IL211388A - DNA replicon system for high-level production of vaccines and monoclonal antibody treatments in plants - Google Patents
DNA replicon system for high-level production of vaccines and monoclonal antibody treatments in plantsInfo
- Publication number
- IL211388A IL211388A IL211388A IL21138811A IL211388A IL 211388 A IL211388 A IL 211388A IL 211388 A IL211388 A IL 211388A IL 21138811 A IL21138811 A IL 21138811A IL 211388 A IL211388 A IL 211388A
- Authority
- IL
- Israel
- Prior art keywords
- vaccines
- plants
- monoclonal antibody
- rapid production
- antibody therapeutics
- Prior art date
Links
- 229940124691 antibody therapeutics Drugs 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9231808P | 2008-08-27 | 2008-08-27 | |
| PCT/US2009/055237 WO2010025285A1 (en) | 2008-08-27 | 2009-08-27 | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL211388A0 IL211388A0 (en) | 2011-05-31 |
| IL211388A true IL211388A (en) | 2016-09-29 |
Family
ID=41721933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL211388A IL211388A (en) | 2008-08-27 | 2011-02-24 | DNA replicon system for high-level production of vaccines and monoclonal antibody treatments in plants |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8513397B2 (https=) |
| EP (1) | EP2328401B8 (https=) |
| JP (1) | JP5785080B2 (https=) |
| AU (1) | AU2009285667B2 (https=) |
| CA (1) | CA2736796A1 (https=) |
| IL (1) | IL211388A (https=) |
| WO (1) | WO2010025285A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| WO2009076778A1 (en) | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| AU2009267769B2 (en) | 2008-07-08 | 2015-07-16 | Medicago Inc. | Soluble recombinant influenza antigens |
| CA2736796A1 (en) | 2008-08-27 | 2010-03-04 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| HUE039100T2 (hu) | 2009-06-24 | 2018-12-28 | Medicago Inc | Hemagglutinint tartalmazó kimer influenzavírus-jellegû részecskék |
| KR101773431B1 (ko) | 2009-09-22 | 2017-09-12 | 메디카고 인코포레이티드 | 식물-유래 ｖｌｐ의 제조방법 |
| WO2012058762A1 (en) | 2010-11-04 | 2012-05-10 | Medicago Inc. | Plant expression system |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| KR101963792B1 (ko) | 2011-06-13 | 2019-07-31 | 메디카고 인코포레이티드 | 식물에서 광견병 바이러스 유사 입자 생성 |
| NZ622731A (en) | 2011-09-30 | 2016-04-29 | Medicago Inc | Increasing virus-like particle yield in plants |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| EA032089B1 (ru) | 2012-05-11 | 2019-04-30 | Медикаго Инк. | Получение ротавирус-подобных частиц в растениях |
| JP2015528285A (ja) | 2012-09-05 | 2015-09-28 | メディカゴ インコーポレイテッド | 植物におけるピコルナウイルス様粒子の産生 |
| US10125373B2 (en) * | 2013-01-22 | 2018-11-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
| ES2803508T3 (es) | 2013-03-28 | 2021-01-27 | Medicago Inc | Producción de partículas similares al virus de la gripe en plantas |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| RU2731295C2 (ru) | 2014-07-11 | 2020-09-01 | Медикаго Инк. | Модификация продуцирования белков в растениях |
| US9340604B1 (en) | 2014-10-29 | 2016-05-17 | Aridis Pharmaceuticals, Inc. | Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV) |
| WO2016079739A2 (en) * | 2014-11-20 | 2016-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells |
| US11078491B2 (en) | 2017-05-24 | 2021-08-03 | Arizona Board Of Regents On Behalf Of Arizona State University | Vaccines against Zika virus based on Zika structure proteins |
| US11130956B2 (en) | 2017-06-05 | 2021-09-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Reducing the toxicity of agrobacterium endotoxin |
