JP2012224636A5 - - Google Patents

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Publication number

JP2012224636A5

JP2012224636A5 JP2012166700A JP2012166700A JP2012224636A5 JP 2012224636 A5 JP2012224636 A5 JP 2012224636A5 JP 2012166700 A JP2012166700 A JP 2012166700A JP 2012166700 A JP2012166700 A JP 2012166700A JP 2012224636 A5 JP2012224636 A5 JP 2012224636A5

Authority

JP

Japan

Prior art keywords

glucan

conjugate according

conjugate

laminarin

bacterial toxoid

Prior art date

2012-07-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims 21
• 229920002498 Beta-glucan Polymers 0.000 claims 19
• 229920001503 Glucan Polymers 0.000 claims 5
• 230000001580 bacterial effect Effects 0.000 claims 5
• DBTMGCOVALSLOR-DEVYUCJPSA-N (2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](CO)O[C@H](O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-DEVYUCJPSA-N 0.000 claims 4
• 229920001543 Laminarin Polymers 0.000 claims 4
• 239000005717 Laminarin Substances 0.000 claims 4
• 230000002538 fungal effect Effects 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 229960005486 vaccine Drugs 0.000 claims 3
• 241000222120 Candida <Saccharomycetales> Species 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• 239000004365 Protease Substances 0.000 claims 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
• 230000001681 protective effect Effects 0.000 claims 2
• 102100024023 Histone PARylation factor 1 Human genes 0.000 claims 1
• 101001047783 Homo sapiens Histone PARylation factor 1 Proteins 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 229940121375 antifungal agent Drugs 0.000 claims 1
• 239000003429 antifungal agent Substances 0.000 claims 1
• 210000002421 cell wall Anatomy 0.000 claims 1
• 244000053095 fungal pathogen Species 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1