JP2011527667A5 - - Google Patents

Download PDF

Info

Publication number
JP2011527667A5
JP2011527667A5 JP2011513994A JP2011513994A JP2011527667A5 JP 2011527667 A5 JP2011527667 A5 JP 2011527667A5 JP 2011513994 A JP2011513994 A JP 2011513994A JP 2011513994 A JP2011513994 A JP 2011513994A JP 2011527667 A5 JP2011527667 A5 JP 2011527667A5
Authority
JP
Japan
Prior art keywords
methyl
tetrahydro
methoxy
pyrimido
ylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2011513994A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011527667A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2009/057144 external-priority patent/WO2009153197A1/en
Publication of JP2011527667A publication Critical patent/JP2011527667A/ja
Publication of JP2011527667A5 publication Critical patent/JP2011527667A5/ja
Abandoned legal-status Critical Current

Links

JP2011513994A 2008-06-18 2009-06-10 ハロ置換ピリミドジアゼピン Abandoned JP2011527667A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7338808P 2008-06-18 2008-06-18
US61/073,388 2008-06-18
PCT/EP2009/057144 WO2009153197A1 (en) 2008-06-18 2009-06-10 Halo-substituted pyrimidodiazepines as plkl inhibitors

Publications (2)

Publication Number Publication Date
JP2011527667A JP2011527667A (ja) 2011-11-04
JP2011527667A5 true JP2011527667A5 (https=) 2012-08-02

Family

ID=41431858

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011513994A Abandoned JP2011527667A (ja) 2008-06-18 2009-06-10 ハロ置換ピリミドジアゼピン

Country Status (4)

Country Link
US (1) US8003785B2 (https=)
EP (1) EP2303889A1 (https=)
JP (1) JP2011527667A (https=)
WO (1) WO2009153197A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2205241B1 (en) 2007-09-25 2014-05-21 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
US8993808B2 (en) 2009-01-21 2015-03-31 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
CN102548994A (zh) * 2009-09-25 2012-07-04 沃泰克斯药物股份有限公司 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法
CN103492391A (zh) 2009-09-25 2014-01-01 沃泰克斯药物股份有限公司 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法
US8859555B2 (en) 2009-09-25 2014-10-14 Oryzon Genomics S.A. Lysine Specific Demethylase-1 inhibitors and their use
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
JP5504898B2 (ja) * 2010-01-08 2014-05-28 セントラル硝子株式会社 ジフルオロシクロプロパン化合物の製造方法
WO2011106574A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
WO2011106106A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
CA2796726C (en) 2010-04-19 2021-02-16 Oryzon Genomics S.A. Lysine specific demethylase-1 inhibitors and their use
BR112013002164B1 (pt) 2010-07-29 2021-11-09 Oryzon Genomics S.A. Inibidores de desmetilase à base de arilciclopropilamina de lsd1, seus usos, e composição farmacêutica
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
JP6046154B2 (ja) 2011-10-20 2016-12-14 オリソン ヘノミクス エセ. アー. Lsd1阻害剤としての(ヘテロ)アリールシクロプロピルアミン化合物
EP2768805B1 (en) 2011-10-20 2020-03-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
AR091023A1 (es) 2012-05-11 2014-12-30 Abbvie Inc Inhibidores del nampt
US9975896B2 (en) 2013-07-25 2018-05-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
US10793571B2 (en) 2014-01-31 2020-10-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
EP3099677A4 (en) 2014-01-31 2017-07-26 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
CN106715437A (zh) 2014-08-08 2017-05-24 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
CN105646398B (zh) * 2014-12-05 2018-09-07 上海医药工业研究院 N-((1r,4r)-4-(4-(环丙基甲基)哌嗪-1-基)环己基)乙酰胺的制备方法
WO2016201370A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
RU2018112953A (ru) 2015-09-11 2019-10-14 Дана-Фарбер Кэнсер Инститьют, Инк. Ацетамидтиенотриазолодиазепины и пути их применения
EP3347021A4 (en) 2015-09-11 2019-07-24 Dana-Farber Cancer Institute, Inc. CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF
MX2018006499A (es) 2015-11-25 2018-08-01 Dana Farber Cancer Inst Inc Inhibidores de bromodominio bivalentes y usos de los mismos.
KR20210122163A (ko) * 2020-03-27 2021-10-08 (주) 업테라 Plk1의 선택적 분해를 유도하는 피라졸로퀴나졸린 유도체 화합물
WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체
PE20240894A1 (es) * 2021-08-10 2024-04-24 Uppthera Inc Compuesto inductor de la degradacion de plk1 novedoso
GB202313514D0 (en) 2023-09-05 2023-10-18 Cambridge Entpr Ltd Treatment of inflammatory diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02002938A (es) 1999-09-17 2004-12-06 Abbott Gmbh & Co Kg Inhibidores de cinasa como agentes agentes terapeuticos.
US6806272B2 (en) * 2001-09-04 2004-10-19 Boehringer Ingelheim Pharma Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
UA76512C2 (en) 2001-09-04 2006-08-15 Boehringer Ingelheim Pharma Dihydropteridinones, a method for producing thereof and use thereof as medicament
US7622463B2 (en) 2006-02-14 2009-11-24 Vertex Pharmaceuticals Incorporated Dihydrodiazepines useful as inhibitors of protein kinases
TW200808325A (en) 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds
AU2008228303B2 (en) * 2007-03-22 2012-04-19 Takeda Pharmaceutical Company Limited Substituted pyrimidodiazepines useful as PLK1 inhibitors
EP2205241B1 (en) * 2007-09-25 2014-05-21 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors

Similar Documents

Publication Publication Date Title
JP2011527667A5 (https=)
JP2010521514A5 (https=)
JP2013537203A5 (https=)
JP2019104748A5 (https=)
JP2008530099A5 (https=)
JP2013519684A5 (https=)
JP2010155827A5 (https=)
RU2009142434A (ru) Производные триазолопиридин-карбоксамидов и триазолопиримидин-карбоксамидов, их получение и их применение в терапии
JP2017504635A5 (https=)
RU2009142431A (ru) Производные триазолопиридинкарбоксамидов и триазолопиримидинкарбоксамидов, их получение и их применение в терапии
JP2012508252A5 (https=)
JP2011513305A5 (https=)
JP2013542218A5 (https=)
JP2012502067A5 (https=)
JP2021522262A5 (https=)
JP2012504608A5 (https=)
JP2009516727A5 (https=)
WO2009156861A8 (en) Substituted pyrimidone derivatives
WO2010089510A3 (fr) Dérivés d'azaspiranyl-alkylcarbamates d'hétérocycles à 5 chaînons, leur préparation et leur application en thérapeutique
JP2010504344A5 (https=)
JP2012516355A5 (https=)
JP2013540712A5 (https=)
JP2011517443A5 (https=)
JP2012502111A5 (https=)
JP2013515037A5 (https=)