) | 2012-03-02 | 2015-10-13 | Microsoft Technology Licensing, Llc | Force concentrator |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5913791A (ja) * | 1982-07-15 | 1984-01-24 | Kao Corp | リン酸ジエステルの製造法 |
| US4578063A (en) * | 1984-09-14 | 1986-03-25 | W. L. Gore & Assoc., Inc. | Central venous catheter |
| IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5674844A (en) | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US5849686A (en) | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
| US5656593A (en) | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
| US6506729B1 (en) | 1991-03-11 | 2003-01-14 | Curis, Inc. | Methods and compositions for the treatment and prevention of Parkinson's disease |
| US6800603B2 (en) | 1991-03-11 | 2004-10-05 | Curis, Inc. | Morphogen-induced neural cell adhesion |
| US6949505B1 (en) | 1991-03-11 | 2005-09-27 | Curis, Inc. | Morphogen-induced dendritic growth |
| CZ282231B6 (cs) * | 1991-06-05 | 1997-06-11 | The Procter And Gamble Company | Prostředek na generování nového růstu kosti v savci |
| US5693615A (en) * | 1991-06-05 | 1997-12-02 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| KR100259827B1 (ko) | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
| CA2129820C (en) | 1992-02-12 | 2003-06-17 | Helge Neidhardt | Dna sequences encoding novel growth/differentiation factors |
| WO1994010203A2 (en) | 1992-11-03 | 1994-05-11 | Creative Biomolecules, Inc. | Op-3-induced morphogenesis |
| WO1994015966A1 (en) | 1993-01-12 | 1994-07-21 | Johns Hopkins University School Of Medicine | Growth differentiation factor-9 |
| EP0690871A4 (en) | 1993-01-12 | 1999-10-20 | Univ Johns Hopkins Med | GROWTH DIFFERENTIATION FACTOR-5 |
| CA2157577C (en) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
| ATE265529T1 (de) | 1993-05-12 | 2004-05-15 | Inst Genetics Llc | Bmp-10 zusammensetzungen |
| EP0698094B1 (en) | 1993-05-12 | 2004-02-04 | Genetics Institute, LLC | Bmp-11 compositions |
| US5447725A (en) | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
| JPH09503903A (ja) | 1993-07-09 | 1997-04-22 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−６ |
| EP0725796A4 (en) | 1993-10-08 | 1999-12-01 | Univ Johns Hopkins | Growth differentiation factor-10 |
| JP3300500B2 (ja) | 1993-10-12 | 2002-07-08 | 新日本製鐵株式会社 | 疲労強度、降伏強度および被削性に優れる熱間鍛造用鋼の製造方法 |
| US5399677A (en) | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
| EP0733109B9 (en) | 1993-12-07 | 2006-07-05 | Genetics Institute, LLC | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
| IL114397A0 (en) | 1994-07-01 | 1995-10-31 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF-beta-family |
| DE69534468T2 (de) | 1994-07-08 | 2006-07-13 | The Johns Hopkins University School Of Medicine | Wachstums-differenzierungsfaktor-11 |
| WO1996014335A1 (en) | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
| US5635372A (en) | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
| ATE493141T1 (de) * | 1996-03-22 | 2011-01-15 | Stryker Corp | Verfahren zur verbesserten funktionellen erholung der motorischen koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns |
| US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| WO1999015191A2 (en) * | 1997-09-19 | 1999-04-01 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Cytokines having neurotrophic activity |
| US20030170213A1 (en) * | 1998-01-23 | 2003-09-11 | Marc F. Charette | Methods and compositions for enhancing cognitive function using morphogenic proteins |
| US7147839B2 (en) * | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
| US6846906B1 (en) | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| JP3762222B2 (ja) | 1998-10-07 | 2006-04-05 | ストライカー・コーポレーション | 改変型ＴＧＦ−βスーパーファミリータンパク質 |
| US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
| US20030104977A1 (en) * | 2000-03-31 | 2003-06-05 | Ugo Ripamonti | Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors |
| BR0209198A (pt) * | 2001-04-26 | 2004-06-08 | Control Delivery Sys Inc | Métodos de sìntese de compostos contendo fenol |
| DK1677735T3 (da) * | 2003-10-17 | 2014-10-27 | Joslin Diabetes Center Inc | Fremgangsmåder og sammensætninger til modulering af adipocytfunktion |
| CA2561809A1 (en) | 2004-03-31 | 2005-10-20 | Xencor, Inc. | Bmp-7 variants with improved properties |
| EP1750743A4 (en) * | 2004-04-29 | 2009-07-08 | Glaxosmithkline Zagreb | ORAL PREPARATIONS CONTAINING BONE MORPHOGENETIC PROTEINS FOR THE TREATMENT OF METABOLIC BONE DISEASES |
| US20090042780A1 (en) | 2004-05-20 | 2009-02-12 | Acceleron Pharma Inc | Modified TGF-Beta Superfamily Polypeptides and Related Methods |
| CA2567405A1 (en) | 2004-05-25 | 2005-12-08 | Stryker Corporation | Use of morphogenic proteins for treating cartilage defects |
| AU2005251741B2 (en) * | 2004-06-03 | 2009-09-24 | Genera Istrazivanja D.O.O. | Insulin-independent, bone morphogenetic protein (BMP)-mediated uptake of blood glucose by peripheral cells and tissues |
| US7901395B2 (en) * | 2005-08-16 | 2011-03-08 | Borden Jonathan R | Catheter having staggered lumens and method |
| ATE543833T1 (de) | 2005-12-22 | 2012-02-15 | Janssen Biotech Inc | Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen |
| JP2011211450A (ja) | 2010-03-30 | 2011-10-20 | Victor Co Of Japan Ltd | 立体映像表示装置、立体映像撮像装置および立体映像表示方法 |
-
2010
- 2010-02-12 EP EP10705490A patent/EP2396026A2/en not_active Withdrawn
- 2010-02-12 AU AU2010213591A patent/AU2010213591B2/en not_active Ceased
- 2010-02-12 US US12/705,367 patent/US20100204124A1/en not_active Abandoned
- 2010-02-12 WO PCT/US2010/024124 patent/WO2010093941A2/en not_active Ceased
- 2010-02-12 CN CN2010800147720A patent/CN102369017A/zh active Pending
- 2010-02-12 JP JP2011550278A patent/JP5819734B2/ja not_active Expired - Fee Related
- 2010-02-12 SG SG2011057684A patent/SG173634A1/en unknown
- 2010-02-12 CA CA2752160A patent/CA2752160A1/en not_active Abandoned
-
2012
- 2012-12-07 US US13/707,717 patent/US20130316949A1/en not_active Abandoned
-
2013
- 2013-08-07 US US13/961,490 patent/US20140187473A1/en not_active Abandoned
-
2014
- 2014-03-17 US US14/215,232 patent/US20140342976A1/en not_active Abandoned
- 2014-06-24 JP JP2014128943A patent/JP2014169337A/ja active Pending
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