JP2012501182A5 - - Google Patents
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- JP2012501182A5 JP2012501182A5 JP2011525208A JP2011525208A JP2012501182A5 JP 2012501182 A5 JP2012501182 A5 JP 2012501182A5 JP 2011525208 A JP2011525208 A JP 2011525208A JP 2011525208 A JP2011525208 A JP 2011525208A JP 2012501182 A5 JP2012501182 A5 JP 2012501182A5
- Authority
- JP
- Japan
- Prior art keywords
- replicon
- lir
- coding region
- region
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091026890 Coding region Proteins 0.000 claims 43
- 241000702463 Geminiviridae Species 0.000 claims 23
- 108091029795 Intergenic region Proteins 0.000 claims 22
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 102000004169 proteins and genes Human genes 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 241000196324 Embryophyta Species 0.000 claims 7
- 101710090029 Replication-associated protein A Proteins 0.000 claims 5
- 230000030279 gene silencing Effects 0.000 claims 5
- 238000012226 gene silencing method Methods 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 230000003321 amplification Effects 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 241000710145 Tomato bushy stunt virus Species 0.000 claims 3
- 230000010076 replication Effects 0.000 claims 3
- 230000010474 transient expression Effects 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 230000036963 noncompetitive effect Effects 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 101710132601 Capsid protein Proteins 0.000 claims 1
- 102100023321 Ceruloplasmin Human genes 0.000 claims 1
- 101900322896 Norwalk virus Capsid protein VP1 Proteins 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9231808P | 2008-08-27 | 2008-08-27 | |
| US61/092,318 | 2008-08-27 | ||
| PCT/US2009/055237 WO2010025285A1 (en) | 2008-08-27 | 2009-08-27 | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012501182A JP2012501182A (ja) | 2012-01-19 |
| JP2012501182A5 true JP2012501182A5 (https=) | 2013-01-10 |
| JP5785080B2 JP5785080B2 (ja) | 2015-09-24 |
Family
ID=41721933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525208A Expired - Fee Related JP5785080B2 (ja) | 2008-08-27 | 2009-08-27 | 植物におけるワクチン及びモノクローナル抗体治療薬の高レベル迅速生産のためのｄｎａレプリコン系 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8513397B2 (https=) |
| EP (1) | EP2328401B8 (https=) |
| JP (1) | JP5785080B2 (https=) |
| AU (1) | AU2009285667B2 (https=) |
| CA (1) | CA2736796A1 (https=) |
| IL (1) | IL211388A (https=) |
| WO (1) | WO2010025285A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| WO2009076778A1 (en) | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| AU2009267769B2 (en) | 2008-07-08 | 2015-07-16 | Medicago Inc. | Soluble recombinant influenza antigens |
| CA2736796A1 (en) | 2008-08-27 | 2010-03-04 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| HUE039100T2 (hu) | 2009-06-24 | 2018-12-28 | Medicago Inc | Hemagglutinint tartalmazó kimer influenzavírus-jellegû részecskék |
| KR101773431B1 (ko) | 2009-09-22 | 2017-09-12 | 메디카고 인코포레이티드 | 식물-유래 ｖｌｐ의 제조방법 |
| WO2012058762A1 (en) | 2010-11-04 | 2012-05-10 | Medicago Inc. | Plant expression system |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| KR101963792B1 (ko) | 2011-06-13 | 2019-07-31 | 메디카고 인코포레이티드 | 식물에서 광견병 바이러스 유사 입자 생성 |
| NZ622731A (en) | 2011-09-30 | 2016-04-29 | Medicago Inc | Increasing virus-like particle yield in plants |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| EA032089B1 (ru) | 2012-05-11 | 2019-04-30 | Медикаго Инк. | Получение ротавирус-подобных частиц в растениях |
| JP2015528285A (ja) | 2012-09-05 | 2015-09-28 | メディカゴ インコーポレイテッド | 植物におけるピコルナウイルス様粒子の産生 |
| US10125373B2 (en) * | 2013-01-22 | 2018-11-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
