JP2011518839A - キトサン−含有保護用組成物 - Google Patents
キトサン−含有保護用組成物 Download PDFInfo
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- JP2011518839A JP2011518839A JP2011506466A JP2011506466A JP2011518839A JP 2011518839 A JP2011518839 A JP 2011518839A JP 2011506466 A JP2011506466 A JP 2011506466A JP 2011506466 A JP2011506466 A JP 2011506466A JP 2011518839 A JP2011518839 A JP 2011518839A
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- Prior art keywords
- polysaccharide
- chitosan
- composition
- protective layer
- linking agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
【選択図】 なし
Description
a) 部分的に架橋された多糖溶液を含む第1の成分と多糖用のさらなる架橋剤を含む第2の成分との二成分組成物を混合する工程(ここで、多糖またはさらなる架橋剤がキトサンまたはキトサン誘導体を含む);
b) 生体組織または構造上に向けられる流体としての混合された二成分を適用して、その上に保護層を形成する工程;
を含む、生体組織または構造を治療するための方法を提供する。
[0012] 以下の詳細な説明は、特定の態様を記述し、そして限定する意味では利用されない。本明細書中の全ての重量、量、および比は、特に記載しない限り重量である。以下に示される用語は、以下の意味を有する。
[0020] 用語“体温”は、哺乳動物に関連して使用される場合、通常の直腸温を意味する(例えば、ヒトの場合には約37℃;ネコ、ウシ、イヌ、またはウマの場合には約38℃;そしてヒツジの場合には約39℃)。
[0073] キトサン溶液を、水またはPBS中、様々な量のキトサングルタメート(FMC BioPolymer ASのNovaMatrixユニットから入手したPROTASANTM UP G 113、または“G 113”)を溶解することにより調製した。酸化メチルセルロース(“OXMC”)溶液を、部分的に酸化されたメチルセルロース(Sigma Aldrich Companyから入手したMO387)を過ヨウ素酸ナトリウムと反応させることにより、調製した。溶液を様々な比で混合し、ガラスペトリ皿に注ぎ入れ、そして冷凍乾燥させることにより凍結乾燥させて、白色泡状生成物を提供した。凍結乾燥させた生成物を、水中に浸漬し、そして定性的な水の取り込み速度を決定する様に観察した。結果を、表1に示す。
[0076] PBS中G113キトサングルタメートの5%溶液の1.5 mL部分およびPBS中グルタルアルデヒドの0.015%溶液の1.5 mL部分を、それぞれ3 mL単一バレルシリンジ中に入れた。シリンジの先端は、カニューレを使用して接続され、そしてその含有物は2本のシリンジプランジャーを交互に押し込んだり引き出したりすることにより均一になるまで混合した。混合物を一晩おいた。得られた部分的に架橋された多糖は、2.5%キトサングルタメート溶液と75 ppmグルタルアルデヒドとの反応生成物を含有した。
[0077] PBS中ジアルデヒドでんぷん(Monomer-Polymer & Dajac Labs, Inc.から入手したNo. 9056、>80%酸化でんぷん)溶液を凍結乾燥し、その後凍結乾燥生成物を十分に脱イオン化した水中に溶解することにより水和して、5%酸化でんぷんを含有するさらなる架橋剤溶液を提供した。ガス補助アプリケーター(Micromedics, Inc.から入手したFIBRIJET SA-6030レギュレータ、一対の3 ccシリンジを附属したFIBRIJET SA-3652スプレーセットを調節する)を使用して、実施例2で得られた部分的に架橋された多糖溶液と5%酸化でんぷん溶液とを1:1の比で垂直方向のヒトの手に対してスプレー適用し、体温で実質的に垂直な組織表面に対する設定時間と接着とを観察した。約3〜4 mLの混合物をスプレーして、流体保護層を形成した。組成物は、良好なスプレー特性を示し、付着部位に十分に接着しているようであり、そして付着部位を薄く共形なフィルムで被覆している様であり、そしてこぼれたりたれたりまたは流れたりしなかった。得られた保護層は、粘着性で、柔軟性があり、十分に接着し、そして水に曝されると滑らかになった。保護層を除去するためには洗浄(Scrubbing)が必要であった。
