JP2011523549A5 - - Google Patents
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- JP2011523549A5 JP2011523549A5 JP2011508777A JP2011508777A JP2011523549A5 JP 2011523549 A5 JP2011523549 A5 JP 2011523549A5 JP 2011508777 A JP2011508777 A JP 2011508777A JP 2011508777 A JP2011508777 A JP 2011508777A JP 2011523549 A5 JP2011523549 A5 JP 2011523549A5
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- 239000000090 biomarker Substances 0.000 claims description 70
- 230000014509 gene expression Effects 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 38
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 22
- 239000000523 sample Substances 0.000 claims description 22
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 19
- 239000002131 composite material Substances 0.000 claims description 15
- 238000004393 prognosis Methods 0.000 claims description 14
- 238000001514 detection method Methods 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims description 9
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims description 9
- 102100039246 Elongator complex protein 1 Human genes 0.000 claims description 9
- 102100029109 Endothelin-3 Human genes 0.000 claims description 9
- 102100028121 Fos-related antigen 2 Human genes 0.000 claims description 9
- 101000813117 Homo sapiens Elongator complex protein 1 Proteins 0.000 claims description 9
- 101000841213 Homo sapiens Endothelin-3 Proteins 0.000 claims description 9
- 101001059934 Homo sapiens Fos-related antigen 2 Proteins 0.000 claims description 9
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims description 9
- 101000807596 Homo sapiens Orotidine 5'-phosphate decarboxylase Proteins 0.000 claims description 9
- 101001021281 Homo sapiens Protein HEXIM1 Proteins 0.000 claims description 9
- 101001074602 Homo sapiens Protein PIMREG Proteins 0.000 claims description 9
- 101000789523 Homo sapiens Sodium/potassium-transporting ATPase subunit beta-1 Proteins 0.000 claims description 9
- 101000697510 Homo sapiens Stathmin-2 Proteins 0.000 claims description 9
- 101000680652 Homo sapiens Tripartite motif-containing protein 14 Proteins 0.000 claims description 9
- 101000818690 Homo sapiens Zinc finger protein 236 Proteins 0.000 claims description 9
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims description 9
- 102100031623 Myelin transcription factor 1-like protein Human genes 0.000 claims description 9
- 101150059596 Myt1l gene Proteins 0.000 claims description 9
- 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 claims description 9
- 102000019009 Neural Cell Adhesion Molecule L1 Human genes 0.000 claims description 9
- 102100037214 Orotidine 5'-phosphate decarboxylase Human genes 0.000 claims description 9
- 102100036307 Protein HEXIM1 Human genes 0.000 claims description 9
- 102100036258 Protein PIMREG Human genes 0.000 claims description 9
- 102100028844 Sodium/potassium-transporting ATPase subunit beta-1 Human genes 0.000 claims description 9
- 102100028051 Stathmin-2 Human genes 0.000 claims description 9
- 102100022350 Tripartite motif-containing protein 14 Human genes 0.000 claims description 9
- 102100021120 Zinc finger protein 236 Human genes 0.000 claims description 9
- 238000011226 adjuvant chemotherapy Methods 0.000 claims description 7
- 101000615238 Homo sapiens Proto-oncogene DBL Proteins 0.000 claims description 5
- 102100021384 Proto-oncogene DBL Human genes 0.000 claims description 5
- 102100037420 Regulator of G-protein signaling 4 Human genes 0.000 claims description 5
- 101710140404 Regulator of G-protein signaling 4 Proteins 0.000 claims description 5
- 102100029785 UDP-glucuronosyltransferase 2B4 Human genes 0.000 claims description 5
- 101710200334 UDP-glucuronosyltransferase 2B4 Proteins 0.000 claims description 5
- 238000003753 real-time PCR Methods 0.000 claims description 5
- 230000000153 supplemental effect Effects 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 238000003499 nucleic acid array Methods 0.000 claims 1
- 230000004083 survival effect Effects 0.000 description 11
- 150000007523 nucleic acids Chemical group 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 238000004590 computer program Methods 0.000 description 3
- 239000013068 control sample Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 241000269627 Amphiuma means Species 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7172808P | 2008-05-14 | 2008-05-14 | |
| US61/071,728 | 2008-05-14 | ||
