BR112018004400A2 - composições de vacina vlp estabilizadas - Google Patents
composições de vacina vlp estabilizadasInfo
- Publication number
- BR112018004400A2 BR112018004400A2 BR112018004400A BR112018004400A BR112018004400A2 BR 112018004400 A2 BR112018004400 A2 BR 112018004400A2 BR 112018004400 A BR112018004400 A BR 112018004400A BR 112018004400 A BR112018004400 A BR 112018004400A BR 112018004400 A2 BR112018004400 A2 BR 112018004400A2
- Authority
- BR
- Brazil
- Prior art keywords
- vaccines
- vaccine compositions
- vlp vaccine
- vaccine
- directed
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10123—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10141—Use of virus, viral particle or viral elements as a vector
- C12N2730/10142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
a invenção é dirigida a composições e métodos para a estabilização de vacinas virais e bacterianas. as vacinas da invenção estão contidas em vlps com agentes estabilizadores, tais como, por exemplo, álcoois de açúcar (por exemplo, sorbitol) e gelatinas degradadas. de preferência, a gelatina tem um peso molecular médio de 10 000 quilodaltons ou menos. estas vacinas têm uma termoestabilidade substancialmente melhorada, bem como a estabilidade a longo prazo. a invenção também é dirigida a fabricação de uma vacina ou a invenção e métodos para a administração de uma vacina da invenção a pacientes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562214526P | 2015-09-04 | 2015-09-04 | |
PCT/US2016/050375 WO2017041083A1 (en) | 2015-09-04 | 2016-09-06 | Vlp stabilized vaccine compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018004400A2 true BR112018004400A2 (pt) | 2018-12-04 |
Family
ID=58188631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018004400A BR112018004400A2 (pt) | 2015-09-04 | 2016-09-06 | composições de vacina vlp estabilizadas |
Country Status (8)
Country | Link |
---|---|
US (3) | US10758606B2 (pt) |
EP (1) | EP3344293A4 (pt) |
KR (2) | KR20180041237A (pt) |
CN (1) | CN108472357A (pt) |
BR (1) | BR112018004400A2 (pt) |
PH (1) | PH12018500458A1 (pt) |
WO (1) | WO2017041083A1 (pt) |
ZA (1) | ZA201801496B (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3087188A1 (en) | 2013-12-23 | 2016-11-02 | Theravectys | Lyophilized lentiviral vector particles, compositions and methods |
CN108025053A (zh) * | 2015-04-16 | 2018-05-11 | 创赏有限公司 | 百日咳杆菌免疫原性的疫苗组合物 |
MY177587A (en) | 2015-09-10 | 2020-09-22 | Inventprise Llc | Multivalent vlp conjugates |
EP4282955A1 (en) * | 2021-01-19 | 2023-11-29 | Nitta Gelatin Inc. | Virus stabilizer, gelatin hydrolysate for virus stabilizer, and virus-containing composition |
CN114569717B (zh) * | 2022-03-05 | 2023-11-14 | 广西博生生物科技有限公司 | 一种抗hpv病毒的卵黄免疫球蛋白凝胶及其制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL183781B1 (pl) * | 1994-05-16 | 2002-07-31 | Merck & Co Inc | Sposób wytwarzania szczepionki przeciwko ludzkiemu wirusowi brodawczaków |
US6290967B1 (en) * | 1996-12-20 | 2001-09-18 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
CU22871A1 (es) | 1998-12-02 | 2003-10-21 | Ct Ingenieria Genetica Biotech | Formulaciones conteniendo partículas semejantes a virus como inmunopotenciadores por vía mucosal |
EP1135408B1 (en) * | 1998-12-04 | 2011-09-21 | Biogen Idec MA Inc. | Hbv core antigen particles with multiple immunogenic components attached via peptide ligands |
