EA201171035A1 - Композиции, включающие модуляторы pde4, и способ их применения для лечения, профилактики и сопровождения туберкулеза - Google Patents

Композиции, включающие модуляторы pde4, и способ их применения для лечения, профилактики и сопровождения туберкулеза

Info

Publication number
EA201171035A1
EA201171035A1 EA201171035A EA201171035A EA201171035A1 EA 201171035 A1 EA201171035 A1 EA 201171035A1 EA 201171035 A EA201171035 A EA 201171035A EA 201171035 A EA201171035 A EA 201171035A EA 201171035 A1 EA201171035 A1 EA 201171035A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
tuberculosis
pde4
methods
compositions
Prior art date
Application number
EA201171035A
Other languages
English (en)
Inventor
Джером Б. Зелдис
Гилла Каплан
Original Assignee
Селджин Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42077260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201171035(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Селджин Корпорейшн filed Critical Селджин Корпорейшн
Publication of EA201171035A1 publication Critical patent/EA201171035A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

В изобретении раскрыты способы лечения, профилактики и сопровождения туберкулеза и других родственных расстройств. Эти способы включают введение модулятора PDE4 или его фармацевтически приемлемой соли, сольвата, гидрата, клатрата, стереоизомера или пролекарства, необязательно в комбинации со вторым действующим агентом и/или другими традиционными способами лечения. Кроме того, в изобретении раскрыты фармацевтические композиции, дозированные лекарственные формы и наборы, подходящие для применения в указанных способах.
EA201171035A 2009-02-10 2010-02-09 Композиции, включающие модуляторы pde4, и способ их применения для лечения, профилактики и сопровождения туберкулеза EA201171035A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15146709P 2009-02-10 2009-02-10
PCT/US2010/023533 WO2010093588A1 (en) 2009-02-10 2010-02-09 Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis

Publications (1)

Publication Number Publication Date
EA201171035A1 true EA201171035A1 (ru) 2012-02-28

Family

ID=42077260

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171035A EA201171035A1 (ru) 2009-02-10 2010-02-09 Композиции, включающие модуляторы pde4, и способ их применения для лечения, профилактики и сопровождения туберкулеза

Country Status (23)

Country Link
US (1) US20120149716A1 (ru)
EP (2) EP2395995A1 (ru)
JP (2) JP2012517441A (ru)
KR (1) KR20110116049A (ru)
CN (1) CN102387798A (ru)
AP (1) AP3437A (ru)
AU (1) AU2010213936B2 (ru)
BR (1) BRPI1007500A2 (ru)
CA (1) CA2750123A1 (ru)
CO (1) CO6410289A2 (ru)
CR (1) CR20110411A (ru)
EA (1) EA201171035A1 (ru)
EC (1) ECSP11011295A (ru)
HK (1) HK1205681A1 (ru)
IL (1) IL214176A (ru)
MX (1) MX2011008132A (ru)
MY (1) MY160002A (ru)
NI (1) NI201100154A (ru)
NZ (1) NZ594193A (ru)
PE (2) PE20151143A1 (ru)
SG (2) SG173149A1 (ru)
UA (1) UA103791C2 (ru)
WO (1) WO2010093588A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2753198T5 (es) 2010-12-16 2023-05-31 Amgen Europe Gmbh Formas farmacéuticas orales de liberación controlada de fármacos poco solubles y sus usos
MX356105B (es) 2011-09-14 2018-05-14 Celgene Corp Formulaciones de ácido ciclopropancarboxílico de {2-[(1s)-1-(3-etoxi-4-metoxi-fenil)-2-metansulfonil-etil]-3-oxo-2 ,3-dihidro-1h-isoindol-4-il}-amida.
PL2797581T3 (pl) 2011-12-27 2020-10-05 Amgen (Europe) GmbH Formulacje (+)-2-[1-(3-etoksy-4-metoksy-fenylo)-2-metanosulfonylo-etylo]- 4acetyloaminoizoindolino-1,3-dionu
WO2013119607A2 (en) * 2012-02-08 2013-08-15 Celgene Corporation Modified release formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
US10011611B2 (en) 2015-08-14 2018-07-03 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
WO2017070291A1 (en) * 2015-10-21 2017-04-27 Celgene Corporation Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris)
DE102018201827A1 (de) * 2017-02-28 2018-08-30 Aktiebolaget Skf Wälzlager
CN112220785B (zh) * 2020-09-22 2021-12-31 北京鑫开元医药科技有限公司 一种pde4抑制剂药物组合物及其制备方法与用途

