JP2011528334A5 - - Google Patents
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- Publication number
- JP2011528334A5 JP2011528334A5 JP2011517956A JP2011517956A JP2011528334A5 JP 2011528334 A5 JP2011528334 A5 JP 2011528334A5 JP 2011517956 A JP2011517956 A JP 2011517956A JP 2011517956 A JP2011517956 A JP 2011517956A JP 2011528334 A5 JP2011528334 A5 JP 2011528334A5
- Authority
- JP
- Japan
- Prior art keywords
- human beta
- beta defensin
- seq
- composition
- defensin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 7
- 108060002187 Def1 Proteins 0.000 claims 5
- 230000037396 body weight Effects 0.000 claims 4
- 108091005293 human DEFB4A protein Proteins 0.000 claims 3
- 102000028366 human DEFB4A protein Human genes 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 101000233317 DEFB1 Proteins 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 102000012265 beta-defensin family Human genes 0.000 claims 1
- 108050002883 beta-defensin family Proteins 0.000 claims 1
- 102000038635 human DEFB1 protein Human genes 0.000 claims 1
- 108091003827 human DEFB103A protein Proteins 0.000 claims 1
- 102000037916 human DEFB103A protein Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (7)
- 関節リウマチの治療のための医薬組成物であって、ヒト・ベータ・ディフェンシンを含む前記組成物。
- 非経口で、好ましくは皮下又は静脈内投与される、請求項１に記載の組成物。
- 前記ヒト・ベータ・ディフェンシンが、１日当たり０．１ｍｇ／ｋｇ体重〜１日当たり１００ｍｇ／ｋｇ体重、好ましくは１日当たり０．１ｍｇ／ｋｇ体重〜１日当たり１０ｍｇ／ｋｇ体重の用量で投与される、請求項１又は２に記載の組成物。
- 前記ヒト・ベータ・ディフェンシンが、配列番号１、配列番号２、配列番号３、又は配列番号４のアミノ酸配列と少なくとも８０％の同一性を有する、請求項１〜３のいずれか一項に記載の組成物。
- 前記ヒト・ベータ・ディフェンシンが、ヒト・ベータ・ディフェンシン１、ヒト・ベータ・ディフェンシン２、ヒト・ベータ・ディフェンシン３、又はヒト・ベータ・ディフェンシン４である、請求項１〜４のいずれか一項に記載の組成物。
- 前記ヒト・ベータ・ディフェンシンが、配列番号２のアミノ酸配列と少なくとも８０％の同一性を有する、請求項１〜５のいずれか一項に記載の組成物。
- 前記ヒト・ベータ・ディフェンシンが、ヒト・ベータ・ディフェンシン２（配列番号２）である、請求項１〜６のいずれか一項に記載の組成物。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08160761.6 | 2008-07-18 | ||
| EP08160761 | 2008-07-18 | ||
| EP09160448 | 2009-05-15 | ||
| EP09160448.8 | 2009-05-15 | ||
| PCT/EP2009/059255 WO2010007168A2 (en) | 2008-07-18 | 2009-07-17 | Treatment of rheumatoid arthritis with mammal beta defensins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528334A JP2011528334A (ja) | 2011-11-17 |
| JP2011528334A5 true JP2011528334A5 (ja) | 2012-04-12 |
Family
ID=41530821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517956A Pending JP2011528334A (ja) | 2008-07-18 | 2009-07-17 | 哺乳動物のベータ・ディフェンシンを用いた、関節リウマチの治療 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8232248B2 (ja) |
| EP (1) | EP2320928B1 (ja) |
| JP (1) | JP2011528334A (ja) |
| KR (1) | KR20110031970A (ja) |
| CN (1) | CN102159234A (ja) |
| AP (1) | AP2011005536A0 (ja) |
| AR (1) | AR072525A1 (ja) |
| AU (1) | AU2009272683A1 (ja) |
| BR (1) | BRPI0915778A2 (ja) |
| CA (1) | CA2730666A1 (ja) |
| EA (1) | EA201170220A1 (ja) |
| IL (1) | IL210716A0 (ja) |
| MX (1) | MX2011000567A (ja) |
| NZ (1) | NZ590469A (ja) |
| TW (1) | TW201004639A (ja) |
| WO (1) | WO2010007168A2 (ja) |
| ZA (1) | ZA201100460B (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110092325A (ko) | 2008-07-18 | 2011-08-17 | 노보자임스 아데니움 바이오테크 에이/에스 | 포유류 베타 방어소를 이용한 염증성 장질환의 치료 |
