JP2011514337A - 糖ガラス化ウィルス様粒子（ｖｌｐ） - Google Patents
糖ガラス化ウィルス様粒子（ｖｌｐ） Download PDFInfo
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- JP2011514337A JP2011514337A JP2010547860A JP2010547860A JP2011514337A JP 2011514337 A JP2011514337 A JP 2011514337A JP 2010547860 A JP2010547860 A JP 2010547860A JP 2010547860 A JP2010547860 A JP 2010547860A JP 2011514337 A JP2011514337 A JP 2011514337A
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- sugar glass
- sugar
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16023—Virus like particles [VLP]
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3124308P | 2008-02-25 | 2008-02-25 | |
| PCT/US2009/035122 WO2009108689A1 (en) | 2008-02-25 | 2009-02-25 | Sugar glassified virus like particles (vlps) |
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| JP2011514337A true JP2011514337A (ja) | 2011-05-06 |
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| EP (1) | EP2254554A1 (enExample) |
| JP (1) | JP2011514337A (enExample) |
| CN (1) | CN102014873A (enExample) |
| BR (1) | BRPI0908861A2 (enExample) |
| CA (1) | CA2716546A1 (enExample) |
| MX (1) | MX2010009351A (enExample) |
| RU (1) | RU2010139478A (enExample) |
| WO (1) | WO2009108689A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017502962A (ja) * | 2013-12-31 | 2017-01-26 | インフェクシャス ディズィーズ リサーチ インスティチュート | 単一バイアルのワクチン製剤 |
| JP2017507165A (ja) * | 2013-12-16 | 2017-03-16 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| WO2025058011A1 (ja) * | 2023-09-13 | 2025-03-20 | 国立大学法人大阪大学 | 経鼻投与用組成物 |
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| PL3067064T3 (pl) | 2008-12-09 | 2020-11-02 | Novavax, Inc. | Zmodyfikowane białka f rsv i sposoby ich wykorzystania |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| US20130028933A1 (en) * | 2009-12-28 | 2013-01-31 | Ligocyte Pharmaceuticals, Inc. | Methods for stabilizing influenza antigen enveloped virus-based virus-like particle solutions |
| GB201002419D0 (en) * | 2010-02-12 | 2010-03-31 | Isis Innovation | Stable live vaccine formulations |
| EA201390810A1 (ru) | 2010-12-02 | 2013-09-30 | Онколитикс Байотек Инк. | Жидкие вирусные составы |
| ES2630012T3 (es) * | 2010-12-02 | 2017-08-17 | Oncolytics Biotech Inc. | Formulaciones virales liofilizadas |
| WO2012177970A1 (en) | 2011-06-24 | 2012-12-27 | Merck Sharp & Dohme Corp. | Hpv vaccine formulations comprising aluminum adjuvant and methods of producing same |
| CA2849471A1 (en) * | 2011-09-30 | 2013-04-04 | Novavax, Inc. | Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus |
| US20130089638A1 (en) * | 2011-10-11 | 2013-04-11 | Mead Johnson Nutrition Company | Compositions Comprising Maltotriose And Methods Of Using Same To Inhibit Damage Caused By Dehydration Processes |
| CN105579059B (zh) | 2013-09-03 | 2020-07-31 | 佐治亚科技研究公司 | 热稳定的疫苗配制物、工艺和包含疫苗配制物的微针 |
| MX2016007786A (es) | 2013-12-16 | 2017-03-03 | Massachusetts Inst Technology | Formulaciones de sal de micronutrientes fortificadas. |
| US11273127B2 (en) | 2014-05-06 | 2022-03-15 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for thermally stable multi-targeted antigens |
| WO2015171810A1 (en) * | 2014-05-06 | 2015-11-12 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for thermally stable human papillomavirus formulations |
| US10426829B2 (en) | 2015-09-03 | 2019-10-01 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
| KR20180041237A (ko) * | 2015-09-04 | 2018-04-23 | 인벤트프라이즈 엘엘씨 | Vlp 안정화된 백신 조성물 |
| ES3028362T3 (en) | 2017-07-24 | 2025-06-19 | Novavax Inc | Methods and compositions for treating respiratory disease |
| CA3092984A1 (en) | 2018-03-19 | 2019-09-26 | Novavax, Inc. | Multivalent influenza nanoparticle vaccines |
