JP2011515462A - 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用 - Google Patents

置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用 Download PDF

Info

Publication number
JP2011515462A
JP2011515462A JP2011501736A JP2011501736A JP2011515462A JP 2011515462 A JP2011515462 A JP 2011515462A JP 2011501736 A JP2011501736 A JP 2011501736A JP 2011501736 A JP2011501736 A JP 2011501736A JP 2011515462 A JP2011515462 A JP 2011515462A
Authority
JP
Japan
Prior art keywords
difluoromethyl
morpholinyl
triazin
methoxy
chloroacetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2011501736A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011515462A5 (enExample
Inventor
ウイルリアム レウカストレ ゴルドン
ロビン シェプヘルド ペテル
チャウスサデ クライレ
アレクアンデル デンンイ ウイルリアム
アクラトイヤ ガマゲ スワルナラトハ
Original Assignee
アウククランド ウニセルビセス リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アウククランド ウニセルビセス リミテッド filed Critical アウククランド ウニセルビセス リミテッド
Publication of JP2011515462A publication Critical patent/JP2011515462A/ja
Publication of JP2011515462A5 publication Critical patent/JP2011515462A5/ja
Abandoned legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2011501736A 2008-03-27 2009-03-26 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用 Abandoned JP2011515462A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4006408P 2008-03-27 2008-03-27
US61/040,064 2008-03-27
PCT/NZ2009/000038 WO2009120094A2 (en) 2008-03-27 2009-03-26 Substituted pyrimidines and triazines and their use in cancer therapy

Publications (2)

Publication Number Publication Date
JP2011515462A true JP2011515462A (ja) 2011-05-19
JP2011515462A5 JP2011515462A5 (enExample) 2012-05-17

Family

ID=40810252

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011501736A Abandoned JP2011515462A (ja) 2008-03-27 2009-03-26 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用

Country Status (4)

