JP2011526185A - 減圧治療及び軟骨細胞を用いた軟骨形成の刺激 - Google Patents
減圧治療及び軟骨細胞を用いた軟骨形成の刺激 Download PDFInfo
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Abstract
【選択図】図3
Description
本出願は、2008年6月26日に出願されここに引用されている米国仮出願番号61/076,028の利益を主張する。
無傷の頭蓋骨の膜面への減圧治療の適用に応じて軟骨形成が観察された。これらの観察結果は、治療に応じた軟骨形成がユニークで再生医療の分野で非常に関心が高いという点で重要である。これらの形成は、足場材料がなく、減圧の適用のみで観察された。減圧を適用しなかった対照には軟骨形成が観察されなかった。
Claims (57)
- 哺乳類の組織部位における軟骨形成の刺激方法であって、前記方法が:
前記組織部位に軟骨細胞又は軟骨細胞の前駆体を適用するステップと;
前記組織部位に新たな軟骨形成を引き起こすのに十分な時間、前記組織部位に減圧を適用するステップと;
を具えることを特徴とする方法。 - 前記軟骨細胞又は軟骨細胞の前駆体が、前記組織部位に適用される生体適合性の足場にあることを特徴とする請求項1に記載の方法。
- 前記組織部位が、軟骨欠損を有することを特徴とする請求項1に記載の方法。
- 前記欠損が、先天性又は関節炎、ガン又は負傷によるものであることを特徴とする請求項3に記載の方法。
- 前記減圧が、減圧源に結合されたマニホルドを介して前記組織部位に適用されることを特徴とする請求項1に記載の方法。
- 前記マニホルドが、前記組織部位に適用される生体適合性の足場であることを特徴とする請求項5に記載の方法。
- 前記軟骨細胞又は軟骨細胞の前駆体が、軟骨細胞であることを特徴とする請求項1に記載の方法。
- 前記軟骨細胞又は軟骨細胞の前駆体が、間葉幹細胞であることを特徴とする請求項1に記載の方法。
- 前記生体適合性の足場が、生体吸収性であることを特徴とする請求項2に記載の方法。
- 前記生体適合性の足場が、ポリヒドロキシ酸、ポリ(カプロラクトン)、ポリカーボネート、ポリアミド、ポリ無水物、ポリアミノ酸、ポリオルトエステル、ポリアセタール、分解性ポリシアノアクリレート又は分解性ポリウレタンを含むことを特徴とする請求項2に記載の方法。
- 前記生体適合性の足場が、ポリラクチド−co−グリコリド(PLAGA)ポリマ、またはポリエチレングリコール−PLAGAコポリマであることを特徴とする請求項10に記載の方法。
- さらに、前記組織部位にサイトカインを適用するステップを具えることを特徴とする請求項1に記載の方法。
- 前記サイトカインが、生体適合性足場の中にあることを特徴とする請求項12に記載の請求項12に記載の方法。
- 前記サイトカインが、骨形成タンパク質(BMP)−2、BMP−6、BMP−7、トランスホーミング増殖因子−β(TGF−β)、インスリン様増殖因子(IGF)、血小板由来増殖因子(PDGF)、又は軟骨由来レチノイン酸感受性タンパク質(CD−RAP)であることを特徴とする請求項12に記載の方法。
- 細胞が前記足場の上に播種され、
前記足場が移植の前にインキュベートされることを特徴とする請求項2に記載の方法。 - 前記組織部位に抗生物質を適用することを特徴とする請求項1に記載の方法。
- 前記抗生物質が、前記組織部位に適用される生体適合性の足場に適用されることを特徴とする請求項16に記載の方法。
- 前記哺乳類がヒトであることを特徴とする請求項1に記載の方法。
- 新たな軟骨が、レシピエント組織部位に移植されることを特徴とする請求項1に記載の方法。
- 足場が、軟骨細胞又は軟骨細胞の前駆体を含んでおり、
前記足場が、それを通して減圧を伝えるよう十分に多孔質であることを特徴とする生体適合性の足場。 - 前記軟骨細胞又は軟骨細胞の前駆体が、軟骨細胞であることを特徴とする請求項20に記載の足場。
- 前記軟骨細胞又は軟骨細胞の前駆体が、間葉幹細胞であることを特徴とする請求項20に記載の足場。
- 前記軟骨細胞又は軟骨細胞の前駆体が、組み換え核酸を含むことを特徴とする請求項20に記載の足場。
- 前記組み換え核酸が、タンパク質をコードすることを特徴とする請求項23に記載の足場。
