JP2012512700A - 一酸化窒素放出医療装置を作製するための乾質ジアゼニウムジオレート化方法 - Google Patents
一酸化窒素放出医療装置を作製するための乾質ジアゼニウムジオレート化方法 Download PDFInfo
- Publication number
- JP2012512700A JP2012512700A JP2011542183A JP2011542183A JP2012512700A JP 2012512700 A JP2012512700 A JP 2012512700A JP 2011542183 A JP2011542183 A JP 2011542183A JP 2011542183 A JP2011542183 A JP 2011542183A JP 2012512700 A JP2012512700 A JP 2012512700A
- Authority
- JP
- Japan
- Prior art keywords
- medical device
- polymer
- agent
- stent
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/114—Nitric oxide, i.e. NO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
- A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/340,089 | 2008-12-19 | ||
US12/340,089 US8158187B2 (en) | 2008-12-19 | 2008-12-19 | Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices |
PCT/US2009/065076 WO2010080213A2 (fr) | 2008-12-19 | 2009-11-19 | Procédés de diazéniumdiolation à l'état sec pour produire des dispositifs médicaux libérant de l'oxyde nitrique |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2012512700A true JP2012512700A (ja) | 2012-06-07 |
Family
ID=42266514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011542183A Pending JP2012512700A (ja) | 2008-12-19 | 2009-11-19 | 一酸化窒素放出医療装置を作製するための乾質ジアゼニウムジオレート化方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8158187B2 (fr) |
EP (1) | EP2376136A4 (fr) |
JP (1) | JP2012512700A (fr) |
CN (1) | CN102256635A (fr) |
WO (1) | WO2010080213A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020515688A (ja) * | 2017-03-28 | 2020-05-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill | 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景 |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2606565C (fr) | 2005-05-27 | 2016-05-10 | The University Of North Carolina At Chapel Hill | Particules liberant de l'oxyde nitrique pour therapie a base d'oxyde nitrique et applications biomedicales |
EP2367505B1 (fr) | 2008-09-29 | 2020-08-12 | Edwards Lifesciences CardiAQ LLC | Valvule cardiaque |
EP2341871B1 (fr) | 2008-10-01 | 2017-03-22 | Edwards Lifesciences CardiAQ LLC | Système de mise en place pour implant vasculaire |
EP2810620B1 (fr) | 2009-04-15 | 2022-09-14 | Edwards Lifesciences CardiAQ LLC | Implant vasculaire et système de distribution |
ES2958410T3 (es) | 2009-08-21 | 2024-02-08 | Novan Inc | Geles tópicos |
BR112012003804B1 (pt) | 2009-08-21 | 2019-02-19 | Novan, Inc. | Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
WO2012118829A2 (fr) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Xérogels libérant de l'oxyde nitrique modifiés par des groupements s-nitrosothiols tertiaires et procédés d'utilisation associés |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
GB201112407D0 (en) * | 2011-07-19 | 2011-08-31 | Neoss Ltd | Surface treatment process for implantable medical device |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
CN104587534A (zh) * | 2013-10-31 | 2015-05-06 | 先健科技(深圳)有限公司 | 可吸收铁基合金支架 |
CN105968256B (zh) * | 2016-06-22 | 2017-12-12 | 山东师范大学 | 一种二醇二氮烯鎓结构的一氧化氮供体及其制备方法和应用 |
CN110267627B (zh) | 2016-12-09 | 2023-07-11 | 真复灵公司 | 用于在前列腺尿道中准确展开植入物的系统、装置和方法 |
WO2019046853A1 (fr) * | 2017-09-02 | 2019-03-07 | Biocrede Inc. | Dispositif médical comprenant un biocapteur intégré |
CN109908407A (zh) * | 2019-03-14 | 2019-06-21 | 西南交通大学 | 具有一氧化氮储存性能的功能薄膜材料及其制备方法 |
AU2020387396A1 (en) | 2019-11-19 | 2022-04-21 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment and imaging of an implant in the prostatic urethra |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954526A (en) | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
US5039705A (en) | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
US5212204A (en) | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
US5155137A (en) | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
JPH04140766A (ja) * | 1990-10-01 | 1992-05-14 | Mita Ind Co Ltd | 画像形成装置 |
US5268465A (en) | 1991-01-18 | 1993-12-07 | The Johns Hopkins University | Purification and molecular cloning of nitric oxide synthase |
US5380758A (en) | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
AU668107B2 (en) | 1991-09-24 | 1996-04-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
US5525357A (en) | 1992-08-24 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5405919A (en) | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
US5650447A (en) | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5910316A (en) | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
US5658565A (en) | 1994-06-24 | 1997-08-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inducible nitric oxide synthase gene for treatment of disease |
WO1994012645A2 (fr) | 1992-11-25 | 1994-06-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | CLONE D'ADNc DE SYNTHASE D'OXYDE NITRIQUE INDUCTIBLE CHEZ L'HOMME ET PROCEDE DE PREPARATION |
EP0689465A1 (fr) | 1993-03-18 | 1996-01-03 | Cedars-Sinai Medical Center | Revetement polymere pour bioprothese integrant et liberant un medicament |
US5428070A (en) | 1993-06-11 | 1995-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity |
US5891459A (en) | 1993-06-11 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity |
US5945452A (en) | 1993-06-11 | 1999-08-31 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity |
US6087479A (en) | 1993-09-17 | 2000-07-11 | Nitromed, Inc. | Localized use of nitric oxide-adducts to prevent internal tissue damage |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5583101A (en) | 1994-07-15 | 1996-12-10 | Harvard College | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
US5665077A (en) | 1995-04-24 | 1997-09-09 | Nitrosci Pharmaceuticals Llc | Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis |
US6232434B1 (en) | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
KR20000068229A (ko) | 1996-08-21 | 2000-11-25 | 오흘러 로스 제이. | 안정한 비-흡습성의 결정성 형태의 n-[n-n-(4-(피페리딘-4-일)부타노일)-n-에틸글리실] 화합물 |
CA2705474C (fr) | 1996-09-27 | 2013-07-16 | The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services | Diazen-1-ium-1,2-diolates substitues en position 1 et glycosyles en position 02 |
JP4856295B2 (ja) | 1997-07-03 | 2012-01-18 | アメリカ合衆国政府 | 新規な一酸化窒素放出アミジン誘導ジアゼニウムジオレート及びその組成物 |
US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
US7378105B2 (en) | 1997-09-26 | 2008-05-27 | Abbott Laboratories | Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens |
GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
DE69820023T2 (de) | 1998-03-26 | 2004-09-02 | Biomat B.V. | Endovaskuläre Gefässprothesen mit polymerer Beschichtung |
US6379691B1 (en) | 1998-09-29 | 2002-04-30 | Medtronic/Ave, Inc. | Uses for medical devices having a lubricious, nitric oxide-releasing coating |
US6299980B1 (en) | 1998-09-29 | 2001-10-09 | Medtronic Ave, Inc. | One step lubricious coating |
EP1207811A4 (fr) | 1999-08-04 | 2007-03-07 | Bard Inc C R | Dispositifs medicaux liberant de l'oxyde nitrique |
US6737447B1 (en) | 1999-10-08 | 2004-05-18 | The University Of Akron | Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof |
US6270779B1 (en) * | 2000-05-10 | 2001-08-07 | United States Of America | Nitric oxide-releasing metallic medical devices |
