JP2012500783A5

JP2012500783A5 -

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Publication number: JP2012500783A5
Authority: JP; Japan
Prior art keywords: methyl; methoxy; amino; sulfonyl; carboxamide
Prior art date: 2009-08-10
Legal status : Pending

Application number

JP2011523386A

Other languages

English (en)

Japanese (ja)

Other versions

JP2012500783A (ja

Filing date

2009-08-10

Publication date

2012-09-13

2009-08-10 Application filed filed Critical

2009-08-10 Priority claimed from PCT/EP2009/060339 external-priority patent/WO2010020556A1/en

2012-01-12 Publication of JP2012500783A publication Critical patent/JP2012500783A/ja

2012-09-13 Publication of JP2012500783A5 publication Critical patent/JP2012500783A5/ja

Status Pending legal-status Critical Current

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-1 pyridine compound Chemical class 0.000 claims 92
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 78
125000000217 alkyl group Chemical group 0.000 claims 54
125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 43
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 39
229910052736 halogen Inorganic materials 0.000 claims 28
150000001875 compounds Chemical class 0.000 claims 24
CHKFOGJYAICJSR-UHFFFAOYSA-N benzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.NS(=O)(=O)C1=CC=CC=C1 CHKFOGJYAICJSR-UHFFFAOYSA-N 0.000 claims 22
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 17
150000002367 halogens Chemical class 0.000 claims 16
229910052739 hydrogen Inorganic materials 0.000 claims 14
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 12
125000005843 halogen group Chemical group 0.000 claims 12
208000002193 Pain Diseases 0.000 claims 9
125000000304 alkynyl group Chemical group 0.000 claims 9
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 9
KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 8
AQODNVBMXWKERL-UHFFFAOYSA-N FC(C(=O)O)(F)F.O1C=C(C=C1)C(=O)N Chemical compound FC(C(=O)O)(F)F.O1C=C(C=C1)C(=O)N AQODNVBMXWKERL-UHFFFAOYSA-N 0.000 claims 8
230000036407 pain Effects 0.000 claims 8
229920006395 saturated elastomer Polymers 0.000 claims 7
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 6
DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 6
125000000623 heterocyclic group Chemical group 0.000 claims 6
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 5
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 4
125000003342 alkenyl group Chemical group 0.000 claims 4
125000005605 benzo group Chemical group 0.000 claims 4
239000008194 pharmaceutical composition Substances 0.000 claims 4
150000003839 salts Chemical class 0.000 claims 4
208000011580 syndromic disease Diseases 0.000 claims 4
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims 3
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 3
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims 3
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims 3
206010035664 Pneumonia Diseases 0.000 claims 3
230000001154 acute effect Effects 0.000 claims 3
125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 3
230000001684 chronic effect Effects 0.000 claims 3
125000004855 decalinyl group Chemical group C1(CCCC2CCCCC12)* 0.000 claims 3
206010012601 diabetes mellitus Diseases 0.000 claims 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 3
125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 3
208000014674 injury Diseases 0.000 claims 3
125000001624 naphthyl group Chemical group 0.000 claims 3
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 3
125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 3
208000033116 Asbestos intoxication Diseases 0.000 claims 2
206010003645 Atopy Diseases 0.000 claims 2
125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
208000005615 Interstitial Cystitis Diseases 0.000 claims 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
206010033645 Pancreatitis Diseases 0.000 claims 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
150000001408 amides Chemical class 0.000 claims 2
206010003441 asbestosis Diseases 0.000 claims 2
208000006673 asthma Diseases 0.000 claims 2
125000004429 atom Chemical group 0.000 claims 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
201000010099 disease Diseases 0.000 claims 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
230000002757 inflammatory effect Effects 0.000 claims 2
201000006417 multiple sclerosis Diseases 0.000 claims 2
RYJXPZMMXKYVIA-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=CC(C(=O)N2CCN(CC3CCN(C)CC3)CC2)=CO1 RYJXPZMMXKYVIA-UHFFFAOYSA-N 0.000 claims 2
201000001119 neuropathy Diseases 0.000 claims 2
230000007823 neuropathy Effects 0.000 claims 2
229910052757 nitrogen Inorganic materials 0.000 claims 2
125000004433 nitrogen atom Chemical group N* 0.000 claims 2
201000008482 osteoarthritis Diseases 0.000 claims 2
208000033808 peripheral neuropathy Diseases 0.000 claims 2
206010035653 pneumoconiosis Diseases 0.000 claims 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
206010039073 rheumatoid arthritis Diseases 0.000 claims 2
230000008733 trauma Effects 0.000 claims 2
VBXZSFNZVNDOPB-UHFFFAOYSA-N 1,4,5,6-tetrahydropyrimidine Chemical compound C1CNC=NC1 VBXZSFNZVNDOPB-UHFFFAOYSA-N 0.000 claims 1
BPWBZOJHKCIULN-UHFFFAOYSA-N 1-[[4-[[[5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]furan-3-carbonyl]-methylamino]methyl]phenyl]methyl]-n,n-dimethylpyrrolidine-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)C(=O)N(C)C)=CC=2)=CO1 BPWBZOJHKCIULN-UHFFFAOYSA-N 0.000 claims 1
