JP2012512237A - アナグレリドの製造法 - Google Patents
アナグレリドの製造法 Download PDFInfo
- Publication number
- JP2012512237A JP2012512237A JP2011541590A JP2011541590A JP2012512237A JP 2012512237 A JP2012512237 A JP 2012512237A JP 2011541590 A JP2011541590 A JP 2011541590A JP 2011541590 A JP2011541590 A JP 2011541590A JP 2012512237 A JP2012512237 A JP 2012512237A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- alkyl
- optionally substituted
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 Cc1c(*)c([N+]([O-])=O)c(C=O)c(*)c1* Chemical compound Cc1c(*)c([N+]([O-])=O)c(C=O)c(*)c1* 0.000 description 2
- OCSXCROLWYVFAO-UHFFFAOYSA-N [O-][N+](c(cc1)c(CO)c(Cl)c1Cl)=O Chemical compound [O-][N+](c(cc1)c(CO)c(Cl)c1Cl)=O OCSXCROLWYVFAO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0822970.0A GB0822970D0 (en) | 2008-12-17 | 2008-12-17 | Process for the preparation of anagrelide and analogues |
| GB0822970.0 | 2008-12-17 | ||
| PCT/GB2009/051621 WO2010070318A1 (en) | 2008-12-17 | 2009-11-30 | Process for the preparation of anagrelide and analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512237A true JP2012512237A (ja) | 2012-05-31 |
| JP2012512237A5 JP2012512237A5 (ru) | 2013-01-24 |
Family
ID=40326232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541590A Pending JP2012512237A (ja) | 2008-12-17 | 2009-11-30 | アナグレリドの製造法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8530651B2 (ru) |
| EP (1) | EP2373654A1 (ru) |
| JP (1) | JP2012512237A (ru) |
| KR (1) | KR20110100628A (ru) |
| CN (1) | CN102256981A (ru) |
| AU (1) | AU2009329320A1 (ru) |
| BR (1) | BRPI0922992A2 (ru) |
| CA (1) | CA2746145A1 (ru) |
| GB (1) | GB0822970D0 (ru) |
| IL (1) | IL213146A0 (ru) |
| MX (1) | MX2011006469A (ru) |
| NZ (1) | NZ593814A (ru) |
| RU (1) | RU2011121240A (ru) |
| SG (1) | SG172267A1 (ru) |
| WO (1) | WO2010070318A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
| GB201017783D0 (en) * | 2010-10-21 | 2010-12-01 | Shire Llc | Process for the preparation of anagrelide and analogues thereof |
| WO2014206484A1 (en) | 2013-06-28 | 2014-12-31 | Synthon B.V. | Process for making anagrelide |
| CN107903269B (zh) * | 2017-11-16 | 2021-05-04 | 湖北省宏源药业科技股份有限公司 | 一种阿那格雷三氯衍生物的制备方法 |
| CN107903217B (zh) * | 2017-11-16 | 2021-11-23 | 湖北省宏源药业科技股份有限公司 | 一种阿那格雷杂质b的制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008065445A1 (en) * | 2006-11-28 | 2008-06-05 | Shire Llc | Amino quinazolines derivatives wuth blood platelet reducing properties |
| WO2008065444A2 (en) * | 2006-11-28 | 2008-06-05 | Shire Llc | Substituted quinazolines |
| WO2008096145A1 (en) * | 2007-02-06 | 2008-08-14 | Cipla Limited | Process for the preparation of ethyl-n-(2, 3-dichloro-6-nitrobenzyl) glycine hydrochloride |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7807507A (nl) | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
| CA2171073A1 (en) | 1995-12-04 | 1997-06-05 | Philip C. Lang | Process for the preparation of ethyl-n-(2,3 dichloro-6- nitrobenzyl) glycine |
| US6388073B1 (en) | 2000-07-26 | 2002-05-14 | Shire Us Inc. | Method for the manufacture of anagrelide |
-
2008
- 2008-12-17 GB GBGB0822970.0A patent/GB0822970D0/en active Pending
-
2009
- 2009-11-30 WO PCT/GB2009/051621 patent/WO2010070318A1/en active Application Filing
- 2009-11-30 NZ NZ593814A patent/NZ593814A/xx not_active IP Right Cessation
- 2009-11-30 SG SG2011044930A patent/SG172267A1/en unknown
- 2009-11-30 AU AU2009329320A patent/AU2009329320A1/en not_active Abandoned
- 2009-11-30 RU RU2011121240/04A patent/RU2011121240A/ru not_active Application Discontinuation
- 2009-11-30 JP JP2011541590A patent/JP2012512237A/ja active Pending
- 2009-11-30 CA CA2746145A patent/CA2746145A1/en not_active Abandoned
- 2009-11-30 BR BRPI0922992A patent/BRPI0922992A2/pt not_active IP Right Cessation
- 2009-11-30 US US13/132,001 patent/US8530651B2/en not_active Expired - Fee Related
- 2009-11-30 MX MX2011006469A patent/MX2011006469A/es not_active Application Discontinuation
- 2009-11-30 KR KR1020117014167A patent/KR20110100628A/ko not_active Application Discontinuation
- 2009-11-30 CN CN2009801513257A patent/CN102256981A/zh active Pending
- 2009-11-30 EP EP09760970A patent/EP2373654A1/en not_active Withdrawn
-
2011
- 2011-05-26 IL IL213146A patent/IL213146A0/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008065445A1 (en) * | 2006-11-28 | 2008-06-05 | Shire Llc | Amino quinazolines derivatives wuth blood platelet reducing properties |
| WO2008065444A2 (en) * | 2006-11-28 | 2008-06-05 | Shire Llc | Substituted quinazolines |
| WO2008096145A1 (en) * | 2007-02-06 | 2008-08-14 | Cipla Limited | Process for the preparation of ethyl-n-(2, 3-dichloro-6-nitrobenzyl) glycine hydrochloride |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011121240A (ru) | 2013-01-27 |
| US20110263850A1 (en) | 2011-10-27 |
| EP2373654A1 (en) | 2011-10-12 |
| IL213146A0 (en) | 2011-07-31 |
| CA2746145A1 (en) | 2010-06-24 |
| SG172267A1 (en) | 2011-07-28 |
| BRPI0922992A2 (pt) | 2018-10-09 |
| KR20110100628A (ko) | 2011-09-14 |
| US8530651B2 (en) | 2013-09-10 |
| WO2010070318A1 (en) | 2010-06-24 |
| NZ593814A (en) | 2013-07-26 |
| MX2011006469A (es) | 2011-07-20 |
| AU2009329320A1 (en) | 2011-06-30 |
| CN102256981A (zh) | 2011-11-23 |
| GB0822970D0 (en) | 2009-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20121129 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20121129 |
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| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20140206 |
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| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140218 |
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| A02 | Decision of refusal |
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