| US20100016232A1 (en) * | 2008-07-18 | 2010-01-21 | Novozymes A/S | Treatment Of Inflammatory Diseases With Mammal Beta Defensins |
| KR101249702B1 (ko) * | 2010-06-16 | 2013-04-05 | 주식회사 나이벡 | 항균 또는 항염증 활성을 가지는 펩타이드 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| CN107362171A (zh) | 2011-04-15 | 2017-11-21 | 海洋聚合物技术公司 | 用聚‑n‑乙酰基葡糖胺纳米纤维治疗疾病 |
| JP6219277B2 (ja) | 2011-07-08 | 2017-10-25 | ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ | 炎症性腸疾患の経口治療 |
| WO2013026794A1 (en) | 2011-08-19 | 2013-02-28 | Novozymes | Novel immunomodulatory peptide |
| KR102631542B1 (ko) * | 2018-03-14 | 2024-02-01 | 서울대학교산학협력단 | 염증 감소능 및 줄기세포로부터 연골세포로의 분화 촉진능을 가지는 이중 기능성 펩타이드 및 이의 용도 |
| KR102244161B1 (ko) * | 2018-08-31 | 2021-04-26 | 주식회사 나이벡 | 다중의 질환 바이오마커의 기능 및 발현을 억제하는 펩타이드의 신규한 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| US20060115480A1 (en) * | 2002-12-19 | 2006-06-01 | Yitzchak Hillman | Disease treatment via antimicrobial peptide inhibitors |
| GB0514482D0 (en) * | 2005-07-14 | 2005-08-17 | Ares Trading Sa | Protein |
| WO2007081486A2 (en) | 2005-12-15 | 2007-07-19 | Ventria Bioscience | Oral administration of defensins to treat intestinal diseases |
| CA2676483A1 (en) | 2006-01-24 | 2007-08-02 | University Of Maryland Biotechnology Institute | Surface-layer protein coated microspheres and uses thereof |
| AU2008297551A1 (en) | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a defensin peptide as a therapeutic agent |
| KR20110092325A (ko) | 2008-07-18 | 2011-08-17 | 노보자임스 아데니움 바이오테크 에이/에스 | 포유류 베타 방어소를 이용한 염증성 장질환의 치료 |
| US20100016232A1 (en) * | 2008-07-18 | 2010-01-21 | Novozymes A/S | Treatment Of Inflammatory Diseases With Mammal Beta Defensins |
-
2009
- 2009-07-17 WO PCT/EP2009/059255 patent/WO2010007168A2/en active Application Filing
- 2009-07-17 AP AP2011005536A patent/AP2011005536A0/xx unknown
- 2009-07-17 BR BRPI0915778A patent/BRPI0915778A2/pt not_active IP Right Cessation
- 2009-07-17 EA EA201170220A patent/EA201170220A1/ru unknown
- 2009-07-17 AU AU2009272683A patent/AU2009272683A1/en not_active Abandoned
- 2009-07-17 CA CA2730666A patent/CA2730666A1/en not_active Abandoned
- 2009-07-17 MX MX2011000567A patent/MX2011000567A/es not_active Application Discontinuation
- 2009-07-17 NZ NZ590469A patent/NZ590469A/xx not_active IP Right Cessation
- 2009-07-17 AR ARP090102742A patent/AR072525A1/es not_active Application Discontinuation
- 2009-07-17 CN CN200980136396XA patent/CN102159234A/zh active Pending
- 2009-07-17 KR KR1020117002949A patent/KR20110031970A/ko not_active Application Discontinuation
- 2009-07-17 EP EP09780793A patent/EP2320928B1/en active Active
- 2009-07-17 US US12/504,920 patent/US8232248B2/en not_active Expired - Fee Related
- 2009-07-17 JP JP2011517956A patent/JP2011528334A/ja active Pending
- 2009-07-20 TW TW098124400A patent/TW201004639A/zh unknown
-
2011
- 2011-01-18 ZA ZA2011/00460A patent/ZA201100460B/en unknown
- 2011-01-18 IL IL210716A patent/IL210716A0/en unknown
-
2012
- 2012-07-09 US US13/544,237 patent/US20120309686A1/en not_active Abandoned
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