- 前記組み換え核酸が、miRNA又はアンチセンス分子をコードすることを特徴とする請求項23に記載の足場。
- 前記足場が、生体吸収性であることを特徴とする請求項20に記載の足場。
- ポリヒドロキシ酸、ポリ(カプロラクトン)、ポリカーボネート、ポリアミド、ポリ無水物、ポリアミノ酸、ポリオルトエステル、ポリアセタール、分解性ポリシアノアクリレート又は分解性ポリウレタンを含むことを特徴とする請求項20に記載の足場。
- ポリラクチド−co−グリコリド(PLAGA)ポリマ又はポリエチレングリコール−PLAGAコポリマを含むことを特徴とする請求項20に記載の足場。
- さらに、サイトカインを含むことを特徴とする請求項20に記載の足場。
- 前記サイトカインが、骨形成タンパク質(BMP)−2、BMP−6、BMP−7、トランスホーミング増殖因子−β(TGF−β)、インスリン様増殖因子(IGF)、血小板由来増殖因子(PDGF)、又は軟骨由来レチノイン酸感受性タンパク質(CD−RAP)であることを特徴とする請求項29に記載の足場。
- さらに、抗生物質を含むことを特徴とする請求項20に記載の足場。
- 組織部位において軟骨形成を刺激するためのシステムであって、前記システムが:
軟骨細胞又は軟骨細胞の前駆体と;
減圧源と;
前記組織部位から前記減圧源に減圧を伝え得るマニホルドと;
を具えることを特徴とするシステム。 - 前記マニホルドが、生体適合性の足場であることを特徴とする請求項32に記載のシステム。
- 前記足場が、軟骨細胞又は軟骨細胞の前駆体を具えることを特徴とする請求項33に記載のシステム。
- 前記軟骨細胞又は軟骨細胞の前駆体が、軟骨細胞であることを特徴とする請求項34に記載のシステム。
- 前記軟骨細胞又は軟骨細胞の前駆体が、間葉幹細胞であることを特徴とする請求項34に記載のシステム。
- 前記軟骨細胞又は軟骨細胞の前駆体が、組み換え核酸を含むことを特徴とする請求項34に記載のシステム。
- 前記生体適合性の足場が、生体吸収性であることを特徴とする請求項33に記載のシステム。
- 前記足場が、ポリヒドロキシ酸、ポリ(カプロラクトン)、ポリカーボネート、ポリアミド、ポリ無水物、ポリアミノ酸、ポリオルトエステル、ポリアセタール、分解性ポリシアノアクリレート又は分解性ポリウレタンを含むことを特徴とする請求項33に記載のシステム。
- 前記足場が、ポリラクチド−co−グリコリド(PLAGA)ポリマ又はポリエチレングリコール−PLAGAコポリマを含むことを特徴とする請求項39に記載のシステム。
- さらに、サイトカインを含むことを特徴とする請求項32に記載のシステム。
- 前記サイトカインが、骨形成タンパク質(BMP)−2、BMP−6、BMP−7、トランスホーミング増殖因子−β(TGF−β)、インスリン様増殖因子(IGF)、血小板由来増殖因子(PDGF)、又は軟骨由来レチノイン酸感受性タンパク質(CD−RAP)であることを特徴とする請求項41に記載のシステム。
- さらに、抗生物質を含むことを特徴とする請求項32に記載のシステム。
- 哺乳類の組織部位において軟骨形成を刺激するための請求項32に記載のシステムの使用。
- 組織部位において軟骨形成を刺激するためのシステムであって、前記システムが:
前記組織部位に減圧を適用するための減圧源と;
前記組織部位に隣接して配置され、軟骨細胞又は軟骨細胞の前駆体を有する足場と;
前記減圧に流体接続するよう前記足場に隣接して配置され、前記組織部位に前記減圧を供給するマニホルドと;
前記組織部位の中の前記マニホルド及び前記足場を覆って実質的にシールするよう構成され、適用されたときに前記組織部位における前記減圧を保持するドレープと;
を具えており、
これによって、前記軟骨細胞又は軟骨細胞の前駆体及び減圧が、前記組織部位における新たな軟骨の形成を刺激することを特徴とするシステム。 - 前記足場が、生体適合性であることを特徴とする請求項45に記載のシステム。
- 前記足場が、軟骨細胞又は軟骨細胞の前駆体であることを特徴とする請求項46に記載のシステム。
- 前記軟骨細胞又は軟骨細胞の前駆体が、軟骨細胞であることを特徴とする請求項47に記載のシステム。
- 前記軟骨細胞又は軟骨細胞の前駆体が、軟骨細胞であることを特徴とする請求項47に記載のシステム。
- 前記軟骨細胞又は軟骨細胞の前駆体が、組み換え核酸を含むことを特徴とする請求項47に記載のシステム。