BEYAGQUVQBVAFG-UHFFFAOYSA-N 1-[[4-[[[5-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]furan-3-carbonyl]-methylamino]methyl]phenyl]methyl]-n,n-dimethylpyrrolidine-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=CC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)C(=O)N(C)C)=CC=2)=CO1 BEYAGQUVQBVAFG-UHFFFAOYSA-N 0.000 claims 1
UWVBNFPFVSOTCY-UHFFFAOYSA-N 2,6-dichloro-n-methyl-n-[[4-[4-(2-pyridin-4-ylethyl)piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound ClC=1C=CC=C(Cl)C=1S(=O)(=O)N(C)CC(OC=1)=CC=1C(=O)N(CC1)CCN1CCC1=CC=NC=C1 UWVBNFPFVSOTCY-UHFFFAOYSA-N 0.000 claims 1
ISUQVTPHXAHSPV-UHFFFAOYSA-N 2,6-dichloro-n-methyl-n-[[4-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound ClC=1C=CC=C(Cl)C=1S(=O)(=O)N(C)CC(OC=1)=CC=1C(=O)N(CC1)CCN1CC1CCN(C)CC1 ISUQVTPHXAHSPV-UHFFFAOYSA-N 0.000 claims 1
WYZZNMWIWHRXRM-UHFFFAOYSA-N 2,8-diazaspiro[4.5]decane Chemical group C1NCCC21CCNCC2 WYZZNMWIWHRXRM-UHFFFAOYSA-N 0.000 claims 1
NMFPYVWBYWNGRI-UHFFFAOYSA-N 2-[[(4-chloro-2,5-dimethylphenyl)sulfonyl-cyclopropylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methyl-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC(Cl)=C(C)C=2)C)=NC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 NMFPYVWBYWNGRI-UHFFFAOYSA-N 0.000 claims 1
LFPBERXJMFKTRX-UHFFFAOYSA-N 2-[[(4-chloro-2,5-dimethylphenyl)sulfonyl-cyclopropylamino]methyl]-n-methyl-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC(Cl)=C(C)C=2)C)=NC=1C(=O)N(C)CC(C=C1)=CC=C1CN1CCCC1 LFPBERXJMFKTRX-UHFFFAOYSA-N 0.000 claims 1
MNXLMMADZWCMEO-UHFFFAOYSA-N 2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)NCC=2C=C(CN3CCCC3)C=CC=2)=CO1 MNXLMMADZWCMEO-UHFFFAOYSA-N 0.000 claims 1
KGXPLYNRNABAFL-UHFFFAOYSA-N 2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-[[4-[(3-methoxypiperidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound C1C(OC)CCCN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 KGXPLYNRNABAFL-UHFFFAOYSA-N 0.000 claims 1
LOLAQGHSLDINHB-UHFFFAOYSA-N 2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-[[4-[(3-methoxypyrrolidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound C1C(OC)CCN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 LOLAQGHSLDINHB-UHFFFAOYSA-N 0.000 claims 1
ASALFMGLJOVPLM-UHFFFAOYSA-N 2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-[[4-[(4-methoxypiperidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound C1CC(OC)CCN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 ASALFMGLJOVPLM-UHFFFAOYSA-N 0.000 claims 1
JXHGBSUENNWTHV-UHFFFAOYSA-N 2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-n-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=C(CN3CCCC3)C=CC=2)=CO1 JXHGBSUENNWTHV-UHFFFAOYSA-N 0.000 claims 1
TXTCZXLGRWAURK-UHFFFAOYSA-N 2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-n-[[4-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2-yl]methyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2SC=C(CN3CCCC3)N=2)=CO1 TXTCZXLGRWAURK-UHFFFAOYSA-N 0.000 claims 1
WJHNGKGECGKAIG-UHFFFAOYSA-N 2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CCCC3)=CC=2)=CO1 WJHNGKGECGKAIG-UHFFFAOYSA-N 0.000 claims 1
FRGAEOLAPPKLPK-UHFFFAOYSA-N 2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-n-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-thiadiazol-2-yl]methyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2SC(CN3CCCC3)=NN=2)=CO1 FRGAEOLAPPKLPK-UHFFFAOYSA-N 0.000 claims 1
GCHDDQMSKRMILS-UHFFFAOYSA-N 2-[[cyclopropyl-(2,4,6-trichlorophenyl)sulfonylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methyl-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)=NC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 GCHDDQMSKRMILS-UHFFFAOYSA-N 0.000 claims 1
OUUIABBHPTYNBR-UHFFFAOYSA-N 2-[[cyclopropyl-(2,4,6-trichlorophenyl)sulfonylamino]methyl]-n-methyl-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)=NC=1C(=O)N(C)CC(C=C1)=CC=C1CN1CCCC1 OUUIABBHPTYNBR-UHFFFAOYSA-N 0.000 claims 1
ARVLTASMEJMKIC-UHFFFAOYSA-N 2-[[cyclopropyl-(2,4-dichlorophenyl)sulfonylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methyl-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2)Cl)=NC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 ARVLTASMEJMKIC-UHFFFAOYSA-N 0.000 claims 1
NGVULYAUFGBOGO-UHFFFAOYSA-N 2-[[cyclopropyl-(2,6-dichlorophenyl)sulfonylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methyl-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=NC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 NGVULYAUFGBOGO-UHFFFAOYSA-N 0.000 claims 1
UIWTWYKVYNNECH-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-(2-piperidin-3-ylethyl)-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)NCCC2CNCCC2)=CO1 UIWTWYKVYNNECH-UHFFFAOYSA-N 0.000 claims 1
JSRFYNVJFDVBOD-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CCC=2C=CC(=CC=2)C=2NCCN=2)=CO1 JSRFYNVJFDVBOD-UHFFFAOYSA-N 0.000 claims 1
VPXLCGWJMHRLJW-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[3-(4-ethylpiperazin-1-yl)propyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1CN(CC)CCN1CCCNC(=O)C1=COC(CN(C2CC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 VPXLCGWJMHRLJW-UHFFFAOYSA-N 0.000 claims 1
NUGZVCLYPYIFIN-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)NCC=2C=C(CN3CCCC3)C=CC=2)=CO1 NUGZVCLYPYIFIN-UHFFFAOYSA-N 0.000 claims 1
PIPFUQOGXXSGIS-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)NCC=2C=CC(CN3CCCC3)=CC=2)=CO1 PIPFUQOGXXSGIS-UHFFFAOYSA-N 0.000 claims 1
PTNUMGWNCKQMTD-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[(3,4-dihydroxypyrrolidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(O)C(O)C3)=CC=2)=CO1 PTNUMGWNCKQMTD-UHFFFAOYSA-N 0.000 claims 1
