JP2011525477A5 - - Google Patents
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- Publication number
- JP2011525477A5 JP2011525477A5 JP2010549861A JP2010549861A JP2011525477A5 JP 2011525477 A5 JP2011525477 A5 JP 2011525477A5 JP 2010549861 A JP2010549861 A JP 2010549861A JP 2010549861 A JP2010549861 A JP 2010549861A JP 2011525477 A5 JP2011525477 A5 JP 2011525477A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine composition
- particles
- aspect ratio
- antigen
- immunostimulatory agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 claims 22
- 229960005486 vaccine Drugs 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 230000003308 immunostimulating effect Effects 0.000 claims 8
- 230000005847 immunogenicity Effects 0.000 claims 4
- 230000002596 correlated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6822708P | 2008-03-04 | 2008-03-04 | |
| US61/068,227 | 2008-03-04 | ||
| PCT/US2009/036068 WO2009111588A1 (en) | 2008-03-04 | 2009-03-04 | Immunomodulator particles and methods of treating |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014238952A Division JP2015078204A (ja) | 2008-03-04 | 2014-11-26 | 免疫調節剤粒子および処置方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525477A JP2011525477A (ja) | 2011-09-22 |
| JP2011525477A5 true JP2011525477A5 (cg-RX-API-DMAC7.html) | 2012-04-26 |
Family
ID=41056361
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010549861A Pending JP2011525477A (ja) | 2008-03-04 | 2009-03-04 | 免疫調節剤粒子および処置方法 |
| JP2014238952A Pending JP2015078204A (ja) | 2008-03-04 | 2014-11-26 | 免疫調節剤粒子および処置方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014238952A Pending JP2015078204A (ja) | 2008-03-04 | 2014-11-26 | 免疫調節剤粒子および処置方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110151015A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2262480B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2011525477A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102014874A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009111588A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027571A2 (en) * | 2006-08-30 | 2008-03-06 | Liquidia Technologies, Inc. | Nanoparticles having functional additives for self and directed assembly and methods of fabricating same |
| US20100190654A1 (en) * | 2006-12-05 | 2010-07-29 | Liquidia Technologies , Inc. | Nanoarrays and methods and materials for fabricating same |
| EP3269384A1 (en) | 2007-03-07 | 2018-01-17 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of autoimmune conditions |
| AU2010254549B2 (en) | 2009-05-27 | 2016-10-20 | Selecta Biosciences, Inc. | Nanocarriers possessing components with different rates of release |
| US20130209564A1 (en) * | 2010-02-22 | 2013-08-15 | Shyam M. Rele | Polysaccharide Particle Vaccines |
| CN105194665A (zh) | 2010-05-26 | 2015-12-30 | 西莱克塔生物科技公司 | 具有不偶合的佐剂的纳米载体组合物 |
| WO2012037358A1 (en) | 2010-09-16 | 2012-03-22 | The University Of North Carolina At Chapel Hill | Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| CN118078979A (zh) | 2011-04-29 | 2024-05-28 | 西莱克塔生物科技公司 | 用于降低针对治疗性蛋白的免疫应答的致耐受性合成纳米载体 |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| WO2013082111A2 (en) | 2011-11-29 | 2013-06-06 | The University Of North Carolina At Chapel Hill | Geometrically engineered particles and methods for modulating macrophage or immune responses |
| US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
| US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
| WO2014165728A1 (en) * | 2013-04-05 | 2014-10-09 | The University Of North Carolina At Chapel Hill | Particles having peg-ylated surfaces modified for lymphatic trafficking |
| AU2014343379B2 (en) | 2013-11-04 | 2019-02-14 | Uti Limited Partnership | Methods and compositions for sustained immunotherapy |
| AU2016275312B2 (en) | 2015-05-06 | 2021-12-23 | Uti Limited Partnership | Nanoparticle compositions for sustained therapy |
| EP3426290A1 (en) | 2016-03-07 | 2019-01-16 | GlaxoSmithKline Biologicals SA | Drug delivery particles |
| JP2019519489A (ja) | 2016-05-05 | 2019-07-11 | リクイディア・テクノロジーズ・インコーポレーテッド | 肺高血圧症を治療するための乾燥粉末トレプロスチニル |
| EP3716949A4 (en) | 2017-11-29 | 2022-05-18 | UTI Limited Partnership | Methods of treating autoimmune disease |
| EP4135769A4 (en) * | 2020-04-16 | 2024-09-04 | Emory University | Immune cell redirecting compositions and therapeutic uses thereof |
| CN116407624B (zh) * | 2023-04-14 | 2024-04-09 | 吉林省农业科学院(中国农业科技东北创新中心) | 一种鸡传染性支气管炎细菌样颗粒疫苗的制备方法和应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090406A (en) | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
| US5709879A (en) | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| GB9227068D0 (en) * | 1992-12-29 | 1993-02-24 | British Bio Technology | Novel proteinaceous particles |
| FR2723849B1 (fr) | 1994-08-31 | 1997-04-11 | Biovector Therapeutics Sa | Procede pour augmenter l'immunogenicite, produit obtenu et composition pharmaceutique |
| US5686113A (en) | 1995-03-21 | 1997-11-11 | Temple University Of The Commonwealth System Of Higher Education | Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses |
