JP5785080B2 - 植物におけるワクチン及びモノクローナル抗体治療薬の高レベル迅速生産のためのｄｎａレプリコン系 - Google Patents

植物におけるワクチン及びモノクローナル抗体治療薬の高レベル迅速生産のためのｄｎａレプリコン系 Download PDF

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JP5785080B2
JP5785080B2 JP2011525208A JP2011525208A JP5785080B2 JP 5785080 B2 JP5785080 B2 JP 5785080B2 JP 2011525208 A JP2011525208 A JP 2011525208A JP 2011525208 A JP2011525208 A JP 2011525208A JP 5785080 B2 JP5785080 B2 JP 5785080B2
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replicon
lir
coding region
promoter
protein
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JP2012501182A (ja
JP2012501182A5 (https=
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メイソン，フー，エス．
ファン，ツォン
チエン，シアン
アルンツエン，チャールズ，ジェー．
ユアン，シュオ
ヘリム，ブルーケ
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Arizona State University ASU
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8203—Virus mediated transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2011525208A 2008-08-27 2009-08-27 植物におけるワクチン及びモノクローナル抗体治療薬の高レベル迅速生産のためのｄｎａレプリコン系 Expired - Fee Related JP5785080B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9231808P 2008-08-27 2008-08-27
US61/092,318 2008-08-27
PCT/US2009/055237 WO2010025285A1 (en) 2008-08-27 2009-08-27 A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants

Publications (3)

Publication Number Publication Date
JP2012501182A JP2012501182A (ja) 2012-01-19
JP2012501182A5 JP2012501182A5 (https=) 2013-01-10
JP5785080B2 true JP5785080B2 (ja) 2015-09-24

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JP2011525208A Expired - Fee Related JP5785080B2 (ja) 2008-08-27 2009-08-27 植物におけるワクチン及びモノクローナル抗体治療薬の高レベル迅速生産のためのｄｎａレプリコン系

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Country Link
US (2) US8513397B2 (https=)
EP (1) EP2328401B8 (https=)
JP (1) JP5785080B2 (https=)
AU (1) AU2009285667B2 (https=)
CA (1) CA2736796A1 (https=)
IL (1) IL211388A (https=)
WO (1) WO2010025285A1 (https=)

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CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
WO2009076778A1 (en) 2007-11-27 2009-06-25 Medicago Inc. Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
AU2009267769B2 (en) 2008-07-08 2015-07-16 Medicago Inc. Soluble recombinant influenza antigens
CA2736796A1 (en) 2008-08-27 2010-03-04 Arizona Board Of Regents For And On Behalf Of Arizona State University A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants
HUE039100T2 (hu) 2009-06-24 2018-12-28 Medicago Inc Hemagglutinint tartalmazó kimer influenzavírus-jellegû részecskék
KR101773431B1 (ko) 2009-09-22 2017-09-12 메디카고 인코포레이티드 식물-유래 ｖｌｐ의 제조방법
WO2012058762A1 (en) 2010-11-04 2012-05-10 Medicago Inc. Plant expression system
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
KR101963792B1 (ko) 2011-06-13 2019-07-31 메디카고 인코포레이티드 식물에서 광견병 바이러스 유사 입자 생성
NZ622731A (en) 2011-09-30 2016-04-29 Medicago Inc Increasing virus-like particle yield in plants
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
EA032089B1 (ru) 2012-05-11 2019-04-30 Медикаго Инк. Получение ротавирус-подобных частиц в растениях
JP2015528285A (ja) 2012-09-05 2015-09-28 メディカゴ インコーポレイテッド 植物におけるピコルナウイルス様粒子の産生
US10125373B2 (en) * 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
ES2803508T3 (es) 2013-03-28 2021-01-27 Medicago Inc Producción de partículas similares al virus de la gripe en plantas
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
RU2731295C2 (ru) 2014-07-11 2020-09-01 Медикаго Инк. Модификация продуцирования белков в растениях
US9340604B1 (en) 2014-10-29 2016-05-17 Aridis Pharmaceuticals, Inc. Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV)
WO2016079739A2 (en) * 2014-11-20 2016-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
US11078491B2 (en) 2017-05-24 2021-08-03 Arizona Board Of Regents On Behalf Of Arizona State University Vaccines against Zika virus based on Zika structure proteins
US11130956B2 (en) 2017-06-05 2021-09-28 Arizona Board Of Regents On Behalf Of Arizona State University Reducing the toxicity of agrobacterium endotoxin
US12297443B2 (en) * 2018-03-02 2025-05-13 Arizona Board Of Regents On Behalf Of Arizona State University Optimized plant expression systems
US11058766B2 (en) 2018-05-04 2021-07-13 Arizona Board Of Regents On Behalf Of Arizona State University Universal vaccine platform
US12466862B2 (en) * 2019-06-04 2025-11-11 Arizona Board Of Regents On Behalf Of Arizona State University Plant-produced mABs against chikungunya virus with enhanced effector function and efficacy
WO2022260849A1 (en) 2021-06-09 2022-12-15 Nant Holdings Ip, Llc Methods and systems for producing a protein of interest in a plant
US20240417698A1 (en) * 2021-11-01 2024-12-19 Arizona Board Of Regents On Behalf Of Arizona State University A method for production of self-replicating, nucleic acid-loaded, virus-like particles (vlp-na) and the uses thereof
WO2024097732A2 (en) * 2022-11-01 2024-05-10 Arizona Board Of Regents On Behalf Of Arizona State University A method for production of self-replicating, nucleic acid-loaded, virus-like particles (vlp-na) and the uses thereof
WO2025019375A2 (en) * 2023-07-14 2025-01-23 Inari Argiculture Technology, Inc. Replicons for precise genome editing in plants

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US6392121B1 (en) * 1998-10-07 2002-05-21 Boyce Thompson Institute For Plant Research Gemini virus vectors for gene expression in plants
KR20030004305A (ko) * 1999-11-22 2003-01-14 플랜트 바이오사이언스 리미티드 전사 후 유전자 사일런싱（ｐｔｇｓ）의 억제제와 함께발현시킴으로써 이식 유전자의 발현을 증가시키는 방법
ATE530654T1 (de) * 2001-07-06 2011-11-15 Monsanto Technology Llc Verfahren zur förderung der aufspaltung von transgenen bei pflanzen und zusammensetzungen dafür
US20040170606A1 (en) * 2002-06-07 2004-09-02 Palmer Kenneth E. Production of peptides in plants as viral coat protein fusions
US7618815B2 (en) * 2006-03-08 2009-11-17 University Of Kentucky Research Foundation Viral vectors useful in soybean and methods of use
CA2736796A1 (en) 2008-08-27 2010-03-04 Arizona Board Of Regents For And On Behalf Of Arizona State University A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants
US10125373B2 (en) 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab

Also Published As

Publication number Publication date
EP2328401A1 (en) 2011-06-08
US8513397B2 (en) 2013-08-20
JP2012501182A (ja) 2012-01-19
IL211388A (en) 2016-09-29
CA2736796A1 (en) 2010-03-04
IL211388A0 (en) 2011-05-31
AU2009285667A1 (en) 2010-03-04
US20140141515A1 (en) 2014-05-22
US9506079B2 (en) 2016-11-29
EP2328401B1 (en) 2017-02-08
WO2010025285A1 (en) 2010-03-04
US20110262966A1 (en) 2011-10-27
EP2328401A4 (en) 2012-07-11
AU2009285667B2 (en) 2015-05-28
EP2328401B8 (en) 2017-04-19

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