JP2011525890A - 大環状ラクトン化合物およびそれらの使用方法 - Google Patents

大環状ラクトン化合物およびそれらの使用方法 Download PDF

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Publication number
JP2011525890A
JP2011525890A JP2010550655A JP2010550655A JP2011525890A JP 2011525890 A JP2011525890 A JP 2011525890A JP 2010550655 A JP2010550655 A JP 2010550655A JP 2010550655 A JP2010550655 A JP 2010550655A JP 2011525890 A JP2011525890 A JP 2011525890A
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compound
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poly
independently
administration
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Pending
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JP2010550655A
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English (en)
Japanese (ja)
Inventor
ジョン・ヤン
チェン・シャオシア
ビナヤク・ディ・バット
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Elixir Medical Corp
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Elixir Medical Corp
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Publication of JP2011525890A publication Critical patent/JP2011525890A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
JP2010550655A 2008-03-11 2008-03-11 大環状ラクトン化合物およびそれらの使用方法 Pending JP2011525890A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/056501 WO2009114010A1 (fr) 2008-03-11 2008-03-11 Composés de lactone macrocycliques et leurs procédés d’utilisation

Publications (1)

Publication Number Publication Date
JP2011525890A true JP2011525890A (ja) 2011-09-29

Family

ID=41065507

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010550655A Pending JP2011525890A (ja) 2008-03-11 2008-03-11 大環状ラクトン化合物およびそれらの使用方法

Country Status (6)

Country Link
EP (1) EP2254412A4 (fr)
JP (1) JP2011525890A (fr)
CN (1) CN102215682A (fr)
BR (1) BRPI0822405A8 (fr)
IL (1) IL208026A0 (fr)
WO (1) WO2009114010A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10695327B2 (en) 2006-09-13 2020-06-30 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US8088789B2 (en) 2006-09-13 2012-01-03 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US10307292B2 (en) 2011-07-18 2019-06-04 Mor Research Applications Ltd Device for adjusting the intraocular pressure
CN103387572B (zh) * 2013-07-17 2015-09-30 成都雅途生物技术有限公司 依维莫司杂质检测用参比标示物及其制备方法
CN107759616B (zh) * 2016-08-23 2020-11-17 上海微创医疗器械（集团）有限公司 一种化合物及其制备方法和用途
US11654036B2 (en) 2020-05-26 2023-05-23 Elixir Medical Corporation Anticoagulant compounds and methods and devices for their use
CN113801104B (zh) * 2020-06-15 2023-12-08 鲁南制药集团股份有限公司 一种依维莫司大环内酯水解杂质的制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012655A1 (fr) * 1992-11-20 1994-06-09 Smithkline Beecham Corporation Procede de production de derives de rapamycine
JPH07509246A (ja) * 1992-07-17 1995-10-12 スミスクライン・ビーチャム・コーポレイション ラパマイシン誘導体
JPH08502266A (ja) * 1992-10-09 1996-03-12 サンド・リミテッド Ｏ−アルキル化ラパマイシン誘導体および、特に免疫抑制剤としてのその使用
WO2006108065A2 (fr) * 2005-04-05 2006-10-12 Elixir Medical Corporation Dispositifs medicaux implantables degradables
WO2007011880A2 (fr) * 2005-07-18 2007-01-25 Minu, L.L.C. Neuro-protection/neuro-stimulation oculaire amelioree
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
JP2010503699A (ja) * 2006-09-13 2010-02-04 エリクサー・メディカル・コーポレイション 大環状ラクトン化合物およびその使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070014760A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07509246A (ja) * 1992-07-17 1995-10-12 スミスクライン・ビーチャム・コーポレイション ラパマイシン誘導体
JPH08502266A (ja) * 1992-10-09 1996-03-12 サンド・リミテッド Ｏ−アルキル化ラパマイシン誘導体および、特に免疫抑制剤としてのその使用
WO1994012655A1 (fr) * 1992-11-20 1994-06-09 Smithkline Beecham Corporation Procede de production de derives de rapamycine
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
WO2006108065A2 (fr) * 2005-04-05 2006-10-12 Elixir Medical Corporation Dispositifs medicaux implantables degradables
WO2007011880A2 (fr) * 2005-07-18 2007-01-25 Minu, L.L.C. Neuro-protection/neuro-stimulation oculaire amelioree
JP2010503699A (ja) * 2006-09-13 2010-02-04 エリクサー・メディカル・コーポレイション 大環状ラクトン化合物およびその使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN5012005125; ＶＩＧＮＯＴ，Ｓ．，ＥＴ　ＡＬ．: '"ｍＴＯＲ-ｔａｒｇｅｔｅｄ　ｔｈｅｒａｐｙ　ｏｆ　ｃａｎｃｅｒ　ｗｉｔｈ　ｒａｐａｍｙｃｉｎ　ｄｅｒｉｖａｔｉｖｅｓ"' ＡＮＮＡＬＳ　ＯＦ　ＯＮＣＯＬＯＧＹ ＶＯＬ．１６，ＮＯ．４, 2005, ＰＰ．５２５-５３７ *

Also Published As

Publication number Publication date
EP2254412A4 (fr) 2012-05-09
IL208026A0 (en) 2010-12-30
EP2254412A1 (fr) 2010-12-01
BRPI0822405A2 (pt) 2018-05-15
BRPI0822405A8 (pt) 2018-06-05
CN102215682A (zh) 2011-10-12
WO2009114010A1 (fr) 2009-09-17

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