JP2012031147A5 - - Google Patents

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Publication number
JP2012031147A5
JP2012031147A5 JP2011136591A JP2011136591A JP2012031147A5 JP 2012031147 A5 JP2012031147 A5 JP 2012031147A5 JP 2011136591 A JP2011136591 A JP 2011136591A JP 2011136591 A JP2011136591 A JP 2011136591A JP 2012031147 A5 JP2012031147 A5 JP 2012031147A5
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JP
Japan
Prior art keywords
salt
loxoprofen
pharmaceutical composition
dextromethorphan
composition according
Prior art date
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Pending
Application number
JP2011136591A
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Japanese (ja)
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JP2012031147A (en
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Priority to JP2011136591A priority Critical patent/JP2012031147A/en
Priority claimed from JP2011136591A external-priority patent/JP2012031147A/en
Publication of JP2012031147A publication Critical patent/JP2012031147A/en
Publication of JP2012031147A5 publication Critical patent/JP2012031147A5/ja
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Claims (14)

リゾチーム又はその塩、及びデキストロメトルファン又はその塩からなる群より選ばれる１種以上と、ロキソプロフェン又はその塩とを実質的に互いに接しないように含有する医薬組成物。 Li Zochimu or a salt thereof, and at least one member selected from the group consisting of dextromethorphan or a salt thereof, pharmaceutical compositions containing such substantially contact with each other and loxoprofen or a salt thereof. ロキソプロフェン又はその塩が、ロキソプロフェンナトリウム水和物である請求項１記載の医薬組成物。   The pharmaceutical composition according to claim 1, wherein the loxoprofen or a salt thereof is loxoprofen sodium hydrate. ロキソプロフェン又はその塩を、ロキソプロフェンナトリウム無水物換算で、１０〜３００ｍｇを１日量として含有する請求項１又は２記載の医薬組成物。 The pharmaceutical composition according to claim 1 or 2, wherein loxoprofen or a salt thereof is contained in an amount of 10 to 300 mg per day in terms of anhydrous loxoprofen sodium. リゾチーム又はその塩が、リゾチーム塩酸塩である請求項１〜３いずれか１項記載の医薬組成物。The pharmaceutical composition according to any one of claims 1 to 3, wherein the lysozyme or a salt thereof is lysozyme hydrochloride. デキストロメトルファン又はその塩が、デキストロメトルファン臭化水素酸塩水和物及びデキストロメトルファンフェノールフタリン塩から選ばれる１種以上である請求項１〜４いずれか１項記載の医薬組成物。The pharmaceutical composition according to any one of claims 1 to 4, wherein the dextromethorphan or a salt thereof is at least one selected from dextromethorphan hydrobromide hydrate and dextromethorphan phenolphthaline salt. リゾチーム又はその塩を、リゾチーム塩酸塩の力価換算で、５〜４５０ｍｇ（力価）を１日量として含有する請求項１〜５いずれか１項記載の医薬組成物。The pharmaceutical composition according to any one of claims 1 to 5, comprising lysozyme or a salt thereof as a daily dose of 5 to 450 mg (titer) in terms of titer of lysozyme hydrochloride. デキストロメトルファン臭化水素酸塩水和物を、６〜６０ｍｇを１日量として含有する請求項５記載の医薬組成物。6. The pharmaceutical composition according to claim 5, comprising 6 to 60 mg of dextromethorphan hydrobromide hydrate as a daily dose. デキストロメトルファンフェノールフタリン塩を、９〜９０ｍｇを１日量として含有する請求項５記載の医薬組成物。The pharmaceutical composition according to claim 5, comprising 9 to 90 mg of dextromethorphan phenolphthalein salt as a daily dose. ロキソプロフェン又はその塩が、ロキソプロフェン又はその塩を含有する粒状物である請求項１〜８いずれか１項記載の医薬組成物。 The pharmaceutical composition according to any one of claims 1 to 8 , wherein loxoprofen or a salt thereof is a granular material containing loxoprofen or a salt thereof. リゾチーム又はその塩、及びデキストロメトルファン又はその塩からなる群より選ばれる１種以上が、リゾチーム又はその塩、及びデキストロメトルファン又はその塩からなる群より選ばれる１種以上を含有する粒状物である請求項１〜９いずれか１項記載の医薬組成物。One or more selected from the group consisting of lysozyme or a salt thereof and dextromethorphan or a salt thereof is a granular material containing one or more selected from the group consisting of lysozyme or a salt thereof and dextromethorphan or a salt thereof. The pharmaceutical composition according to any one of claims 1 to 9. （Ａ）ロキソプロフェン若しくはその塩そのもの、又はロキソプロフェン若しくはその塩を含有する固形組成物と、（Ｂ）リゾチーム若しくはその塩そのもの、又はリゾチーム若しくはその塩を含有する固形組成物とを含有し、これらの固形組成物を構成する成分によって、ロキソプロフェン又はその塩とリゾチーム又はその塩とが互いに接しないように配置されている医薬組成物（但し、成分（Ａ）がロキソプロフェン又はその塩そのものであり、かつ成分（Ｂ）がリゾチーム又はその塩そのものである場合を除く）。(A) Loxoprofen or a salt thereof itself, or a solid composition containing loxoprofen or a salt thereof, and (B) a solid composition containing lysozyme or a salt thereof, or a lysozyme or a salt thereof, and these solids A pharmaceutical composition in which loxoprofen or a salt thereof and lysozyme or a salt thereof are arranged so as not to contact each other depending on the components constituting the composition (provided that component (A) is loxoprofen or a salt thereof itself and the component ( Except when B) is lysozyme or a salt thereof). （Ａ）ロキソプロフェン若しくはその塩そのもの、又はロキソプロフェン若しくはその塩を含有する固形組成物と、（Ｂ）デキストロメトルファン若しくはその塩そのもの、又はデキストロメトルファン若しくはその塩を含有する固形組成物とを含有し、これらの固形組成物を構成する成分によって、ロキソプロフェン又はその塩とデキストロメトルファン又はその塩とが互いに接しないように配置されている医薬組成物（但し、成分（Ａ）がロキソプロフェン又はその塩そのものであり、かつ成分（Ｂ）がデキストロメトルファン又はその塩そのものである場合を除く）。(A) Loxoprofen or a salt thereof itself, or a solid composition containing loxoprofen or a salt thereof, and (B) a solid composition containing dextromethorphan or a salt thereof, or dextromethorphan or a salt thereof. The pharmaceutical composition in which loxoprofen or a salt thereof and dextromethorphan or a salt thereof are arranged so as not to contact each other depending on the components constituting these solid compositions (provided that component (A) is a loxoprofen or a salt thereof itself) And component (B) is dextromethorphan or a salt thereof). 固形製剤である請求項１〜１２いずれか１項記載の医薬組成物。 The pharmaceutical composition according to any one of claims 1 to 12, which is a solid preparation. 剤形が、カプセル剤、丸剤、顆粒剤、細粒剤、散剤又は錠剤である請求項１〜１３いずれか１項記載の医薬組成物。 The pharmaceutical composition according to any one of claims 1 to 13 , wherein the dosage form is a capsule, pill, granule, fine granule, powder or tablet.
JP2011136591A 2010-01-29 2011-06-20 Loxoprofen-containing pharmaceutical composition Pending JP2012031147A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2011136591A JP2012031147A (en) 2010-01-29 2011-06-20 Loxoprofen-containing pharmaceutical composition

