JP2012513418A5 - - Google Patents
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- Publication number
- JP2012513418A5 JP2012513418A5 JP2011542689A JP2011542689A JP2012513418A5 JP 2012513418 A5 JP2012513418 A5 JP 2012513418A5 JP 2011542689 A JP2011542689 A JP 2011542689A JP 2011542689 A JP2011542689 A JP 2011542689A JP 2012513418 A5 JP2012513418 A5 JP 2012513418A5
- Authority
- JP
- Japan
- Prior art keywords
- leukemia
- acute
- chronic
- lymphocytic leukemia
- myeloid leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008062826A DE102008062826A1 (de) | 2008-12-23 | 2008-12-23 | Pyridazinonderivate |
| DE102008062826.3 | 2008-12-23 | ||
| PCT/EP2009/008360 WO2010072296A1 (de) | 2008-12-23 | 2009-11-24 | Pyridazinonderivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012513418A JP2012513418A (ja) | 2012-06-14 |
| JP2012513418A5 true JP2012513418A5 (https=) | 2014-07-17 |
| JP5592395B2 JP5592395B2 (ja) | 2014-09-17 |
Family
ID=41628227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542689A Expired - Fee Related JP5592395B2 (ja) | 2008-12-23 | 2009-11-24 | ピリダジノン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8637518B2 (https=) |
| EP (1) | EP2367815B1 (https=) |
| JP (1) | JP5592395B2 (https=) |
| KR (1) | KR20110098854A (https=) |
| CN (1) | CN102264727B (https=) |
| AR (1) | AR074688A1 (https=) |
| AU (1) | AU2009331991B2 (https=) |
| BR (1) | BRPI0923497A2 (https=) |
| CA (1) | CA2747863C (https=) |
| CY (1) | CY1116191T1 (https=) |
| DE (1) | DE102008062826A1 (https=) |
| DK (1) | DK2367815T3 (https=) |
| EA (1) | EA201100966A1 (https=) |
| ES (1) | ES2532139T3 (https=) |
| HR (1) | HRP20150375T1 (https=) |
| HU (1) | HUE025138T2 (https=) |
| MX (1) | MX2011006652A (https=) |
| PL (1) | PL2367815T3 (https=) |
| PT (1) | PT2367815E (https=) |
| SI (1) | SI2367815T1 (https=) |
| WO (1) | WO2010072296A1 (https=) |
| ZA (1) | ZA201105440B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009003954A1 (de) * | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| JP2016507496A (ja) * | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． | ブロモドメイン阻害剤としての新規複素環式化合物 |
| HUE032863T2 (en) * | 2013-02-07 | 2017-11-28 | Merck Patent Gmbh | Piridazinonamid derivatives |
| SI3010503T1 (sl) | 2013-06-21 | 2020-07-31 | Zenith Epigenetics Ltd. | Novi biciklični inhibitorji bromodomene |
| JP6461118B2 (ja) | 2013-06-21 | 2019-01-30 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | ブロモドメイン阻害剤としての新規の置換された二環式化合物 |
| JP6542212B2 (ja) | 2013-07-31 | 2019-07-10 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | ブロモドメイン阻害剤としての新規キナゾリノン |
| US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| WO2016092375A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Corp. | Substituted heterocycles as bromodomain inhibitors |
| CA2966450A1 (en) | 2014-12-17 | 2016-06-23 | Olesya KHARENKO | Inhibitors of bromodomains |
| HRP20201985T1 (hr) * | 2016-10-27 | 2021-02-05 | Fujian Cosunter Pharmaceutical Co., Ltd. | Piridonski spoj kao c-met inhibitor |
| IL278281B2 (en) * | 2018-04-26 | 2025-01-01 | Fujian Cosunter Pharmaceutical Co Ltd | Crystalline form of C–MET inhibitor and its salt form and method for preparing them |
| CN108752322A (zh) | 2018-09-12 | 2018-11-06 | 广州新民培林医药科技有限公司 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
| IL286481B2 (en) * | 2019-03-20 | 2025-12-01 | Goldfinch Bio Inc | Pyridazinones and methods of use thereof |
| WO2022063869A2 (en) * | 2020-09-24 | 2022-03-31 | Merck Patent Gmbh | Compounds for the treatment of viral infections |
| CN114736191B (zh) * | 2022-04-01 | 2023-08-08 | 上海工程技术大学 | 特普替尼中间体及其制备方法和应用 |
| CN115583939A (zh) * | 2022-11-04 | 2023-01-10 | 苏州莱安医药化学技术有限公司 | 一种特泊替尼中间体的合成方法 |
| KR20240075764A (ko) * | 2022-11-22 | 2024-05-29 | 주식회사 이노큐어테라퓨틱스 | cMET 단백질을 분해하는 디그레이더 및 이를 포함하는 약학 조성물 |
| CN116768868B (zh) * | 2023-08-15 | 2023-12-08 | 云南省药物研究所 | 一种哒嗪酮硫代衍生物及其制备方法和应用 |