| PCT/CA2009/000650 WO2009137921A1 (en) | 2008-05-14 | 2009-05-14 | Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523549A JP2011523549A (ja) | 2011-08-18 |
| JP2011523549A5 true JP2011523549A5 (https=) | 2012-07-05 |
| JP5583117B2 JP5583117B2 (ja) | 2014-09-03 |
Family
ID=41318311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508777A Expired - Fee Related JP5583117B2 (ja) | 2008-05-14 | 2009-05-14 | 非小細胞肺癌およびアジュバント化学療法に関する予後診断的および予測的な遺伝子シグネチャー |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8211643B2 (https=) |
| EP (1) | EP2288741B1 (https=) |
| JP (1) | JP5583117B2 (https=) |
| AU (1) | AU2009246009A1 (https=) |
| CA (1) | CA2761571A1 (https=) |
| WO (1) | WO2009137921A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5583117B2 (ja) | 2008-05-14 | 2014-09-03 | ユニバーシティー ヘルス ネットワーク | 非小細胞肺癌およびアジュバント化学療法に関する予後診断的および予測的な遺伝子シグネチャー |
| US20100184063A1 (en) * | 2008-05-14 | 2010-07-22 | Ming-Sound Tsao | Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy |
| US20110238322A1 (en) * | 2008-11-03 | 2011-09-29 | Precision Therapeutics, Inc. | Methods of simulating chemotherapy for a patient |
| CN101705306B (zh) * | 2009-12-01 | 2012-07-11 | 华中农业大学 | 应用as-pcr检测牛尿苷酸合酶缺乏症的方法 |
| US9607202B2 (en) | 2009-12-17 | 2017-03-28 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of generating trophectoderm and neurectoderm from human embryonic stem cells |
| WO2011160118A2 (en) * | 2010-06-18 | 2011-12-22 | Med Biogene Inc. | Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy |
| US9200325B2 (en) * | 2011-04-01 | 2015-12-01 | Indiana University Research And Technology Corporation | Diagnostic methods and kit for detecting cancer |
| RU2013157589A (ru) * | 2011-05-25 | 2015-06-27 | Новартис Аг | Биомаркеры для рака легкого |
| CA2843887A1 (en) * | 2011-08-03 | 2013-02-07 | Signal Pharmaceuticals, Llc | Identification of gene expression profile as a predictive biomarker for lkb1 status |
| AU2014207429B2 (en) | 2013-01-18 | 2018-11-01 | Ellis KLINE | Selective glycosidase regimen for immune programming and treatment of cancer |
| EP2954331B1 (en) | 2013-02-11 | 2018-03-28 | Incuron LLC | Use of facilitates chromatin transcription complex (fact) in cancer |
| WO2014151026A1 (en) * | 2013-03-15 | 2014-09-25 | Myriad Genetics, Inc. | Genes and gene signatures for diagnosis and treatment of melanoma |
| KR101830700B1 (ko) * | 2013-11-11 | 2018-02-21 | 주식회사 파나진 | 클램핑 프로브 및 검출 프로브를 이용한 다중 표적핵산 검출방법 |
| KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| WO2016003810A1 (en) | 2014-07-02 | 2016-01-07 | Myriad Genetics, Inc. | Genes and gene signatures for diagnosis and treatment of melanoma |
| WO2016047688A1 (ja) * | 2014-09-24 | 2016-03-31 | 国立研究開発法人国立がん研究センター | 扁平上皮がんに対する化学放射線療法の有効性を評価するための方法 |
| WO2016050623A1 (en) * | 2014-09-29 | 2016-04-07 | Institut Gustave Roussy | Prognosis markers in lung cancer |
| CN106755309A (zh) * | 2016-11-18 | 2017-05-31 | 北京致成生物医学科技有限公司 | 分子标记物在制备胰腺癌预后评估产品中的应用 |
| JP7106810B2 (ja) * | 2018-04-19 | 2022-07-27 | 学校法人 埼玉医科大学 | 新規肺がんマーカー |
| CN108949997A (zh) * | 2018-08-24 | 2018-12-07 | 南京求臻基因科技有限公司 | 一种肺癌检测标志物及诊断试剂盒 |
| CN109859801B (zh) * | 2019-02-14 | 2023-09-19 | 辽宁省肿瘤医院 | 一种含有七个基因作为生物标志物预测肺鳞癌预后的模型及建立方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| JP2005503145A (ja) | 2001-08-16 | 2005-02-03 | ザ ユナイテッド ステイツ オブ アメリカ リプレゼンティッド バイ ザ シークレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 非小細胞肺癌の分子特性 |
| US20040241725A1 (en) | 2003-03-25 | 2004-12-02 | Wenming Xiao | Lung cancer detection |
| JP5583117B2 (ja) | 2008-05-14 | 2014-09-03 | ユニバーシティー ヘルス ネットワーク | 非小細胞肺癌およびアジュバント化学療法に関する予後診断的および予測的な遺伝子シグネチャー |
| US20100184063A1 (en) * | 2008-05-14 | 2010-07-22 | Ming-Sound Tsao | Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy |
-
2009
- 2009-05-14 JP JP2011508777A patent/JP5583117B2/ja not_active Expired - Fee Related
- 2009-05-14 AU AU2009246009A patent/AU2009246009A1/en not_active Abandoned
- 2009-05-14 WO PCT/CA2009/000650 patent/WO2009137921A1/en not_active Ceased
- 2009-05-14 EP EP09745336.9A patent/EP2288741B1/en not_active Not-in-force
- 2009-05-14 CA CA2761571A patent/CA2761571A1/en not_active Abandoned
- 2009-05-14 US US12/465,954 patent/US8211643B2/en not_active Expired - Fee Related
-
2012
- 2012-05-15 US US13/471,915 patent/US20120323594A1/en not_active Abandoned
-
2015
- 2015-08-07 US US14/820,975 patent/US20160024596A1/en not_active Abandoned
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