US7416559B2 (en) | 2000-10-27 | 2008-08-26 | Poly-Med, Inc. | Micromantled drug-eluting stent |
US6706274B2 (en) | 2001-01-18 | 2004-03-16 | Scimed Life Systems, Inc. | Differential delivery of nitric oxide |
US6841166B1 (en) | 2001-08-21 | 2005-01-11 | The Regents Of The University Of Michigan | Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives |
US6673338B1 (en) | 2001-09-10 | 2004-01-06 | The United States Of America As Represented By The Department Of Health And Human Services | Nitric oxide-releasing imidate and thioimidate diazeniumdiolates, compositions, uses thereof and method of making same |
US6703046B2 (en) | 2001-10-04 | 2004-03-09 | Medtronic Ave Inc. | Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use |
US7919075B1 (en) | 2002-03-20 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
US7070798B1 (en) | 2002-06-21 | 2006-07-04 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine |
US6949530B2 (en) | 2002-07-18 | 2005-09-27 | The United States Of America As Represented By The Department Of Health And Human Services | Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same |
WO2004012874A1 (fr) | 2002-08-02 | 2004-02-12 | The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Substrats reticules enduits de polyamine a liberation d'oxyde nitrique, compositions contenant ces substance s et methode de production associee |
US6951902B2 (en) | 2002-08-16 | 2005-10-04 | Michigan Biotechnology Institute | Two dimensional polymer that generates nitric oxide |
AU2003285947A1 (en) * | 2002-10-22 | 2004-05-13 | Medtronic Vascular, Inc. | Stent with eccentric coating |
US20040180131A1 (en) | 2003-03-14 | 2004-09-16 | Medtronic Ave. | Stent coating method |
WO2005037339A1 (fr) | 2003-10-14 | 2005-04-28 | Cube Medical A/S | Ballonnet utilisable en angioplastie |
US8298563B2 (en) | 2004-01-22 | 2012-10-30 | The University Of Akron | Polymer no donor predrug nanofiber coating for medical devices and therapy |
US20050171596A1 (en) | 2004-02-03 | 2005-08-04 | Furst Joseph G. | Stents with amphiphilic copolymer coatings |
US7569559B2 (en) | 2004-02-09 | 2009-08-04 | Noxilizer, Inc. | Nitric oxide-releasing molecules |
EP1718603A4 (fr) | 2004-02-09 | 2009-09-23 | Noxilizer Inc | Molecules liberant du monoxyde d'azote |
US20050265958A1 (en) | 2004-05-14 | 2005-12-01 | West Jennifer L | Nitric oxide releasing compositions and associated methods |
WO2005115489A2 (fr) | 2004-05-24 | 2005-12-08 | Genzyme Corporation | Compositions polymeres adherentes |
US20060008529A1 (en) | 2004-07-12 | 2006-01-12 | Meyerhoff Mark E | Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers |
EP1794195B1 (fr) | 2004-09-27 | 2014-12-17 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes |
US20060099235A1 (en) | 2004-11-11 | 2006-05-11 | Medtronic Vascular, Inc. | Medical devices and compositions useful for treating or inhibiting restenosis |
US20060251824A1 (en) | 2005-05-05 | 2006-11-09 | Boulais Dennis R | Coating of medical devices with solids |
WO2007024501A2 (fr) | 2005-08-25 | 2007-03-01 | Medtronic Vascular, Inc. | Polymeres biodegradables liberant de l'oxyde nitrique utiles comme dispositifs medicaux et revetements associes |
US20070053952A1 (en) | 2005-09-07 | 2007-03-08 | Medtronic Vascular, Inc. | Nitric oxide-releasing polymers derived from modified polymers |
EP1942942A2 (fr) | 2005-10-31 | 2008-07-16 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Diazeniumdiolates lies par un carbone, liberant de l'oxyde nitrique et derives de polysaccharides |