AZRKLGAPLLHNNO-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[(3-hydroxy-3-methylpyrrolidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(C)(O)CC3)=CC=2)=CO1 AZRKLGAPLLHNNO-UHFFFAOYSA-N 0.000 claims 1
DORPJQZKVMUMIF-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[(3-hydroxyazetidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(O)C3)=CC=2)=CO1 DORPJQZKVMUMIF-UHFFFAOYSA-N 0.000 claims 1
FQABQNRNQDNOEO-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[(3-methoxyazetidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound C1C(OC)CN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C2CC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 FQABQNRNQDNOEO-UHFFFAOYSA-N 0.000 claims 1
CWWHDFRWFJMRBV-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[(3-methoxypiperidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound C1C(OC)CCCN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C2CC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 CWWHDFRWFJMRBV-UHFFFAOYSA-N 0.000 claims 1
YVPQFIKLGFHDRG-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[(3-methoxypyrrolidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound C1C(OC)CCN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C2CC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 YVPQFIKLGFHDRG-UHFFFAOYSA-N 0.000 claims 1
KSTBTSQETYXWGI-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[(4-hydroxypiperidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CCC(O)CC3)=CC=2)=CO1 KSTBTSQETYXWGI-UHFFFAOYSA-N 0.000 claims 1
TYIYQSIXZJUAET-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[(4-methoxypiperidin-1-yl)methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound C1CC(OC)CCN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C2CC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 TYIYQSIXZJUAET-UHFFFAOYSA-N 0.000 claims 1
IFVRNRNHMXUTJK-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[[3-(dimethylamino)pyrrolidin-1-yl]methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)N(C)C)=CC=2)=CO1 IFVRNRNHMXUTJK-UHFFFAOYSA-N 0.000 claims 1
PNQXCXRZYRWTRX-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-[[4-[[3-(dimethylcarbamoyl)pyrrolidin-1-yl]methyl]phenyl]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)C(=O)N(C)C)=CC=2)=CO1 PNQXCXRZYRWTRX-UHFFFAOYSA-N 0.000 claims 1
ZCAYRBRATABBKW-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-n-[(2-methyl-1,3-dihydroisoindol-5-yl)methyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=C3CN(C)CC3=CC=2)=CO1 ZCAYRBRATABBKW-UHFFFAOYSA-N 0.000 claims 1
NMIFEIJJKWSCAA-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-n-[3-(4-methylpiperazin-1-yl)cyclohexyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)C2CC(CCC2)N2CCN(C)CC2)=CO1 NMIFEIJJKWSCAA-UHFFFAOYSA-N 0.000 claims 1
VYWGQEUXXYFERB-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-n-[4-(4-methylpiperazin-1-yl)cyclohexyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)C2CCC(CC2)N2CCN(C)CC2)=CO1 VYWGQEUXXYFERB-UHFFFAOYSA-N 0.000 claims 1
NRGFSSYKDWSBRH-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-n-[[2-(pyrrolidin-1-ylmethyl)-1,3-thiazol-4-yl]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2N=C(CN3CCCC3)SC=2)=CO1 NRGFSSYKDWSBRH-UHFFFAOYSA-N 0.000 claims 1
YOOUCFKKTGKJSY-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-n-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=C(CN3CCCC3)C=CC=2)=CO1 YOOUCFKKTGKJSY-UHFFFAOYSA-N 0.000 claims 1
PGBXZVWXFYVGLL-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CCCC3)=CC=2)=CO1 PGBXZVWXFYVGLL-UHFFFAOYSA-N 0.000 claims 1
YIPYLKNQHXOUSG-UHFFFAOYSA-N 2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-n-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-thiadiazol-2-yl]methyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2SC(CN3CCCC3)=NN=2)=CO1 YIPYLKNQHXOUSG-UHFFFAOYSA-N 0.000 claims 1
BHFWDSYHMUNZOA-UHFFFAOYSA-N 2-[[cyclopropyl-[2-(trifluoromethyl)phenyl]sulfonylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methyl-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC=CC=2)C(F)(F)F)=NC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 BHFWDSYHMUNZOA-UHFFFAOYSA-N 0.000 claims 1
CVMOKSXBJNXCIE-UHFFFAOYSA-N 2-[[cyclopropyl-[2-(trifluoromethyl)phenyl]sulfonylamino]methyl]-n-methyl-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,3-oxazole-4-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC=CC=2)C(F)(F)F)=NC=1C(=O)N(C)CC(C=C1)=CC=C1CN1CCCC1 CVMOKSXBJNXCIE-UHFFFAOYSA-N 0.000 claims 1
IZOZYLLIPVJXMJ-UHFFFAOYSA-N 3-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-1,2,4-oxadiazole-5-carboxamide;2,2,2-trifluoroacetamide Chemical compound NC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NOC(C(=O)N(C)CC=2C=CC(CN3CCCC3)=CC=2)=N1 IZOZYLLIPVJXMJ-UHFFFAOYSA-N 0.000 claims 1
JYRZADNNPILWIR-UHFFFAOYSA-N 3-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-n-[[4-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2-yl]methyl]-1,2,4-oxadiazole-5-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NOC(C(=O)N(C)CC=2SC=C(CN3CCCC3)N=2)=N1 JYRZADNNPILWIR-UHFFFAOYSA-N 0.000 claims 1
YIWYYXKSBCPGHI-UHFFFAOYSA-N 4-(pyrrolidin-1-ylmethyl)-1,3-thiazole Chemical compound C=1SC=NC=1CN1CCCC1 YIWYYXKSBCPGHI-UHFFFAOYSA-N 0.000 claims 1
BCVGJNURYNZOJN-UHFFFAOYSA-N 4-bromo-2-ethyl-n-methyl-n-[[4-[4-(3-pyrrolidin-1-ylpropyl)-1,4-diazepane-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CCC1=CC(Br)=CC=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CCN(CCCN3CCCC3)CCC2)=CO1 BCVGJNURYNZOJN-UHFFFAOYSA-N 0.000 claims 1
OVHVZEAGLYCQHD-UHFFFAOYSA-N 4-methoxy-2,6-dimethyl-n-[[5-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]-1,3,4-oxadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)NCC1=NN=C(C(=O)N2CCN(CC3CCN(C)CC3)CC2)O1 OVHVZEAGLYCQHD-UHFFFAOYSA-N 0.000 claims 1