- 前記生体適合性の足場が、生体吸収性であることを特徴とする請求項46に記載のシステム。
- 前記足場が、ポリヒドロキシ酸、ポリカプロラクトン、ポリカーボネート、ポリアミド、ポリ無水物、ポリアミノ酸、ポリオルトエステル、ポリアセタール、分解性ポリシアノアクリレート又は分解性ポリウレタンを含むことを特徴とする請求項46に記載のシステム。
- 前記足場が、ポリラクチド−co−グリコリド(PLAGA)ポリマ又はポリエチレングリコール−PLAGAコポリマを含むことを特徴とする請求項52に記載のシステム。
- さらに、サイトカインを含むことを特徴とする請求項55に記載のシステム。
- 前記サイトカインが、骨形成タンパク質(BMP)−2、BMP−6、BMP−7、トランスホーミング増殖因子−β(TGF−β)、インスリン様増殖因子(IGF)、血小板由来増殖因子(PDGF)、又は軟骨由来レチノイン酸感受性タンパク質(CD−RAP)であることを特徴とする請求項54に記載のシステム。
- さらに、抗生物質を含むことを特徴とする請求項55に記載のシステム。
- 哺乳類の組織部位における軟骨形成を刺激するための請求項55に記載のシステムの使用。
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- 2009-06-25 KR KR1020117001803A patent/KR20110022706A/ko not_active Application Discontinuation
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- 2009-06-25 CN CN201310464870.XA patent/CN103655040A/zh active Pending
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- 2009-06-25 EP EP09771012.3A patent/EP2288396B1/en active Active
- 2009-06-25 MX MX2010014304A patent/MX2010014304A/es not_active Application Discontinuation
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Also Published As
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MX2010014304A (es) | 2011-02-15 |
KR20110022706A (ko) | 2011-03-07 |
US8197806B2 (en) | 2012-06-12 |
AU2009262163A1 (en) | 2009-12-30 |
CA2726283C (en) | 2017-10-03 |
CN102065929A (zh) | 2011-05-18 |
CN102065929B (zh) | 2013-11-06 |
EP2288396B1 (en) | 2016-06-15 |
CN103655040A (zh) | 2014-03-26 |
RU2011101665A (ru) | 2012-08-10 |
AU2009262163B2 (en) | 2015-07-09 |
US20110218504A1 (en) | 2011-09-08 |
JP5538380B2 (ja) | 2014-07-02 |
WO2009158480A3 (en) | 2010-06-17 |
CA2726283A1 (en) | 2009-12-30 |
US20090326423A1 (en) | 2009-12-31 |
EP2288396A2 (en) | 2011-03-02 |
US8246948B2 (en) | 2012-08-21 |
JP2014000424A (ja) | 2014-01-09 |
TW201006447A (en) | 2010-02-16 |
WO2009158480A2 (en) | 2009-12-30 |
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