| CN114340665A (zh) * | 2019-05-25 | 2022-04-12 | 传染病研究所 | 用于对佐剂疫苗乳剂进行喷雾干燥的组合物和方法 |
| CN115835856A (zh) | 2020-05-13 | 2023-03-21 | 麻省理工学院 | 聚合物微装置的组合物以及其在癌症免疫疗法中的用途 |
| CN115350281A (zh) * | 2022-09-20 | 2022-11-18 | 华派生物工程集团有限公司 | 一种病毒样颗粒疫苗冻干保护剂及其制备方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002504090A (ja) * | 1997-03-18 | 2002-02-05 | クアドラント ホールディングス ケンブリッジ リミテッド | 液体調合物における安定な粒子 |
| WO2006017246A2 (en) * | 2004-07-12 | 2006-02-16 | Sd Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| JP2006518761A (ja) * | 2003-02-24 | 2006-08-17 | ファーマシューティカル プロダクションズ， インコーポレイテッド | 経粘膜薬物送達システム |
| WO2006085082A1 (en) * | 2005-02-09 | 2006-08-17 | Stabilitech Ltd. | A desiccated product |
| WO2006088336A1 (en) * | 2005-02-21 | 2006-08-24 | Lg Life Sciences, Ltd. | Sustained release composition of protein drug |
| JP2007535514A (ja) * | 2004-04-30 | 2007-12-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乾燥方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
-
2009
- 2009-02-25 CA CA2716546A patent/CA2716546A1/en not_active Abandoned
- 2009-02-25 MX MX2010009351A patent/MX2010009351A/es unknown
- 2009-02-25 RU RU2010139478/15A patent/RU2010139478A/ru not_active Application Discontinuation
- 2009-02-25 JP JP2010547860A patent/JP2011514337A/ja active Pending
- 2009-02-25 BR BRPI0908861A patent/BRPI0908861A2/pt not_active IP Right Cessation
- 2009-02-25 EP EP09713904A patent/EP2254554A1/en not_active Withdrawn
- 2009-02-25 CN CN2009801146099A patent/CN102014873A/zh active Pending
- 2009-02-25 WO PCT/US2009/035122 patent/WO2009108689A1/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002504090A (ja) * | 1997-03-18 | 2002-02-05 | クアドラント ホールディングス ケンブリッジ リミテッド | 液体調合物における安定な粒子 |
| JP2006518761A (ja) * | 2003-02-24 | 2006-08-17 | ファーマシューティカル プロダクションズ， インコーポレイテッド | 経粘膜薬物送達システム |
| JP2007535514A (ja) * | 2004-04-30 | 2007-12-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乾燥方法 |
| WO2006017246A2 (en) * | 2004-07-12 | 2006-02-16 | Sd Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| WO2006085082A1 (en) * | 2005-02-09 | 2006-08-17 | Stabilitech Ltd. | A desiccated product |
| WO2006088336A1 (en) * | 2005-02-21 | 2006-08-24 | Lg Life Sciences, Ltd. | Sustained release composition of protein drug |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017507165A (ja) * | 2013-12-16 | 2017-03-16 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| US10300136B2 (en) | 2013-12-16 | 2019-05-28 | Massachusetts Institute Of Technology | Micromolded or 3-D printed pulsatile release vaccine formulations |
| JP2020055818A (ja) * | 2013-12-16 | 2020-04-09 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| US10960073B2 (en) | 2013-12-16 | 2021-03-30 | Tokitae Llc | Micromolded or 3-D printed pulsatile release vaccine formulations |
| JP2021120413A (ja) * | 2013-12-16 | 2021-08-19 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2023075311A (ja) * | 2013-12-16 | 2023-05-30 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| US11975069B2 (en) | 2013-12-16 | 2024-05-07 | Massachusetts Institute Of Technology | Micromolded or 3-D printed pulsatile release vaccine formulations |
| JP2017502962A (ja) * | 2013-12-31 | 2017-01-26 | インフェクシャス ディズィーズ リサーチ インスティチュート | 単一バイアルのワクチン製剤 |
| WO2025058011A1 (ja) * | 2023-09-13 | 2025-03-20 | 国立大学法人大阪大学 | 経鼻投与用組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102014873A (zh) | 2011-04-13 |
| EP2254554A1 (en) | 2010-12-01 |
| BRPI0908861A2 (pt) | 2018-02-06 |
| CA2716546A1 (en) | 2009-09-03 |
| RU2010139478A (ru) | 2012-05-20 |
| MX2010009351A (es) | 2011-03-04 |
| WO2009108689A1 (en) | 2009-09-03 |
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