CN102215682A - 大环内酯化合物及它们的使用方法 - Google Patents

大环内酯化合物及它们的使用方法 Download PDF

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Publication number
CN102215682A
CN102215682A CN200880128027.1A CN200880128027A CN102215682A CN 102215682 A CN102215682 A CN 102215682A CN 200880128027 A CN200880128027 A CN 200880128027A CN 102215682 A CN102215682 A CN 102215682A
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CN
China
Prior art keywords
compound
described compound
independently
poly
group
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Pending
Application number
CN200880128027.1A
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English (en)
Chinese (zh)
Inventor
J·严
郑小霞
V·D·巴塔
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Elixir Medical Corp
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Elixir Medical Corp
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Publication date
Application filed by Elixir Medical Corp filed Critical Elixir Medical Corp
Priority to CN201510330210.1A priority Critical patent/CN105380947A/zh
Publication of CN102215682A publication Critical patent/CN102215682A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
CN200880128027.1A 2008-03-11 2008-03-11 大环内酯化合物及它们的使用方法 Pending CN102215682A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510330210.1A CN105380947A (zh) 2008-03-11 2008-03-11 大环内酯化合物及它们的使用方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/056501 WO2009114010A1 (fr) 2008-03-11 2008-03-11 Composés de lactone macrocycliques et leurs procédés d’utilisation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510330210.1A Division CN105380947A (zh) 2008-03-11 2008-03-11 大环内酯化合物及它们的使用方法

Publications (1)

Publication Number Publication Date
CN102215682A true CN102215682A (zh) 2011-10-12

Family

ID=41065507

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880128027.1A Pending CN102215682A (zh) 2008-03-11 2008-03-11 大环内酯化合物及它们的使用方法

Country Status (6)

Country Link
EP (1) EP2254412A4 (fr)
JP (1) JP2011525890A (fr)
CN (1) CN102215682A (fr)
BR (1) BRPI0822405A8 (fr)
IL (1) IL208026A0 (fr)
WO (1) WO2009114010A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103387572A (zh) * 2013-07-17 2013-11-13 成都雅途生物技术有限公司 依维莫司杂质检测用参比标示物及其制备方法
CN107759616A (zh) * 2016-08-23 2018-03-06 上海微创医疗器械（集团）有限公司 一种化合物及其制备方法和用途
CN113801104A (zh) * 2020-06-15 2021-12-17 鲁南制药集团股份有限公司 一种依维莫大环内酯水解杂质的制备方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10695327B2 (en) 2006-09-13 2020-06-30 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US8088789B2 (en) 2006-09-13 2012-01-03 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US10307292B2 (en) 2011-07-18 2019-06-04 Mor Research Applications Ltd Device for adjusting the intraocular pressure
US11654036B2 (en) 2020-05-26 2023-05-23 Elixir Medical Corporation Anticoagulant compounds and methods and devices for their use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012655A1 (fr) * 1992-11-20 1994-06-09 Smithkline Beecham Corporation Procede de production de derives de rapamycine
CN1087913A (zh) * 1992-07-17 1994-06-15 史密丝克莱恩比彻姆公司 雷帕霉素衍生物
US20070015697A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced ocular neuroprotection and neurostimulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
JP5312018B2 (ja) * 2005-04-05 2013-10-09 エリクシアー メディカル コーポレイション 分解性の移植可能な医療装置
AU2006270041B2 (en) * 2005-07-18 2011-08-18 Minu, Llc Enhanced ocular neuroprotection/neurostimulation
US7867988B2 (en) * 2006-09-13 2011-01-11 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1087913A (zh) * 1992-07-17 1994-06-15 史密丝克莱恩比彻姆公司 雷帕霉素衍生物
WO1994012655A1 (fr) * 1992-11-20 1994-06-09 Smithkline Beecham Corporation Procede de production de derives de rapamycine
US20070015697A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced ocular neuroprotection and neurostimulation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103387572A (zh) * 2013-07-17 2013-11-13 成都雅途生物技术有限公司 依维莫司杂质检测用参比标示物及其制备方法
CN103387572B (zh) * 2013-07-17 2015-09-30 成都雅途生物技术有限公司 依维莫司杂质检测用参比标示物及其制备方法
CN107759616A (zh) * 2016-08-23 2018-03-06 上海微创医疗器械（集团）有限公司 一种化合物及其制备方法和用途
CN107759616B (zh) * 2016-08-23 2020-11-17 上海微创医疗器械（集团）有限公司 一种化合物及其制备方法和用途
CN113801104A (zh) * 2020-06-15 2021-12-17 鲁南制药集团股份有限公司 一种依维莫大环内酯水解杂质的制备方法
CN113801104B (zh) * 2020-06-15 2023-12-08 鲁南制药集团股份有限公司 一种依维莫司大环内酯水解杂质的制备方法

Also Published As

Publication number Publication date
EP2254412A4 (fr) 2012-05-09
JP2011525890A (ja) 2011-09-29
IL208026A0 (en) 2010-12-30
EP2254412A1 (fr) 2010-12-01
BRPI0822405A2 (pt) 2018-05-15
BRPI0822405A8 (pt) 2018-06-05
WO2009114010A1 (fr) 2009-09-17

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Application publication date: 20111012