Country Link
US (1) US20110053907A1 (enExample)
EP (1) EP2276750A2 (enExample)
JP (1) JP2011515462A (enExample)
WO (1) WO2009120094A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012521983A (ja) * 2009-03-27 2012-09-20 パトフワイ トヘラペウトイクス インコーポレイテッド ピリミジニル及び１，３，５−トリアジニルベンゾイミダゾールスルホンアミド及びガンの療法におけるその使用
JP2013525419A (ja) * 2010-04-30 2013-06-20 ユニバーシティ・オブ・バーゼル 抗増殖性障害の処置における使用のためのｐｉ３ｋ阻害剤としてのピペラジノトリアジン
JP2016516702A (ja) * 2013-03-13 2016-06-09 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2683805C (en) 2007-04-13 2014-09-23 The Regents Of The University Of Michigan Systems and methods for tissue imaging
CA2716940C (en) * 2008-02-29 2016-01-19 The Regents Of The University Of Michigan Systems and methods for imaging changes in tissue
EP2397479A4 (en) * 2009-02-12 2012-08-01 Astellas Pharma Inc HETERO RING DERIVATIVE
CA2755285C (en) 2009-03-20 2014-02-11 Yunxin Y. Bo Inhibitors of pi3 kinase
WO2010110686A1 (en) * 2009-03-27 2010-09-30 Pathway Therapeutics Limited Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
CA2767008C (en) 2009-07-07 2018-01-30 Pathway Therapeutics, Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
US8569296B2 (en) * 2009-09-29 2013-10-29 Xcovery Holding Company, Llc PI3K (delta) selective inhibitors
WO2011049625A1 (en) 2009-10-20 2011-04-28 Mansour Samadpour Method for aflatoxin screening of products
LT2496567T (lt) 2009-11-05 2017-11-27 Rhizen Pharmaceuticals S.A. Nauji benzopirano kinazės moduliatoriai
ES2570177T3 (es) * 2010-08-10 2016-05-17 Astellas Pharma Inc Compuesto heterocíclico
WO2012044641A1 (en) 2010-09-29 2012-04-05 Pathway Therapeutics Inc. 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
CN107501241B (zh) 2011-03-28 2020-10-13 梅制药公司 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途
PT2705029T (pt) 2011-05-04 2019-02-01 Rhizen Pharmaceuticals S A Novos compostos como moduladores de proteína quinases
US9773311B2 (en) 2011-06-29 2017-09-26 The Regents Of The University Of Michigan Tissue phasic classification mapping system and method
MX342326B (es) 2011-09-27 2016-09-26 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
US9365562B2 (en) 2011-10-06 2016-06-14 Merck Sharp & Dohme Corp. 1,3 substituted azetidine PDE10 inhibitors
WO2013078370A1 (en) 2011-11-23 2013-05-30 The Regents Of The University Of Michigan Voxel-based approach for disease detection and evolution
ES2661510T3 (es) 2011-12-15 2018-04-02 Novartis Ag Uso de inhibidores de la actividad o función de PI3K
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
EP2845023A1 (en) 2012-05-04 2015-03-11 The Regents of the University of Michigan Mean diffusivity measurement corrections for gradient non-linearity
PT2870157T (pt) 2012-07-04 2017-11-27 Rhizen Pharmaceuticals S A Inibidores seletivos de delta pi3k
WO2014055647A1 (en) * 2012-10-03 2014-04-10 Mei Pharma, Inc. (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
CA2903979A1 (en) 2013-03-14 2014-09-18 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
WO2017210545A1 (en) 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
US10650512B2 (en) 2016-06-14 2020-05-12 The Regents Of The University Of Michigan Systems and methods for topographical characterization of medical image data
JP2019519593A (ja) 2016-07-06 2019-07-11 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法
EP3571193B1 (en) 2017-01-23 2021-12-01 Cadent Therapeutics, Inc. Potassium channel modulators
EP3630118A4 (en) 2017-05-23 2021-03-31 MEI Pharma, Inc. COMBINATION THERAPY
AU2018316175B2 (en) 2017-08-11 2023-02-23 The Regents Of The University Of Michigan Inhibitors of MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR and MEK/PI3K3k/mTOR biological pathways and methods for improving lymphatic uptake, bioavailability, and solubility of therapeutic compounds
MX2020001727A (es) 2017-08-14 2020-03-20 Mei Pharma Inc Terapia de combinacion.
WO2019119206A1 (en) * 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Purine inhibitors of human phosphatidylinositol 3-kinase delta
MX2021004647A (es) 2018-10-22 2021-08-16 Novartis Ag Formas cristalinas de moduladores de los canales de potasio.
CN113004246B (zh) * 2021-02-22 2022-02-01 广西医科大学 1，3，5-三嗪-2-胺-4，6取代衍生物或其药学上可接受的盐和用途
EP4320110A1 (en) * 2021-04-09 2024-02-14 Universität Basel Triazine derivative as covalent inhibitors of pi3k
CN117751127B (zh) * 2021-08-20 2026-07-03 南京大美生物制药有限公司 一种五元含氮杂环并杂芳基类衍生物及其用途

