JP2012509295A5 - - Google Patents

Info

Publication number

JP2012509295A5

JP2012509295A5 JP2011536843A JP2011536843A JP2012509295A5 JP 2012509295 A5 JP2012509295 A5 JP 2012509295A5 JP 2011536843 A JP2011536843 A JP 2011536843A JP 2011536843 A JP2011536843 A JP 2011536843A JP 2012509295 A5 JP2012509295 A5 JP 2012509295A5

Authority

JP

Japan

Prior art keywords

peptide

amyloid

seq

binds

sequence

Prior art date

2009-11-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 102000013455 Amyloid beta-Peptides Human genes 0.000 claims description 20
• 108010090849 Amyloid beta-Peptides Proteins 0.000 claims description 20
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 10
• 239000012634 fragment Substances 0.000 claims description 6
• 208000024827 Alzheimer disease Diseases 0.000 claims description 5
• 238000003745 diagnosis Methods 0.000 claims description 3
• 230000004807 localization Effects 0.000 claims description 3
• 238000011002 quantification Methods 0.000 claims description 3
• 150000008574 D-amino acids Chemical class 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 230000006806 disease prevention Effects 0.000 claims 3
• 150000008575 L-amino acids Chemical class 0.000 claims 2
• 210000004102 animal cell Anatomy 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 210000004754 hybrid cell Anatomy 0.000 claims 1
• 238000002649 immunization Methods 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000002955 isolation Methods 0.000 claims 1
• 201000000050 myeloid neoplasm Diseases 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000001514 detection method Methods 0.000 description 2
• 230000001900 immune effect Effects 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1