RSUZONCMADONIX-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[3-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N2CCN(CC3CCN(C)CC3)CC2)=NO1 RSUZONCMADONIX-UHFFFAOYSA-N 0.000 claims 1
WMDXQHYGWSKZCB-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[3-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]-1h-1,2,4-triazol-5-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)N2CCN(CC3CCN(C)CC3)CC2)N1 WMDXQHYGWSKZCB-UHFFFAOYSA-N 0.000 claims 1
QGTOAYYCAHPJFG-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-(1-methylpiperidin-4-yl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N2CCN(CC2)C2CCN(C)CC2)=CO1 QGTOAYYCAHPJFG-UHFFFAOYSA-N 0.000 claims 1
QLNJYQZIQGRMCU-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-(2-morpholin-4-ylethyl)piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CCN(CCN3CCOCC3)CC2)=CO1 QLNJYQZIQGRMCU-UHFFFAOYSA-N 0.000 claims 1
UHKAOZRQOOREFZ-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-(2-pyridin-4-ylethyl)piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CCN(CCC=3C=CN=CC=3)CC2)=CO1 UHKAOZRQOOREFZ-UHFFFAOYSA-N 0.000 claims 1
YRALDABOTMCBLI-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-(2-pyrrolidin-1-ylethyl)piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CCN(CCN3CCCC3)CC2)=CO1 YRALDABOTMCBLI-UHFFFAOYSA-N 0.000 claims 1
ASRSJMGGROQBQX-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-(3-pyrrolidin-1-ylpropyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N2CCN(CCCN3CCCC3)CC2)=CO1 ASRSJMGGROQBQX-UHFFFAOYSA-N 0.000 claims 1
VMSHIBFXXIWTRK-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-(pyridin-4-ylmethyl)piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CCN(CC=3C=CN=CC=3)CC2)=CO1 VMSHIBFXXIWTRK-UHFFFAOYSA-N 0.000 claims 1
CKYWSYFDIHIFSY-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-(pyrrolidin-1-ylmethyl)piperidine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CCC(CN3CCCC3)CC2)=CO1 CKYWSYFDIHIFSY-UHFFFAOYSA-N 0.000 claims 1
BPIYXBQEHFVNIJ-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-[(1-methylpiperidin-3-yl)methyl]piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CCN(CC3CN(C)CCC3)CC2)=CO1 BPIYXBQEHFVNIJ-UHFFFAOYSA-N 0.000 claims 1
VEMQEMPKJBFPLF-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[4-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CCN(CC3CCN(C)CC3)CC2)=CO1 VEMQEMPKJBFPLF-UHFFFAOYSA-N 0.000 claims 1
GRHNYCXAUATRQH-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[5-[4-[(1-methylpiperidin-3-yl)methyl]piperazine-1-carbonyl]-1,3,4-oxadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)N2CCN(CC3CN(C)CCC3)CC2)O1 GRHNYCXAUATRQH-UHFFFAOYSA-N 0.000 claims 1
LEMVIHLNCAVSMR-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[5-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]-1,3,4-oxadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)N2CCN(CC3CCN(C)CC3)CC2)O1 LEMVIHLNCAVSMR-UHFFFAOYSA-N 0.000 claims 1
BQVXXIOACFHHRO-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[5-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]-1,3,4-thiadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)N2CCN(CC3CCN(C)CC3)CC2)S1 BQVXXIOACFHHRO-UHFFFAOYSA-N 0.000 claims 1
HZDALIWFXIKUEU-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[5-[4-[(2-methylpyridin-4-yl)methyl]piperazine-1-carbonyl]-1,3,4-oxadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)N2CCN(CC=3C=C(C)N=CC=3)CC2)O1 HZDALIWFXIKUEU-UHFFFAOYSA-N 0.000 claims 1
BSPXSOXPOZXDDD-UHFFFAOYSA-N 4-methoxy-n,2,6-trimethyl-n-[[5-[4-[(3-methylimidazol-4-yl)methyl]piperazine-1-carbonyl]-1,3,4-oxadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)N2CCN(CC=3N(C=NC=3)C)CC2)O1 BSPXSOXPOZXDDD-UHFFFAOYSA-N 0.000 claims 1
OMTBRQKVUVMNEJ-UHFFFAOYSA-N 5-[[(2,4-dichlorophenyl)sulfonyl-methylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methylfuran-3-carboxamide Chemical compound C=1OC(CN(C)S(=O)(=O)C=2C(=CC(Cl)=CC=2)Cl)=CC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 OMTBRQKVUVMNEJ-UHFFFAOYSA-N 0.000 claims 1
YREFKTONZZIDDQ-UHFFFAOYSA-N 5-[[(2,4-dichlorophenyl)sulfonyl-methylamino]methyl]-n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-n-methylfuran-3-carboxamide Chemical compound C=1OC(CN(C)S(=O)(=O)C=2C(=CC(Cl)=CC=2)Cl)=CC=1C(=O)N(C)CC(C=C1)=CC=C1C1=NCCN1 YREFKTONZZIDDQ-UHFFFAOYSA-N 0.000 claims 1
CVFMWPCBXOICNX-UHFFFAOYSA-N 5-[[(2,6-dichlorophenyl)sulfonyl-methylamino]methyl]-n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-n-methylfuran-3-carboxamide Chemical compound C=1OC(CN(C)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=CC=1C(=O)N(C)CC(C=C1)=CC=C1C1=NCCN1 CVFMWPCBXOICNX-UHFFFAOYSA-N 0.000 claims 1
HQEWZTRCJZPKLX-UHFFFAOYSA-N 5-[[(2,6-dichlorophenyl)sulfonyl-methylamino]methyl]-n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]furan-3-carboxamide Chemical compound ClC=1C=CC=C(Cl)C=1S(=O)(=O)N(C)CC(OC=1)=CC=1C(=O)NCC(C=C1)=CC=C1C1=NCCN1 HQEWZTRCJZPKLX-UHFFFAOYSA-N 0.000 claims 1
QXWBBVLSPXDPBB-UHFFFAOYSA-N 5-[[(4-bromo-2,6-dichlorophenyl)sulfonyl-cyclopropylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methylfuran-3-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC(Br)=CC=2Cl)Cl)=CC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 QXWBBVLSPXDPBB-UHFFFAOYSA-N 0.000 claims 1
YEXXJLFTFXCBDO-UHFFFAOYSA-N 5-[[(4-bromo-2,6-dichlorophenyl)sulfonyl-cyclopropylamino]methyl]-n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-n-methylfuran-3-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1OC(CN(C2CC2)S(=O)(=O)C=2C(=CC(Br)=CC=2Cl)Cl)=CC=1C(=O)N(C)CC(C=C1)=CC=C1C1=NCCN1 YEXXJLFTFXCBDO-UHFFFAOYSA-N 0.000 claims 1
