JP2012502906A5 - - Google Patents
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- Publication number
- JP2012502906A5 JP2012502906A5 JP2011526875A JP2011526875A JP2012502906A5 JP 2012502906 A5 JP2012502906 A5 JP 2012502906A5 JP 2011526875 A JP2011526875 A JP 2011526875A JP 2011526875 A JP2011526875 A JP 2011526875A JP 2012502906 A5 JP2012502906 A5 JP 2012502906A5
- Authority
- JP
- Japan
- Prior art keywords
- protease inhibitor
- compound
- compound according
- water
- soluble non
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 33
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 25
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 25
- 208000006454 hepatitis Diseases 0.000 claims description 10
- 231100000283 hepatitis Toxicity 0.000 claims description 10
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- 229940122604 HCV protease inhibitor Drugs 0.000 claims description 2
- 229940122440 HIV protease inhibitor Drugs 0.000 claims description 2
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- LHHCSNFAOIFYRV-DOVBMPENSA-N boceprevir Chemical compound O=C([C@@H]1[C@@H]2[C@@H](C2(C)C)CN1C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)NC(C(=O)C(N)=O)CC1CCC1 LHHCSNFAOIFYRV-DOVBMPENSA-N 0.000 claims description 2
- 229960000517 boceprevir Drugs 0.000 claims description 2
- PJZPDFUUXKKDNB-KNINVFKUSA-N ciluprevir Chemical compound N([C@@H]1C(=O)N2[C@H](C(N[C@@]3(C[C@H]3\C=C/CCCCC1)C(O)=O)=O)C[C@H](C2)OC=1C2=CC=C(C=C2N=C(C=1)C=1N=C(NC(C)C)SC=1)OC)C(=O)OC1CCCC1 PJZPDFUUXKKDNB-KNINVFKUSA-N 0.000 claims description 2
- ZVTDLPBHTSMEJZ-JSZLBQEHSA-N danoprevir Chemical compound O=C([C@@]12C[C@H]1\C=C/CCCCC[C@@H](C(N1C[C@@H](C[C@H]1C(=O)N2)OC(=O)N1CC2=C(F)C=CC=C2C1)=O)NC(=O)OC(C)(C)C)NS(=O)(=O)C1CC1 ZVTDLPBHTSMEJZ-JSZLBQEHSA-N 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000004030 hiv protease inhibitor Substances 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 229960002935 telaprevir Drugs 0.000 claims description 2
- BBAWEDCPNXPBQM-GDEBMMAJSA-N telaprevir Chemical group N([C@H](C(=O)N[C@H](C(=O)N1C[C@@H]2CCC[C@@H]2[C@H]1C(=O)N[C@@H](CCC)C(=O)C(=O)NC1CC1)C(C)(C)C)C1CCCCC1)C(=O)C1=CN=CC=N1 BBAWEDCPNXPBQM-GDEBMMAJSA-N 0.000 claims description 2
- 108010017101 telaprevir Proteins 0.000 claims description 2
- QECVIPBZOPUTRD-UHFFFAOYSA-N N=S(=O)=O Chemical class N=S(=O)=O QECVIPBZOPUTRD-UHFFFAOYSA-N 0.000 claims 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 1
- 235000013877 carbamide Nutrition 0.000 claims 1
- 150000002170 ethers Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000003672 ureas Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19243808P | 2008-09-17 | 2008-09-17 | |
| US61/192,438 | 2008-09-17 | ||
| PCT/US2009/005215 WO2010033226A1 (en) | 2008-09-17 | 2009-09-17 | Oligomer-protease inhibitor conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012502906A JP2012502906A (ja) | 2012-02-02 |
| JP2012502906A5 true JP2012502906A5 (https=) | 2012-08-23 |
Family
ID=41569912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011526875A Pending JP2012502906A (ja) | 2008-09-17 | 2009-09-17 | オリゴマー−プロテアーゼ阻害剤コンジュゲート |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110195912A1 (https=) |
| EP (1) | EP2344201A1 (https=) |
| JP (1) | JP2012502906A (https=) |
| WO (1) | WO2010033226A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101631568B (zh) | 2007-03-12 | 2012-08-22 | 尼克塔治疗公司 | 低聚物-蛋白酶抑制剂偶联物 |
| US20110195940A1 (en) | 2008-09-17 | 2011-08-11 | Nektar Therapeutics | Protease Inhibitors Having Enhanced Features |
| WO2013090420A2 (en) * | 2011-12-12 | 2013-06-20 | Catabasis Pharmaceuticals, Inc. | Fatty acid antiviral conjugates and their uses |
| WO2020069125A1 (en) * | 2018-09-28 | 2020-04-02 | Dana-Farber Cancer Institute, Inc. | Degraders of hepatitis c virus ns3/4a protein |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3380726D1 (en) * | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| JP2758154B2 (ja) * | 1995-04-06 | 1998-05-28 | エフ・ホフマン−ラ ロシユ アーゲー | インターフェロンを含む液体製剤 |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| FR2773994B1 (fr) * | 1998-01-23 | 2002-10-11 | Univ Nice Sophia Antipolis | Prodrogues issues d'anti-proteases inhibitrices du virus de l'immunodeficience humaine (vih) pour l'amelioration de leur biodisponibilite, de leur tropisme vers et/ou de leur delivrance dans le systeme nerveux central |
| TR200200763T2 (tr) * | 1999-09-24 | 2003-09-22 | Janssen Pharmaceutica N.V. | Antiviral bileşimler |
| DE10102878A1 (de) * | 2001-01-23 | 2002-08-01 | Haemosys Gmbh | Oligo- oder Polyalkylengekoppelte Thrombininhibitoren |
| US20040152769A1 (en) * | 2002-11-09 | 2004-08-05 | Ekwuribe Nnochiri Nkem | Modified carbamate-containing prodrugs and methods of synthesizing same |
| US7947261B2 (en) * | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
| US7044188B2 (en) * | 2003-06-12 | 2006-05-16 | Dürr Systems, Inc. | Apparatus for mounting and inflating a tire and wheel assembly |
| AU2004268144A1 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Modified protease inhibitors |
| WO2005058367A2 (en) * | 2003-12-16 | 2005-06-30 | Nektar Therapeutics Al, Corporation | Pegylated small molecules |
| CN101014611A (zh) * | 2004-07-13 | 2007-08-08 | 拜尔药品公司 | 改良的抑酶肽变体 |
| KR100626767B1 (ko) * | 2005-07-07 | 2006-09-25 | 한국과학기술연구원 | 사슬 말단 기능성화된 폴리에틸렌옥사이드 및 이를 사용한나노 크기 전이금속 및 금속염의 제조 방법 |
| US7705138B2 (en) * | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
| JP5290186B2 (ja) * | 2006-11-15 | 2013-09-18 | ヴァイロケム ファーマ インコーポレイテッド | フラビウイルス感染症の治療または予防用のチオフェン類似体 |
| CN101631568B (zh) * | 2007-03-12 | 2012-08-22 | 尼克塔治疗公司 | 低聚物-蛋白酶抑制剂偶联物 |
| US9095620B2 (en) * | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
-
2009
- 2009-09-17 WO PCT/US2009/005215 patent/WO2010033226A1/en not_active Ceased
- 2009-09-17 EP EP09740205A patent/EP2344201A1/en not_active Withdrawn
- 2009-09-17 JP JP2011526875A patent/JP2012502906A/ja active Pending
- 2009-09-17 US US13/119,107 patent/US20110195912A1/en not_active Abandoned
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