JP2012505892A5 - - Google Patents
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- Publication number
- JP2012505892A5 JP2012505892A5 JP2011532177A JP2011532177A JP2012505892A5 JP 2012505892 A5 JP2012505892 A5 JP 2012505892A5 JP 2011532177 A JP2011532177 A JP 2011532177A JP 2011532177 A JP2011532177 A JP 2011532177A JP 2012505892 A5 JP2012505892 A5 JP 2012505892A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- optionally
- hydroxyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000001424 substituent group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- -1 amino, hydroxyl Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10545508P | 2008-10-15 | 2008-10-15 | |
| US61/105,455 | 2008-10-15 | ||
| PCT/US2009/060439 WO2010045190A1 (en) | 2008-10-15 | 2009-10-13 | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012505892A JP2012505892A (ja) | 2012-03-08 |
| JP2012505892A5 true JP2012505892A5 (OSRAM) | 2012-11-29 |
Family
ID=41382316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532177A Withdrawn JP2012505892A (ja) | 2008-10-15 | 2009-10-13 | Ｍｍｐ−１３阻害剤として有用な縮合ヘテロアリールジアミド化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8338367B2 (OSRAM) |
| EP (1) | EP2344480A1 (OSRAM) |
| JP (1) | JP2012505892A (OSRAM) |
| CA (1) | CA2739488A1 (OSRAM) |
| WO (1) | WO2010045190A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012505892A (ja) | 2008-10-15 | 2012-03-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｍｐ−１３阻害剤として有用な縮合ヘテロアリールジアミド化合物 |
| US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
| EP2346831B1 (en) | 2008-11-17 | 2015-01-07 | Boehringer Ingelheim International GmbH | Heteroaryl diamide compounds useful as mmp-13 inhibitors |
| BR112013006016A2 (pt) | 2010-09-15 | 2016-06-07 | Hoffmann La Roche | compostos de azabenzotiazol, composições e métodos de uso |
| AR086113A1 (es) | 2011-04-30 | 2013-11-20 | Abbott Lab | Isoxazolinas como agentes terapeuticos |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000033836A1 (en) | 1998-12-04 | 2000-06-15 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulators of selectins |
| US20020165222A1 (en) * | 1999-02-19 | 2002-11-07 | Smithkline Beecham Corporation | Protease inhibitors |
| HK1039108A1 (zh) * | 1999-03-15 | 2002-04-12 | Axys Pharmaceuticals, Inc. | 以n-氰甲基酰胺作为蛋白酶抑制剂 |
| GB0018758D0 (en) | 2000-07-31 | 2000-09-20 | Smithkline Beecham Plc | Novel use and compunds |
| IL153645A0 (en) | 2000-07-31 | 2003-07-06 | Smithkline Beecham Plc | Carboxamide compounds and their use as antagonists of a human 11cby receptor |
| AU2001277621A1 (en) | 2000-08-09 | 2002-03-04 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| DE10229070A1 (de) | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
| US20050004111A1 (en) * | 2003-01-03 | 2005-01-06 | Aventis Pharma Deutschland Gmbh | Selective MMP-13 inhibitors |
| WO2005016862A1 (en) | 2003-08-14 | 2005-02-24 | Asahi Kasei Pharma Corporation | Substituted arylalkanoic acid derivative and use thereof |
| RU2403247C2 (ru) | 2004-07-20 | 2010-11-10 | СЬЕНА БИОТЕК С.п.А. | Модуляторы никотиновых ацетилхолиновых рецепторов альфа 7 и их терапевтические применения |
| AU2005318465A1 (en) | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with Kv4 ion channel activity |
| GT200600042A (es) | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
| JP2009504761A (ja) | 2005-08-19 | 2009-02-05 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 睡眠剤と置換ビスアリール及びヘテロアリール化合物の組み合わせ物及び治療でのその使用 |
| JP2012505892A (ja) | 2008-10-15 | 2012-03-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｍｐ−１３阻害剤として有用な縮合ヘテロアリールジアミド化合物 |
| US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
| EP2346831B1 (en) | 2008-11-17 | 2015-01-07 | Boehringer Ingelheim International GmbH | Heteroaryl diamide compounds useful as mmp-13 inhibitors |
-
2009
- 2009-10-13 JP JP2011532177A patent/JP2012505892A/ja not_active Withdrawn
- 2009-10-13 WO PCT/US2009/060439 patent/WO2010045190A1/en not_active Ceased
- 2009-10-13 US US13/123,002 patent/US8338367B2/en active Active
- 2009-10-13 EP EP09740587A patent/EP2344480A1/en not_active Withdrawn
- 2009-10-13 CA CA2739488A patent/CA2739488A1/en not_active Abandoned
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