MRDZWHFIJIJTQZ-UHFFFAOYSA-N 5-[[(4-bromo-2,6-dichlorophenyl)sulfonyl-methylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]furan-3-carboxamide Chemical compound ClC=1C=C(Br)C=C(Cl)C=1S(=O)(=O)N(C)CC(OC=1)=CC=1C(=O)NCCC(C=C1)=CC=C1C1=NCCN1 MRDZWHFIJIJTQZ-UHFFFAOYSA-N 0.000 claims 1
VRRDFNAYJKWXIJ-UHFFFAOYSA-N 5-[[(4-bromo-2,6-dichlorophenyl)sulfonyl-methylamino]methyl]-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]furan-3-carboxamide Chemical compound ClC=1C=C(Br)C=C(Cl)C=1S(=O)(=O)N(C)CC(OC=1)=CC=1C(=O)NCC(C=C1)=CC=C1CN1CCCC1 VRRDFNAYJKWXIJ-UHFFFAOYSA-N 0.000 claims 1
CMWCWMQQBFVABN-UHFFFAOYSA-N 5-[[(4-bromo-2-ethylphenyl)sulfonyl-methylamino]methyl]-n-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]furan-3-carboxamide Chemical compound CCC1=CC(Br)=CC=C1S(=O)(=O)N(C)CC1=CC(C(=O)NCC=2C=C(CN3CCCC3)C=CC=2)=CO1 CMWCWMQQBFVABN-UHFFFAOYSA-N 0.000 claims 1
IZKCBMAWEWLSAQ-UHFFFAOYSA-N 5-[[(4-chloro-2,5-dimethylphenyl)sulfonyl-methylamino]methyl]-n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-n-methylfuran-3-carboxamide Chemical compound C=1OC(CN(C)S(=O)(=O)C=2C(=CC(Cl)=C(C)C=2)C)=CC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 IZKCBMAWEWLSAQ-UHFFFAOYSA-N 0.000 claims 1
FOYJIBMGVLBVMY-UHFFFAOYSA-N 5-[[(4-chloro-2,5-dimethylphenyl)sulfonyl-methylamino]methyl]-n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-n-methylfuran-3-carboxamide Chemical compound C=1OC(CN(C)S(=O)(=O)C=2C(=CC(Cl)=C(C)C=2)C)=CC=1C(=O)N(C)CC(C=C1)=CC=C1C1=NCCN1 FOYJIBMGVLBVMY-UHFFFAOYSA-N 0.000 claims 1
ZANMIGCUYFPYFM-UHFFFAOYSA-N 5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-(1,2,2,6,6-pentamethylpiperidin-4-yl)furan-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NC2CC(C)(C)N(C)C(C)(C)C2)=CO1 ZANMIGCUYFPYFM-UHFFFAOYSA-N 0.000 claims 1
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UDRIHPKYHCCEOA-UHFFFAOYSA-N n-[(4-imidazol-1-ylphenyl)methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(=CC=2)N2C=NC=C2)=CO1 UDRIHPKYHCCEOA-UHFFFAOYSA-N 0.000 claims 1
SZMCMLYUUMQAOY-UHFFFAOYSA-N n-[1-[4-[(3-hydroxypyrrolidin-1-yl)methyl]phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]furan-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NC(C)C=2C=CC(CN3CC(O)CC3)=CC=2)=CO1 SZMCMLYUUMQAOY-UHFFFAOYSA-N 0.000 claims 1
VIVHASHZNMSLAB-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CCC=2C=CC(=CC=2)C=2NCCN=2)=CO1 VIVHASHZNMSLAB-UHFFFAOYSA-N 0.000 claims 1
SUZIDHZMCNXTLX-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-thiazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CCC=2C=CC(=CC=2)C=2NCCN=2)=CS1 SUZIDHZMCNXTLX-UHFFFAOYSA-N 0.000 claims 1
FCYUQUIOTNHRDA-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-3-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-1,2,4-oxadiazole-5-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NOC(C(=O)NCCC=2C=CC(=CC=2)C=2NCCN=2)=N1 FCYUQUIOTNHRDA-UHFFFAOYSA-N 0.000 claims 1
KSADDEKYZXRQJT-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-3-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-1,2,4-thiadiazole-5-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NSC(C(=O)NCCC=2C=CC(=CC=2)C=2NCCN=2)=N1 KSADDEKYZXRQJT-UHFFFAOYSA-N 0.000 claims 1
UGTKPEWJBVOUHE-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-3-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,2,4-oxadiazole-5-carboxamide;2,2,2-trifluoroacetamide Chemical compound NC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NOC(C(=O)N(C)CCC=2C=CC(=CC=2)C=2NCCN=2)=N1 UGTKPEWJBVOUHE-UHFFFAOYSA-N 0.000 claims 1
XVXTVFOUUIUZHP-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-1,3,4-oxadiazole-2-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)NCCC=2C=CC(=CC=2)C=2NCCN=2)O1 XVXTVFOUUIUZHP-UHFFFAOYSA-N 0.000 claims 1
FGVHGQDMRXHAFT-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-1,3,4-thiadiazole-2-carboxamide;2,2,2-trifluoroacetamide Chemical compound NC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)NCCC=2C=CC(=CC=2)C=2NCCN=2)S1 FGVHGQDMRXHAFT-UHFFFAOYSA-N 0.000 claims 1
SVYAIHSOPKRION-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-2-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NCCC=2C=CC(=CC=2)C=2NCCN=2)=C(C)O1 SVYAIHSOPKRION-UHFFFAOYSA-N 0.000 claims 1
LETGEUYAERRGHN-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n,2-dimethylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CCC=2C=CC(=CC=2)C=2NCCN=2)=C(C)O1 LETGEUYAERRGHN-UHFFFAOYSA-N 0.000 claims 1
VUHPESKOPHIOSQ-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3,4-oxadiazole-2-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)N(C)CCC=2C=CC(=CC=2)C=2NCCN=2)O1 VUHPESKOPHIOSQ-UHFFFAOYSA-N 0.000 claims 1
SGKOFDMPFZOZKG-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]furan-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NCCC=2C=CC(=CC=2)C=2NCCN=2)=CO1 SGKOFDMPFZOZKG-UHFFFAOYSA-N 0.000 claims 1
PZAJRGPBIBFQPP-UHFFFAOYSA-N n-[2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]ethyl]-5-[[ethyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound CC=1C=C(OC)C=C(C)C=1S(=O)(=O)N(CC)CC(OC=1)=CC=1C(=O)N(C)CCC(C=C1)=CC=C1C1=NCCN1 PZAJRGPBIBFQPP-UHFFFAOYSA-N 0.000 claims 1
FUPZRSSLYMRCQT-UHFFFAOYSA-N n-[2-[4-[(2-aminopyrimidin-4-yl)amino]phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]furan-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NCCC=2C=CC(NC=3N=C(N)N=CC=3)=CC=2)=CO1 FUPZRSSLYMRCQT-UHFFFAOYSA-N 0.000 claims 1