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP2010018015 2010-01-29
JP2010018015 2010-01-29
JP2010149115 2010-06-30
JP2010149061 2010-06-30
JP2010149089 2010-06-30
JP2010149115 2010-06-30
JP2010149061 2010-06-30
JP2010149089 2010-06-30
JP2011136591A JP2012031147A (en) 2010-01-29 2011-06-20 Loxoprofen-containing pharmaceutical composition

Related Parent Applications (1)

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JP2011512760A Division JP4787912B2 (en) 2010-01-29 2011-01-31 Loxoprofen-containing pharmaceutical composition

Related Child Applications (1)

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JP2013182739A Division JP5575961B2 (en) 2010-01-29 2013-09-04 Loxoprofen-containing pharmaceutical composition

Publications (2)

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JP2012031147A JP2012031147A (en) 2012-02-16
JP2012031147A5 true JP2012031147A5 (en) 2013-03-14

Family

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Family Applications (5)

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JP2011512760A Active JP4787912B2 (en) 2010-01-29 2011-01-31 Loxoprofen-containing pharmaceutical composition
JP2011017776A Pending JP2012031131A (en) 2010-01-29 2011-01-31 Loxoprofen-containing pharmaceutical composition
JP2011136591A Pending JP2012031147A (en) 2010-01-29 2011-06-20 Loxoprofen-containing pharmaceutical composition
JP2013182739A Active JP5575961B2 (en) 2010-01-29 2013-09-04 Loxoprofen-containing pharmaceutical composition
JP2014130149A Active JP5809736B2 (en) 2010-01-29 2014-06-25 New pharmaceutical composition containing loxoprofen

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JP2011512760A Active JP4787912B2 (en) 2010-01-29 2011-01-31 Loxoprofen-containing pharmaceutical composition
JP2011017776A Pending JP2012031131A (en) 2010-01-29 2011-01-31 Loxoprofen-containing pharmaceutical composition

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JP2013182739A Active JP5575961B2 (en) 2010-01-29 2013-09-04 Loxoprofen-containing pharmaceutical composition
JP2014130149A Active JP5809736B2 (en) 2010-01-29 2014-06-25 New pharmaceutical composition containing loxoprofen

Country Status (4)

Country Link
JP (5) JP4787912B2 (en)
KR (1) KR20120112644A (en)
CN (1) CN102740854A (en)
WO (1) WO2011093498A1 (en)

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CN104224740A (en) * 2014-09-28 2014-12-24 白杨 Preparation method for lilium compound antiphlogistic pill with treated coating
CN104225160A (en) * 2014-09-28 2014-12-24 白杨 Method for preparing coating-treated seven-ingredient qi tonifying pill
CN104257984A (en) * 2014-09-28 2015-01-07 白杨 Method for preparing six-ingredient rehmannia pills subjected to coating treatment
CN104225162A (en) * 2014-09-28 2014-12-24 白杨 Preparation method for cinnamon and monkshood rehmannia pill with treated coating
CN104288433A (en) * 2014-09-28 2015-01-21 白杨 Preparation method of coated Goujudihuang pill
CN104225161A (en) * 2014-09-28 2014-12-24 白杨 Preparation method for angelica sinensis and paeonia lactiflora rehmannia pill with treated coating
CN104225187A (en) * 2014-09-28 2014-12-24 白杨 Preparation method of rhizoma anemarrhenae and golden cypress rehmannia pill with treated coating
CN106580968A (en) * 2016-11-22 2017-04-26 郑州仁宏医药科技有限公司 Western medicine powder for treating swelling and aching of gum and preparation method thereof
EP3415143A1 (en) * 2017-06-16 2018-12-19 Kai-Uwe Kern Bromhexine for the treatment of pain
CN113332252A (en) * 2021-06-07 2021-09-03 大桐制药（中国）有限责任公司 Preparation method of loxoprofen sodium tablets

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