JP2012517441A - 結核の治療、予防及び管理のためのｐｄｅ４モジュレーターの使用法及び含有組成物 - Google Patents

結核の治療、予防及び管理のためのｐｄｅ４モジュレーターの使用法及び含有組成物 Download PDF

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Publication number
JP2012517441A
JP2012517441A JP2011549315A JP2011549315A JP2012517441A JP 2012517441 A JP2012517441 A JP 2012517441A JP 2011549315 A JP2011549315 A JP 2011549315A JP 2011549315 A JP2011549315 A JP 2011549315A JP 2012517441 A JP2012517441 A JP 2012517441A
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Japan
Prior art keywords
carbon atoms
alkyl
substituted
phenyl
amino
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Pending
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JP2011549315A
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Japanese (ja)
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JP2012517441A5 (https=
Inventor
ビー． ゼルディス ジェロメ
カプラン ギルラ
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Celgene Corp
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Celgene Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42077260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2012517441(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of JP2012517441A publication Critical patent/JP2012517441A/ja
Publication of JP2012517441A5 publication Critical patent/JP2012517441A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2011549315A 2009-02-10 2010-02-09 結核の治療、予防及び管理のためのｐｄｅ４モジュレーターの使用法及び含有組成物 Pending JP2012517441A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15146709P 2009-02-10 2009-02-10
US61/151,467 2009-02-10
PCT/US2010/023533 WO2010093588A1 (en) 2009-02-10 2010-02-09 Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015081559A Division JP2015164928A (ja) 2009-02-10 2015-04-13 結核の治療、予防及び管理のためのｐｄｅ４モジュレーターの使用法及び含有組成物

Publications (2)

Publication Number Publication Date
JP2012517441A true JP2012517441A (ja) 2012-08-02
JP2012517441A5 JP2012517441A5 (https=) 2013-03-28

Family

ID=42077260

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011549315A Pending JP2012517441A (ja) 2009-02-10 2010-02-09 結核の治療、予防及び管理のためのｐｄｅ４モジュレーターの使用法及び含有組成物
JP2015081559A Pending JP2015164928A (ja) 2009-02-10 2015-04-13 結核の治療、予防及び管理のためのｐｄｅ４モジュレーターの使用法及び含有組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015081559A Pending JP2015164928A (ja) 2009-02-10 2015-04-13 結核の治療、予防及び管理のためのｐｄｅ４モジュレーターの使用法及び含有組成物

Country Status (23)

Country Link
US (1) US20120149716A1 (https=)
EP (2) EP2395995A1 (https=)
JP (2) JP2012517441A (https=)
KR (1) KR20110116049A (https=)
CN (1) CN102387798A (https=)
AP (1) AP3437A (https=)
AU (1) AU2010213936B2 (https=)
BR (1) BRPI1007500A2 (https=)
CA (1) CA2750123A1 (https=)
CO (1) CO6410289A2 (https=)
CR (1) CR20110411A (https=)
EA (1) EA201171035A1 (https=)
EC (1) ECSP11011295A (https=)
HK (1) HK1205681A1 (https=)
IL (1) IL214176A (https=)
MX (1) MX2011008132A (https=)
MY (1) MY160002A (https=)
NI (1) NI201100154A (https=)
NZ (1) NZ594193A (https=)
PE (2) PE20120580A1 (https=)
SG (2) SG173149A1 (https=)
UA (1) UA103791C2 (https=)
WO (1) WO2010093588A1 (https=)

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RS60415B1 (sr) 2011-12-27 2020-07-31 Amgen (Europe) GmbH Formulacije (+)-2-[1-(3-etoksi-4-metoksi-fenil)-2-metansulfonil-etil]-4-acetil aminoizoindolin-1,3-diona
WO2013119607A2 (en) * 2012-02-08 2013-08-15 Celgene Corporation Modified release formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
WO2017070291A1 (en) * 2015-10-21 2017-04-27 Celgene Corporation Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris)
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CN112220785B (zh) * 2020-09-22 2021-12-31 北京鑫开元医药科技有限公司 一种pde4抑制剂药物组合物及其制备方法与用途

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Also Published As

Publication number Publication date
KR20110116049A (ko) 2011-10-24
AU2010213936B2 (en) 2014-07-31
WO2010093588A1 (en) 2010-08-19
HK1205681A1 (en) 2015-12-24
CO6410289A2 (es) 2012-03-30
SG10201402158VA (en) 2014-07-30
SG173149A1 (en) 2011-08-29
NI201100154A (es) 2012-01-24
US20120149716A1 (en) 2012-06-14
NZ594193A (en) 2013-09-27
EP2818164A1 (en) 2014-12-31
EP2395995A1 (en) 2011-12-21
CA2750123A1 (en) 2010-08-19
PE20120580A1 (es) 2012-05-23
MX2011008132A (es) 2011-09-06
AP2011005849A0 (en) 2011-08-31
BRPI1007500A2 (pt) 2016-02-16
ECSP11011295A (es) 2011-09-30
EA201171035A1 (ru) 2012-02-28
UA103791C2 (uk) 2013-11-25
AP3437A (en) 2015-10-31
IL214176A (en) 2016-09-29
PE20151143A1 (es) 2015-08-07
CR20110411A (es) 2012-01-06
CN102387798A (zh) 2012-03-21
AU2010213936A1 (en) 2011-08-11
MY160002A (en) 2017-02-15
IL214176A0 (en) 2011-08-31
JP2015164928A (ja) 2015-09-17

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