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1222049B (it) * 1987-07-16 1990-08-31 Ciba Geygi Spa Composti piperidin triazinici utilizzabili come stabilizzanti per polimeri sintetici
US5244948A (en) * 1988-06-30 1993-09-14 Ciba-Geigy Corporation Process for the stabilization of polyolefins
US5306495A (en) * 1988-08-04 1994-04-26 Ciba-Geigy Corporation Compounds containing substituted piperidine groups for use as stabilizers for organic materials
IT1237126B (it) * 1989-11-07 1993-05-18 Ciba Geigy Spa Stabilizzanti polimerici contenenti gruppi amminici impediti e gruppi idrossilamminici
US5258138A (en) * 1990-07-20 1993-11-02 Ciba-Geigy Corporation Process for stabilizing ethylenically unsaturated compounds and stabilized monomer compositions
TW224983B (enExample) * 1991-08-28 1994-06-11 Hoechst Ag
AU665238B2 (en) * 1992-02-28 1995-12-21 Zenyaku Kogyo Kabushiki Kaisha S-triazine derivative and remedy for estrogen-dependent diseases containing the same as active ingredient
HU209678B (en) * 1992-06-09 1994-10-28 Richter Gedeon Vegyeszet Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them
IT1263993B (it) * 1993-04-05 1996-09-06 Ciba Geigy Spa Composti piperidin-triazinici atti all'impiego come stabilizzanti per materiali organici
IT1270975B (it) * 1993-06-03 1997-05-26 Ciba Geigy Spa Composti piperidin-triazinici atti all'impiego come stabilizzanti allaluce, al calore e alla ossidazione per materiali organici
DE59505941D1 (de) * 1994-01-19 1999-06-24 Ciba Geigy Ag Stabilisieren von Leder gegen thermische und photochemische Zersetzung
ES2128025T3 (es) * 1994-10-12 1999-05-01 Ciba Geigy Ag Fosforinanos hals como estabilizadores.
EP0711804A3 (de) * 1994-11-14 1999-09-22 Ciba SC Holding AG Kryptolichtschutzmittel
DE19522137A1 (de) * 1995-06-19 1997-01-02 Hoechst Schering Agrevo Gmbh 2-Amino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
JP3512911B2 (ja) * 1995-07-11 2004-03-31 富士写真フイルム株式会社 紫外線吸収剤前駆体化合物、それを含有する感光性樹脂組成物及び画像形成方法
US6046304A (en) * 1995-12-04 2000-04-04 Ciba Specialty Chemicals Corporation Block oligomers containing 2,2,6,6-tetramethyl-4-piperidyl groups as stabilizers for organic materials
US6432947B1 (en) * 1997-02-19 2002-08-13 Berlex Laboratories, Inc. N-heterocyclic derivatives as NOS inhibitors
ES2213286T3 (es) * 1997-07-24 2004-08-16 Zenyaku Kogyo Kabushiki Kaisha Compuestos heterociclicos y agente antitumoral que los contiene como ingredientes activos.
JPH11174638A (ja) * 1997-12-08 1999-07-02 Konica Corp ハロゲン化銀カラー写真感光材料
US6150362A (en) * 1997-12-12 2000-11-21 Henkin; Jack Triazine angiogenesis inhibitors
US5990208A (en) * 1997-12-15 1999-11-23 Ciba Specialty Chemicals Corporation Stabilization of polycarbonate/ABS blends with mixtures of hindered amines and UV absorbers
EP1140100A2 (en) * 1999-01-13 2001-10-10 Biomes, Inc. Use of (s)-triazines for treating apicomplexan parasitic infections
JP2002543067A (ja) * 1999-04-22 2002-12-17 シナプティック・ファーマスーティカル・コーポレーション 選択的なｎｐｙ（ｙ５）のアンタゴニスト
WO2002006271A1 (en) * 2000-07-19 2002-01-24 F. Hoffmann-La Roche Ag Pyrimidine derivatives
US6465645B1 (en) * 2001-04-17 2002-10-15 Ciba Specialty Chemicals Corporation Long chain hindered amines and compositions stabilized therewith
KR100833371B1 (ko) * 2001-04-27 2008-05-28 젠야쿠코교가부시키가이샤 헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제
KR101046015B1 (ko) * 2002-10-25 2011-07-01 젠야쿠코교가부시키가이샤 헤테로고리 화합물 및 이것을 유효성분으로 하는 항종양제
US7223759B2 (en) * 2003-09-15 2007-05-29 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
KR101130913B1 (ko) * 2004-03-31 2012-03-28 젠야쿠코교가부시키가이샤 헤테로시클릭 화합물 및 이를 활성 성분으로서 포함하는항악성종양제
WO2006071538A2 (en) * 2004-12-13 2006-07-06 Neurogen Corporation Substituted biaryl analogues
CA2590299A1 (en) * 2004-12-13 2006-06-22 Neurogen Corporation Piperazinyl-pyridine analogues
GB0503962D0 (en) * 2005-02-25 2005-04-06 Kudos Pharm Ltd Compounds
SI1864665T1 (sl) * 2005-03-11 2012-09-28 Zenyaku Kogyo Kk Imunosupresivno sredstvo, ki obsega heterociklično spojino kot učinkovino
CN101801971A (zh) * 2005-09-30 2010-08-11 沃泰克斯药物股份有限公司 可用作janus激酶抑制剂的脱氮嘌呤
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US20070244110A1 (en) * 2006-04-14 2007-10-18 Zenyaku Kogyo Kabushiki Kaisha Treatment of prostate cancer, melanoma or hepatic cancer
PL2041139T3 (pl) * 2006-04-26 2012-05-31 Hoffmann La Roche Związki farmaceutyczne
EP2057147A1 (en) * 2006-09-14 2009-05-13 Astra Zeneca AB Pyrimidine derivatives
EP2061784A1 (en) * 2006-09-14 2009-05-27 AstraZeneca AB 2-benzimidazolyl-6-morpholino-4-phenylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
CN101563339A (zh) * 2006-09-14 2009-10-21 阿斯利康(瑞典)有限公司 作为 p i 3 k和 m t o r抑制剂用于治疗增殖性疾病的 2 -苯并咪唑基 - 6 -吗啉代 - 4 - (氮杂环丁烷、吡咯烷、哌啶或氮杂)嘧啶衍生物
CN101563340A (zh) * 2006-09-14 2009-10-21 阿斯利康(瑞典)有限公司 用作pi3k和mtor抑制剂用于治疗增殖性疾病的2-苯并咪唑基-6-吗啉代-4-哌啶-4-基嘧啶衍生物
WO2008072850A1 (en) * 2006-12-11 2008-06-19 Amorepacific Corporation Triazine derivatives having inhibitory activity against acetyl-coa carboxylase
MX2010007746A (es) * 2008-01-15 2010-08-18 Wyeth Llc Compuestos de 3h-[1,2,3]triazolo[4,5-d]pirimidina, su uso como inhibidores de diana de rapamicina de mamifero quinasa y fosfatidilinositol quinasa y su sintesis.
US20090192176A1 (en) * 2008-01-30 2009-07-30 Wyeth 1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012521983A (ja) * 2009-03-27 2012-09-20 パトフワイ トヘラペウトイクス インコーポレイテッド ピリミジニル及び１，３，５−トリアジニルベンゾイミダゾールスルホンアミド及びガンの療法におけるその使用
US9108980B2 (en) 2009-03-27 2015-08-18 Vetdc, Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
JP2013525419A (ja) * 2010-04-30 2013-06-20 ユニバーシティ・オブ・バーゼル 抗増殖性障害の処置における使用のためのｐｉ３ｋ阻害剤としてのピペラジノトリアジン
JP2016516702A (ja) * 2013-03-13 2016-06-09 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法