VJOYUMHGIQOZEZ-VSGBNLITSA-N n-[2-[4-[(3ar,7ar)-3a,4,5,6,7,7a-hexahydro-1h-benzimidazol-2-yl]phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]furan-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NCCC=2C=CC(=CC=2)C=2N[C@@H]3CCCC[C@H]3N=2)=CO1 VJOYUMHGIQOZEZ-VSGBNLITSA-N 0.000 claims 1
WVLMDJHZUGSTPC-UHFFFAOYSA-N n-[2-[4-[(4-aminopyrimidin-2-yl)amino]phenyl]ethyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]furan-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NCCC=2C=CC(NC=3N=C(N)C=CN=3)=CC=2)=CO1 WVLMDJHZUGSTPC-UHFFFAOYSA-N 0.000 claims 1
PWXRDCZHOXJIMM-UHFFFAOYSA-N n-[[3-fluoro-5-(pyrrolidin-1-ylmethyl)phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=C(CN3CCCC3)C=C(F)C=2)=CO1 PWXRDCZHOXJIMM-UHFFFAOYSA-N 0.000 claims 1
IPNOSMQAFBJISM-UHFFFAOYSA-N n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)NCC=2C=CC(=CC=2)C=2NCCN=2)=CO1 IPNOSMQAFBJISM-UHFFFAOYSA-N 0.000 claims 1
IIOQLQAXEVNNJM-UHFFFAOYSA-N n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(=CC=2)C=2NCCN=2)=CO1 IIOQLQAXEVNNJM-UHFFFAOYSA-N 0.000 claims 1
XBSMHRIOXCQAIX-UHFFFAOYSA-N n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-thiazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(=CC=2)C=2NCCN=2)=CS1 XBSMHRIOXCQAIX-UHFFFAOYSA-N 0.000 claims 1
HWFVCUPXPNAEMY-UHFFFAOYSA-N n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-5-[(n-(4-methoxy-2,6-dimethylphenyl)sulfonylanilino)methyl]-n-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C=1C=CC=CC=1)CC1=CC(C(=O)N(C)CC=2C=CC(=CC=2)C=2NCCN=2)=CO1 HWFVCUPXPNAEMY-UHFFFAOYSA-N 0.000 claims 1
OJAMFCJEUCYGLZ-UHFFFAOYSA-N n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n,2-dimethylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(=CC=2)C=2NCCN=2)=C(C)O1 OJAMFCJEUCYGLZ-UHFFFAOYSA-N 0.000 claims 1
TVXKEDSFIRKDNO-UHFFFAOYSA-N n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(=CC=2)C=2NCCN=2)=CO1 TVXKEDSFIRKDNO-UHFFFAOYSA-N 0.000 claims 1
ABSVZPDNLZFEIC-UHFFFAOYSA-N n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]furan-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NCC=2C=CC(=CC=2)C=2NCCN=2)=CO1 ABSVZPDNLZFEIC-UHFFFAOYSA-N 0.000 claims 1
JYHIIJGCMAUJOH-UHFFFAOYSA-N n-[[4-[(3-acetamidopyrrolidin-1-yl)methyl]phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)NC(C)=O)=CC=2)=CO1 JYHIIJGCMAUJOH-UHFFFAOYSA-N 0.000 claims 1
HTNWIHBSDQUZGD-UHFFFAOYSA-N n-[[4-[(3-acetamidopyrrolidin-1-yl)methyl]phenyl]methyl]-2-[[cyclopropyl-(4-methoxy-2,6-dimethylphenyl)sulfonylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)NC(C)=O)=CC=2)=CO1 HTNWIHBSDQUZGD-UHFFFAOYSA-N 0.000 claims 1
DMBGZGNQLFAROH-UHFFFAOYSA-N n-[[4-[(3-acetamidopyrrolidin-1-yl)methyl]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)NC(C)=O)=CC=2)=CO1 DMBGZGNQLFAROH-UHFFFAOYSA-N 0.000 claims 1
DVNWJJJQBFILEB-UHFFFAOYSA-N n-[[4-[(3-hydroxyazetidin-1-yl)methyl]phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(O)C3)=CC=2)=CO1 DVNWJJJQBFILEB-UHFFFAOYSA-N 0.000 claims 1
XETRAOUPSJGSIK-UHFFFAOYSA-N n-[[4-[(3-hydroxyazetidin-1-yl)methyl]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(CN3CC(O)C3)=CC=2)=CO1 XETRAOUPSJGSIK-UHFFFAOYSA-N 0.000 claims 1
LAWBKUJCEUIISI-UHFFFAOYSA-N n-[[4-[(3-hydroxypiperidin-1-yl)methyl]phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(O)CCC3)=CC=2)=CO1 LAWBKUJCEUIISI-UHFFFAOYSA-N 0.000 claims 1
IUZXECBLSKASRB-UHFFFAOYSA-N n-[[4-[(3-hydroxypiperidin-1-yl)methyl]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(CN3CC(O)CCC3)=CC=2)=CO1 IUZXECBLSKASRB-UHFFFAOYSA-N 0.000 claims 1
AIYYSUGAGOZEPZ-UHFFFAOYSA-N n-[[4-[(3-hydroxypyrrolidin-1-yl)methyl]phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(O)CC3)=CC=2)=CO1 AIYYSUGAGOZEPZ-UHFFFAOYSA-N 0.000 claims 1
FSHNEVQQDGBMGT-UHFFFAOYSA-N n-[[4-[(3-hydroxypyrrolidin-1-yl)methyl]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(CN3CC(O)CC3)=CC=2)=CO1 FSHNEVQQDGBMGT-UHFFFAOYSA-N 0.000 claims 1
MUBLHBNOXWZRSM-UHFFFAOYSA-N n-[[4-[(3-methoxyazetidin-1-yl)methyl]phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound C1C(OC)CN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=N1 MUBLHBNOXWZRSM-UHFFFAOYSA-N 0.000 claims 1
BLNPTANNIDGEQE-UHFFFAOYSA-N n-[[4-[(3-methoxyazetidin-1-yl)methyl]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3,4-oxadiazole-2-carboxamide Chemical compound C1C(OC)CN1CC(C=C1)=CC=C1CN(C)C(=O)C(O1)=NN=C1CN(C)S(=O)(=O)C1=C(C)C=C(OC)C=C1C BLNPTANNIDGEQE-UHFFFAOYSA-N 0.000 claims 1
SCDSVNJNZPRWAG-UHFFFAOYSA-N n-[[4-[(3-methoxyazetidin-1-yl)methyl]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound C1C(OC)CN1CC(C=C1)=CC=C1CN(C)C(=O)C1=COC(CN(C)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=C1 SCDSVNJNZPRWAG-UHFFFAOYSA-N 0.000 claims 1
HZKVEEUPNLVUPR-UHFFFAOYSA-N n-[[4-[(4-aminopyrimidin-2-yl)amino]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]furan-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)NCC=2C=CC(NC=3N=C(N)C=CN=3)=CC=2)=CO1 HZKVEEUPNLVUPR-UHFFFAOYSA-N 0.000 claims 1
PHLHQUUIERYQJL-UHFFFAOYSA-N n-[[4-[3-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]piperidine-1-carbonyl]furan-2-yl]methyl]-4-methoxy-n,2,6-trimethylbenzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N2CC(CCC2)C=2C=CC(=CC=2)C=2NCCN=2)=CO1 PHLHQUUIERYQJL-UHFFFAOYSA-N 0.000 claims 1
SXRAXKYOPKRMKN-UHFFFAOYSA-N n-[[4-[5-(1-azabicyclo[2.2.2]octan-3-yl)-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridine-2-carbonyl]-1,3-oxazol-2-yl]methyl]-n-cyclopropyl-4-methoxy-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CC3CN(CCC3C2)C2C3CCN(CC3)C2)=CO1 SXRAXKYOPKRMKN-UHFFFAOYSA-N 0.000 claims 1
ARGNGIHIYQFBNT-UHFFFAOYSA-N n-[[4-[[3-(dimethylamino)pyrrolidin-1-yl]methyl]phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)N(C)C)=CC=2)=CO1 ARGNGIHIYQFBNT-UHFFFAOYSA-N 0.000 claims 1
