JP2011529886A5 - - Google Patents
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- Publication number
- JP2011529886A5 JP2011529886A5 JP2011521135A JP2011521135A JP2011529886A5 JP 2011529886 A5 JP2011529886 A5 JP 2011529886A5 JP 2011521135 A JP2011521135 A JP 2011521135A JP 2011521135 A JP2011521135 A JP 2011521135A JP 2011529886 A5 JP2011529886 A5 JP 2011529886A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- disease
- composition according
- dimethylpyridin
- difluoromethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- -1 1-cyclopropyl-2-methoxyethyl Chemical group 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- LGFBVFFBJBSDGC-UHFFFAOYSA-N 1,2-dihydropyrazine-5-carbonitrile Chemical compound N#CC1=CNCC=N1 LGFBVFFBJBSDGC-UHFFFAOYSA-N 0.000 claims 1
- PJMUNXORSUNUCV-OAHLLOKOSA-N 4-[(1s)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethylpyridin-3-yl]amino]-5-oxopyrazine-2-carbonitrile Chemical compound C1([C@@H](COC)N2C(C(NC=3C(=NC(OC(F)F)=C(C)C=3)C)=NC(=C2)C#N)=O)CC1 PJMUNXORSUNUCV-OAHLLOKOSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000029650 alcohol withdrawal Diseases 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8523008P | 2008-07-31 | 2008-07-31 | |
| US61/085,230 | 2008-07-31 | ||
| PCT/US2009/041793 WO2010014280A1 (en) | 2008-07-31 | 2009-04-27 | Pyrazinone modulator of corticotropin-releasing factor receptor activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529886A JP2011529886A (ja) | 2011-12-15 |
| JP2011529886A5 true JP2011529886A5 (https=) | 2012-05-24 |
| JP5396474B2 JP5396474B2 (ja) | 2014-01-22 |
Family
ID=40651774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521135A Expired - Fee Related JP5396474B2 (ja) | 2008-07-31 | 2009-04-27 | 副腎皮質刺激ホルモン放出因子受容体活性のピラジノンモジュレーター |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7932256B2 (https=) |
| EP (1) | EP2303867B1 (https=) |
| JP (1) | JP5396474B2 (https=) |
| KR (1) | KR20110040870A (https=) |
| CN (1) | CN102171205B (https=) |
| AR (1) | AR072639A1 (https=) |
| AU (1) | AU2009277057A1 (https=) |
| MX (1) | MX2011000754A (https=) |
| TW (1) | TW201008926A (https=) |
| WO (1) | WO2010014280A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| US10077443B2 (en) | 2012-11-15 | 2018-09-18 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| CN104955952A (zh) | 2013-01-30 | 2015-09-30 | 弗·哈夫曼-拉罗切有限公司 | Lna寡核苷酸碳水化合物缀合物 |
| WO2015112642A1 (en) | 2014-01-21 | 2015-07-30 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
| CA3121920A1 (en) | 2018-12-07 | 2020-06-11 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia |
| JP7623365B2 (ja) | 2019-09-27 | 2025-01-28 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Ｃｒｆ受容体アンタゴニストおよび使用方法 |
| IT201900021216A1 (it) | 2019-11-14 | 2021-05-14 | Isagro Spa | Processo per la preparazione di derivati piridinici e corrispondenti piridil-formammidine |
| CN112552184B (zh) * | 2020-12-18 | 2022-05-10 | 诚达药业股份有限公司 | 一种含环丙基手性胺盐酸盐的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159980A (en) * | 1996-09-16 | 2000-12-12 | Dupont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
| CN1231473C (zh) * | 2000-02-16 | 2005-12-14 | 神经能质公司 | 取代的芳基吡嗪 |
| RU2003136151A (ru) * | 2001-06-12 | 2005-05-20 | Ньюроджин Корпорейшн (US) | 2, 5-диарилпиразины, 2, 5-диарилпиридины и 2, 5-диарилпиримидины в качестве модуляторов рецептора кортикотропин-рилизинг-фактора 1 (крф1) |
| WO2004046136A1 (en) | 2002-11-21 | 2004-06-03 | Pharmacia & Upjohn Company Llc | Pyrazine compounds as crf modulators |
-
2009
- 2009-04-24 US US12/429,810 patent/US7932256B2/en active Active
- 2009-04-27 EP EP09789614.6A patent/EP2303867B1/en not_active Not-in-force
- 2009-04-27 CN CN2009801386016A patent/CN102171205B/zh not_active Expired - Fee Related
- 2009-04-27 JP JP2011521135A patent/JP5396474B2/ja not_active Expired - Fee Related
- 2009-04-27 AU AU2009277057A patent/AU2009277057A1/en not_active Abandoned
- 2009-04-27 KR KR1020117002253A patent/KR20110040870A/ko not_active Withdrawn
- 2009-04-27 WO PCT/US2009/041793 patent/WO2010014280A1/en not_active Ceased
- 2009-04-27 MX MX2011000754A patent/MX2011000754A/es active IP Right Grant
- 2009-07-22 TW TW098124751A patent/TW201008926A/zh unknown
- 2009-07-30 AR ARP090102928A patent/AR072639A1/es not_active Application Discontinuation
-
2011
- 2011-03-21 US US13/052,458 patent/US8372847B2/en active Active
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