JP2011520903A5 - - Google Patents

Info

Publication number

JP2011520903A5

JP2011520903A5 JP2011509679A JP2011509679A JP2011520903A5 JP 2011520903 A5 JP2011520903 A5 JP 2011520903A5 JP 2011509679 A JP2011509679 A JP 2011509679A JP 2011509679 A JP2011509679 A JP 2011509679A JP 2011520903 A5 JP2011520903 A5 JP 2011520903A5

Authority

JP

Japan

Prior art keywords

compound

salt

cyano

salt according

cyclopenta

Prior art date

2009-05-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 11
• 150000003839 salts Chemical class 0.000 claims 11
• 208000010228 Erectile Dysfunction Diseases 0.000 claims 3
• 201000001881 impotence Diseases 0.000 claims 3
• 208000029725 Metabolic bone disease Diseases 0.000 claims 2
• 206010049088 Osteopenia Diseases 0.000 claims 2
• 208000001132 Osteoporosis Diseases 0.000 claims 2
• 210000000988 bone and bone Anatomy 0.000 claims 2
• 210000003205 muscle Anatomy 0.000 claims 2
• FBCDRHDULQYRTB-UHFFFAOYSA-N 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1h-imidazo[5,1-f][1,2,4]triazin-4-one;trihydrate;hydrochloride Chemical compound O.O.O.Cl.CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 FBCDRHDULQYRTB-UHFFFAOYSA-N 0.000 claims 1
• KBRSJPHSCOAFDR-UHFFFAOYSA-N 3-chloro-6-methyl-5,5-dioxo-11h-benzo[c][2,1]benzothiazepin-11-ol Chemical compound O=S1(=O)N(C)C2=CC=CC=C2C(O)C2=CC=C(Cl)C=C21 KBRSJPHSCOAFDR-UHFFFAOYSA-N 0.000 claims 1
• -1 5-fluoro-2-hydroxy-benzyl Chemical group 0.000 claims 1
• PKKNBXJMCHCHSP-INIZCTEOSA-N C(N)(OC(C)(C)[C@H]1CC2=C(N(C=3C=CC(=CC23)C#N)CC2=C(C=CC=C2)O)C1)=O Chemical class C(N)(OC(C)(C)[C@H]1CC2=C(N(C=3C=CC(=CC23)C#N)CC2=C(C=CC=C2)O)C1)=O PKKNBXJMCHCHSP-INIZCTEOSA-N 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• RUXJDAYOICLRHH-INIZCTEOSA-N propan-2-yl n-[(2s)-7-cyano-4-[(3-fluoro-2-hydroxyphenyl)methyl]-2,3-dihydro-1h-cyclopenta[b]indol-2-yl]carbamate Chemical compound C([C@H](C1)NC(=O)OC(C)C)C2=C1C1=CC(C#N)=CC=C1N2CC1=CC=CC(F)=C1O RUXJDAYOICLRHH-INIZCTEOSA-N 0.000 claims 1
• GAVLUGRJEJKCRF-RVHYNSKXSA-N propan-2-yl n-[(2s)-7-cyano-4-[[(2r,3s)-3-hydroxy-1-methylpyrrolidin-2-yl]methyl]-2,3-dihydro-1h-cyclopenta[b]indol-2-yl]carbamate Chemical compound C([C@H](C1)NC(=O)OC(C)C)C2=C1C1=CC(C#N)=CC=C1N2C[C@@H]1[C@@H](O)CCN1C GAVLUGRJEJKCRF-RVHYNSKXSA-N 0.000 claims 1
• 229960002639 sildenafil citrate Drugs 0.000 claims 1
• DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 claims 1
• 229960000835 tadalafil Drugs 0.000 claims 1
• IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 229960001540 vardenafil hydrochloride Drugs 0.000 claims 1