JP2012504941A5 - - Google Patents

Info

Publication number

JP2012504941A5

JP2012504941A5 JP2011530354A JP2011530354A JP2012504941A5 JP 2012504941 A5 JP2012504941 A5 JP 2012504941A5 JP 2011530354 A JP2011530354 A JP 2011530354A JP 2011530354 A JP2011530354 A JP 2011530354A JP 2012504941 A5 JP2012504941 A5 JP 2012504941A5

Authority

JP

Japan

Prior art keywords

peptide

pharmaceutical composition

administration

human

treatment

Prior art date

2009-09-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims description 32
• 239000008194 pharmaceutical composition Substances 0.000 claims description 28
• 241001465754 Metazoa Species 0.000 claims description 15
• 201000011510 cancer Diseases 0.000 claims description 8
• 239000003814 drug Substances 0.000 claims description 8
• 206010016654 Fibrosis Diseases 0.000 claims description 7
• 230000004761 fibrosis Effects 0.000 claims description 7
• 230000002265 prevention Effects 0.000 claims description 7
• 206010028980 Neoplasm Diseases 0.000 claims description 6
• 241000282412 Homo Species 0.000 claims description 5
• 239000003937 drug carrier Substances 0.000 claims description 4
• 238000002347 injection Methods 0.000 claims description 4
• 239000007924 injection Substances 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 4
• 239000005517 L01XE01 - Imatinib Substances 0.000 claims description 2
• 206010027476 Metastases Diseases 0.000 claims description 2
• 239000002246 antineoplastic agent Substances 0.000 claims description 2
• 229940127089 cytotoxic agent Drugs 0.000 claims description 2
• 229940080856 gleevec Drugs 0.000 claims description 2
• KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims description 2
• 238000003780 insertion Methods 0.000 claims description 2
• 230000037431 insertion Effects 0.000 claims description 2
• 238000007918 intramuscular administration Methods 0.000 claims description 2
• 238000010255 intramuscular injection Methods 0.000 claims description 2
• 239000007927 intramuscular injection Substances 0.000 claims description 2
• 238000001990 intravenous administration Methods 0.000 claims description 2
• 210000003734 kidney Anatomy 0.000 claims description 2
• 210000004185 liver Anatomy 0.000 claims description 2
• 210000004072 lung Anatomy 0.000 claims description 2
• 230000009401 metastasis Effects 0.000 claims description 2
• 239000002773 nucleotide Substances 0.000 claims description 2
• 125000003729 nucleotide group Chemical group 0.000 claims description 2
• 238000007920 subcutaneous administration Methods 0.000 claims description 2
• 238000010254 subcutaneous injection Methods 0.000 claims description 2
• 239000007929 subcutaneous injection Substances 0.000 claims description 2
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
• 235000018102 proteins Nutrition 0.000 description 2
• 108090000623 proteins and genes Proteins 0.000 description 2
• 102000004169 proteins and genes Human genes 0.000 description 2
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 2
• 238000001262 western blot Methods 0.000 description 2
• 102000007469 Actins Human genes 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 description 1
• 101150018665 MAPK3 gene Proteins 0.000 description 1
• 229940124647 MEK inhibitor Drugs 0.000 description 1
• 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 1
• 210000004027 cell Anatomy 0.000 description 1
• 210000002889 endothelial cell Anatomy 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
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• 230000026731 phosphorylation Effects 0.000 description 1
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• 230000019491 signal transduction Effects 0.000 description 1
• 210000003606 umbilical vein Anatomy 0.000 description 1