JP2011517944A5 - - Google Patents
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- JP2011517944A5 JP2011517944A5 JP2011504171A JP2011504171A JP2011517944A5 JP 2011517944 A5 JP2011517944 A5 JP 2011517944A5 JP 2011504171 A JP2011504171 A JP 2011504171A JP 2011504171 A JP2011504171 A JP 2011504171A JP 2011517944 A5 JP2011517944 A5 JP 2011517944A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic composition
- chimeric receptor
- pbmc
- pbl
- pmbc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 28
- 108700010039 chimeric receptor Proteins 0.000 claims description 26
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 claims description 22
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 21
- 210000004027 cell Anatomy 0.000 claims description 10
- 230000000284 resting effect Effects 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 108020004999 messenger RNA Proteins 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 210000000822 natural killer cell Anatomy 0.000 claims description 4
- 210000005259 peripheral blood Anatomy 0.000 claims description 4
- 239000011886 peripheral blood Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 230000000735 allogeneic effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 15
- 230000002601 intratumoral effect Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4365308P | 2008-04-09 | 2008-04-09 | |
| US61/043,653 | 2008-04-09 | ||
| PCT/US2009/040040 WO2009126789A2 (en) | 2008-04-09 | 2009-04-09 | Engineering and delivery of therapeutic compositions of freshly isolated cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015138578A Division JP6630074B2 (ja) | 2008-04-09 | 2015-07-10 | 新規に単離された細胞の治療組成物の操作および送達 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517944A JP2011517944A (ja) | 2011-06-23 |
| JP2011517944A5 true JP2011517944A5 (https=) | 2012-05-31 |
| JP5779090B2 JP5779090B2 (ja) | 2015-09-16 |
Family
ID=41162602
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504171A Active JP5779090B2 (ja) | 2008-04-09 | 2009-04-09 | 新規に単離された細胞の治療組成物の操作および送達 |
| JP2015138578A Active JP6630074B2 (ja) | 2008-04-09 | 2015-07-10 | 新規に単離された細胞の治療組成物の操作および送達 |
| JP2017131791A Pending JP2017184759A (ja) | 2008-04-09 | 2017-07-05 | 新規に単離された細胞の治療組成物の操作および送達 |
| JP2019194124A Active JP6944497B2 (ja) | 2008-04-09 | 2019-10-25 | 新規に単離された細胞の治療組成物の操作および送達 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015138578A Active JP6630074B2 (ja) | 2008-04-09 | 2015-07-10 | 新規に単離された細胞の治療組成物の操作および送達 |
| JP2017131791A Pending JP2017184759A (ja) | 2008-04-09 | 2017-07-05 | 新規に単離された細胞の治療組成物の操作および送達 |
| JP2019194124A Active JP6944497B2 (ja) | 2008-04-09 | 2019-10-25 | 新規に単離された細胞の治療組成物の操作および送達 |
Country Status (5)
| Country | Link |
|---|---|
| US (8) | US8450112B2 (https=) |
| EP (1) | EP2279253B1 (https=) |
| JP (4) | JP5779090B2 (https=) |
| DK (1) | DK2279253T3 (https=) |
| WO (1) | WO2009126789A2 (https=) |
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| JP5572863B2 (ja) * | 2011-06-24 | 2014-08-20 | 国立大学法人九州大学 | Ｎｋ細胞の増幅方法 |
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| US11059880B2 (en) | 2015-06-30 | 2021-07-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with MHC chimeric receptors and methods of use in immunotherapy |
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2009
- 2009-04-09 US US12/421,352 patent/US8450112B2/en active Active
- 2009-04-09 EP EP09731422.3A patent/EP2279253B1/en active Active
- 2009-04-09 WO PCT/US2009/040040 patent/WO2009126789A2/en not_active Ceased
- 2009-04-09 JP JP2011504171A patent/JP5779090B2/ja active Active
- 2009-04-09 DK DK09731422.3T patent/DK2279253T3/en active
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2013
- 2013-05-24 US US13/902,444 patent/US9132153B2/en active Active
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2015
- 2015-07-10 JP JP2015138578A patent/JP6630074B2/ja active Active
- 2015-08-25 US US14/834,932 patent/US9669058B2/en active Active
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2017
- 2017-05-23 US US15/602,536 patent/US10660917B2/en active Active
- 2017-07-05 JP JP2017131791A patent/JP2017184759A/ja active Pending
- 2017-10-06 US US15/726,740 patent/US11331344B2/en active Active
-
2019
- 2019-10-25 JP JP2019194124A patent/JP6944497B2/ja active Active
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2020
- 2020-04-15 US US16/849,954 patent/US20200237825A1/en not_active Abandoned
- 2020-07-02 US US16/946,730 patent/US20200330519A1/en not_active Abandoned
-
2022
- 2022-05-16 US US17/744,970 patent/US20220265722A1/en not_active Abandoned
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