| CN118084871B (zh) * | 2024-04-29 | 2024-07-09 | 中国药科大学 | 一种靶向降解c-Met蛋白的化合物及其制法和应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5795964A (en) | 1980-12-04 | 1982-06-15 | Morishita Seiyaku Kk | Preparation of 2-substituted-3(2h)-pyridazinone derivative |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| AU691673B2 (en) | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
| US5635494A (en) | 1995-04-21 | 1997-06-03 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE19604388A1 (de) | 1996-02-07 | 1997-08-14 | Merck Patent Gmbh | Arylalkyl-diazinone |
| DE69720965T2 (de) | 1996-02-13 | 2004-02-05 | Astrazeneca Ab | Chinazolinderivate und deren verwendung als vegf hemmer |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| US6348468B1 (en) | 1997-11-19 | 2002-02-19 | Kowa Co., Ltd. | Pyridazine compounds and compositions containing the same |
| TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| AU2001258628A1 (en) | 2000-05-31 | 2001-12-11 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como inhibidores de angiogenesis. |
| US20040259863A1 (en) | 2001-10-31 | 2004-12-23 | Hans-Michael Eggenweiler | Type 4 phosphodiesterase inhibitors and uses thereof |
| DE102005042742A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| DE102005055355A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | 3,6-Dihydro-2-oxo-6H-[1,3,4]thiadiazinderivate |
| DE102005055354A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
| DE102005057924A1 (de) | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102006037478A1 (de) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| DE102007025718A1 (de) | 2007-06-01 | 2008-12-04 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007025717A1 (de) * | 2007-06-01 | 2008-12-11 | Merck Patent Gmbh | Arylether-pyridazinonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007061963A1 (de) * | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| SI2361250T1 (sl) * | 2008-12-22 | 2013-12-31 | Merck Patent Gmbh | Nove polimorfne oblike 6-(1-metil-1h-pirazol-4-il)-2-(3-(5-(2-morfolin-4-il-etoksi)-pirimidin- 2-il)-benzil)-2h-piridazin-3-on dihidrogenfosfata in postopki za proizvodnjo le-tega |
| BRPI1013159A2 (pt) * | 2009-03-30 | 2015-09-15 | Sumitomo Chemical Co | Uso de composto de piridazinona para controle de peste artrópode |
-
2008
- 2008-12-23 DE DE102008062826A patent/DE102008062826A1/de not_active Withdrawn
-
2009
- 2009-11-24 BR BRPI0923497A patent/BRPI0923497A2/pt not_active IP Right Cessation
- 2009-11-24 AU AU2009331991A patent/AU2009331991B2/en not_active Ceased
- 2009-11-24 PL PL09759895T patent/PL2367815T3/pl unknown
- 2009-11-24 JP JP2011542689A patent/JP5592395B2/ja not_active Expired - Fee Related
- 2009-11-24 ES ES09759895.7T patent/ES2532139T3/es active Active
- 2009-11-24 DK DK09759895T patent/DK2367815T3/en active
- 2009-11-24 KR KR1020117017357A patent/KR20110098854A/ko not_active Withdrawn
- 2009-11-24 HR HRP20150375TT patent/HRP20150375T1/hr unknown
- 2009-11-24 HU HUE09759895A patent/HUE025138T2/en unknown
- 2009-11-24 WO PCT/EP2009/008360 patent/WO2010072296A1/de not_active Ceased
- 2009-11-24 US US13/141,400 patent/US8637518B2/en not_active Expired - Fee Related
- 2009-11-24 CN CN200980152038.8A patent/CN102264727B/zh not_active Expired - Fee Related
- 2009-11-24 MX MX2011006652A patent/MX2011006652A/es not_active Application Discontinuation
- 2009-11-24 EP EP09759895.7A patent/EP2367815B1/de active Active
- 2009-11-24 SI SI200931166T patent/SI2367815T1/sl unknown
- 2009-11-24 EA EA201100966A patent/EA201100966A1/ru unknown
- 2009-11-24 CA CA2747863A patent/CA2747863C/en active Active
- 2009-11-24 PT PT97598957T patent/PT2367815E/pt unknown
- 2009-12-16 AR ARP090104911A patent/AR074688A1/es unknown
-
2011
- 2011-07-22 ZA ZA2011/05440A patent/ZA201105440B/en unknown
-
2015
- 2015-04-09 CY CY20151100345T patent/CY1116191T1/el unknown
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