JP2012511320A5 - - Google Patents
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- Publication number
- JP2012511320A5 JP2012511320A5 JP2011540199A JP2011540199A JP2012511320A5 JP 2012511320 A5 JP2012511320 A5 JP 2012511320A5 JP 2011540199 A JP2011540199 A JP 2011540199A JP 2011540199 A JP2011540199 A JP 2011540199A JP 2012511320 A5 JP2012511320 A5 JP 2012511320A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- nucleic acid
- acid vector
- modified nucleic
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 claims 41
- 102000039446 nucleic acids Human genes 0.000 claims 41
- 150000007523 nucleic acids Chemical class 0.000 claims 41
- 239000013598 vector Substances 0.000 claims 41
- 229920000642 polymer Polymers 0.000 claims 29
- 238000000034 method Methods 0.000 claims 10
- 125000003277 amino group Chemical group 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- 230000000975 bioactive effect Effects 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 150000007857 hydrazones Chemical class 0.000 claims 2
- 230000000813 microbial effect Effects 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 210000004940 nucleus Anatomy 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 108700012359 toxins Proteins 0.000 claims 2
- 241001515965 unidentified phage Species 0.000 claims 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 claims 1
- 102000007592 Apolipoproteins Human genes 0.000 claims 1
- 108010071619 Apolipoproteins Proteins 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 241000125945 Protoparvovirus Species 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000710924 Togaviridae Species 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000002318 adhesion promoter Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 229940088623 biologically active substance Drugs 0.000 claims 1
- 230000021164 cell adhesion Effects 0.000 claims 1
- 229920006237 degradable polymer Polymers 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002228 disulfide group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002829 reductive effect Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBPCT/GB08/04097 | 2008-12-11 | ||
| PCT/GB2008/004097 WO2010067041A1 (en) | 2008-12-11 | 2008-12-11 | Modification of nucleic acid vectors with polymers comprising charged quaternary amino groups |
| PCT/GB2009/002869 WO2010067081A2 (en) | 2008-12-11 | 2009-12-11 | Modification of nucleic acid vectors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012511320A JP2012511320A (ja) | 2012-05-24 |
| JP2012511320A5 true JP2012511320A5 (enExample) | 2012-11-22 |
Family
ID=40263320
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540186A Pending JP2012511319A (ja) | 2008-12-11 | 2008-12-11 | 荷電４級アミノ基を含むポリマーによる核酸ベクターの改変 |
| JP2011540199A Pending JP2012511320A (ja) | 2008-12-11 | 2009-12-11 | 核酸ベクターの改変 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540186A Pending JP2012511319A (ja) | 2008-12-11 | 2008-12-11 | 荷電４級アミノ基を含むポリマーによる核酸ベクターの改変 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20110243897A1 (enExample) |
| EP (2) | EP2370108A1 (enExample) |
| JP (2) | JP2012511319A (enExample) |
| KR (2) | KR20110097938A (enExample) |
| CN (2) | CN102245215A (enExample) |
| AU (2) | AU2008365111B2 (enExample) |
| BR (2) | BRPI0823363A2 (enExample) |
| CA (2) | CA2744959A1 (enExample) |
| EA (2) | EA201100915A1 (enExample) |
| WO (2) | WO2010067041A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0907989D0 (en) * | 2009-05-08 | 2009-06-24 | Hybrid Systems Ltd | Multivalent adjuvant display |
| WO2012051459A1 (en) * | 2010-10-14 | 2012-04-19 | Nitto Denko Corporation | Nucleic acid delivery compounds |
| WO2012113413A1 (en) * | 2011-02-21 | 2012-08-30 | Curevac Gmbh | Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates |
| ES2526154T3 (es) * | 2012-01-27 | 2015-01-07 | Deutsches Krebsforschungszentrum | Parvovirus modificado útil para silenciamiento génico |
| US9758606B2 (en) | 2012-07-31 | 2017-09-12 | The Trustees Of Columbia University In The City Of New York | Cyclopropenium polymers and methods for making the same |
| ES2684552T3 (es) | 2012-09-03 | 2018-10-03 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Anticuerpos dirigidos contra ICOS para tratar la enfermedad de injerto contra hospedador |
| EP2931903B1 (en) * | 2012-12-14 | 2021-07-28 | The Regents of the University of California | Viral vector nanocapsule for targeting gene therapy and its preparation |
| EP3007711B1 (en) | 2013-06-14 | 2020-10-21 | Psioxus Therapeutics Limited | A dosing regime and formulations for type b adenoviruses |
| ES2747762T3 (es) | 2013-08-21 | 2020-03-11 | Curevac Ag | Vacuna contra el virus respiratorio sincitial (RSV) |
| GB201510197D0 (en) | 2014-06-12 | 2015-07-29 | Psioxus Therapeutics Ltd | Method of treating ovarian cancer |
| CN105153339B (zh) * | 2015-10-13 | 2017-10-24 | 浙江大学 | 一种氧化响应去正电荷的阳离子聚合物、制备方法和应用 |
| BR112019020853A2 (pt) | 2017-04-04 | 2020-05-12 | Avidea Technologies, Inc. | Vacinas à base de peptídeo, métodos de fabricação e usos das mesmas para induzir uma resposta imune |
| GB201708203D0 (en) * | 2017-05-22 | 2017-07-05 | Sagetis Biotech Sl | Chemical compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7634694A (en) * | 1993-08-20 | 1995-03-21 | University Of Medicine And Dentistry Of New Jersey | Bridged polycationic polymer-oligonucleotide conjugates and methods for preparing same |
| GB9623051D0 (en) * | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
| WO1998044143A1 (en) | 1997-04-03 | 1998-10-08 | Genzyme Corporation | Polymer-modified viruses |
| GB9913359D0 (en) | 1999-06-09 | 1999-08-11 | Cancer Res Campaign Tech | Polymer modified biological elements |
| CZ294996B6 (cs) * | 2003-07-16 | 2005-04-13 | Ústav Makromolekulární Chemie Av Čr | Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů |
| WO2006085664A1 (ja) * | 2005-02-10 | 2006-08-17 | The University Of Tokyo | ポリカチオン荷電性ポリマー及び核酸のキャリヤーとしての使用 |
-
2008
- 2008-12-11 CN CN2008801322927A patent/CN102245215A/zh active Pending
- 2008-12-11 KR KR1020117015840A patent/KR20110097938A/ko not_active Withdrawn
- 2008-12-11 BR BRPI0823363-2A patent/BRPI0823363A2/pt not_active IP Right Cessation
- 2008-12-11 CA CA2744959A patent/CA2744959A1/en not_active Abandoned
- 2008-12-11 JP JP2011540186A patent/JP2012511319A/ja active Pending
- 2008-12-11 AU AU2008365111A patent/AU2008365111B2/en not_active Ceased
- 2008-12-11 WO PCT/GB2008/004097 patent/WO2010067041A1/en not_active Ceased
- 2008-12-11 EA EA201100915A patent/EA201100915A1/ru unknown
- 2008-12-11 EP EP08875669A patent/EP2370108A1/en not_active Withdrawn
- 2008-12-11 US US13/139,151 patent/US20110243897A1/en not_active Abandoned
-
2009
- 2009-12-11 EP EP09785206A patent/EP2373347A2/en not_active Withdrawn
- 2009-12-11 CA CA2744938A patent/CA2744938A1/en not_active Abandoned
- 2009-12-11 JP JP2011540199A patent/JP2012511320A/ja active Pending
- 2009-12-11 BR BRPI0922957A patent/BRPI0922957A2/pt not_active IP Right Cessation
- 2009-12-11 CN CN2009801494608A patent/CN102245213A/zh active Pending
- 2009-12-11 KR KR1020117015838A patent/KR20110099034A/ko not_active Withdrawn
- 2009-12-11 WO PCT/GB2009/002869 patent/WO2010067081A2/en not_active Ceased
- 2009-12-11 EA EA201100914A patent/EA201100914A1/ru unknown
- 2009-12-11 US US13/139,185 patent/US20110243939A1/en not_active Abandoned
- 2009-12-11 AU AU2009326176A patent/AU2009326176A1/en not_active Abandoned
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