WO2007053578A2 (fr) | 2005-10-31 | 2007-05-10 | Amulet Pharmaceuticals, Inc. | Revêtements multiphasiques pour stent comprenant en co-élution de l'oxyde nitrique et un médicament |
US20070182041A1 (en) | 2006-02-07 | 2007-08-09 | Tepha, Inc. | Toughened Polylactic Acid Polymers and Copolymers |
US8241619B2 (en) | 2006-05-15 | 2012-08-14 | Medtronic Vascular, Inc. | Hindered amine nitric oxide donating polymers for coating medical devices |
US7811600B2 (en) | 2007-03-08 | 2010-10-12 | Medtronic Vascular, Inc. | Nitric oxide donating medical devices and methods of making same |
US8273828B2 (en) | 2007-07-24 | 2012-09-25 | Medtronic Vascular, Inc. | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation |
US20090222088A1 (en) | 2008-02-29 | 2009-09-03 | Medtronic Vascular, Inc. | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition |
US20090232868A1 (en) | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Nitric Oxide Releasing Polymer Composition |
US20090232863A1 (en) | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers |
US8709465B2 (en) | 2009-04-13 | 2014-04-29 | Medtronic Vascular, Inc. | Diazeniumdiolated phosphorylcholine polymers for nitric oxide release |
-
2008
- 2008-12-19 US US12/340,089 patent/US8158187B2/en not_active Expired - Fee Related
-
2009
- 2009-11-19 EP EP09837779.9A patent/EP2376136A4/fr not_active Withdrawn
- 2009-11-19 CN CN2009801518405A patent/CN102256635A/zh active Pending
- 2009-11-19 WO PCT/US2009/065076 patent/WO2010080213A2/fr active Application Filing
- 2009-11-19 JP JP2011542183A patent/JP2012512700A/ja active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020515688A (ja) * | 2017-03-28 | 2020-05-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill | 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景 |
JP7403152B2 (ja) | 2017-03-28 | 2023-12-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景 |
Also Published As
Publication number | Publication date |
---|---|
EP2376136A4 (fr) | 2013-04-10 |
US20100159119A1 (en) | 2010-06-24 |
WO2010080213A2 (fr) | 2010-07-15 |
US8158187B2 (en) | 2012-04-17 |
EP2376136A2 (fr) | 2011-10-19 |
WO2010080213A3 (fr) | 2010-10-07 |
CN102256635A (zh) | 2011-11-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2012512700A (ja) | 一酸化窒素放出医療装置を作製するための乾質ジアゼニウムジオレート化方法 | |
US20070053952A1 (en) | Nitric oxide-releasing polymers derived from modified polymers | |
US11185614B2 (en) | Balloon catheter coated with an anti-restenotic active ingredient and a molecular dispersion agent that promotes transport | |
US8021679B2 (en) | Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore | |
US8709465B2 (en) | Diazeniumdiolated phosphorylcholine polymers for nitric oxide release | |
EP1280567B1 (fr) | Dispositifs medicaux metalliques a liberation d'oxyde nitrique | |
EP2023968B1 (fr) | Polymères donneurs d'oxydes nitriques à amines encombrées pour enrobage de dispositifs médicaux | |
US20090232863A1 (en) | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers | |
US7901703B2 (en) | Polycationic peptides for cardiovascular therapy | |
US7811600B2 (en) | Nitric oxide donating medical devices and methods of making same | |
US20090232868A1 (en) | Nitric Oxide Releasing Polymer Composition | |
US20090222088A1 (en) | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition | |
JP2009526605A (ja) | 一酸化窒素を発生させる医療機器 | |
JP2006506214A (ja) | 生体適合性管腔内プロテーゼを提供する二酸化炭素アシスト法。 | |
JP6387359B2 (ja) | ラパマイシン誘導体を含む埋め込み型医療用デバイスの製造方法 | |
JP5695107B2 (ja) | ホスホリルコリン基を含有する共重合体とその製造及び利用方法 | |
JP2009542335A (ja) | メトキシエチルメタクリレートのミッドブロックを含むブロックコポリマー | |
JP2016500686A (ja) | 大環状トリエン活性薬剤及び酸化防止剤を含む植え込み型医療機器の製作方法 |