| JP4918188B2 (ja) * | 1997-12-16 | 2012-04-18 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
| US6086881A (en) | 1998-05-15 | 2000-07-11 | Children's Medical Center Corp. | Spatially aligned conjugated composition having a thioether bond linkage |
| JP2002529064A (ja) * | 1998-11-11 | 2002-09-10 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ | 多糖類シンターゼによるポリマーグラフティング |
| US6326021B1 (en) | 1999-06-18 | 2001-12-04 | The Ohio State University Research Foundation | Biocompatible polymeric delivery systems having functional groups attached to the surface thereof |
| EP1246597B1 (en) * | 1999-08-03 | 2015-01-14 | The Ohio State University | Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein |
| US20020061312A1 (en) * | 2000-07-31 | 2002-05-23 | Ruslan Medzhitov | Innate immune system-directed vaccines |
| US20030232055A1 (en) * | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
| US20030175287A1 (en) * | 2001-01-03 | 2003-09-18 | Yale University | Innate immune system-directed vaccines |
| CA2446458A1 (en) * | 2001-05-09 | 2002-11-14 | Yale University | Toll/interleukin-1 receptor adaptor protein (tirap) |
| AU2003235685A1 (en) | 2002-01-09 | 2003-07-30 | Ruslan M. Medzhitov | Rip2: a method of signaling in the innate and adaptive immune systems |
| EP1573030A2 (en) | 2002-01-09 | 2005-09-14 | Yale University | Irak-m is a negative regulator of toll-like receptor signaling |
| US20060051373A1 (en) * | 2002-04-05 | 2006-03-09 | Olson William C | Particle-bound human immunodeficiency virus envelope glycoproteins and related compositions and methods |
| AU2003225054A1 (en) | 2002-04-19 | 2003-11-03 | Yale University | Toll-like receptor 11 and toll-like receptor 12 |
| US20040009943A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Pathogen vaccines and methods for using the same |
| US7393493B2 (en) * | 2003-02-27 | 2008-07-01 | A Enterprises, Inc. | Crosslinkable polymeric materials and their applications |
| US20050163764A1 (en) | 2003-09-22 | 2005-07-28 | Yale University | Treatment with agonists of toll-like receptors |
| US20050118199A1 (en) * | 2003-10-07 | 2005-06-02 | Esser Mark T. | Process for covalently conjugating polysaccharides to microspheres or biomolecules |
| AU2004289210B2 (en) * | 2003-11-05 | 2010-07-15 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer |
| KR20120105062A (ko) | 2003-12-19 | 2012-09-24 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 소프트 또는 임프린트 리소그래피를 이용하여 분리된 마이크로- 및 나노- 구조를 제작하는 방법 |
| US9040090B2 (en) * | 2003-12-19 | 2015-05-26 | The University Of North Carolina At Chapel Hill | Isolated and fixed micro and nano structures and methods thereof |
| EP1713508A2 (en) * | 2004-01-29 | 2006-10-25 | Biosynexus Incorporated | Use of amino-oxy functional groups in the preparation of vaccine conjugates |
| JP2008532929A (ja) * | 2005-02-01 | 2008-08-21 | メディバス エルエルシー | ワクチン送達組成物および使用法 |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CN102016814B (zh) * | 2005-06-17 | 2013-10-23 | 北卡罗来纳大学查珀尔希尔分校 | 纳米粒子制备方法、系统及材料 |
| WO2007094829A2 (en) | 2005-11-07 | 2007-08-23 | The University Of North Carolina At Chapel Hill | Isolated and fixed micro and nano structures and methods thereof |
| WO2007081876A2 (en) * | 2006-01-04 | 2007-07-19 | Liquidia Technologies, Inc. | Nanostructured surfaces for biomedical/biomaterial applications and processes thereof |
| US20090220789A1 (en) | 2006-01-27 | 2009-09-03 | The University Of North Carolina At Chapel Hill | Taggants and methods and systems for fabricating same |
| EP3006041B1 (en) * | 2006-03-17 | 2017-11-29 | The Government of the United States of America, as represented by The Secretary, Department of Health and Human Services | Methods for preparing complex multivalent immunogenic conjugates |
| US20080181958A1 (en) * | 2006-06-19 | 2008-07-31 | Rothrock Ginger D | Nanoparticle fabrication methods, systems, and materials |
| WO2008027571A2 (en) * | 2006-08-30 | 2008-03-06 | Liquidia Technologies, Inc. | Nanoparticles having functional additives for self and directed assembly and methods of fabricating same |
| NZ575901A (en) * | 2006-09-12 | 2012-04-27 | Alphavax Inc | Alphavirus replicon particles matched to protein antigens as immunological adjuvants |
| WO2008045486A2 (en) | 2006-10-09 | 2008-04-17 | The University Of North Carolina At Chapel Hill | Nanoparticle compositions for controlled delivery of nucleic acids |
| AU2008241470B2 (en) * | 2007-04-16 | 2013-11-07 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
-
2009
- 2009-03-04 JP JP2010549861A patent/JP2011525477A/ja active Pending
- 2009-03-04 EP EP09717401.5A patent/EP2262480B1/en not_active Not-in-force
- 2009-03-04 US US12/920,944 patent/US20110151015A1/en not_active Abandoned
- 2009-03-04 CN CN2009801168810A patent/CN102014874A/zh active Pending
- 2009-03-04 WO PCT/US2009/036068 patent/WO2009111588A1/en not_active Ceased
-
2014
- 2014-11-26 JP JP2014238952A patent/JP2015078204A/ja active Pending
-
2015
- 2015-06-11 US US14/737,180 patent/US20150273079A1/en not_active Abandoned
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