JP2012046484A5 - - Google Patents

Claims (13)

Bed Romuhekishin or a salt thereof and ambroxol or with one or more selected from a salt thereof or Ranaru group, pharmaceutical compositions containing such substantially contact with each other and loxoprofen or a salt thereof. Loxoprofen or a salt thereof, a pharmaceutical composition of claim 1 wherein the Loxoprofensodium hydrate. The pharmaceutical composition according to claim 1 or 2 , wherein loxoprofen or a salt thereof is contained in an amount of 10 to 300 mg per day in terms of anhydrous loxoprofen sodium. The pharmaceutical composition according to any one of claims 1 to 3, wherein the bromhexine or a salt thereof is bromhexine hydrochloride. The pharmaceutical composition according to any one of claims 1 to 4, wherein the ambroxol or a salt thereof is ambroxol hydrochloride. The pharmaceutical composition according to any one of claims 1 to 5, which contains 0.1 to 50 mg of bromhexine or a salt thereof as a daily dose in terms of bromhexine hydrochloride. The pharmaceutical composition according to any one of claims 1 to 6, which contains 0.1 to 150 mg of ambroxol or a salt thereof in terms of ambroxol hydrochloride as a daily dose.   The pharmaceutical composition according to any one of claims 1 to 7, wherein the loxoprofen or a salt thereof is a granular material containing loxoprofen or a salt thereof. One or more selected from the group consisting of bromhexine or a salt thereof and ambroxol or a salt thereof is a granular material containing one or more selected from the group consisting of bromhexine or a salt thereof and ambroxol or a salt thereof A pharmaceutical composition according to any one of claims 1 to 8. (A) Loxoprofen or a salt thereof itself, or a solid composition containing loxoprofen or a salt thereof, and (B) bromhexine or a salt thereof itself, or a solid composition containing bromhexine or a salt thereof, and these solids A pharmaceutical composition in which loxoprofen or a salt thereof and bromhexine or a salt thereof are arranged so as not to contact each other depending on the components constituting the composition (provided that component (A) is loxoprofen or a salt thereof itself and the component ( Except when B) is bromhexine or a salt thereof). (A) Loxoprofen or a salt thereof itself, or a solid composition containing loxoprofen or a salt thereof, and (B) ambroxol or a salt thereof, or a solid composition containing ambroxol or a salt thereof. The pharmaceutical composition in which loxoprofen or a salt thereof and ambroxol or a salt thereof are arranged so as not to contact each other depending on the components constituting these solid compositions (provided that component (A) is a loxoprofen or a salt thereof itself) And the component (B) is ambroxol or a salt thereof). The pharmaceutical composition according to any one of claims 1 to 11, which is a solid preparation. The pharmaceutical composition according to any one of claims 1 to 12 , wherein the dosage form is a capsule, pill, granule, fine granule, powder or tablet.