Also Published As

Publication number Publication date
EP2276750A2 (en) 2011-01-26
WO2009120094A2 (en) 2009-10-01
WO2009120094A3 (en) 2010-01-28
US20110053907A1 (en) 2011-03-03

Similar Documents

Publication Publication Date Title
JP5766177B2 (ja) ピリミジニル及び１，３，５−トリアジニルベンゾイミダゾールスルホンアミド及びガンの療法におけるその使用
US11787788B2 (en) Benzimidazole derivatives, and pharmaceutical compositions and methods of use thereof
DK3072890T3 (en) Pyrimidinyl and 1,3,5-triazinylbenzimidazoles and their use in cancer therapy
US20110053907A1 (en) Substituted pyrimidines and triazines and their use in cancer therapy
JP6042406B2 (ja) （α−置換アラルキルアミノ及びヘテロアリールアルキルアミノ）ピリミジニル及び１，３，５−トリアジニルベンズイミダゾール、それらを含む医薬組成物、並びに増殖性疾患の治療で使用するためのこれらの化合物
US10590108B2 (en) Benzimidazoles for use in the treatment of cancer and inflammatory diseases
KR102409739B1 (ko) 암 치료용의 ｅｒｂｂ 티로신 키나제 억제제로서의 벤즈이미다졸 유도체
WO2010110686A1 (en) Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
TW201629019A (zh) ３，５－二胺基吡唑激酶抑制劑
HK1228387B (en) Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
HK1228387A1 (en) Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120323

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120323

A762 Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20120702