DK2293807T3 - Cyclopenta[g]quinazolin-derivater til behandling af rheumatoid arthritis eller akut myeloid leukæmi - Google Patents
Cyclopenta[g]quinazolin-derivater til behandling af rheumatoid arthritis eller akut myeloid leukæmiInfo
- Publication number
- DK2293807T3 DK2293807T3 DK09721455.5T DK09721455T DK2293807T3 DK 2293807 T3 DK2293807 T3 DK 2293807T3 DK 09721455 T DK09721455 T DK 09721455T DK 2293807 T3 DK2293807 T3 DK 2293807T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclopenta
- treatment
- rheumatoid arthritis
- acute myeloid
- alkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0805035A GB0805035D0 (en) | 2008-03-18 | 2008-03-18 | Us eof cyclopenta[G]quinazoline derivatives |
| GB0805036A GB0805036D0 (en) | 2008-03-18 | 2008-03-18 | New use of cyclopenta[g]quinazoline derivatives |
| PCT/GB2009/000687 WO2009115776A1 (en) | 2008-03-18 | 2009-03-13 | Cyclopenta[g]quinazoline derivatives for the treatment of rheumatoid arthritis or acute myeloid leukaemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2293807T3 true DK2293807T3 (da) | 2012-07-23 |
Family
ID=40599662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09721455.5T DK2293807T3 (da) | 2008-03-18 | 2009-03-13 | Cyclopenta[g]quinazolin-derivater til behandling af rheumatoid arthritis eller akut myeloid leukæmi |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8466111B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2293807B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5599773B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101616022B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101977620B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE556715T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2717954C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2293807T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2387334T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009115776A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2819510A1 (en) * | 2010-12-22 | 2012-06-28 | Onyx Pharmaceuticals, Inc. | Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta(g)quinazoline trisodium salt |
| US20180236098A1 (en) | 2016-08-12 | 2018-08-23 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| KR102584446B1 (ko) | 2016-08-12 | 2023-10-04 | 엘.이.에이.에프. 홀딩스 그룹 엘엘씨. | 알파 및 감마-d 폴리글루타메이트화 항엽산 및 이의 용도 |
| GB201707864D0 (en) | 2017-05-16 | 2017-06-28 | Inst Of Cancer Research: Royal Cancer Hospital | Platinum-reistant cancer treatment |
| CA3090391A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated raltitrexed and uses thereof |
| JP7491573B2 (ja) | 2018-02-07 | 2024-05-28 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化メトトレキセートおよびその使用 |
| WO2019157146A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| JP7514533B2 (ja) | 2018-02-07 | 2024-07-11 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化テトラヒドロ葉酸およびその使用 |
| EP3749317A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | PEMETREXED ALPHA-POLYGLUTAMATE AND ASSOCIATED USES |
| WO2019157129A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| US12246018B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pemetrexed and uses thereof |
| US12246019B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| CA3090384A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| WO2019157133A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| US12290518B2 (en) | 2018-02-14 | 2025-05-06 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated methotrexate and uses thereof |
| US12048767B2 (en) * | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
| CA3090875A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| JP7442822B2 (ja) | 2018-02-14 | 2024-03-05 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | γポリグルタミン酸化テトラヒドロ葉酸およびその使用 |
| CA3090943A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
| WO2019169029A1 (en) * | 2018-02-28 | 2019-09-06 | Bioxiness Pharmaceuticals, Inc. | Target specific chemotherapeutic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9223352D0 (en) | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
| GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
| ES2373644T3 (es) * | 2001-08-31 | 2012-02-07 | Btg International Limited | Uso de derivados de ciclopenta[g]quinazolina para el tratamiento del c�?ncer. |
| KR100983962B1 (ko) * | 2001-08-31 | 2010-09-27 | 비티지 인터내셔널 리미티드 | 항암제로서 사용되는 시클로펜타[ｇ]퀴나졸린 화합물 |
| AU2003216445A1 (en) * | 2002-02-27 | 2003-09-09 | The Medical College Of Ohio | Therapeutic methods for acute myeloid leukemia |
-
2009
- 2009-03-13 AT AT09721455T patent/ATE556715T1/de active
- 2009-03-13 JP JP2011500282A patent/JP5599773B2/ja active Active
- 2009-03-13 KR KR1020107023279A patent/KR101616022B1/ko active Active
- 2009-03-13 EP EP09721455A patent/EP2293807B1/en active Active
- 2009-03-13 WO PCT/GB2009/000687 patent/WO2009115776A1/en not_active Ceased
- 2009-03-13 ES ES09721455T patent/ES2387334T3/es active Active
- 2009-03-13 US US12/735,743 patent/US8466111B2/en active Active
- 2009-03-13 CA CA2717954A patent/CA2717954C/en active Active
- 2009-03-13 DK DK09721455.5T patent/DK2293807T3/da active
- 2009-03-13 CN CN200980110610.4A patent/CN101977620B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009115776A1 (en) | 2009-09-24 |
| US20110190211A1 (en) | 2011-08-04 |
| EP2293807B1 (en) | 2012-05-09 |
| CN101977620B (zh) | 2014-05-07 |
| CA2717954A1 (en) | 2009-09-24 |
| KR20110002848A (ko) | 2011-01-10 |
| US8466111B2 (en) | 2013-06-18 |
| JP2011515384A (ja) | 2011-05-19 |
| ATE556715T1 (de) | 2012-05-15 |
| CN101977620A (zh) | 2011-02-16 |
| JP5599773B2 (ja) | 2014-10-01 |
| HK1154786A1 (en) | 2012-05-04 |
| CA2717954C (en) | 2019-06-04 |
| KR101616022B1 (ko) | 2016-04-28 |
| ES2387334T3 (es) | 2012-09-20 |
| EP2293807A1 (en) | 2011-03-16 |
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