[0079] 実施例2の方法を使用して、酸化されたメチルセルロース溶液を、架橋されていない形状および部分的に架橋された形状で、様々な量のキトサングルタメートを部分的架橋剤として使用して、調製した。15%の酸化されたメチルセルロース溶液を、MO387メチルセルロース(Sigma-Aldrich Co.)を過ヨウ素酸ナトリウムと脱イオン水中で反応させることにより、作成した。反応生成物を、その後凍結乾燥し、そしてPBS中で再水和した。この溶液の0.5 mLの部分を3 mLのシリンジ中に取り、そしてPBS中0.3%G113キトサングルタメート溶液の0.5 mL部分を含有するシリンジと混合し、脱気し、そして24時間そのままにし、それにより0.15%キトサンと反応させた7.5%酸化メチルセルロースを含有する部分的に架橋された多糖を提供した(溶液A)。同様にして、メチルセルロース溶液の0.5 mL部分を、PBS中0.5%G113キトサングルタメート溶液の0.5 mL部分を含有するシリンジと混合して、それにより0.25%キトサンと反応させた7.5%酸化メチルセルロースを含有する部分的に架橋された多糖を提供した(溶液B)。非-架橋7.5%酸化メチルセルロース溶液を、対照として調製した(溶液C)。
Claims (36)
- 部分的に架橋された多糖を含む第1の成分と多糖用のさらなる架橋剤を含む第2の成分との二成分組成物であって、多糖またはさらなる架橋剤はキトサンまたはキトサン誘導体を含み、そして組成物が水和されそして混合された場合に、組成物をスプレーアプリケータを介して流体として送達し、薄く共形な保護層を体温で実質的に垂直な皮膚表面上に提供することができる、前記二成分組成物。
- 多糖がキトサンまたはキトサン誘導体を含む、請求項1に記載の組成物。
- さらなる架橋剤がキトサンまたはキトサン誘導体を含む、請求項1に記載の組成物。
- 多糖およびさらなる架橋剤がキトサンまたはキトサン誘導体を含む、請求項1に記載の組成物。
- 多糖またはさらなる架橋剤がセルロースまたはセルロース誘導体を含む、請求項1に記載の組成物。
- 多糖またはさらなる架橋剤がでんぷんまたはでんぷん誘導体を含む、請求項1に記載の組成物。
- 多糖またはさらなる架橋剤が、キチン、コンドロイチン硫酸、デキストラン、グリコーゲン、ヒアルロン酸、またはそれらの誘導体を含む、請求項1に記載の組成物。
- 多糖およびさらなる架橋剤を約20:1〜約1:20のモル比で組み合わせる、請求項1に記載の組成物。
- 多糖およびさらなる架橋剤を約3:1〜約1:5のモル比で組み合わせる、請求項1に記載の組成物。
- リン酸イオンをさらに含む、請求項1に記載の組成物。
- シリンジ中にパッケージングされる、請求項1に記載の組成物。
- 多糖が乾燥粒子形状である、請求項11に記載の組成物。
- 水和されそして混合された場合に、組成物が、スプレー適用されて、薄く、共形でそして初めは流体の保護層を、体温で実質的に垂直な皮膚表面上に形成することができ、そしてそのように適用した場合には表面からこぼれたり流れたりしない、請求項1に記載の組成物。
- 最初は部分的に架橋された多糖と多糖用のさらなる架橋剤との流体混合物を含む、体温表面上の保護層であって、多糖またはさらなる架橋剤はキトサンまたはキトサン誘導体を含み、そして部分的に架橋された多糖がさらなる架橋剤との混合前に部分的に架橋されたものである、前記保護層。
- 多糖がキトサンまたはキトサン誘導体を含む、請求項14に記載の保護層。
- さらなる架橋剤がキトサンまたはキトサン誘導体を含む、請求項14に記載の保護層。
- 多糖およびさらなる架橋剤がキトサンまたはキトサン誘導体を含む、請求項14に記載の保護層。
- 多糖またはさらなる架橋剤が、セルロースまたはセルロース誘導体を含む、請求項14に記載の保護層。
- 多糖またはさらなる架橋剤がでんぷんまたはでんぷん誘導体を含む、請求項14に記載の保護層。
- 多糖またはさらなる架橋剤が、キチン、コンドロイチン硫酸、デキストラン、グリコーゲン、ヒアルロン酸またはそれらの誘導体を含む、請求項14に記載の保護層。
- 層が表面からこぼれたり流れたりしない、請求項14に記載の保護層。
