JP2012504766A5 - - Google Patents
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- JP2012504766A5 JP2012504766A5 JP2011530199A JP2011530199A JP2012504766A5 JP 2012504766 A5 JP2012504766 A5 JP 2012504766A5 JP 2011530199 A JP2011530199 A JP 2011530199A JP 2011530199 A JP2011530199 A JP 2011530199A JP 2012504766 A5 JP2012504766 A5 JP 2012504766A5
- Authority
- JP
- Japan
- Prior art keywords
- ions
- mass spectrometry
- amount
- mass
- dht
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 28
- 150000002500 ions Chemical class 0.000 claims 25
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 claims 12
- 238000004949 mass spectrometry Methods 0.000 claims 12
- 229960003473 androstanolone Drugs 0.000 claims 10
- 210000001124 body fluid Anatomy 0.000 claims 7
- 239000010839 body fluid Substances 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 5
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims 5
- 239000002243 precursor Substances 0.000 claims 5
- 238000004128 high performance liquid chromatography Methods 0.000 claims 4
- 238000000746 purification Methods 0.000 claims 4
- 238000004811 liquid chromatography Methods 0.000 claims 3
- 238000004885 tandem mass spectrometry Methods 0.000 claims 3
- 238000011002 quantification Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10320208P | 2008-10-06 | 2008-10-06 | |
| US61/103,202 | 2008-10-06 | ||
| US12/272,663 US7804063B2 (en) | 2008-10-06 | 2008-11-17 | Methods for detecting dihydrotestosterone by mass spectrometry |
| US12/272,663 | 2008-11-17 | ||
| PCT/US2009/059090 WO2010042370A1 (en) | 2008-10-06 | 2009-09-30 | Methods for detecting dihydrotestosterone by mass spectrometry |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015047630A Division JP6151291B2 (ja) | 2008-10-06 | 2015-03-10 | 質量分析によるジヒドロテストステロンの検出法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012504766A JP2012504766A (ja) | 2012-02-23 |
| JP2012504766A5 true JP2012504766A5 (enExample) | 2012-11-22 |
| JP6096412B2 JP6096412B2 (ja) | 2017-03-15 |
Family
ID=42075045
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530199A Active JP6096412B2 (ja) | 2008-10-06 | 2009-09-30 | 質量分析によるジヒドロテストステロンの検出法 |
| JP2015047630A Active JP6151291B2 (ja) | 2008-10-06 | 2015-03-10 | 質量分析によるジヒドロテストステロンの検出法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015047630A Active JP6151291B2 (ja) | 2008-10-06 | 2015-03-10 | 質量分析によるジヒドロテストステロンの検出法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7804063B2 (enExample) |
| EP (2) | EP2344661B1 (enExample) |
| JP (2) | JP6096412B2 (enExample) |
| CN (2) | CN106770756A (enExample) |
| AU (1) | AU2009302641B2 (enExample) |
| BR (1) | BRPI0920028A8 (enExample) |
| CA (1) | CA2739506C (enExample) |
| MX (1) | MX2011003653A (enExample) |
| WO (1) | WO2010042370A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7893399B2 (en) * | 2008-09-09 | 2011-02-22 | Quest Diagnostics Investments Incorporated | Methods for detecting dehydroepiandrosterone by mass spectrometry |
| US7804063B2 (en) * | 2008-10-06 | 2010-09-28 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydrotestosterone by mass spectrometry |
| EP2384437B1 (en) | 2008-12-24 | 2018-12-12 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for pregnenolone and 17-hydroxypregnenolone |
| US9834578B2 (en) * | 2010-05-27 | 2017-12-05 | University Of Utah Research Foundation | Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry |
| EP3702774B1 (en) * | 2011-02-07 | 2025-10-01 | Laboratory Corporation of America Holdings | Method for determining the presence or amount of testosterone in a sample |
| CN104040343A (zh) * | 2012-01-05 | 2014-09-10 | Dh科技发展私人贸易有限公司 | 增强含有酮类固醇和酮基或醛的分析物的灵敏度和特异性 |
| CN107525857B (zh) * | 2017-03-29 | 2019-11-12 | 中国检验检疫科学研究院 | 一种洗护用品中孕激素化学风险物质的筛查方法 |
| CN107064400B (zh) * | 2017-04-20 | 2018-09-21 | 博厚健康科技股份有限公司 | 同时检测血清中五种类固醇激素的方法 |
| CN109633041B (zh) * | 2019-02-26 | 2021-07-02 | 广东食品药品职业学院 | 衍生化hplc法测定药物中双氢睾酮的方法 |