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5463063A (en) 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US5605914A (en) 1993-07-02 1997-02-25 Celgene Corporation Imides
IT1276040B1 (it) * 1993-07-27 1997-10-24 Angelini Francesco Ist Ricerca Uso della benzidamina nel trattamento di stati patologici causati dal tnf
ES2118557T3 (es) * 1994-03-09 1998-09-16 Pfizer Compuestos de isoxazolina como inhibidores de la liberacion de tnf.
US5610198A (en) * 1994-03-18 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services Anti-mycobacterial compositions and their use for the treatment of tuberculosis and related diseases
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5703098A (en) 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
US6429221B1 (en) 1994-12-30 2002-08-06 Celgene Corporation Substituted imides
US5801195A (en) 1994-12-30 1998-09-01 Celgene Corporation Immunotherapeutic aryl amides
US6518281B2 (en) 1995-08-29 2003-02-11 Celgene Corporation Immunotherapeutic agents
US5728844A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents
US5728845A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic nitriles
US5658940A (en) 1995-10-06 1997-08-19 Celgene Corporation Succinimide and maleimide cytokine inhibitors
NZ334148A (en) 1996-08-12 2001-12-21 Celgene Corp 3-Substituted phenyl-ethyl or ethenyl derivatives terminated with a nitrile, alkane, carboxyl or carbamoyl group useful to reduce cytokine levels
CN1265590A (zh) 1997-07-31 2000-09-06 赛尔金有限公司 取代的链烷异羟肟酸及降低肿瘤坏死因子α水平的方法
US6020358A (en) 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
US6667316B1 (en) 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
US6699899B1 (en) 1999-12-21 2004-03-02 Celgene Corporation Substituted acylhydroxamic acids and method of reducing TNFα levels
US6326388B1 (en) 1999-12-21 2001-12-04 Celgene Corporation Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
US8030343B2 (en) * 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
EP1307199A2 (en) * 2000-08-09 2003-05-07 Panacea Biotec Limited Pharmaceutical compositions of anti-tubercular drugs and process for their preparation
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
WO2003080048A1 (en) 2002-03-20 2003-10-02 Celgene Corporation (-)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
BR0316057A (pt) * 2002-11-06 2005-09-20 Celgene Corp Métodos de tratar, controlar ou prevenir um câncer especìfico e uma doença associada com angiogênese indesejada e de reduzir ou evitar um efeito adverso associado com a administração de um segundo ingrediente ativo e com a terapia de radiação, terapia hormonal, terapia biológica ou imunoterapia em um paciente sofrendo de um câncer especìfico, composição farmacêutica e kit
MXPA05005161A (es) 2002-11-18 2005-07-22 Celgene Corp Metodos de utilizacion y composiciones que comprenden (-)3- (3, 4-dimetoxi- fenil)-3 -(1-oxo -1, 3-dihidro- isoindol- 2-il)- propionamida.
CN1802353A (zh) 2002-12-30 2006-07-12 细胞基因公司 氟烷氧基取代的1,3－二氢－异吲哚化合物及其药物用途
CN101053558A (zh) 2003-03-05 2007-10-17 细胞基因公司 二苯基乙烯化合物及其用途
ES2436606T3 (es) 2003-03-12 2014-01-03 Celgene Corporation Compuestos de 7-amido-isoindolilo y sus usos farmacéuticos
ES2362484T3 (es) 2003-03-12 2011-07-06 Celgene Corporation Compuestos de ácido n-alquil-hidroxámico-isoindolilo y sus usos farmacéuticos.
US7244259B2 (en) 2003-10-31 2007-07-17 Ethicon, Inc. Guide for surgical device for the treatment of urinary incontinence
US7244759B2 (en) 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
US7405237B2 (en) 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use
WO2006065814A1 (en) * 2004-12-13 2006-06-22 Celgene Corporation Compositions comprising pde4 modulators and their use for the treatment or prevention of airway inflammation
TW200800997A (en) * 2006-03-22 2008-01-01 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
CN102387798A (zh) 2012-03-21
SG173149A1 (en) 2011-08-29
CA2750123A1 (en) 2010-08-19
NZ594193A (en) 2013-09-27
AP2011005849A0 (en) 2011-08-31
JP2015164928A (ja) 2015-09-17
AP3437A (en) 2015-10-31
HK1205681A1 (en) 2015-12-24
KR20110116049A (ko) 2011-10-24
MY160002A (en) 2017-02-15
IL214176A0 (en) 2011-08-31
PE20120580A1 (es) 2012-05-23
CR20110411A (es) 2012-01-06
EP2818164A1 (en) 2014-12-31
UA103791C2 (ru) 2013-11-25
NI201100154A (es) 2012-01-24
AU2010213936B2 (en) 2014-07-31
AU2010213936A1 (en) 2011-08-11
CO6410289A2 (es) 2012-03-30
WO2010093588A1 (en) 2010-08-19
JP2012517441A (ja) 2012-08-02
PE20151143A1 (es) 2015-08-07
BRPI1007500A2 (pt) 2016-02-16
MX2011008132A (es) 2011-09-06
ECSP11011295A (es) 2011-09-30
EP2395995A1 (en) 2011-12-21
SG10201402158VA (en) 2014-07-30
IL214176A (en) 2016-09-29
US20120149716A1 (en) 2012-06-14