OZZXGATYVQIHBW-UHFFFAOYSA-N n-[[4-[[3-(dimethylamino)pyrrolidin-1-yl]methyl]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3,4-oxadiazole-2-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NN=C(C(=O)N(C)CC=2C=CC(CN3CC(CC3)N(C)C)=CC=2)O1 OZZXGATYVQIHBW-UHFFFAOYSA-N 0.000 claims 1
BONRRIQAXWKTEU-UHFFFAOYSA-N n-[[4-[[3-(dimethylamino)pyrrolidin-1-yl]methyl]phenyl]methyl]-5-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methylfuran-3-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=CC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)N(C)C)=CC=2)=CO1 BONRRIQAXWKTEU-UHFFFAOYSA-N 0.000 claims 1
ZNLPLQGMOJZFSR-UHFFFAOYSA-N n-[[4-[[3-(dimethylcarbamoyl)pyrrolidin-1-yl]methyl]phenyl]methyl]-2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]methyl]-n-methyl-1,3-oxazole-4-carboxamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C)CC1=NC(C(=O)N(C)CC=2C=CC(CN3CC(CC3)C(=O)N(C)C)=CC=2)=CO1 ZNLPLQGMOJZFSR-UHFFFAOYSA-N 0.000 claims 1
UVGKUPFXXWNBJU-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[2-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-5-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=CN=C(C(=O)N2CCN(CC3CCN(C)CC3)CC2)O1 UVGKUPFXXWNBJU-UHFFFAOYSA-N 0.000 claims 1
LSIAEPYTJYMUEG-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-(4-piperidin-4-ylpiperidine-1-carbonyl)-1,3-oxazol-2-yl]methyl]benzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCC(CC2)C2CCNCC2)=CO1 LSIAEPYTJYMUEG-UHFFFAOYSA-N 0.000 claims 1
JUCSMGADSZGWDO-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-(4-pyridin-3-ylpiperazine-1-carbonyl)-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC2)C=2C=NC=CC=2)=CO1 JUCSMGADSZGWDO-UHFFFAOYSA-N 0.000 claims 1
VTGCTUWSLPBDDA-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-[4-(1-methylpiperidin-4-yl)piperazine-1-carbonyl]furan-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=CC(C(=O)N2CCN(CC2)C2CCN(C)CC2)=CO1 VTGCTUWSLPBDDA-UHFFFAOYSA-N 0.000 claims 1
FNANCAHKPCQDSA-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-[4-(quinolin-3-ylmethyl)piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3C=C4C=CC=CC4=NC=3)CC2)=CO1 FNANCAHKPCQDSA-UHFFFAOYSA-N 0.000 claims 1
DQAJKWMGNHWEBA-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-[4-[(2-methyl-1h-imidazol-5-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3N=C(C)NC=3)CC2)=CO1 DQAJKWMGNHWEBA-UHFFFAOYSA-N 0.000 claims 1
ZJFOBPNNDCGDAB-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-[4-[(2-methylpyridin-4-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3C=C(C)N=CC=3)CC2)=CO1 ZJFOBPNNDCGDAB-UHFFFAOYSA-N 0.000 claims 1
ODDUCRZGSVWEGU-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-[4-[(2-pyrrolidin-1-ylpyridin-4-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3C=C(N=CC=3)N3CCCC3)CC2)=CO1 ODDUCRZGSVWEGU-UHFFFAOYSA-N 0.000 claims 1
QSYAMORZGUELOI-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-[4-[(3-methylimidazol-4-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3N(C=NC=3)C)CC2)=CO1 QSYAMORZGUELOI-UHFFFAOYSA-N 0.000 claims 1
XQURWFQNFWGZAP-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[4-[4-[(5-methyl-1h-pyrazol-4-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3C(=NNC=3)C)CC2)=CO1 XQURWFQNFWGZAP-UHFFFAOYSA-N 0.000 claims 1
CCFFPMDUKXZOIH-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-(1-methylpiperidin-4-yl)piperazine-1-carbonyl]-1,2,4-oxadiazol-3-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NOC(C(=O)N2CCN(CC2)C2CCN(C)CC2)=N1 CCFFPMDUKXZOIH-UHFFFAOYSA-N 0.000 claims 1
DRQROXCLOBYDDB-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-(1-methylpiperidin-4-yl)piperazine-1-carbonyl]-1,3,4-oxadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NN=C(C(=O)N2CCN(CC2)C2CCN(C)CC2)O1 DRQROXCLOBYDDB-UHFFFAOYSA-N 0.000 claims 1
RSFPOYGQLBWMMW-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-(1-methylpiperidin-4-yl)piperazine-1-carbonyl]-1,3,4-thiadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NN=C(C(=O)N2CCN(CC2)C2CCN(C)CC2)S1 RSFPOYGQLBWMMW-UHFFFAOYSA-N 0.000 claims 1
AJXPHUVNWINSCR-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-(2-pyrrolidin-1-ylethyl)piperidine-1-carbonyl]-1,2,4-oxadiazol-3-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NOC(C(=O)N2CCC(CCN3CCCC3)CC2)=N1 AJXPHUVNWINSCR-UHFFFAOYSA-N 0.000 claims 1
ZFYJFDQTNCHIER-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-(3-pyrrolidin-1-ylpropyl)piperazine-1-carbonyl]-1,2,4-oxadiazol-3-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NOC(C(=O)N2CCN(CCCN3CCCC3)CC2)=N1 ZFYJFDQTNCHIER-UHFFFAOYSA-N 0.000 claims 1
DQDCLFNUVDZETO-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-(3-pyrrolidin-1-ylpropyl)piperazine-1-carbonyl]-1,3,4-oxadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NN=C(C(=O)N2CCN(CCCN3CCCC3)CC2)O1 DQDCLFNUVDZETO-UHFFFAOYSA-N 0.000 claims 1
UINCVADIWXAAMM-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-(3-pyrrolidin-1-ylpropyl)piperazine-1-carbonyl]-1,3,4-thiadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NN=C(C(=O)N2CCN(CCCN3CCCC3)CC2)S1 UINCVADIWXAAMM-UHFFFAOYSA-N 0.000 claims 1
VIQHSYHYLBIILG-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-[(1-methylpiperidin-3-yl)methyl]piperazine-1-carbonyl]-1,2,4-oxadiazol-3-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NOC(C(=O)N2CCN(CC3CN(C)CCC3)CC2)=N1 VIQHSYHYLBIILG-UHFFFAOYSA-N 0.000 claims 1
HOWRNFMJCJVRHV-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]-1,2,4-oxadiazol-3-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NOC(C(=O)N2CCN(CC3CCN(C)CC3)CC2)=N1 HOWRNFMJCJVRHV-UHFFFAOYSA-N 0.000 claims 1