| ES2803508T3 (es) | 2013-03-28 | 2021-01-27 | Medicago Inc | Producción de partículas similares al virus de la gripe en plantas |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| RU2731295C2 (ru) | 2014-07-11 | 2020-09-01 | Медикаго Инк. | Модификация продуцирования белков в растениях |
| US9340604B1 (en) | 2014-10-29 | 2016-05-17 | Aridis Pharmaceuticals, Inc. | Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV) |
| WO2016079739A2 (en) * | 2014-11-20 | 2016-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells |
| US11078491B2 (en) | 2017-05-24 | 2021-08-03 | Arizona Board Of Regents On Behalf Of Arizona State University | Vaccines against Zika virus based on Zika structure proteins |
| US11130956B2 (en) | 2017-06-05 | 2021-09-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Reducing the toxicity of agrobacterium endotoxin |
| US12297443B2 (en) * | 2018-03-02 | 2025-05-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Optimized plant expression systems |
| US11058766B2 (en) | 2018-05-04 | 2021-07-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Universal vaccine platform |
| US12466862B2 (en) * | 2019-06-04 | 2025-11-11 | Arizona Board Of Regents On Behalf Of Arizona State University | Plant-produced mABs against chikungunya virus with enhanced effector function and efficacy |
| WO2022260849A1 (en) | 2021-06-09 | 2022-12-15 | Nant Holdings Ip, Llc | Methods and systems for producing a protein of interest in a plant |
| US20240417698A1 (en) * | 2021-11-01 | 2024-12-19 | Arizona Board Of Regents On Behalf Of Arizona State University | A method for production of self-replicating, nucleic acid-loaded, virus-like particles (vlp-na) and the uses thereof |
| WO2024097732A2 (en) * | 2022-11-01 | 2024-05-10 | Arizona Board Of Regents On Behalf Of Arizona State University | A method for production of self-replicating, nucleic acid-loaded, virus-like particles (vlp-na) and the uses thereof |
| WO2025019375A2 (en) * | 2023-07-14 | 2025-01-23 | Inari Argiculture Technology, Inc. | Replicons for precise genome editing in plants |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6392121B1 (en) * | 1998-10-07 | 2002-05-21 | Boyce Thompson Institute For Plant Research | Gemini virus vectors for gene expression in plants |
| KR20030004305A (ko) * | 1999-11-22 | 2003-01-14 | 플랜트 바이오사이언스 리미티드 | 전사 후 유전자 사일런싱（ｐｔｇｓ）의 억제제와 함께발현시킴으로써 이식 유전자의 발현을 증가시키는 방법 |
| ATE530654T1 (de) * | 2001-07-06 | 2011-11-15 | Monsanto Technology Llc | Verfahren zur förderung der aufspaltung von transgenen bei pflanzen und zusammensetzungen dafür |
| US20040170606A1 (en) * | 2002-06-07 | 2004-09-02 | Palmer Kenneth E. | Production of peptides in plants as viral coat protein fusions |
| US7618815B2 (en) * | 2006-03-08 | 2009-11-17 | University Of Kentucky Research Foundation | Viral vectors useful in soybean and methods of use |
| CA2736796A1 (en) | 2008-08-27 | 2010-03-04 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| US10125373B2 (en) | 2013-01-22 | 2018-11-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
-
2009
- 2009-08-27 CA CA2736796A patent/CA2736796A1/en not_active Abandoned
- 2009-08-27 AU AU2009285667A patent/AU2009285667B2/en not_active Ceased
- 2009-08-27 WO PCT/US2009/055237 patent/WO2010025285A1/en not_active Ceased
- 2009-08-27 JP JP2011525208A patent/JP5785080B2/ja not_active Expired - Fee Related
- 2009-08-27 EP EP09810603.2A patent/EP2328401B8/en not_active Not-in-force
- 2009-08-27 US US13/060,414 patent/US8513397B2/en active Active
-
2011
- 2011-02-24 IL IL211388A patent/IL211388A/en active IP Right Grant
-
2013
- 2013-07-17 US US13/944,589 patent/US9506079B2/en active Active
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