Similar Documents

Publication Publication Date Title
EA201171035A1 (ru) Композиции, включающие модуляторы pde4, и способ их применения для лечения, профилактики и сопровождения туберкулеза
PH12020500066A1 (en) Carboxamides as modulators of sodium channels
PH12018501807A1 (en) Pyrazolopyrrolidine derivatives and their use in the treatment of diseas
PH12017501046A1 (en) Azabicyclooctane derivatives as fxr agonists for use in the treatment of liver and gastrointestinal diseases
MX2020010484A (es) Derivados de heterociclilos sustituidos como inhibidores de cdk.
GT200600028A (es) Compuestos y composiciones como inhibidores de proteina kinasa
CR20220316A (es) Tetrahidrofuranos sustituidos como moduladores de canales de sodio
MX2015016344A (es) Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades.
TW200745078A (en) Isoindole-imide compounds and compositions comprising and methods of using the same
NO20080141L (no) Indanderivater som modulatorer av ionekanaler
MX2015016421A (es) Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades.
HN2012000023A (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
MX2010003009A (es) Piridil sulfonamidas como moduladores de canales ionicos.
AR086800A1 (es) Composicion farmaceutica oftalmologica topica que contiene regorafenib
EA201591175A1 (ru) Трициклические соединения в качестве ингибиторов cftr
WO2007081808A3 (en) Compounds and derivatives for the treatment of medical conditions by modulating hormone-sensitive lipase activity
JOP20190054B1 (ar) مركبات إندازول للاستخدام في إصابات الأوتار و/ أو الرباط
TW201713630A (en) Substituted quinazoline compounds and methods of use thereof
CL2016002655A1 (es) Composición farmacéutica para el tratamiento de alopatías relacionadas con el dolor, usando como agente activo al ketorolaco trometamina y clorhidrato de tramadol
EA201500368A1 (ru) Фармацевтическая композиция 1-адамантилетилокси-3-морфолино-2-пропанола или его фармацевтически приемлемых солей для лечения кардиоваскулярной патологии
GB201312583D0 (en) Combination and composition for treating obesity
EA202090268A1 (ru) Карбоксамиды в качестве модуляторов натриевых каналов
EA201500366A1 (ru) Применение 1-адамантилетилокси-3-морфолино-2-пропанола или его фармацевтически приемлемых солей в фармацевтических композициях в качестве нейроретинопротектора
CL2010000738A1 (es) Suspension farmaceutica oral que comprende desde 100 hasta 500 mg/5ml de paracetamol, desde 40 hasta 80 mg/5ml de ibuprofeno o desde 200 hasta 400 mg/5ml de paracetamol, desde 100 hasta 200 mg/5ml de ibuprofeno y uno o mas excipientes farmaceuticamente aceptables, util para tratar el dolor pre, peri o postoperatorio.