JP2011515384A5 - - Google Patents
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- Publication number
- JP2011515384A5 JP2011515384A5 JP2011500282A JP2011500282A JP2011515384A5 JP 2011515384 A5 JP2011515384 A5 JP 2011515384A5 JP 2011500282 A JP2011500282 A JP 2011500282A JP 2011500282 A JP2011500282 A JP 2011500282A JP 2011515384 A5 JP2011515384 A5 JP 2011515384A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cyclopenta
- phenylene
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0805035A GB0805035D0 (en) | 2008-03-18 | 2008-03-18 | Us eof cyclopenta[G]quinazoline derivatives |
| GB0805036.1 | 2008-03-18 | ||
| GB0805036A GB0805036D0 (en) | 2008-03-18 | 2008-03-18 | New use of cyclopenta[g]quinazoline derivatives |
| GB0805035.3 | 2008-03-18 | ||
| PCT/GB2009/000687 WO2009115776A1 (en) | 2008-03-18 | 2009-03-13 | Cyclopenta[g]quinazoline derivatives for the treatment of rheumatoid arthritis or acute myeloid leukaemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011515384A JP2011515384A (ja) | 2011-05-19 |
| JP2011515384A5 true JP2011515384A5 (cg-RX-API-DMAC7.html) | 2012-05-10 |
| JP5599773B2 JP5599773B2 (ja) | 2014-10-01 |
Family
ID=40599662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011500282A Active JP5599773B2 (ja) | 2008-03-18 | 2009-03-13 | リウマチ様関節炎又は急性骨髄性白血病の治療のためのシクロペンタ［ｇ］キナゾリン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8466111B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2293807B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5599773B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101616022B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101977620B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE556715T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2717954C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2293807T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2387334T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009115776A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2819510A1 (en) * | 2010-12-22 | 2012-06-28 | Onyx Pharmaceuticals, Inc. | Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta(g)quinazoline trisodium salt |
| US20180236098A1 (en) | 2016-08-12 | 2018-08-23 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| KR102584446B1 (ko) | 2016-08-12 | 2023-10-04 | 엘.이.에이.에프. 홀딩스 그룹 엘엘씨. | 알파 및 감마-d 폴리글루타메이트화 항엽산 및 이의 용도 |
| GB201707864D0 (en) | 2017-05-16 | 2017-06-28 | Inst Of Cancer Research: Royal Cancer Hospital | Platinum-reistant cancer treatment |
| CA3090391A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated raltitrexed and uses thereof |
| JP7491573B2 (ja) | 2018-02-07 | 2024-05-28 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化メトトレキセートおよびその使用 |
| WO2019157146A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| JP7514533B2 (ja) | 2018-02-07 | 2024-07-11 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化テトラヒドロ葉酸およびその使用 |
| EP3749317A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | PEMETREXED ALPHA-POLYGLUTAMATE AND ASSOCIATED USES |
| WO2019157129A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| US12246018B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pemetrexed and uses thereof |
| US12246019B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| CA3090384A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| WO2019157133A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| US12290518B2 (en) | 2018-02-14 | 2025-05-06 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated methotrexate and uses thereof |
| US12048767B2 (en) * | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
| CA3090875A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| JP7442822B2 (ja) | 2018-02-14 | 2024-03-05 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | γポリグルタミン酸化テトラヒドロ葉酸およびその使用 |
| CA3090943A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
| WO2019169029A1 (en) * | 2018-02-28 | 2019-09-06 | Bioxiness Pharmaceuticals, Inc. | Target specific chemotherapeutic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9223352D0 (en) | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
| GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
| ES2373644T3 (es) * | 2001-08-31 | 2012-02-07 | Btg International Limited | Uso de derivados de ciclopenta[g]quinazolina para el tratamiento del c�?ncer. |
| KR100983962B1 (ko) * | 2001-08-31 | 2010-09-27 | 비티지 인터내셔널 리미티드 | 항암제로서 사용되는 시클로펜타[ｇ]퀴나졸린 화합물 |
| AU2003216445A1 (en) * | 2002-02-27 | 2003-09-09 | The Medical College Of Ohio | Therapeutic methods for acute myeloid leukemia |
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2009
- 2009-03-13 AT AT09721455T patent/ATE556715T1/de active
- 2009-03-13 JP JP2011500282A patent/JP5599773B2/ja active Active
- 2009-03-13 KR KR1020107023279A patent/KR101616022B1/ko active Active
- 2009-03-13 EP EP09721455A patent/EP2293807B1/en active Active
- 2009-03-13 WO PCT/GB2009/000687 patent/WO2009115776A1/en not_active Ceased
- 2009-03-13 ES ES09721455T patent/ES2387334T3/es active Active
- 2009-03-13 US US12/735,743 patent/US8466111B2/en active Active
- 2009-03-13 CA CA2717954A patent/CA2717954C/en active Active
- 2009-03-13 DK DK09721455.5T patent/DK2293807T3/da active
- 2009-03-13 CN CN200980110610.4A patent/CN101977620B/zh active Active