CR20110411A - Métodos para utilizar y composiciones moduladores pde4 para tratamiento, prevención y control de tuberculosis - Google Patents
Métodos para utilizar y composiciones moduladores pde4 para tratamiento, prevención y control de tuberculosisInfo
- Publication number
- CR20110411A CR20110411A CR20110411A CR20110411A CR20110411A CR 20110411 A CR20110411 A CR 20110411A CR 20110411 A CR20110411 A CR 20110411A CR 20110411 A CR20110411 A CR 20110411A CR 20110411 A CR20110411 A CR 20110411A
- Authority
- CR
- Costa Rica
- Prior art keywords
- methods
- pde4
- prevention
- control
- tuberculosis treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 title abstract 2
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 title abstract 2
- 201000008827 tuberculosis Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 1
- 238000011443 conventional therapy Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describen métodos para tratar, prevenir, y controlar tuberculosis y otros trastornos relacionados. Los métodos comprenden la administración de un modulador PDE4, o una sal farmacéuticamente aceptable, solvato, hidrato, clatrato, estereoisómero, o profármaco del mismo, opcionalmente en combinación con un segundo agente activo y/u otras terapias convencionales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15146709P | 2009-02-10 | 2009-02-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20110411A true CR20110411A (es) | 2012-01-06 |
Family
ID=42077260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20110411A CR20110411A (es) | 2009-02-10 | 2011-07-29 | Métodos para utilizar y composiciones moduladores pde4 para tratamiento, prevención y control de tuberculosis |
Country Status (23)
Country | Link |
---|---|
US (1) | US20120149716A1 (es) |
EP (2) | EP2818164A1 (es) |
JP (2) | JP2012517441A (es) |
KR (1) | KR20110116049A (es) |
CN (1) | CN102387798A (es) |
AP (1) | AP3437A (es) |
AU (1) | AU2010213936B2 (es) |
BR (1) | BRPI1007500A2 (es) |
CA (1) | CA2750123A1 (es) |
CO (1) | CO6410289A2 (es) |
CR (1) | CR20110411A (es) |
EA (1) | EA201171035A1 (es) |
EC (1) | ECSP11011295A (es) |
HK (1) | HK1205681A1 (es) |
IL (1) | IL214176A (es) |
MX (1) | MX2011008132A (es) |
MY (1) | MY160002A (es) |
NI (1) | NI201100154A (es) |
NZ (1) | NZ594193A (es) |
PE (2) | PE20120580A1 (es) |
SG (2) | SG10201402158VA (es) |
UA (1) | UA103791C2 (es) |
WO (1) | WO2010093588A1 (es) |
Families Citing this family (9)
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MX354210B (es) | 2010-12-16 | 2018-02-16 | Celgene Corp | Formas farmaceuticas orales de liberacion controlada de farmacos escasamente solubles y los usos de estas. |
MX356105B (es) | 2011-09-14 | 2018-05-14 | Celgene Corp | Formulaciones de ácido ciclopropancarboxílico de {2-[(1s)-1-(3-etoxi-4-metoxi-fenil)-2-metansulfonil-etil]-3-oxo-2 ,3-dihidro-1h-isoindol-4-il}-amida. |
HUE050327T2 (hu) | 2011-12-27 | 2020-11-30 | Amgen Europe Gmbh | Készítmények (+)-2-[1-(3-etoxi-4-metoxifenil)-2-metánszulfonil-etil]-4-acetilaminoizoindolin-1,3-dion tartalommal |
WO2013119607A2 (en) * | 2012-02-08 | 2013-08-15 | Celgene Corporation | Modified release formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione |
EP2764866A1 (en) | 2013-02-07 | 2014-08-13 | IP Gesellschaft für Management mbH | Inhibitors of nedd8-activating enzyme |
US10011611B2 (en) | 2015-08-14 | 2018-07-03 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