| JP2022528979A (ja) * | 2019-04-16 | 2022-06-16 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Ｌｃ－ｍｓ／ｍｓによる１１－オキソアンドロゲンの検出のための方法およびシステム |
| KR102046488B1 (ko) * | 2019-07-02 | 2019-11-19 | 건국대학교 글로컬산학협력단 | 모유은행 기증 모유의 다차원 분석방법 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017A (en) * | 1851-04-01 | Splint-machine | ||
| US8016A (en) * | 1851-04-01 | Improvement in the manufacture of india-rubber | ||
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| ATE242485T1 (de) | 1993-05-28 | 2003-06-15 | Baylor College Medicine | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| US5772874A (en) | 1995-11-02 | 1998-06-30 | Cohesive Technologies, Inc. | High performance liquid chromatography method and apparatus |
| DK0840893T3 (da) | 1996-01-19 | 2000-04-03 | Cohesive Tech Inc | Fremgangsmåde og apparat til højeffektiv væskekromatografi |
| GB9717926D0 (en) | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| US6600155B1 (en) | 1998-01-23 | 2003-07-29 | Analytica Of Branford, Inc. | Mass spectrometry from surfaces |
| AU4299301A (en) * | 2000-02-29 | 2001-09-12 | National University Of Singapore, The | A method for modulating steroidogenic activity |
| WO2003012445A1 (en) * | 2001-07-30 | 2003-02-13 | Quest Diagnostics Investments Incorporated | Methods and kits for detecting ita in a biological sample |
| JP3774888B2 (ja) * | 2001-11-28 | 2006-05-17 | 日本化薬株式会社 | ステロイド類化合物のｌｃ−ｍｓによる高感度検出法 |
| US20040033530A1 (en) * | 2002-04-08 | 2004-02-19 | Awrey Donald E. | High throughput purification, characterization and identification of recombinant proteins |
| JP3686657B2 (ja) * | 2003-02-27 | 2005-08-24 | 帝国臓器製薬株式会社 | ステロイド性生体内微量物質の測定方法 |
| US6977143B1 (en) * | 2003-09-08 | 2005-12-20 | Quest Diagnostics Investments Incorporated | Determination of testosterone by mass spectrometry |
| WO2005115361A2 (en) * | 2004-05-17 | 2005-12-08 | Acadia Pharmaceuticals Inc. | Androgen receptor modulators and method of treating disease using the same |
| US7935921B2 (en) * | 2006-05-26 | 2011-05-03 | Laboratory Corporation Of America Holdings | Methods and systems for the quantitative analysis of biomarkers |
| US20080176269A1 (en) | 2006-10-06 | 2008-07-24 | Mohler James L | Method for determination of DHT levels in tissue samples |
| JP3141511U (ja) * | 2008-02-22 | 2008-05-08 | 株式会社島津製作所 | 液体クロマトグラフ質量分析装置 |
| US7893399B2 (en) * | 2008-09-09 | 2011-02-22 | Quest Diagnostics Investments Incorporated | Methods for detecting dehydroepiandrosterone by mass spectrometry |
| US7804063B2 (en) * | 2008-10-06 | 2010-09-28 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydrotestosterone by mass spectrometry |
| EP2384437B1 (en) * | 2008-12-24 | 2018-12-12 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for pregnenolone and 17-hydroxypregnenolone |
-
2008
- 2008-11-17 US US12/272,663 patent/US7804063B2/en active Active
-
2009
- 2009-09-30 AU AU2009302641A patent/AU2009302641B2/en active Active
- 2009-09-30 JP JP2011530199A patent/JP6096412B2/ja active Active
- 2009-09-30 EP EP09819667.8A patent/EP2344661B1/en active Active
- 2009-09-30 WO PCT/US2009/059090 patent/WO2010042370A1/en not_active Ceased
- 2009-09-30 CN CN201611163981.7A patent/CN106770756A/zh active Pending
- 2009-09-30 CN CN2009801488128A patent/CN102239266A/zh active Pending
- 2009-09-30 CA CA2739506A patent/CA2739506C/en active Active
- 2009-09-30 BR BRPI0920028A patent/BRPI0920028A8/pt active IP Right Grant
- 2009-09-30 MX MX2011003653A patent/MX2011003653A/es active IP Right Grant
- 2009-09-30 EP EP16188837.5A patent/EP3124617A1/en not_active Ceased
-
2010
- 2010-08-05 US US12/851,505 patent/US8158931B2/en active Active
-
2012
- 2012-03-21 US US13/426,435 patent/US8410428B2/en active Active
-
2013
- 2013-03-29 US US13/853,668 patent/US8563922B2/en active Active
-
2015
- 2015-03-10 JP JP2015047630A patent/JP6151291B2/ja active Active
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