US6992172B1 (en) * | 1999-11-12 | 2006-01-31 | Fibrogen, Inc. | Recombinant gelatins |
DE60211889T2 (de) | 2001-04-23 | 2007-06-14 | Yokowo Co., Ltd. | Breitbandantenne für die drahtlose kommunikation |
ES2280809T3 (es) * | 2002-11-01 | 2007-09-16 | Glaxosmithkline Biologicals S.A. | Composicion inmunogenica. |
JP5135220B2 (ja) * | 2005-09-01 | 2013-02-06 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 血清群c髄膜炎菌を含む複数ワクチン接種 |
US20070184068A1 (en) | 2005-12-14 | 2007-08-09 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
CN102014873A (zh) * | 2008-02-25 | 2011-04-13 | 诺瓦瓦克斯股份有限公司 | 糖玻璃化的病毒样颗粒 |
BRPI0915076A2 (pt) * | 2008-06-09 | 2017-03-14 | Bharat Biotech Int Ltd | composições de vacina, composição imunogênica, método para expressão dos antígenos quiméricos de hpv-hbsag supramencionados, composição farmacêutica, método para ocasionar resposta de anticorpo protetor para composição antigênica e/ou resposta de célula t citotóxica, uso das formulações antigênicas supramencionadas. |
US20110243988A1 (en) * | 2009-10-01 | 2011-10-06 | Aridis Pharmaceuticals | Methods and Compositions for Stabilization of a Virus Vaccine |
WO2011079260A2 (en) * | 2009-12-23 | 2011-06-30 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Stabilized virus like particles having enhanced mucosal immunogenicity |
WO2012023033A2 (en) | 2010-08-18 | 2012-02-23 | Purdue Pharma L.P. | Improved peptide immunogens |
EP3057612B1 (en) * | 2013-10-16 | 2020-05-06 | Merck Sharp & Dohme Corp. | Method of obtaining thermostable dried vaccine formulations |
WO2016022916A2 (en) | 2014-08-08 | 2016-02-11 | U.S. Army Medical Research Institute Of Infectious Diseases Department Of The Army | Thermostable, chromatographically purified nano-vlp vaccine |
CN104312986A (zh) * | 2014-10-17 | 2015-01-28 | 中国人民解放军第四军医大学 | 嵌合hcv中和表位的hbv s抗原病毒样颗粒及其制备方法和应用 |
-
2016
- 2016-09-06 EP EP16843179.9A patent/EP3344293A4/en active Pending
- 2016-09-06 WO PCT/US2016/050375 patent/WO2017041083A1/en active Application Filing
- 2016-09-06 US US15/257,143 patent/US10758606B2/en active Active
- 2016-09-06 KR KR1020187008780A patent/KR20180041237A/ko active Application Filing
- 2016-09-06 KR KR1020197038405A patent/KR20200000497A/ko not_active Application Discontinuation
- 2016-09-06 CN CN201680062799.4A patent/CN108472357A/zh active Pending
- 2016-09-06 BR BR112018004400A patent/BR112018004400A2/pt active Search and Examination
-
2018
- 2018-03-02 PH PH12018500458A patent/PH12018500458A1/en unknown
- 2018-03-05 ZA ZA2018/01496A patent/ZA201801496B/en unknown
-
2020
- 2020-08-09 US US16/988,659 patent/US11878054B2/en active Active
-
2024
- 2024-01-15 US US18/412,674 patent/US20240148852A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20170065704A1 (en) | 2017-03-09 |
KR20180041237A (ko) | 2018-04-23 |
ZA201801496B (en) | 2019-01-30 |
US20210069318A1 (en) | 2021-03-11 |
KR20200000497A (ko) | 2020-01-02 |
EP3344293A4 (en) | 2019-01-16 |
US11878054B2 (en) | 2024-01-23 |
US20240148852A1 (en) | 2024-05-09 |
US10758606B2 (en) | 2020-09-01 |
WO2017041083A1 (en) | 2017-03-09 |
CN108472357A (zh) | 2018-08-31 |
EP3344293A1 (en) | 2018-07-11 |
PH12018500458A1 (en) | 2018-09-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B25D | Requested change of name of applicant approved |
Owner name: INVENTPRISE, INC. (US) |