JP2012508367A - リン酸化型fms関連チロシンキナーゼ3バイオマーカーアッセイ - Google Patents

リン酸化型fms関連チロシンキナーゼ3バイオマーカーアッセイ Download PDF

Info

Publication number
JP2012508367A
JP2012508367A JP2011534927A JP2011534927A JP2012508367A JP 2012508367 A JP2012508367 A JP 2012508367A JP 2011534927 A JP2011534927 A JP 2011534927A JP 2011534927 A JP2011534927 A JP 2011534927A JP 2012508367 A JP2012508367 A JP 2012508367A
Authority
JP
Japan
Prior art keywords
antibody
flt3
sample
human
pflt3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011534927A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012508367A5 (https=
Inventor
エヌ. グナワルダネ ルワントヒ
Original Assignee
アムビト ビオスシエンセス コルポラチオン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アムビト ビオスシエンセス コルポラチオン filed Critical アムビト ビオスシエンセス コルポラチオン
Publication of JP2012508367A publication Critical patent/JP2012508367A/ja
Publication of JP2012508367A5 publication Critical patent/JP2012508367A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2011534927A 2008-11-06 2009-11-06 リン酸化型fms関連チロシンキナーゼ3バイオマーカーアッセイ Pending JP2012508367A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11211008P 2008-11-06 2008-11-06
US61/112,110 2008-11-06
US12032508P 2008-12-05 2008-12-05
US61/120,325 2008-12-05
PCT/US2009/063534 WO2010054185A1 (en) 2008-11-06 2009-11-06 Phosphorylated fms-related tyrosine kinase 3 biomarker assay

Publications (2)

Publication Number Publication Date
JP2012508367A true JP2012508367A (ja) 2012-04-05
JP2012508367A5 JP2012508367A5 (https=) 2012-12-27

Family

ID=42153250

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011534927A Pending JP2012508367A (ja) 2008-11-06 2009-11-06 リン酸化型fms関連チロシンキナーゼ3バイオマーカーアッセイ

Country Status (4)

Country Link
US (1) US20110275094A1 (https=)
EP (1) EP2353003A4 (https=)
JP (1) JP2012508367A (https=)
WO (1) WO2010054185A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130052669A1 (en) * 2010-04-30 2013-02-28 Amanda G. Paulovich Compositions and methods for reliably detecting and/or measuring the amount of a modified target protein in a sample
CN118772278A (zh) 2017-06-02 2024-10-15 辉瑞公司 Flt3的特异性抗体及其用途
EP4481383A4 (en) * 2022-03-25 2025-06-04 Sekisui Medical Co., Ltd. Immunological analysis method, complex, method for preparing the complex and reagent for immunological analysis

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011470A1 (fr) * 1998-08-20 2000-03-02 Chugai Seiyaku Kabushiki Kaisha Procede de criblage de composes d'interet potentiel destines a un medicament contre les tumeurs
US20030219827A1 (en) * 2002-02-20 2003-11-27 Comb Michael J. Phospho-specific antibodies to Flt3 and uses thereof
JP2004215671A (ja) * 1996-10-18 2004-08-05 Takara Bio Inc レセプター型プロテインキナーゼをコードする核酸
WO2006135644A1 (en) * 2005-06-10 2006-12-21 Janssen Pharmaceutica N.V. Aminopyrimidines as kinase modulators
US20070004660A1 (en) * 2005-06-10 2007-01-04 Baumann Christian A Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines
WO2007125407A1 (en) * 2006-05-03 2007-11-08 Ncl New Concept Lab Gmbh Device and method for chemical, biochemical, biological and physical analysis, reaction, assay and more
JP2008527980A (ja) * 2005-01-25 2008-07-31 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
JP2010520197A (ja) * 2007-02-28 2010-06-10 シェーリング コーポレイション 免疫性障害の処置のための組合せ治療