- 以下の工程:
a) 部分的に架橋された多糖溶液を含む第1の成分と多糖用のさらなる架橋剤を含む第2の成分との二成分組成物を混合する工程、ここで、多糖またはさらなる架橋剤は、キトサンまたはキトサン誘導体を含む;
b) 流体としての混合された成分を生体組織または構造上に向けて適用して、その上に保護層を形成する工程;
を含む、生体組織または構造を処置するための方法。 - 組成物をマルチ-バレルシリンジを使用して混合することを含む、請求項22に記載の方法。
- 流体をスプレーすることにより適用する、請求項22に記載の方法。
- 流体を鼻腔に対して適用することを含む、請求項22に記載の方法。
- 流体を副鼻腔に対して適用することを含む、請求項22に記載の方法。
- 流体を中耳または内耳に対して適用することを含む、請求項22に記載の方法。
- 流体を四肢における開口部、陥凹部、通路、または接合部に対して適用することを含む、請求項22に記載の方法。
- 流体を脊柱における開口部、陥凹部、通路、または接合部に対して適用することを含む、請求項22に記載の方法。
- 混合された成分が組織または構造からこぼれたり流れたりしない、請求項22に記載の方法。
- 多糖がキトサンまたはキトサン誘導体を含む、請求項22に記載の方法。
- さらなる架橋剤がキトサンまたはキトサン誘導体を含む、請求項22に記載の方法。
- 多糖またはさらなる架橋剤がセルロースまたはセルロース誘導体を含む、請求項22に記載の方法。
- 多糖またはさらなる架橋剤がでんぷんまたはでんぷん誘導体を含む、請求項22に記載の方法。
- 多糖またはさらなる架橋剤が、キチン、コンドロイチン硫酸、デキストラン、グリコーゲン、ヒアルロン酸、またはそれらの誘導体を含む、請求項22に記載の方法。
- 組成物がリン酸イオンをさらに含む、請求項22に記載の方法。
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JP2014532479A (ja) * | 2011-10-28 | 2014-12-08 | メドトロニック・ゾーメド・インコーポレーテッド | スプレーデリバリシステム |
JP2014532477A (ja) * | 2011-10-28 | 2014-12-08 | メドトロニック・ゾーメド・インコーポレーテッド | マルチオリフィススプレーヘッド |
JP2018520229A (ja) * | 2015-06-11 | 2018-07-26 | メドトロニック・ゾーメド・インコーポレーテッド | 放射線殺菌後の有用な多糖 |
JP2021517829A (ja) * | 2018-01-12 | 2021-07-29 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 止血を達成するための粉末 |
US11701448B2 (en) | 2018-01-12 | 2023-07-18 | Boston Scientific Scimed, Inc. | Powder for achieving hemostasis |
JP7317839B2 (ja) | 2018-01-12 | 2023-07-31 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 止血を達成するための粉末 |
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CN102883715B (zh) | 2014-11-12 |
CN102883715A (zh) | 2013-01-16 |
EP2296637A1 (en) | 2011-03-23 |
AU2009240513A1 (en) | 2009-10-29 |
CA2721938C (en) | 2016-08-09 |
AU2009240513B2 (en) | 2015-03-26 |
US8530632B2 (en) | 2013-09-10 |
CA2721938A1 (en) | 2009-10-29 |
EP2296637B1 (en) | 2014-04-02 |
WO2009132228A1 (en) | 2009-10-29 |
US20090291912A1 (en) | 2009-11-26 |
JP5757861B2 (ja) | 2015-08-05 |
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