DK2293807T3 - Cyclopenta[g]quinazolin-derivater til behandling af rheumatoid arthritis eller akut myeloid leukæmi - Google Patents

Cyclopenta[g]quinazolin-derivater til behandling af rheumatoid arthritis eller akut myeloid leukæmi

Info

Publication number
DK2293807T3
DK2293807T3 DK09721455.5T DK09721455T DK2293807T3 DK 2293807 T3 DK2293807 T3 DK 2293807T3 DK 09721455 T DK09721455 T DK 09721455T DK 2293807 T3 DK2293807 T3 DK 2293807T3
Authority
DK
Denmark
Prior art keywords
cyclopenta
treatment
rheumatoid arthritis
acute myeloid
alkyl
Prior art date
Application number
DK09721455.5T
Other languages
English (en)
Inventor
Gerrit Jansen
Ann Jackman
Original Assignee
Btg Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0805036A external-priority patent/GB0805036D0/en
Priority claimed from GB0805035A external-priority patent/GB0805035D0/en
Application filed by Btg Int Ltd filed Critical Btg Int Ltd
Application granted granted Critical
Publication of DK2293807T3 publication Critical patent/DK2293807T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK09721455.5T 2008-03-18 2009-03-13 Cyclopenta[g]quinazolin-derivater til behandling af rheumatoid arthritis eller akut myeloid leukæmi DK2293807T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0805036A GB0805036D0 (en) 2008-03-18 2008-03-18 New use of cyclopenta[g]quinazoline derivatives
GB0805035A GB0805035D0 (en) 2008-03-18 2008-03-18 Us eof cyclopenta[G]quinazoline derivatives
PCT/GB2009/000687 WO2009115776A1 (en) 2008-03-18 2009-03-13 Cyclopenta[g]quinazoline derivatives for the treatment of rheumatoid arthritis or acute myeloid leukaemia

Publications (1)

Publication Number Publication Date
DK2293807T3 true DK2293807T3 (da) 2012-07-23

Family

ID=40599662

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09721455.5T DK2293807T3 (da) 2008-03-18 2009-03-13 Cyclopenta[g]quinazolin-derivater til behandling af rheumatoid arthritis eller akut myeloid leukæmi

Country Status (11)

Country Link
US (1) US8466111B2 (da)
EP (1) EP2293807B1 (da)
JP (1) JP5599773B2 (da)
KR (1) KR101616022B1 (da)
CN (1) CN101977620B (da)
AT (1) ATE556715T1 (da)
CA (1) CA2717954C (da)
DK (1) DK2293807T3 (da)
ES (1) ES2387334T3 (da)
HK (1) HK1154786A1 (da)
WO (1) WO2009115776A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2819510A1 (en) * 2010-12-22 2012-06-28 Onyx Pharmaceuticals, Inc. Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta(g)quinazoline trisodium salt
US11344628B2 (en) 2016-08-12 2022-05-31 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
GB201707864D0 (en) 2017-05-16 2017-06-28 Inst Of Cancer Research: Royal Cancer Hospital Platinum-reistant cancer treatment
US12076402B2 (en) 2018-02-07 2024-09-03 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
EP3749316A4 (en) 2018-02-07 2021-10-27 L.E.A.F Holdings Group LLC PRALATREXATE ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
JP7491572B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化ペメトレキセドおよびその使用
EP3755335A4 (en) 2018-02-14 2022-06-22 L.E.A.F Holdings Group LLC GAMMA POLYGLUTAMIC TETRAHYDROFOLATES AND THEIR USES
US11771700B2 (en) 2018-02-14 2023-10-03 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
EP3752156A4 (en) * 2018-02-14 2021-10-27 L.E.A.F Holdings Group LLC PRALATREXATE GAMMA-POLYGLUTAMATE AND ASSOCIATED USES
WO2019169029A1 (en) * 2018-02-28 2019-09-06 Bioxiness Pharmaceuticals, Inc. Target specific chemotherapeutic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9223352D0 (en) 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
EP1420809B1 (en) * 2001-08-31 2011-09-28 BTG International Limited Use of cyclopenta[g]quinazoline derivatives for treating cancer
WO2003020748A1 (en) * 2001-08-31 2003-03-13 Btg International Limited Anti-cancer cyclopenta[g]quinazoline compounds
CA2503094A1 (en) * 2002-02-27 2003-09-04 The Ohio State University Research Foundation Therapeutic methods for acute myeloid leukemia

Also Published As

Publication number Publication date
HK1154786A1 (en) 2012-05-04
ATE556715T1 (de) 2012-05-15
CA2717954C (en) 2019-06-04
JP5599773B2 (ja) 2014-10-01
US8466111B2 (en) 2013-06-18
EP2293807A1 (en) 2011-03-16
CA2717954A1 (en) 2009-09-24
US20110190211A1 (en) 2011-08-04
CN101977620A (zh) 2011-02-16
ES2387334T3 (es) 2012-09-20
KR20110002848A (ko) 2011-01-10
WO2009115776A1 (en) 2009-09-24
JP2011515384A (ja) 2011-05-19
CN101977620B (zh) 2014-05-07
KR101616022B1 (ko) 2016-04-28
EP2293807B1 (en) 2012-05-09

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