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US6495335B2 (en) * 2000-12-07 2002-12-17 Mario Chojkier Compositions and methods for diagnosing alzheimer's disease
AU2006272094B2 (en) * 2005-07-16 2012-01-19 Merck Patent Gmbh Method for measuring tyrosine kinase phosphorylation
US7999080B2 (en) * 2006-07-13 2011-08-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in signaling pathways

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004215671A (ja) * 1996-10-18 2004-08-05 Takara Bio Inc レセプター型プロテインキナーゼをコードする核酸
WO2000011470A1 (fr) * 1998-08-20 2000-03-02 Chugai Seiyaku Kabushiki Kaisha Procede de criblage de composes d'interet potentiel destines a un medicament contre les tumeurs
US20030219827A1 (en) * 2002-02-20 2003-11-27 Comb Michael J. Phospho-specific antibodies to Flt3 and uses thereof
JP2008527980A (ja) * 2005-01-25 2008-07-31 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
WO2006135644A1 (en) * 2005-06-10 2006-12-21 Janssen Pharmaceutica N.V. Aminopyrimidines as kinase modulators
US20070004660A1 (en) * 2005-06-10 2007-01-04 Baumann Christian A Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines
WO2007125407A1 (en) * 2006-05-03 2007-11-08 Ncl New Concept Lab Gmbh Device and method for chemical, biochemical, biological and physical analysis, reaction, assay and more
JP2010520197A (ja) * 2007-02-28 2010-06-10 シェーリング コーポレイション 免疫性障害の処置のための組合せ治療

Also Published As

Publication number Publication date
EP2353003A4 (en) 2012-05-30
EP2353003A1 (en) 2011-08-10
WO2010054185A1 (en) 2010-05-14
US20110275094A1 (en) 2011-11-10

Similar Documents

Publication Publication Date Title
JP5963005B2 (ja) 膵臓癌の治療のためのベバシズマブ組合せ療法のための血漿バイオマーカー
JP2016028251A (ja) 発癌性融合タンパク質を検出するための近接媒介性アッセイ
US12583938B2 (en) Protein biomarker and uses thereof
JP2013534307A (ja) 抗癌治療への応答可能性の増大した患者を同定する方法
JP2015502543A (ja) 乳癌治療向けベバシズマブ併用療法用血漿バイオマーカー
JP2012508367A (ja) リン酸化型fms関連チロシンキナーゼ3バイオマーカーアッセイ
JP7304558B2 (ja) がん免疫療法の予後予測のためのバイオマーカー
CN107615071B (zh) 用于包含乐伐替尼和依维莫司的联合疗法的生物标志
JP7431226B2 (ja) レンバチニブ及びエベロリムスを含む併用療法のためのバイオマーカー
US8124351B2 (en) Quantification of fusion proteins and their activity from chromosomal translocation
JP2025520600A (ja) 子宮内膜症を診断するためおよび子宮内膜症の病期を分類するための方法
JP2013521487A (ja) Egfr阻害剤を用いる処置のための患者を選択する方法
JP2019518970A (ja) 腎臓癌を患う対象の癌治療に対する感受性を予測するための方法およびキット
US20110269139A1 (en) Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
JP6195716B2 (ja) 抗癌剤耐性診断マーカー
US10753935B2 (en) Prognostic method and kits useful in said method
TW202417641A (zh) 預測對egfr激酶活性之抑制劑的反應之方法
WO2010062705A1 (en) Cancer diagnosis using ki-67
Apeltsin et al. Multiplex Detection of Immunoglobulins Uncovers Intrathecal IgA Elevation in Multiple Sclerosis
TW201829019A (zh) 用以預測藉由抗vegf藥之滲出性老年性黃斑部退化的治療有效性之方法
HK1198063A (en) Blood plasma biomarkers for bevacizumab combination therapies for treatment of breast cancer

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121105

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20121105

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20130531

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130702

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130930

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131007

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140408