WKLPVARDHMEFCM-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-2,6-dimethyl-n-[[5-[4-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carbonyl]-1,3,4-oxadiazol-2-yl]methyl]benzenesulfonamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NN=C(C(=O)N2CCN(CC3CCN(C)CC3)CC2)O1 WKLPVARDHMEFCM-UHFFFAOYSA-N 0.000 claims 1
UFRJEGPSOMFVHA-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-n-[[4-[2-[(6-methoxypyridin-3-yl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]-1,3-oxazol-2-yl]methyl]-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CC3CN(CC=4C=NC(OC)=CC=4)CC3C2)=CO1 UFRJEGPSOMFVHA-UHFFFAOYSA-N 0.000 claims 1
YUBAMNJJPTUKOK-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-n-[[4-[3-[(6-methoxypyridin-3-yl)methyl-methylamino]pyrrolidine-1-carbonyl]-1,3-oxazol-2-yl]methyl]-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CC(CC2)N(C)CC=2C=NC(OC)=CC=2)=CO1 YUBAMNJJPTUKOK-UHFFFAOYSA-N 0.000 claims 1
CYYQCHRDTMOLLN-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-n-[[4-[4-[(6-methoxypyridin-3-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3C=NC(OC)=CC=3)CC2)=CO1 CYYQCHRDTMOLLN-UHFFFAOYSA-N 0.000 claims 1
HKLWFLVMYXSNDD-UHFFFAOYSA-N n-cyclopropyl-4-methoxy-n-[[4-[5-[(6-methoxypyridin-3-yl)methyl]-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridine-2-carbonyl]-1,3-oxazol-2-yl]methyl]-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CC3CN(CC=4C=NC(OC)=CC=4)CCC3C2)=CO1 HKLWFLVMYXSNDD-UHFFFAOYSA-N 0.000 claims 1
WFNMQTWLHSTCPH-UHFFFAOYSA-N n-cyclopropyl-n-[[4-[4-[(3,5-dichloropyridin-4-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]-4-methoxy-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3C(=CN=CC=3Cl)Cl)CC2)=CO1 WFNMQTWLHSTCPH-UHFFFAOYSA-N 0.000 claims 1
YQYXZEKXJZFRSE-UHFFFAOYSA-N n-cyclopropyl-n-[[4-[4-[(6-fluoropyridin-3-yl)methyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]-4-methoxy-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CC=3C=NC(F)=CC=3)CC2)=CO1 YQYXZEKXJZFRSE-UHFFFAOYSA-N 0.000 claims 1
JDQLLKJQQJVUMT-UHFFFAOYSA-N n-cyclopropyl-n-[[4-[4-[4-(dimethylamino)butyl]piperazine-1-carbonyl]-1,3-oxazol-2-yl]methyl]-4-methoxy-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCN(CCCCN(C)C)CC2)=CO1 JDQLLKJQQJVUMT-UHFFFAOYSA-N 0.000 claims 1
ZETAJJVASQFQLV-UHFFFAOYSA-N n-cyclopropyl-n-[[4-[4-hydroxy-4-(morpholin-4-ylmethyl)piperidine-1-carbonyl]-1,3-oxazol-2-yl]methyl]-4-methoxy-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCC(O)(CN3CCOCC3)CC2)=CO1 ZETAJJVASQFQLV-UHFFFAOYSA-N 0.000 claims 1
ZXTYZKQNVQSXMN-UHFFFAOYSA-N n-cyclopropyl-n-[[4-[4-hydroxy-4-[(4-methylpiperazin-1-yl)methyl]piperidine-1-carbonyl]-1,3-oxazol-2-yl]methyl]-4-methoxy-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NC(C(=O)N2CCC(O)(CN3CCN(C)CC3)CC2)=CO1 ZXTYZKQNVQSXMN-UHFFFAOYSA-N 0.000 claims 1
XMTLQWLGCUTSME-UHFFFAOYSA-N n-cyclopropyl-n-[[5-[4-[4-(dimethylamino)butyl]piperazine-1-carbonyl]-1,2,4-oxadiazol-3-yl]methyl]-4-methoxy-2,6-dimethylbenzenesulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N(C1CC1)CC1=NOC(C(=O)N2CCN(CCCCN(C)C)CC2)=N1 XMTLQWLGCUTSME-UHFFFAOYSA-N 0.000 claims 1
201000008383 nephritis Diseases 0.000 claims 1
210000005036 nerve Anatomy 0.000 claims 1
230000008764 nerve damage Effects 0.000 claims 1
210000000653 nervous system Anatomy 0.000 claims 1
208000004296 neuralgia Diseases 0.000 claims 1
230000004770 neurodegeneration Effects 0.000 claims 1
208000015122 neurodegenerative disease Diseases 0.000 claims 1
208000021722 neuropathic pain Diseases 0.000 claims 1
230000007935 neutral effect Effects 0.000 claims 1
235000020824 obesity Nutrition 0.000 claims 1
230000000414 obstructive effect Effects 0.000 claims 1
208000007892 occupational asthma Diseases 0.000 claims 1
230000000399 orthopedic effect Effects 0.000 claims 1
208000020629 overactive bladder Diseases 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims 1
125000003386 piperidinyl group Chemical group 0.000 claims 1
230000007824 polyneuropathy Effects 0.000 claims 1
230000002980 postoperative effect Effects 0.000 claims 1
230000003449 preventive effect Effects 0.000 claims 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
229940002612 prodrug Drugs 0.000 claims 1
239000000651 prodrug Substances 0.000 claims 1
201000007094 prostatitis Diseases 0.000 claims 1
201000001474 proteinuria Diseases 0.000 claims 1
230000003252 repetitive effect Effects 0.000 claims 1
208000023504 respiratory system disease Diseases 0.000 claims 1
230000001932 seasonal effect Effects 0.000 claims 1
230000036303 septic shock Effects 0.000 claims 1
208000017520 skin disease Diseases 0.000 claims 1
208000020431 spinal cord injury Diseases 0.000 claims 1
230000036262 stenosis Effects 0.000 claims 1
208000037804 stenosis Diseases 0.000 claims 1
125000000565 sulfonamide group Chemical group 0.000 claims 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
208000024891 symptom Diseases 0.000 claims 1
201000004595 synovitis Diseases 0.000 claims 1
210000002435 tendon Anatomy 0.000 claims 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
229930192474 thiophene Natural products 0.000 claims 1
208000004371 toothache Diseases 0.000 claims 1
230000000472 traumatic effect Effects 0.000 claims 1
206010044652 trigeminal neuralgia Diseases 0.000 claims 1
208000036722 ulnar neuropathy Diseases 0.000 claims 1
230000036325 urinary excretion Effects 0.000 claims 1
208000001319 vasomotor rhinitis Diseases 0.000 claims 1
230000003612 virological effect Effects 0.000 claims 1
208000009935 visceral pain Diseases 0.000 claims 1

JP2011523386A 2008-08-22 2009-08-10 新しいブラジキニンｂ１拮抗薬 Pending JP2012500783A (ja)