WO2017070291A1 (en) * | 2015-10-21 | 2017-04-27 | Celgene Corporation | Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris) |
DE102018201827A1 (de) * | 2017-02-28 | 2018-08-30 | Aktiebolaget Skf | Wälzlager |
CN112220785B (zh) * | 2020-09-22 | 2021-12-31 | 北京鑫开元医药科技有限公司 | 一种pde4抑制剂药物组合物及其制备方法与用途 |
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-
2010
- 2010-02-09 CA CA2750123A patent/CA2750123A1/en not_active Abandoned
- 2010-02-09 US US13/148,659 patent/US20120149716A1/en not_active Abandoned
- 2010-02-09 EA EA201171035A patent/EA201171035A1/ru unknown
- 2010-02-09 UA UAA201110844A patent/UA103791C2/uk unknown
- 2010-02-09 WO PCT/US2010/023533 patent/WO2010093588A1/en active Application Filing
- 2010-02-09 AU AU2010213936A patent/AU2010213936B2/en not_active Ceased
- 2010-02-09 NZ NZ594193A patent/NZ594193A/xx not_active IP Right Cessation
- 2010-02-09 EP EP14170043.5A patent/EP2818164A1/en not_active Withdrawn
- 2010-02-09 SG SG10201402158VA patent/SG10201402158VA/en unknown
- 2010-02-09 SG SG2011054129A patent/SG173149A1/en unknown
- 2010-02-09 JP JP2011549315A patent/JP2012517441A/ja active Pending
- 2010-02-09 BR BRPI1007500A patent/BRPI1007500A2/pt not_active IP Right Cessation
- 2010-02-09 AP AP2011005849A patent/AP3437A/xx active
- 2010-02-09 EP EP10704460A patent/EP2395995A1/en not_active Withdrawn
- 2010-02-09 MY MYPI2011003673A patent/MY160002A/en unknown
- 2010-02-09 KR KR1020117021146A patent/KR20110116049A/ko not_active Application Discontinuation
- 2010-02-09 PE PE2011001445A patent/PE20120580A1/es not_active Application Discontinuation
- 2010-02-09 MX MX2011008132A patent/MX2011008132A/es active IP Right Grant
- 2010-02-09 PE PE2015000636A patent/PE20151143A1/es not_active Application Discontinuation
- 2010-02-09 CN CN2010800159215A patent/CN102387798A/zh active Pending
-
2011
- 2011-07-19 IL IL214176A patent/IL214176A/en not_active IP Right Cessation
- 2011-07-29 CR CR20110411A patent/CR20110411A/es unknown
- 2011-08-09 NI NI201100154A patent/NI201100154A/es unknown
- 2011-08-21 EC EC2011011295A patent/ECSP11011295A/es unknown
- 2011-09-09 CO CO11116668A patent/CO6410289A2/es not_active Application Discontinuation
-
2015
- 2015-04-13 JP JP2015081559A patent/JP2015164928A/ja active Pending
- 2015-06-30 HK HK15106201.5A patent/HK1205681A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010213936A1 (en) | 2011-08-11 |
SG173149A1 (en) | 2011-08-29 |
IL214176A (en) | 2016-09-29 |
BRPI1007500A2 (pt) | 2016-02-16 |
ECSP11011295A (es) | 2011-09-30 |
NI201100154A (es) | 2012-01-24 |
IL214176A0 (en) | 2011-08-31 |
EP2395995A1 (en) | 2011-12-21 |
MY160002A (en) | 2017-02-15 |
PE20151143A1 (es) | 2015-08-07 |
CN102387798A (zh) | 2012-03-21 |
CO6410289A2 (es) | 2012-03-30 |
EA201171035A1 (ru) | 2012-02-28 |
JP2015164928A (ja) | 2015-09-17 |
UA103791C2 (uk) | 2013-11-25 |
HK1205681A1 (en) | 2015-12-24 |
MX2011008132A (es) | 2011-09-06 |
PE20120580A1 (es) | 2012-05-23 |
JP2012517441A (ja) | 2012-08-02 |
EP2818164A1 (en) | 2014-12-31 |
AP2011005849A0 (en) | 2011-08-31 |
AU2010213936B2 (en) | 2014-07-31 |
CA2750123A1 (en) | 2010-08-19 |
KR20110116049A (ko) | 2011-10-24 |
AP3437A (en) | 2015-10-31 |
WO2010093588A1 (en) | 2010-08-19 |
US20120149716A1 (en) | 2012-06-14 |
SG10201402158VA (en) | 2014-07-30 |
NZ594193A (en) | 2013-09-27 |
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