| US12297443B2 (en) * | 2018-03-02 | 2025-05-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Optimized plant expression systems |
| US11058766B2 (en) | 2018-05-04 | 2021-07-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Universal vaccine platform |
| US12466862B2 (en) * | 2019-06-04 | 2025-11-11 | Arizona Board Of Regents On Behalf Of Arizona State University | Plant-produced mABs against chikungunya virus with enhanced effector function and efficacy |
| WO2022260849A1 (en) | 2021-06-09 | 2022-12-15 | Nant Holdings Ip, Llc | Methods and systems for producing a protein of interest in a plant |
| US20240417698A1 (en) * | 2021-11-01 | 2024-12-19 | Arizona Board Of Regents On Behalf Of Arizona State University | A method for production of self-replicating, nucleic acid-loaded, virus-like particles (vlp-na) and the uses thereof |
| WO2024097732A2 (en) * | 2022-11-01 | 2024-05-10 | Arizona Board Of Regents On Behalf Of Arizona State University | A method for production of self-replicating, nucleic acid-loaded, virus-like particles (vlp-na) and the uses thereof |
| WO2025019375A2 (en) * | 2023-07-14 | 2025-01-23 | Inari Argiculture Technology, Inc. | Replicons for precise genome editing in plants |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6392121B1 (en) * | 1998-10-07 | 2002-05-21 | Boyce Thompson Institute For Plant Research | Gemini virus vectors for gene expression in plants |
| KR20030004305A (ko) * | 1999-11-22 | 2003-01-14 | 플랜트 바이오사이언스 리미티드 | 전사 후 유전자 사일런싱（ｐｔｇｓ）의 억제제와 함께발현시킴으로써 이식 유전자의 발현을 증가시키는 방법 |
| ATE530654T1 (de) * | 2001-07-06 | 2011-11-15 | Monsanto Technology Llc | Verfahren zur förderung der aufspaltung von transgenen bei pflanzen und zusammensetzungen dafür |
| US20040170606A1 (en) * | 2002-06-07 | 2004-09-02 | Palmer Kenneth E. | Production of peptides in plants as viral coat protein fusions |
| US7618815B2 (en) * | 2006-03-08 | 2009-11-17 | University Of Kentucky Research Foundation | Viral vectors useful in soybean and methods of use |
| CA2736796A1 (en) | 2008-08-27 | 2010-03-04 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| US10125373B2 (en) | 2013-01-22 | 2018-11-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
-
2009
- 2009-08-27 CA CA2736796A patent/CA2736796A1/en not_active Abandoned
- 2009-08-27 AU AU2009285667A patent/AU2009285667B2/en not_active Ceased
- 2009-08-27 WO PCT/US2009/055237 patent/WO2010025285A1/en not_active Ceased
- 2009-08-27 JP JP2011525208A patent/JP5785080B2/ja not_active Expired - Fee Related
- 2009-08-27 EP EP09810603.2A patent/EP2328401B8/en not_active Not-in-force
- 2009-08-27 US US13/060,414 patent/US8513397B2/en active Active
-
2011
- 2011-02-24 IL IL211388A patent/IL211388A/en active IP Right Grant
-
2013
- 2013-07-17 US US13/944,589 patent/US9506079B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2328401A1 (en) | 2011-06-08 |
| US8513397B2 (en) | 2013-08-20 |
| JP2012501182A (ja) | 2012-01-19 |
| CA2736796A1 (en) | 2010-03-04 |
| IL211388A0 (en) | 2011-05-31 |
| AU2009285667A1 (en) | 2010-03-04 |
| US20140141515A1 (en) | 2014-05-22 |
| US9506079B2 (en) | 2016-11-29 |
| EP2328401B1 (en) | 2017-02-08 |
| JP5785080B2 (ja) | 2015-09-24 |
| WO2010025285A1 (en) | 2010-03-04 |
| US20110262966A1 (en) | 2011-10-27 |
| EP2328401A4 (en) | 2012-07-11 |
| AU2009285667B2 (en) | 2015-05-28 |
| EP2328401B8 (en) | 2017-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |